SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2019
·
IF 2.931
Lulu Guo,Yonghai Song,Keying Cai,Li Wang
Covalent-organic frameworks (COFs) are new porous crystalline materials owning outstanding stability, adsorbability and hypotoxicity. The assembly of fluorescence probes into porous COF provides a good method for ratiometric fluorescence detection avoiding the toxic effects of fluorescence probes to the samples. Herein, a two-dimensional COF (TAPT-DHTA-COF) was employed as a host to encapsulate N-doped carbon dots (NCDs) and Rhodamine B (RhB) (NCDs-RhB@COF). NCDs and RhB were uniformly assembled into the pores of TAPT-DHTA- COF based on the hydrogen bond . The as-prepared NCDs-RhB@COF nanocomposites exhibited blue emission of NCDs at 440 nm and red emission of RhB at 570 nm at excitation of 340 nm. After the addition of Hg 2+ , the blue emission became weaker while the red emission was enhanced due to the strong coordination between NCDs-RhB@COF and Hg 2+ . This “on-off” fluorescence probe was applied in detection of trace Hg 2+ with linear range of 0.048–10 μM and detection limit of 15.9 nM together with appropriate selectivity, acceptable sensitivity and stability. The work shreds some light for COF as platform to construct ratiometric fluorescent sensor for industrial and biological application.
研究领域:
材料科学
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分析化学
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环境科学
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生物技术
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DOI
PubMed
高影响因子
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
·
2022
·Vol. 194
·期 7
·3044-3065
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IF 3.094
Qiu Ren,Dai Jianmin,Meng Lingqiang,Gao Hongmin,Wu Mengdie,Qi Feifan,Feng Jing,Pan Hongzhi
Porous carbon sphere materials have a large variety of applications in several fields due to the large surface area, adaptable porosity, and good conductivity they possess. Obtaining a steady carbon sphere using the green synthesis method remains a significant challenge. In this experiment, covalent organic frameworks (COFs) were used as a precursor and Fe 3 O 4 NPs were integrated into the precursor in order to synthesize a porous carbon sphere material using the one-step pyrolysis method. COFs have an ordered porous structure, perpetual porosity, large surface area, and low density and display good environmental tolerance. These properties make them an excellent precursor for synthesizing porous carbon sphere, which maintains good morphology at high temperatures, and it is not involved in the removal of dangerous reagent and small size restrictions during the synthesis process. In addition to the formation of a porous carbon sphere, transition metal carbon material that contains N element can be an active catalyst. The composites exhibit better activity when Fe is doped into carbon materials containing N element than that of other doped transition metals including Mn and Co. In this situation, the integration of Fe 3 O 4 NPs and N element in the COF precursor exposed the active sites of the composites and the two substances synergistically improved the electrocatalytic properties, and the composites were named Fe 3 O 4 @NPCS. The constructed Fe 3 O 4 @NPCS/GCE immunosensor was applied as a means of detecting CA19-9 antigen and presented a wide linear range from 0.00001 to 10 U/mL with a low detection limit of 2.429 μU/mL (S/N = 3). In addition, the prepared immunosensor was utilized for detecting CA19-9 antigen in the real human serum, and the recovery rates were in the range from 95.24% to 106.38%. Therefore, a porous carbon sphere prepared by COFs as a precursor can be applied for the detection of CA19-9 antigen in real samples, which could be an excellent strategy for CA19-9 antigen detection and could potentially promote the development of COF materials in various electrochemical fields.
研究领域:
分析化学
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材料科学
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生物传感器
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癌症诊断
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产品关联
DOI
PubMed
高影响因子
TALANTA
·
2024
·
IF 5.6
Xueyun Wei,Zhuomin Zhang,Gongke Li
Aromatic disinfection by-products (DBPs) have garnered considerable interest in recent years for their potential carcinogenicity. However, efficient separation and enrichment of DBPs in complex samples is a challenge due to the extremely low content of aromatic DBPs and the complexity of sample matrices. In this study, a MIL-101(Cr)–NH 2 @TAPB-DVA-COF hybrid material was prepared as the enrichment medium of membrane solid-phase extraction (M-SPE) to efficiently determine trace emerging aromatic DBPs. This medium exhibited excellent enrichment capacity and selectivity for aromatic DBPs because of the strong hydrogen bonding, π-π stacking and hydrophobic interactions. An efficient analytical method for five aromatic DBPs in juice drinks was successfully established by use of this hybrid material as the enrichment medium for M-SPE in combination with liquid chromatography tandem mass spectrometry (LC-MS/MS). The limits of detection of the established method were from 0.50 to 3.00 ng/L. Moreover, the method had been successfully used in real juice drinks to determine trace five aromatic DBPs with the spiked recoveries ranging from 84.1% to 125%. The method possessed high analytical sensitivity and accuracy for these five aromatic DBPs in juice drinks with the aid of the efficient M-SPE technology proposed.
研究领域:
分析化学
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环境科学
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食品科学
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产品关联
DOI
PubMed
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2022
·Vol. 414
·期 28
·8071-8079
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IF 4.478
Wei Wei,Lu Zenghui,Wu Ting,Wang Haibo,Han Qiang,Liang Qionglin
In this study, a covalent organic framework (COF)-TpBD-supported melamine sponge (MS) was fabricated through a one-step hydrothermal method. The obtained monolithic column was then applied in in-syringe solid-phase extraction (IS-SPE) for the separation of three volatile ingredients from serum samples. Given credit for the superior adsorption capacity of the COF and the homogeneous microporous property of MS, the developed column exhibited satisfactory separation of the targets. And the dominating adsorption mechanism was the hydrophobic interaction forces between TpBD and targets and the high mass transfer efficiency provided by the large pore structure of MS. The results of dynamic adsorption showed that the MS@TpBD column displayed much better adsorption performance than blank MS and TpBD. And it has featured great reusability up to 5 cycles and obtained satisfied recovery values (87.9 ~ 110.3%) in serum samples. As a result of sample clean-up, this column offers low limit of detections (LODs) down to 0.014, 0.010, and 0.020 μg/mL, respectively. In summary, we believe that this convenient separation column has prominent application promise in the fields of separating activity ingredients in biological samples.
研究领域:
分析化学
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药学
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材料科学
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DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2024
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IF 8.3
Qiaomu Wang,Peng Wang,Yandong Wang,Yang Xu,Haocheng Xu,Kai Xi
Covalent organic framework (COF) aerogels with functional groups offer exceptional processability and functionality for various applications. These hierarchical porous materials combine the advantages of COFs with the benefits of aerogels, overcoming the limitations of conventional insoluble and nonfusible COF powders. However, achieving both high crystallinity and shape retention remains a challenge for functionalized COF aerogels. In this work, we develop a novel and general solvent substitution method for the one-step synthesis of formyl-functionalized COF aerogels without harsh vacuum conditions. These aerogels exhibit excellent processing capabilities, superior mechanical strength, and enhanced functionality. As a proof-of-concept, they were used in adsorption and lithium metal battery applications, significantly maximizing the structural advantages of COFs, e.g.: (i) the hierarchical porous structure is fully wetted by the electrolyte to form continuous transport channels; (ii) the polar groups, which are easier to be acquired, help in desolvation and transfer of Li+; (iii) the regular pore structures stabilize deposition of Li+ and inhibit the growth of lithium dendrites. These combined benefits contribute to a lighter battery with improved energy density and enhanced safety.
研究领域:
材料科学
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能源存储
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电化学
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纳米技术
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产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2022
·
IF 9.136
Yuchen Li,Zhen Chen,Guoxiong Zhan,Bingling Yuan,Lidong Wang,Junhua Li
Catalytic amine-based solvent regeneration with solid acid is a feasible option for reducing energy consumption of CO 2 capture, but facing crucial challenges on designing material structures and understanding reaction mechanisms. Herein, we cover the nanoscale NiFe 2 O 4 cluster with covalent organic frameworks (COFs), to prepare solid acid catalysts. The pristine chemical bonds of Ni(Fe)-O and Ni(Fe)-Ni(Fe) are substituted by Ni(Fe)-N and Ni(Fe)-N-Ni(Fe) by targeting the anchoring of NiFe 2 O 4 cluster over COFs. The created coordination state stimulates the production of Brønsted acid sites. The obtained nanomaterials achieve a considerable improvement in CO 2 desorption of up to 290.1 mmol/(min·g) at 88 °C for spent monoethanolamine (MEA) solvent, representing a substantial increase of 540% relative to traditional thermal desorption. Consequently, the energy consumption of MEA generation is reduced by approximately 58%. Intermediate species (HCO 3− , CO 3 2− , and RNHCOO − ) and reaction pathways are established by combining operando Raman spectroscopy and ex situ 13 C NMR spectrum measurements. Theoretical calculations are performed to clarify the transformation mechanism of the acid sites around Ni/Fe atoms and its intrinsic role in the adsorption equilibrium of solvent regeneration.
研究领域:
环境科学
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化学工程
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材料科学
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DOI
高影响因子
Advanced Composites and Hybrid Materials
·
2025
·Vol. 8
·期 6
·450
·
IF 21.8
Guo Yunfeng,Liu Jiayu,Zhao Cunshi,Fan Wuming,Zhao Linlin,Xiao Zefang,Xie Yanjun,Wang Dong,Wang Yonggui
The design of wettable membranes with tailored micro- and nanostructures for the efficient separation of oily wastewater remains a challenge. Herein, a cellulose acetate nanofiber/covalent organic framework (ETCNF/COF) composite membrane was fabricated, featuring vertically aligned COF nanorods, achieved via an electrospinning-assisted, amino-mediated in situ confined growth method. Utilizing this vertically arranged COF micro/nano rough structure, the superhydrophobic ETCNF/COF-ODM membrane and superhydrophilic ETCNF/COF-CHA membrane was constructed using thiol-ene click chemical grafting of octadecylthiol (ODM) and cysteamine hydrochloride (CHA) methods, respectively. As a result, the ETCNF/COF-ODM membrane exhibited excellent superhydrophobicity (contact angle > 150°) and self-cleaning properties, enabling the efficient separation of water-in-oil emulsions with a separation efficiency exceeding 99%. In contrast, the ETCNF/COF-CHA membrane exhibited outstanding superhydrophilicity (contact angle approaching 0°) and underwater superoleophobicity (underwater oil contact angle > 150°), achieving high-efficiency separation of oil-in-water emulsions with a separation efficiency above 99%. The superior superwetting performance of both membranes is attributed to the synergistic construction of hierarchical porous superwetting interfaces by the COF and the electrospun substrates. In conclusion, the in situ domain-limited growth of vertically aligned COF nanorods for superwetting membranes by electrostatically spun membranes provides an effective strategy for advancing the development of oil-water separation technology.
研究领域:
材料科学
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环境工程
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膜技术
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纳米技术
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分离科学
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产品关联
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2022
·
IF 4.326
Mingyue Zhang,Jianguo Liu,Bo Yang,Longlong Ma,Nan Wang,Xiuzhi Wei
The development of transition-metal heterogeneous catalysts for economical and effective synthesis of N-methylamine, especially for the monomethylation of amines, is still challenging. Herein, two Rh-supported covalent organic framework (COF) heterogeneous catalysts Rh/MelCOF were facile-synthesized by a Schiff base reaction using melamine as a precursor, and, for the first time, it was successfully applied to the effective and high selective tandem reaction of transfer hydrogenation and monomethylation of nitroaromatic hydrocarbons, with methanol as a C1 and hydrogenation source. A series of nitroaromatic hydrocarbons, including heterocyclic or sterically hindered derivatives, can be well tolerated, and the catalyst could also be reused four times without losing significant reactivity. At the same time, the study of the Rh/MelCOF mechanism supports the hydrogen-borrowing mechanism and puts forward the reaction pathway of azobenzene as an intermediate, which is better than the hydrogen-transfer pathway from N-phenylhydroxylamine to aniline directly. This work expands the application of COF catalysts and provides an effective way to obtain mono-N-methylated amines from nitroaromatic hydrocarbons, as well as the detailed mechanism of Rh/COF-catalyzed tandem transfer hydrogenation and monomethylation of amines.
研究领域:
催化
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有机化学
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材料科学
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产品关联
DOI
高影响因子
Analytical Methods
·
2024
·
IF 2.7
Dongping Rao,Luyan Meng,Xiuqin Sheng,Wenying Yu,Chuan-Fan Ding,Yinghua Yan
A hybrid material, M@C-Br@GMA@Glu, consisting of a porphyrin-based metal–organic framework-covalent organic framework (MOF@COF), has been meticulously synthesized using a post-synthetic modification approach. This advanced material has demonstrated exceptional effectiveness in glycopeptide enrichment, characterized by an impressively low detection limit (0.2 fmol μL−1), high selectivity (1 : 2000), and loading capacity for glycopeptides (100 mg g−1). In practical applications with complex biological samples, 210 glycopeptides associated with 87 glycoproteins from the serum of the healthy group, and 156 glycopeptides related to 85 glycoproteins from the serum of cervical cancer were identified after enrichment with M@C-Br@GMA@Glu. Subsequent genetic ontology analysis has elucidated the relationship between cervical cancer and glycosylation, focusing on biological processes such as complement activation, innate immune response mechanisms, and the structural dynamics of the extracellular matrix. The collective findings not only validate the material's proficiency in the sensitive and selective enrichment of glycopeptides, but also underscore its potential in biomarker discovery applications.
研究领域:
材料科学
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分析化学
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生物化学
·
癌症研究
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2024
·Vol. 22
·期 1
·1-15
·
IF 10.6
Zhang Yue,Chen Shuyi,Ma Jie,Zhou Xiaobin,Sun Xinchen,Zhou Chenglin
An effective strategy for enzyme-enhanced electrochemical detection of human epidermal growth factor receptor 2 (HER2) is proposed for breast cancer diagnosis. This strategy utilizes a three-dimensional mesoporous covalent organic framework (COF), immobilized horseradish peroxidase (HRP), and a novel redox mediator, 4-acetamidophenol (APAP). The mesoporous structure, with encapsulation effect, and good biocompatibility of COF, makes the functionalized COF an efficient carrier for HRP immobilization (HRP-Ab-AuNPs@COF). It demonstrates superior catalytic activity, stability, and electrochemical performance compared to free HRP, thus making it an ideal probe for simultaneous target recognition and signal amplification. APAP is screened from four candidate phenolic compounds based on its high formal potential (0.32 V vs. Ag/AgCl), rapid electron transfer activity (k app = 2.80 × 10 5 M − 1 s − 1 ), excellent solubility and stability. These properties prove significantly better than the conventional mediator hydroquinone (HQ), achieving a higher signal-to-background ratio. By integrating decorated multi-walled carbon nanotubes as substrate materials, the electrochemical aptasensor achieves a low HER2 detection limit (0.418 pg mL − 1 ) with high specificity. This method’s selectivity surpasses that of the HQ-mediated method by 59–73%. Moreover, the aptasensor can effectively distinguish breast cancer patients and healthy individuals, as well as patients at different stages of the disease with high accuracy (AUC = 0.928). This performance exceeds traditional biomarkers CEA and CA15-3. This work paves novel avenues for innovative applications of COF-immobilized enzymes and the novel mediator APAP in electrochemical biosensing, thus holding significant promise for individualized breast cancer diagnosis and treatment.
研究领域:
生物医学工程
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癌症诊断
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电化学
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纳米技术
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生物传感器
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Xingyu Wu,Tiantian Feng,Xiaohong Zhu,Dong Dong,Qinxue Gao,Shufan Huang,Rui Huang,Dong Wang,Huayu Xiong,Zigong Wei,Yong Chen,Jichao Liang
Pharmacological treatments of diabetic ulcers remain a huge challenge due to the impaired angiogenesis and uncontrolled bacterial infection. Here, iminopyrazine-based Fe-covalent organic frameworks (Fe-COF) were synthesized via a subcomponent assembly strategy, and functionalized through covalent modification of L-arginine and encapsulated with photosensitizer IR780 and hyaluronic acid for enhancing diabetic wound healing. The functionalized Fe-COF (Fe-COF NRs) showed peroxidase-like activity and near-infrared (NIR)-controlled NO generation property, which can be used for synergistic photothermal/photodynamic antibacterial therapy and NO-based gas therapy. Treatment with Fe-COF NRs + NIR caused pathogenic elimination and enhanced angiogenesis, subsequently leading to accelerated wound healing in a rat model of infected diabetic wound. Mechanistically, the results from RNA sequencing analysis indicated that Fe-COF NRs treatment significantly induced the expression of genes involved in angiogenesis, but obviously inhibited the expression of proinflammatory cytokines. Gene Ontology enrichment and Kyoto Encyclopedia of Genes and Genomes pathway analysis revealed that collagen-containing extracellular matrix, hair follicle development, PI3K-Akt signaling pathway, wound healing and skin development were significantly enriched after Fe-COF NRs treatment. Taken together, Fe-COF NRs provide a novel therapeutic strategy for the treatment of infected diabetic wound.
研究领域:
材料科学
·
纳米技术
·
生物医学工程
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药学
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分子生物学
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基因组学
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产品关联
DOI
高影响因子
ANALYTICAL LETTERS
·
2024
·
IF 1.6
Yan Li,Yaru Li,Fubin Wu,Jie Zhou,Yaoyao Wang,Guoliang Li,Jing Lan,Zongshan Zhao,Rongguang Shi
Hydrogen peroxide (H2O2) is widely used in the food industry as a bactericide due to its strong oxidizing ability. However, excess H2O2 in food can lead to chronic diseases, making it necessary to develop a rapid monitoring method. An electrochemical electrode based upon a glassy carbon electrode (GCE) modified with combined covalent organic framework (COF) and amino-modified multi-walled carbon nanotubes (MWNT-NH2) has been developed. The modifier was prepared by assembling the COF onto the surface of MWNT-NH2. Under optimal conditions, the performance of the modified electrode was evaluated by differential pulse voltammetry (DPV) with a linear range from 20 to 140 μM and a detection limit of 0.14 μM. In addition, the modified electrode had good stability and reproducibility. Good selectivity in presence of potential interferences and the successful application for the determination H2O2 in environmental water and chicken feet suggest its potential for practical analysis.
研究领域:
分析化学
·
电化学
·
纳米材料
·
环境科学
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食品安全
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）