NANO
·
2025
·
IF 1.1
Nana Li,Alexpandi Rajaiah,Kuanjie Ma,Guochao Lu,Yucong Yu,Yurong Cai
To address the need for rapid protein desorption in protein adsorption applications, we developed and characterized polyethyleneimine-functionalized calcium carbonate nanoparticles coated with ferrosoferric oxide (PEI-Fe 3 O 4 @CaCO 3 ) . This hybrid nanostructure integrates the pH-sensitive properties of calcium carbonate with the magnetic responsiveness of Fe 3 O 4 , enabling quick separation by an external magnetic field within 1 min. In adsorption experiments with bovine serum albumin (BSA) as a model protein, PEI-Fe 3 O 4 @CaCO 3 achieved a notable adsorption capacity of 197.6 mg/g at 1 h, representing 77% of its maximum adsorption potential. Saturation was reached at 256.1 mg/g within 4 h. Importantly, the pH-responsive nature of the calcium carbonate component facilitated efficient desorption, achieving a release efficiency of 95.67% ± 2.41% within 1 min in a sodium acetate–acetic acid buffer at pH = 6.2. This pH-responsive and magnetically responsive system demonstrates significant potential for applications requiring fast, controlled protein adsorption and desorption, offering a promising tool for targeted protein recovery in various biochemical and industrial processes.
研究领域:
纳米材料
·
蛋白质纯化
·
生物分离
·
响应性材料
·
磁性纳米颗粒
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Qibin Zhu,Long Chen,Yun Da
The Calcium looping thermochemical reaction directly driven by solar energy effectively addresses the problem of efficient energy storage of concentrated solar power plants (CSP) by shortening the energy conversion path. But new requirements are put forward for energy storage materials, including high solar radiation absorption, high cycling stability and fast kinetics. To meet these challenges, we have designed porous microsphere structures for the purpose of enhancing mass transfer and the capture of solar radiation. Additionally, Zr and Mn oxides with elevated Tammann temperatures were incorporated to stabilize the morphology and prevent sintering. The synthesized porous microspheres retained abundant mesoporous channels on the surface even after undergoing 20 cycles. The addition of Mn oxide significantly enhances solar spectral absorptivity, achieving an impressive 82.88 % absorbance. The incorporation of Mn and Zr oxides increased the sintering resistance, specific surface area and porosity of CaO/CaCO 3 , especially in the 10–100 nm range, which accelerated the CO 2 transport during carbonation. These enhancements significantly improve the chemical control stage of the carbonation reaction, as further supported by kinetic models. After 50 cycle experiments at 800 °C, the energy storage density of the sample remains at 1074 kJ/kg, which is 1.86 times that of the undoped CaCO 3 . This study provides a new way to design CaCO 3 materials suitable for CSP applications.
研究领域:
材料科学
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可再生能源
·
化学工程
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DOI
高影响因子
ACS Sustainable Chemistry & Engineering
·
2026
·
IF 7.6
Gang Li,Han Hua,Qican Zhou,Yiping Su,Chenye Wang,Xuehua Shen,Zuotai Zhang
Mechanochemical carbonation (MC) of alkaline solid wastes (ASW) has emerged as a promising strategy for CO2 sequestration. However, CaCO3 polymorphs formed during carbonation exhibit distinct transformation pathways that influence both sequestration durability and downstream utilization. Here, we elucidate how inherent Mg and Si species in ASW govern CaCO3 polymorph during MC. Using steel slag (SS) and blast furnace slag (BFS) as representative ASW with distinct Si/Mg availabilities, and NaHCO3 as a carbon source, we systematically investigated polymorph evolution, carbonation kinetics, and microstructure development. During carbonation, SS initially forms calcite (31.7 wt %), which transforms into monohydrocalcite (MHC, 20.4 wt % at 12 h), whereas BFS continuously yields aragonite (30.1 wt % at 12 h). These pathways stem from distinct gel-mediated microenvironments: amorphous silica gel in SS creates localized carbonate supersaturation and hydrous conditions, which kinetically promote MHC reprecipitation; whereas magnesium silicate hydrate-like (M-S-H-like) gel in BFS provides Mg-enriched surfaces (Mg/Ca = 0.98) that facilitate aragonite nucleation. Furthermore, model experiments employing carbide slag (CS, primarily Ca(OH)2) with controlled Si/Mg additives further confirm this mechanistic relationship. These findings establish a gel-mediated mechanism for CaCO3 polymorph selection and provide a basis for rationally tuning carbonation products in complex waste-derived systems.
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高影响因子
iScience
·
2026
·Vol. 29
·期 3
·
IF 4.5
Miao Chen,Yan Wang,Yiran Niu,Xiaomin Chen,Hang Su,Liang Xia,Chunbao Liu,Junfen Zhou,Zhen Wang,Bao Li,Diyu Lu
Sonodynamic therapy (SDT) for deep-seated tumors is limited by tumor microenvironment (TME) barriers. We developed a hyaluronic acid (HA)-modified mesoporous calcium carbonate nanoplatform (HA/CaCO 3 @Ce6) to synergistically enhance calcium overload and SDT. The CD44-targeted nanoplatform demonstrated pH-responsive degradation in acidic TME, resulting in the release of Ca 2+ and chlorin e6 (Ce6). The released Ca 2+ induced mitochondrial calcium overload, causing 71% collapse in membrane potential and 1.6-fold increase in reactive oxygen species (ROS) generation, establishing a “Ca 2+ -ROS positive feedback loop.” This synergy triggered robust immunogenic cell death (ICD), enhancing CRT exposure by 94.2%, HMGB1 release by 46.2%, and ATP decrease by 74.5%. In vivo , it achieved 90.9% tumor inhibition and 80% 60-day survival rate, alleviated tumor hypoxia, and inhibited tumor proliferation and angiogenesis. This “ion-interference SDT” paradigm overcomes the limitations of SDT through self-amplified ROS cycle and provides an effective strategy for treating deep-seated solid tumor with significant clinical translation potential.
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DOI
PubMed
高影响因子
JOURNAL OF MATERIALS CHEMISTRY
·
2011
·Vol. 21
·期 40
·16028-16034
·
IF 5.101
Jun Shi,Zhengzheng Zhang,Gefei Li,Shaokui Cao
Alginate/CaCO3 hybrid beads with pH- and thermal-responsive drug release properties were prepared under compressed CO2 using aliphatic poly(urethane-amine)s (PU) as the thermal-responsive component. Polyacrylic acid (PAA) was used as a crystal growth additive to control the structure of the hybrid beads. The hybrid beads were characterized by using scanning electron microscopy, X-ray powder diffraction and thermogravimetric analysis. The interaction between PAA and aliphatic PU contributed to the formation of alginate beads with a compact CaCO3 shell. Indomethacin release behaviour was found to be pH- and thermal-responsive. The release profiles were sustained with CaCO3 microparticles, indicating that the compact CaCO3 shell could hinder the permeability of the encapsulated drug and reduce the drug release effectively. The results suggest that the hybrid alginate beads can be used as “smart” polysaccharide materials for sustained dual-responsive drug delivery.
研究领域:
生物材料
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药物递送系统
·
高分子科学
·
纳米医学
·
药剂学
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生物化学
·
组织工程
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DOI
高影响因子
MOLECULAR PHARMACEUTICS
·
2023
·
IF 4.9
Lixing Xu,Xiao Du,Yao Zhou,Xinyu Cao,Ying Shen,Hongyan Zhu,Haiqin Huang
The lack of effective oral drug delivery systems to treat gastric ulcer is an urgent challenge in clinical practice. Herein, a gastric acid pH-responsive hydrogel of curcumin/sodium alginate/polyaspartic acid@CaCO3 (Cur/SA/PC) was developed for sustained release of Cur, exerting effective protection and treatment of gastric ulcers. The in vitro gelatinization properties and the corresponding gel characteristics of the SA/PC delivery system demonstrated the successful construction of the in situ hydrogel with uniform strength. The cellular uptake illustrated the successful uptake and sustained release of Cur. Besides, Cur effectively inhibited NLRP3-mediated pyroptosis both in vitro and in vivo, exhibited an excellent pro-healing effect by regulating the PI3K/Akt signaling pathway, and alleviated acetic acid-induced chronic gastric injury in rats. Moreover, the relative bioavailability of Cur in the SA/PC hydrogel could effectively increase in the pharmacokinetic study. Importantly, the protective barrier formed by the SA/PC hydrogel could effectively protect against alcohol-induced acute gastric ulcers in rats. Overall, the designed SA/PC oral delivery system is a promising strategy to overcome gastric barriers for oral drug delivery.
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DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2022
·
IF 3.841
Tian Sang,Yan Zhong,Dian-Hui Wang,Chao-Hao Hu,Jun-Chen Ye,Wen-Yi Wang,Hao Liu
To expand the range of application of insulating calcium carbonate (CaCO 3 ), we combined CaCO 3 with narrow bandgap cadmium sulfide (CdS) with the chemical precipitation method and characterized the composite through X-ray powder diffraction, X-ray photoelectron spectroscopy, scanning electron microscopy, and transmission electron microscopy. The photocatalytic activities of composite catalysts with different molar ratios on Cr 6+ are further investigated and compared. The materials showed good photocatalytic reduction effect on Cr 6+ under visible light. At the same time, the catalysts have good catalytic performance and service life, far exceeding pure CdS. The behavior of photogenerated carriers and free radicals in photocatalytic reduction processes were explored with a trapping agent experiment, and the mechanism that enhances catalytic activity in the CaCO 3 composite catalyst was revealed. Overall, results show that CaCO 3 has great potential as a photocatalyst.
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Minjiang Chen,Xiaoju Guo,Lin Shen,Jiayi Ding,Junchao Yu,Xiaoxiao Chen,Fazong Wu,Jianfei Tu,Zhongwei Zhao,Mitsutoshi Nakajima,Jingjing Song,Gaofeng Shu,Jiansong Ji
Transarterial chemoembolization (TACE) is an important approach for the treatment of unresectable hepatocellular carcinoma (HCC). However, the lactic acid-induced acidic tumor microenvironment (TME) may reduce the therapeutic outcome of TACE. Herein, monodispersed gelatin microspheres loaded with calcium carbonate nanoparticles (CaNPs@Gel-MS) as novel embolic agents were prepared by a simplified microfluidic device. It was found that the particle size and homogeneity of as-prepared CaNPs@Gel-MS were strongly dependent on the flow rates of continuous and dispersed phases, and the inner diameter of syringe needle. The introduction of CaNPs provided the gelatin microspheres with an enhanced ability to encapsulate the chemotherapeutic drug of DOX, as well as a pH-responsive sustained drug release behavior. In vitro results revealed that CaNPs@Gel-MS could largely increase the cellular uptake and chemotoxicity of DOX by neutralizing the lactic acid in the culture medium. In addition, CaNPs@Gel-MS exhibited an excellent and persistent embolic efficiency in a rabbit renal model. Finally, we found that TACE treatment with DOX-loaded CaNPs@Gel-MS (DOX/CaNPs@Gel-MS) had a much stronger ability to inhibit tumor growth than the DOX-loaded gelatin microspheres without CaNPs (DOX@Gel-MS). Overall, CaNPs@Gel-MS could be a promising embolic microsphere that can significantly improve anti-HCC ability by reversing lactic acid-induced chemotherapy resistance during TACE treatment.
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DOI
PubMed
高影响因子
BIOCHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 3.9
Peng-Cheng Chen,Yao-Dan Zhang,Pu Zheng,Ruo-Xi Sun,Dan Wu
The efficiency of multi-enzyme immobilization is often influenced by the carrier and immobilization techniques employed. In this work, we proposed a ternary enzyme cascade reaction system composed of β-glucosidase (β-G), glucose oxidase (GOD) and horseradish peroxidase (HRP). CaCO 3 microspheres served as a template for in situ immobilization, while poly (allylamine hydrochloride) (PAH) and sodium poly (4-styrene sulfonate) (PSS) were utilized to create PAH-CaCO 3 and PSS-CaCO 3 templates for layer-by-layer multi-enzyme immobilization. The effects of template structure, glutaraldehyde (GA) addition, ethylenediaminetetraacetic acid (EDTA) concentration, and the structure of layer-by-layer assembly were systematically investigated. Our results indicated that an assembly of PSS-CaCO 3 --PAH--β-G--HRP--GOD presented simultaneous high enzyme loading and relative activity. The loadings of β-G, GOD and HRP were 75.2 ± 2.0%, 87.7 ± 4.4% and 85.5 ± 3.2%, respectively, while the relative activities were 81.8 ± 2.7%, 93.6 ± 4.7% and 90.6 ± 3.1%, respectively. Kinetic parameters confirmed that the reaction rate of the immobilized ternary enzymes in this assembly was close to that of the free enzymes. This work provides insights for constructing other multi-enzyme cascade reaction systems using immobilization techniques.
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DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2015
·
IF 2.711
Lixia Bao,Simei Yang,Xin Luo,Jingxin Lei,Qiue Cao,Jiliang Wang
The hydroxylated PVC (PVC-OH) was successfully synthesized by a suspension polymerization of vinyl chloride (VC), butyl acrylate (BA) and hydroxyethyl acrylate (HEA). Novel hydrophobic CaCO 3 was then prepared by a urethane formation reaction between methylene diphenyl diisocyanate (MDI) and the OH groups both in the PVC-OH chains and on the surface of pristine CaCO 3 particles. The effect of the PVC-OH content on the grafting ratio of treated CaCO 3 particles was extensively investigated. Combining the result of Fourier transform infrared (FTIR) with that of water contact angle, it can be concluded that the hydrophobicity of CaCO 3 had been efficiently improved by the PVC-OH segments grafted on the surface of CaCO 3 particles. X-ray diffraction (XRD), thermal gravity analysis (TGA), scanning electron microscope (SEM) and transmission electron microscope (TEM) were also used to study crystalline behaviors, thermal stability and surface morphology of the modified CaCO 3 particles, respectively. The change of specific surface area implying surface modification was investigated as well.
研究领域:
材料科学
·
化学工程
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高影响因子
RENEWABLE ENERGY
·
2023
·
IF 8.7
Azhar Abbas Khosa,Xinyue Han,C.Y. Zhao
CaCO 3 /CaO thermochemical energy storage (TCES) system has been widely studied on laboratory scale for its potential in concentrated solar power (CSP) plants. However, there is still need for the large-scale experiments based on which a detailed analysis can be obtained to improve this system for real-time applications. In this study, we developed a packed bed reactor capable of operating at high temperature and pressure providing the carbonation and decarbonation reactions of CaCO 3 /CaO reaction pair. The heat storage process is studied with the aspect of different decarbonation temperatures and different sample sizes (amount of sample in grams) placed in the reactor. Furthermore, we compared the heat storage performance of pure and composite samples. The heat release process is performed by varying the concentration of CO 2 and the sample size of the loaded material. The results showed that the heat storage rate and efficiency improve by increasing the temperature of the decarbonation, implying that this reaction must be carried out above 925 °C for better performance. The heat is released smoothly and at a good rate when the concentration of CO 2 is high in the reactor. Also, carbonation reaction (heat release process) depicts that CaCO 3 /CaO TCES system has a great potential to be used as a heat pump and is capable of upgrading the temperature of the released heat from lower to higher value.
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高影响因子
Acta Biomaterialia
·
2021
·
IF 8.947
Yuan Liu,Yingxin Li,Guilan Xue,Wenxiong Cao,Zhanlin Zhang,Chaomin Wang,Xiaohong Li
Geometry and mechanical property have emerged as important parameters in designing nanocarriers, in addition to their size, surface charge, and hydrophilicity . However, inconsistent and even contradictory demands regarding the shape and stiffness of nanoparticles have been noted in blood circulation, tumor accumulation, and tumor cell internalization . Herein, CaCO 3 nanorods (NRs) with an aspect ratio of around 2.4 are assembled with hyaluronic acid (HA) hydrogel layers to prepare CaCO 3 @HA NRs. The rod geometry enables lower recognition by macrophages and higher extravasation into tumor tissues than the spherical counterpart. In response to the slightly acidic tumor matrix, the acid-labile removal of CaCO 3 templates achieves shape switching into spherical HA nanocapsules (NCs). The shape switchable CaCO 3 @HA NRs show significantly higher uptake and cytotoxicities to 4T1 cells than CaCO 3 [email protected] NRs with silica layers on CaCO 3 cores to inhibit shape switching. In addition, HA NCs with 2 − 8 layers of HA hydrogels exhibit stiffness from 1.85 to 12.3 N/m, and the assembly of 4 layers shows 2- to 3-fold higher cellular uptake than those of other NCs. The shape shift satisfies long-term blood circulation of NRs, and the resulting stiffness-adjustable NCs promote tissue infiltration and intracellular accommodation, resulting in a 4-fold higher drug accumulation in tumors. The CaCO 3 @HA NR treatment significantly suppresses tumor growth; prolongs animal survival; inhibits lung metastasis; and eliminates systemic toxicities to blood, liver, kidney, and heart tissues. This study achieves a comprehensive understanding of the shape and stiffness effects and demonstrates a hierarchical targeting strategy to address the multiple delivery barriers for chemotherapeutic agents. Statement of significance The different barriers involved in the drug delivery pathway have inconsistent and even contradictory demands on the shape and stiffness of nanoparticles. In the current study, in situ switching of nanorods (NRs) into spherical nanocapsules (NCs) in tumor tissues is proposed to address these dilemmas. The NR shape ensures long-term blood circulation and high tumor tissue accumulation , while the in situ switching into NCs promotes tissue infiltration and cellular internalization. NCs with different numbers of hydrogel layers also provide a robust system wherein NC stiffness is controlled as a single variable to study stiffness-dependent cellular behaviors. Thus, this straightforward design offers a comprehensive understanding of how the shape and stiffness of nanocarriers affect their biological pathways.
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PubMed
高影响因子
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