JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2019
·
IF 2.606
Xin Zhou,Yao Liu,Yamei Huang,Ya Ma,Jun Lv,Bo Xiao
Oral nanotherapeutics have been proven to have great potential in the treatment of ulcerative colitis (UC). However, their therapeutic efficacies are mainly restricted by the lack of mucus-penetrating capacity. To overcome this obstacle, we functionalized the surface of curcumin (CUR)-loaded polymeric nanoparticles (NPs) with various amounts of pluronic F127 (PF127). The obtained NPs (NPs-I, NPs-II, NPs-III and NPs-IV) had hydrodynamic particle sizes around 250 nm with highly monodisperse size distributions, negatively charged surfaces and constant CUR release properties. It was found that the functionalization with PF127 notably improved the mucus-penetrating ability of NPs. Further cell experiments revealed that they showed negative cytotoxicities, and PF127-functionalized NPs (NPs-II, NPs-III and NPs-IV) yielded remarkably higher internalization rates of CUR in macrophages as compared to NPs without PF127 modification (NPs-I). Interestingly, NPs-III exhibited notably stronger capacity to decrease the secretion of TNF-α from macrophages when they were compared with other NPs. Finally, mouse experiments demonstrated that NPs-III achieved the best therapeutic efficacy against UC among all the tested NPs. Our results clearly suggest that PF127-functionalized polymeric NPs with desirable compositional proportions are promising and efficient nanotherapeutics for UC therapy.
研究领域:
药学
·
纳米技术
·
胃肠病学
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产品关联
DOI
高影响因子
ACTA PHARMACOLOGICA SINICA
·
2018
·Vol. 39
·期 9
·1522-1532
·
IF 3.562
Xue Cai-fu,Zhang Zhe,Jin Yan,Zhu Bin,Xing Jun-fen,Ma Guo,Xiang Xiao-qiang,Cai Wei-min
Liver metabolism is commonly considered the major determinant in drug discovery and development. Many in vitro drug metabolic studies have been developed and applied to understand biotransformation. However, these methods have disadvantages, resulting in inconsistencies between in vivo and in vitro experiments. A major factor is that they are static systems that do not consider the transport process in the liver. Here we developed an in vitro dynamic metabolic system (Bio-PK metabolic system) to mimic the human pharmacokinetics of tolbutamide. Human liver microsomes (HLMs) encapsulated in a F127'-Acr-Bis hydrogel (FAB hydrogel) were placed in the incubation system. A microdialysis sampling technique was used to monitor the metabolic behavior of tolbutamide in hydrogels. The measured results in the system were used to fit the in vitro intrinsic clearance of tolbutamide with a mathematical model. Then, a PBPK model that integrated the corresponding in vitro intrinsic clearance was developed to verify the system. Compared to the traditional incubation method, reasonable PK profiles and the in vivo clearance of tolbutamide could be predicted by integrating the intrinsic clearance of tolbutamide obtained from the Bio-PK metabolic system into the PBPK model. The predicted maximum concentration ( C
max ), area under the concentration-time curve (AUC), time to reach the maximum plasma concentration ( T
max ) and in vivo clearance were consistent with the clinically observed data. This novel in vitro dynamic metabolic system can compensate for some limitations of traditional incubation methods; it may provide a new method for screening compounds and predicting pharmacokinetics in the early stages, supporting the development of compounds.
研究领域:
药理学
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药物代谢
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
International Journal of Nanomedicine
·
2014
·
IF 4.195
Jie Lou,Wenjing Hu,Rui Tian,Hua Zhang,Yuntao Jia,Jingqing Zhang,Liangke Zhang
This study aimed to optimize and evaluate a thermoresponsive ophthalmic in situ gel containing curcumin-loaded albumin nanoparticles (Cur-BSA-NPs-Gel). Albumin nanoparticles were prepared via a desolvation method, and the gels were prepared via a cold method. The central composite design and response surface method was used to evaluate the effects of varying Pluronic ® F127 and Pluronic ® F68 concentrations on the sol–gel transition temperature, which is an indicator of optimum formulations. The optimized formulation was a free-flowing liquid below 30.9°C that transformed into a semi-solid gel above 34.2°C after dilution with simulated tear fluid. Results of the in vitro release and erosion behavior study indicated that Cur-BSA-NPs-Gel achieved superior sustained-release effects and that incorporation of albumin nanoparticles exerted minimal effects on the gel structure. In addition, in vivo ophthalmic experiments employing Cur-BSA-NPs-Gel were subsequently performed in rabbits. In vivo eye irritation results showed that Cur-BSA-NPs-Gel might be considered safe for ophthalmic drug delivery. The in vivo study also revealed that the formulation could significantly increase curcumin bioavailability in the aqueous humor. In conclusion, the optimized in situ gel formulation developed in this work has significant potential for ocular application.
研究领域:
药学
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纳米技术
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眼科学
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药物递送系统
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF POWER SOURCES
·
2021
·
IF 9.127
Qiannan Zhou,Wei Li,Mengyou Gao,Huizhong Xu,Yu Guo,Lei Sun,Dehua Zheng,Jianjian Lin
Metal-organic frameworks (MOFs), as 3D porous precursors, have demonstrated great potential as electrode materials for lithium storage on account of high specific area and tunable structure. To enhance the intrinsic performance and endow MOFs with versatility, constructing distinctive morphology of MOFs while maintaining their porous structure to satisfy various application is highly desirable. Herein, we successfully developed a facile strategy for rationally designing and synthesizing the morphology of MOFs from circular plate shape to truncated octahedron gem shape via regulating the ratio of Pluronic F127 to terephthalic acid . In addition, the as-prepared Pluronic F127-regulated Ti-based MOFs (F-MIL-125-Ti) sacrifice as precursor to derive 3D mesoporous titanium dioxide (TiO 2 ) and as template for in situ growth of molybdenum disulfide (MoS 2 ) nanosheets to prepare a truncated octahedron TiO 2 @C@MoS 2 hierarchical composite. As expected, the distinctive 3D hierarchical TiO 2 @C@MoS 2 electrode exhibits superb rate capability (775 mAh g −1 at 5 C) and outstanding cycling stability (822 mAh g −1 after 1000 cycles at 1 C), which is benefiting from the 3D mesoporous TiO 2 and synergies between TiO 2 and MoS 2 nanosheets. This work develops new insight to design novel and controllable morphology MOFs-derived materials for application of energy storage devices.
研究领域:
材料科学
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能量存储
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纳米技术
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电化学
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产品关联
DOI
高影响因子
RSC Advances
·
2019
·Vol. 9
·期 59
·34457-34464
·
IF 3.049
Lingmei Yang,Huiwen Li,Jun ying Fu,Ming Li,Changlin Miao,Zhongming Wang,Pengmei Lv,Zhenhong Yuan
In this article, a novel nano-rod-shaped SAPO-11 molecular sieve (SAPO-11-A-F) with a thickness of ca. 100 nm was successfully fabricated by the in situ seed-induced steam-assisted method using the cationic surfactant cetyltrimethylammonium bromide (CTAB) as a mesoporous template and a nonionic copolymer poly(ethylene oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide), F127, as the crystal growth inhibitor. The fabricated nano-rod-shaped SAPO-11-A-F possessed nanocrystalline size, a hierarchical porous structure, and enhanced acidic sites. The added CTAB was mainly used to enhance the mesoporous structure and acid, and F127 acted as a grain growth inhibitor. According to the orientation growth mechanism of the molecular sieves, the crystallization mechanism of the nano-rod-shaped hierarchical porous molecular sieves with different crystallization times was investigated. It was found that the nano-rod-shaped molecular sieves were formed by the accumulation of nano-sheets. Compared to three nickel catalysts with different silicoaluminophosphate SAPO-11 molecular sieves in the hydroisomerization of oleic acid to iso-alkanes, the bifunctional catalyst of 7% Ni/SAPO-11-A-F had higher isomeric selectivity (79.8%); in particular, the isomeric octadecane showed stronger selectivity, indicating that the nano-rod-shaped SAPO-11 molecular sieve is more beneficial for the hydrodehydration reaction.
研究领域:
材料科学
·
化学工程
·
催化
·
纳米技术
✓ 已验证
DOI
高影响因子
PHYSICS OF FLUIDS
·
2023
·Vol. 35
·期 12
·
IF 4.6
Liao Junjie,Liu Shuai,Li Ning,Huang Ju,Fan Haiming,Fang Shenwen,Duan Ming
Previous studies have found that ionic surfactant micelles can induce depletion forces between oil droplets, whereas the depletion forces induced by nonionic surfactant micelles cannot be measured. Nonionic surfactants are usually mixed with ionic surfactants to induce depletion forces. Here, we report that mixing of nonionic polymer micelles and inorganic salt is also an effective method for inducing depletion between oil droplets. Optical tweezers are used to measure the interaction forces between oil droplets in the aqueous solution of polyoxyethylene–polyoxypropylene–polyoxyethylene nonionic polymer. Without salts, there is no depletion force between oil droplets regardless of whether the concentration of polymer is above or below the critical micelle concentration (CMC). This result is consistent with literature that the oil drops adsorbed by the nonionic polymers were stable against coalescence. However, the depletion force between oil droplets generates when NaCl is added, and the concentration of Pluronic F127 is above or equal to the CMC. This suggests that salts can enhance the depletion force induced by nonionic polymer micelles. These findings have significant implications for the stability of emulsions in the food, oilfield, and medicine industries.
研究领域:
胶体科学
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表面化学
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材料科学
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生物物理学
✓ 已验证
产品关联
DOI
高影响因子
Biomedical Materials
·
2024
·
IF 3.9
Xinchen Du,Tongxing Zhang,Tong Li,Taosheng Sun,Yadong Liu
The development of a composite sponge with high water absorbency and active coagulation mechanism for traumatic hemostasis and anti-infection remains a challenge. Herein, we developed a composite sponge using gelation, swelling, and freeze-drying methods based on quaternized chitosan, succinimidyl-modified F127, and bioactive glass. The sponge exhibited macroporous structure, high porosity, and water absorbency. When exposed to blood, it strongly interacted with blood cells, promoting their adhesion, aggregation, and activation. Moreover, it activated the intrinsic coagulation pathway. The sponge/ powder demonstrated superior hemostatic capacity to commercial gauze, gelatin sponge, Yunnan Baiyao, and chitosan hemostatic powder in rat tail amputation, liver superficial injury, liver resection, and liver semi-perforation wound models. The sponge also presented robust anti-infection activity against methicillin-resistant Staphylococcus aureus and Escherichia coli. Additionally, the sponge showed low cytotoxicity, hemolysis activity, inflammation response, and systemic toxicity, demonstrating its favorable biocompatibility.
研究领域:
材料科学
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生物医学工程
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止血
·
感染控制
·
生物材料
✓ 已验证
DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2024
·
IF 4.3
Yuanyuan Han,Qiang Gao,Xianhong Zhang,Xiaoying Chen,Mengmeng Wei,Ruming Jiang,Feifan Zhao,Yu Ma,Jiaoli He,Qin Ma,Le Li,Yujiong Wang,Yen Wei,Haijun Ma
Near-infrared organic fluorescent probes have great need in biological sciences and medicine but most of them are still largely unable to meet demand. In this work, a delicate multipurpose organic fluorescent probe (DPPM-TPA) with aggregation-induced emission performances is designed and prepared by facile method to reflect fluorescence labeling, two-photon imaging, and long-term fluorescent tracking. Specifically, DPPM-TPA NPs was constructed from 4-(diphenylamino)phenylboronic acid and DPPM-Br by classical Suzuki coupling reaction and then coated with F127. Such nanoprobe possessed high stability in diverse medium under ambient temperatures, low cytotoxicity, and brilliant fluorescence performance. More importantly, DPPM-TPA NPs showed excellent two-photon imaging and extraordinary long-term fluorescence tracing capacity to malignant tumor, and it can last up to 9 days. These results indicated that DPPM-TPA NPs is expected to serve as a fluorescent probe for photodiagnostic and providing a new idea for the development of long-term fluorescent tracker.
研究领域:
生物科学
·
医学
·
材料科学
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纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Green Energy & Environment
·
2022
·
IF 12.781
Ran Xi,Yiwei Tang,Richard Lee Smith,Xiaoning Liu,Le Liu,Xinhua Qi
Ni–Ru bimetallic porous carbon sphere (Ni–Ru@PCS) catalysts were synthesized via formaldehyde-assisted, metal-coordinated crosslinking sol–gel chemistry, in which biomass-derived tannic acid and F127 surfactant were used as carbon precursor and soft template, respectively, and Ni 2+ and Ru 3+ were used as cross-linkers. In the developed method, Ni–Ru particles became uniformly dispersed in the carbon skeleton due to strong coordination bonds between metal ions (Ni 2+ and Ru 3+ ) and tannic acid molecules and bimetal interactions. The as-synthesized Ni–Ru 10:1 @PCS catalyst with a loading Ni:Ru mole ratio of 10:1 was applied for the selective hydrogenation of glucose to sorbitol, and provided 99% glucose conversion with a sorbitol selectivity of 100% at 140 °C in 150 min reaction time and exhibited good stability and recyclability in which sorbitol yield remained at 98% after 4 cycles with little or no metal agglomeration. The catalyst was applied to glucose solutions as high as 20 wt% with 97% sorbitol yields being obtained at 140 °C in 20 h. The developed bimetallic porous carbon sphere catalysts take advantage of sustainably-derived materials in their structure and are applicable to related biomass conversion reactions.
研究领域:
催化
·
化学工程
·
材料科学
·
生物质转化
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产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2024
·
IF 6.1
Junwei Yang,Xianzhen Dong,Wenying Wei,Kun Liu,Xiaopei Wu,Honglian Dai
The healing of scalded wounds faces many challenges such as chronic inflammation, oxidative stress, wound infection, and difficulties in vascular and nerve regeneration. Treating a single problem cannot effectively coordinate the complex regenerative microenvironment of scalded wounds, limiting the healing and functional recovery of the skin. Therefore, there is a need to develop a multi-effect treatment plan that can adaptively address the issues at each stage of wound healing. In this study, we propose a scheme for on-demand release of hydrogen sulfide (H2S) based on the concentration of reactive oxygen species (ROS) in the wound microenvironment. This is achieved by encapsulating peroxythiocarbamate (PTCM) in the ROS-responsive polymer poly(ethylene glycol)–poly(L-methionine) (PMet) to form nanoparticles, which are loaded into a thermosensitive injectable hydrogel, F127-poly(L-aspartic acid-N-hydroxysuccinimide) (F127-P(Asp-NHS)), to create a scald dressing. The H2S released by the hydrogel dressing on demand regulates the wound microenvironment by alleviating infection, reducing oxidative stress, and remodeling inflammation, thereby accelerating the healing of full-thickness scalded wounds. This hydrogel dressing for the adaptive release of H2S has great potential in addressing complex scalded wounds associated with infection and chronic inflammation.
研究领域:
材料科学
·
生物医学工程
·
伤口愈合
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
AAPS PHARMSCITECH
·
2023
·Vol. 24
·期 2
·1-16
·
IF 3.3
Wu Wenting,Ding Quan,Zhou Zhiwei,Kuang Wenliang,Jiang Lipeng,Liu Peng,Ai Weiping,Zhu Weifeng
In order to better promote the application of the polymeric mixed micelles (PMMs) in oral delivery, in addition to focusing on the improvement of micellar structural stability, it is necessary to obtain the absorption characteristics of the intact micellar particles. In this work, the transport behavior across Caco-2 cells of FS/PMMs composed of Pluronic F127 and Solutol HS15 was tracked by encapsulating an environment-responsive probe into the particles. The specific property of the probe is the water-initiated aggregation-caused quenching (ACQ) ability, by which integral particles can be identified accurately. The influence of polymeric ratios (FS) on the transcellular behavior of FS/PMMs was explored and the single pass intestinal perfusion experiment was used to further illustrate it. Moreover, pharmacokinetics parameters were detected to analyze the relationship among FS ratios, transport behavior, and pharmacokinetic parameters. FS ratios were found to hardly affect the endocytosis pathways and intracellular itinerary of FS/PMMs, but do affect the proportion of each path. FS/PMMs with high HS15 content, namely System-I, were found to primarily undergo receptor-mediated endocytosis pathway and be less susceptible to lysosomal degradation, which would lead to more absorption and higher Cmax and AUC than drug suspension. In contrast, despite System-II with high F127 content cannot contribute to drug plasma concentration, it can prolong the in vivo retention time. These findings provided evidence for the role of polymeric ratios in modulating the transcellular absorption and pharmacokinetic parameters of the drug-loaded PMMs, and would be a step forward in helping PMMs’ design to enhance oral drug delivery. Graphical Abstract
研究领域:
药学
·
药物递送系统
·
药理学
·
生物药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Bio-Design and Manufacturing
·
2023
·
IF 7.9
Zhao Pengcheng,Wang Biling,Wang Lu,Fu Zexin,Hu Jun,Liu Yande,Wang Ji,He Yong
Prosthesis implantation and fat transplantation are common breast reconstruction methods. In general, prosthesis implantation alone does not achieve a realistic enough appearance, and fat transplantation alone is difficult to achieve in the correct capacity. To date, no reports have focused on methods of combining fat with implanted prostheses for breast reconstruction. Using a newly designed bionic ink (i.e., polyether F127 diacrylate (F127DA) & poly(ethylene glycol) diacrylate (PEGDA)) and projection-based three-dimensional bioprinting (PBP), we report the development of a new method for printing porous prostheses. PEGDA was used to improve the printing precision of the prosthesis by increasing the gel point of F127DA and reducing the impact of external temperature. The compression modulus of the printed prosthesis was very close to that of prostheses currently used in clinical practice and to that of natural breasts. Finally, stromal vascular fraction gel (SVF-gel), a human fat extract, was injected into the pores of the synthesized prostheses to prepare a prosthesis mixed with adipose tissue. These were implanted subcutaneously in nude mice to observe their biological performance. After 14 and 28 days of observation, the prosthesis showed good biocompatibility, and adipose tissues grew well in and around the prosthesis. This result shows that a porous prosthesis containing pre-placed adipose tissues is a promising breast reconstruction material. Graphic abstract
研究领域:
生物医学工程
·
组织工程
·
外科肿瘤学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）