ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Ranxi Liang,Feize Li,Xijian Chen,Fuyuan Tan,Tu Lan,Jijun Yang,Jiali Liao,Yuanyou Yang,Ning Liu
Nano-metal–organic frameworks (nano-MOFs) labeled with radionuclides have shown great potential in the anticancer field. In this work, we proposed to combine fluorescence imaging (FI) with nuclear imaging to systematically evaluate the tumor inhibition of new nanomedicines from living cancer cells to the whole body, guiding the design and application of a high-performance anticancer radiopharmaceutical to glioma. An Fe-based nano-MOF vector, MIL-101(Fe)/PEG-FA, was decorated with fluorescent sulfo-cyanine7 (Cy7) to investigate the binding affinity of the targeting nanocarriers toward glioma cells in vitro, as well as possible administration modes for in vivo cancer therapy. Then, lutetium-177 (177Lu)-labeled MIL-101(Fe)/PEG-FA was prepared for high-sensitive imaging and targeted radiotherapy of glioma in vivo. It has been demonstrated that the obtained 177Lu-labeled MIL-101(Fe)/PEG-FA can work as a complementary probe to rectify the cancer binding affinity of the prepared nanocarrier given by fluorescence imaging, providing more precise biodistribution information. Besides, 177Lu-labeled MIL-101(Fe)/PEG-FA has excellent antitumor effect, leading to cell proliferation inhibition, upregulation of intracellular reactive oxygen species, tumor growth suppression, and immune response-related protein and cytokine upregulation. This work reveals that optical imaging and nuclear imaging can work complementarily as multimodal imaging in the design and evaluation of anticancer nanomedicine, offering a MIL-101(Fe)/PEG-FA-based pharmaceutical with potential in tumor endoradiotherapy.
研究领域:
纳米技术
·
放射学
·
肿瘤学
·
药学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
Solar RRL
·
2020
·Vol. 5
·期 4
·2000661
·
IF 7.527
Yi Wei,Baoquan Chen,Fan Zhang,Yuyang Tian,Xichuan Yang,Bin Cai,Jijun Zhao
Perovskite solar cells have emerged as one of the most promising candidates for next-generation solar cells. However, their instability remains challenging for practical applications. Here, the authors aim to enhance the stability and efficiency simultaneously by tuning the organic components in 2D Ruddlesden−Popper perovskites (2D-RPPs). Four groups of 2D-RPPs are prepared and the influence of 4-fluorophenethylammonium (FPEA) and formamidinium (FA) cations on the film properties and device performance are investigated. The (FPEA) 2 (FA) 8 Pb 9 I 28 film is found to be exceptionally vertically orientated, showing enhanced charge transport and lower defect density. Its absorption edge substantially extends in the IR region, which greatly increases the photocurrent. A high efficiency of 16.15% along with a V oc of 1.07 V and a J sc of 20.88 mA cm −2 is achieved for the (FPEA) 2 (FA) 8 Pb 9 I 28 solar cell. Notably, the (FPEA) 2 (FA) 8 Pb 9 I 28 film exhibits good humidity stability and remarkably enhanced thermal stability. Its unencapsulated device maintains 95% of its starting efficiency after 2112 h when exposed to ambient air with 30–70% relative humidity, which is superior than those of the reported (PEA) 2 (MA) 8 Pb 9 I 28 and (FPEA) 2 (MA) 8 Pb 9 I 28 solar cells. The study demonstrates that enhanced performance of 2D-RPPs can be obtained by strategically designing organic compositions, which paves an avenue toward the commercialization of 2D-RPP devices.
研究领域:
材料科学
·
光伏技术
·
化学
·
能源材料
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Weipeng Song,Junhua Zhang,Yong Sun,Rui Zhang,Lincai Peng,Huai Liu
Functionalizing biomass-derived furanic chemicals is of great importance towards biorefinery processes but challenging, especially working at elevated substrate concentrations. We herein report the intervention of 1,4-dioxane co-solvent availably to catalyze hydroxymethylation of furfuryl alcohol (FA) in formalin over Hβ zeolite, giving high yield to 2,5-dihydroxymethylfuran (DHMF), a versatile building block. Impressively, the facilitating effect of 1,4-dioxane on DHMF production became more pronounced with increasing FA feeding concentration, and the yield raised from 19.5 % to 67.8 % from a high FA concentration of 10 wt%. The 1,4-dioxane served not only as a catcher of formaldehyde hydrate to access substrate FA, but also as a shield to restrain undesirable condensation side-reactions. The developed protocol demonstrated an excellent universality in boosting the hydroxymethylation of electrondrawing-group-free furanic molecules (e.g., furan, 2-methylfuran). The understanding of these solvation effects can be employed to effectively manipulate and improve the hydroxymethylation of furanic compounds.
研究领域:
化学工程
·
催化
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绿色化学
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生物炼制
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产品关联
DOI
高影响因子
Nanoscale
·
2018
·Vol. 10
·期 20
·9707-9719
·
IF 7.233
Jia Zhou,Tianliang Li,Chunlei Zhang,Junyuan Xiao,Daxiang Cui,Yingsheng Cheng
Multifunctional nanoplatforms have been developed into advanced drug delivery systems for cancer therapy. In this study, we report a charge-switchable nanocapsule with multistage pH-responsive behaviors. First, DOX-encapsulated and oleylamine-embedded hollow structures with a diameter of 132 ± 21 nm are prepared via the double emulsion method. Subsequently, the hollow structures are encompassed by Gd-DTPA-, chlorin e6 (Ce6)-, and folate (FA)-modified BSA to form tumour-targeted, dual NIR/MR imaging-guided and chemo–photodynamic therapeutic nanoplatforms. Importantly, the nanocapsule can intelligently switch its surface charge to positive under mildly acidic conditions (pH 6.5) with no release of Ce6 and DOX, which is confirmed by ξ-potential and cumulative release measurements. Moreover, confocal imaging pictures demonstrate that acid-sensitive DOX sealed in nanocapsules is progressively released into the nuclei of MGC-803 cells. These advantages as well as FA-targeting facilitate effective endocytosis and synergistic therapeutic efficacy. Selective tumour accumulation and long tumour retention time are further indicated by NIR/MR in vivo imaging. In addition, excellent therapeutic efficacy combined with chemotherapy (DOX) and photodynamic therapy (PDT) is observed with the tumour eventually ablating at the 15th day. All results demonstrate that the as-prepared nanocapsules hold great potential for clinical cancer theranostics.
研究领域:
癌症治疗
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药物递送系统
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纳米技术
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成像技术
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Feng-Ying Wu,Yan Cheng,Xin-Yue Yuan,Qi-Lei Sun,Fu-Min Xue
The study investigated the extraction of alkaloids and glycosides from the Camptotheca acuminata Decne using deep eutectic solvent (DES). 18 types of deep eutectic solvents (DESs) were prepared, and it was found that the extraction performance of choline chloride (ChCl)-formic acid (FA) was optimal, surpassing traditional solvents such as methanol/70 % methanol. In comparison to methanol, the extracted amount of compounds by DES was 2–3 times higher. The extraction processes involving the molar ratio of ChCl-FA, pH, DES/H 2 O mass ratio, solid/liquid ratio, as well as ultrasonic power were optimized. A mathematical model for solid/liquid extraction kinetics from Camptotheca acuminata Decne was developed. The extraction mechanism was investigated using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), and 1 H nuclear magnetic resonance( 1 H NMR). The results revealed that the DES caused dissociation in Camptotheca acuminata Decne and formed hydrogen bonds with Camptothecin (CPT). Meanwhile, density functional theory (DFT) calculations verified that FA-based exhibited the highest extracted amount for CPT. In addition, this study investigated the recovery rate of DES, and the results showed that after 10 cycles, the DES system remained effective for the extraction of alkaloids and glycosides.
研究领域:
药学
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分析化学
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植物化学
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提取技术
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产品关联
DOI
高影响因子
Polymer Chemistry
·
2014
·Vol. 6
·期 5
·780-796
·
IF 5.368
Cheng Wang,Xiuli Bao,Xuefang Ding,Yang Ding,Sarra Abbad,Yazhe Wang,Min Li,Yujie Su,Wei Wang,Jianping Zhou
A new pH-responsive charge-conversion and rapidly self-dissociative multifunctional polymer lauric acid-polyethyleneimine-cyclohexanedicarboxylic anhydride-folic acid (LA-PEI-HHPA-FA, LPHF) is developed. LPHF as an amide with neighboring carboxylic acid groups becomes negatively charged at physiological pH and was used as a coating polymer to shield positively charged DNA/polyethyleneimine 25 k (DP) binary polyplexes, resulting in the formation of DPLPHF ternary polyplexes. The characterization using various methods proved that DPLPHF ternary polyplexes are stable at physiological pH, while in acidic endosomes, the coating polymer LPHF could quickly self-dissociate from the DP binary polyplexes. As compared with DP binary polyplexes, DPLPHF ternary polyplexes containing the tumor targeting ligand folic acid (FA), the absorption enhancer lauric acid (LA) and the charge-conversion entity cis-1,2-cyclohexanedicarboxylic anhydride (HHPA) exhibited more effective cellular uptake and higher transfection efficiency with lower non-therapeutic cytotoxicity in vitro. Moreover, in vivo studies revealed the significantly stronger tumor targeting and tumor inhibiting efficacy of DPLPHF ternary polyplexes. All these findings demonstrated the potential of LPHF as a promising coating polymer for enhanced gene transfection efficiency of DP binary polyplexes in vitro and in vivo.
研究领域:
生物医学工程
·
分子生物学
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基因治疗
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聚合物科学
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药剂学
✓ 已验证
DOI
高影响因子
JOURNAL OF DRUG TARGETING
·
2021
·
IF 5.121
Chunjing Guo,Yanguo Su,Bingjie Wang,Qiang Chen,Huimin Guo,Ming Kong,Daquan Chen
With the increasing number of oncology patients and the use of chemotherapeutic agents, tumour multidrug resistance is becoming more and more prevalent. The search for new tumour treatment strategies to overcome tumour multidrug resistance is urgent. In this study, we designed GSH and ROS dual-responsive tumour-associated macrophages (TAMs)-targeted nanoparticles (NPs) for the co-delivery of the clinical first-line anti-breast cancer chemotherapy drug paclitaxel (PTX) and baicalin (Bai), which re-educates TAMs to alter their phenotype. We synthesised oligohyaluronic acid-mannose-folic acid (oHA-Man-FA, HMF) and astragalus polysaccharide-dithiodipropionic acid-paeoniflorol (APS-S-Pae, ASP), two hybrid materials that can self-assemble in water to form hybrid nanoparticles (HP-NPs) co-loaded with paclitaxel and baicalin (HP-NPs@PTX/Bai). The experimental results show that our designed hybrid nanoparticles can be specifically released in the tumour microenvironment and deliver the antitumor drug PTX as well as Bai, which reshapes the phenotype of TAMs, to the tumour site. The hybrid nanoparticles not only effectively re-educated TAMs from M2 TAM to M1 TAM, but also ameliorated the cytotoxic side effects caused by free PTX and provided better tumour suppression than free PTX and HP.
研究领域:
肿瘤学
·
药学
·
纳米技术
·
免疫治疗
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Today
·
2023
·
IF 24.2
Xiao-Kang Jin,Jun-Long Liang,Shi-Man Zhang,Qian-Xiao Huang,Shun-Kang Zhang,Chuan-Jun Liu,Xian-Zheng Zhang
Owing to the deficiency of infiltrating immune cells and the accumulation of immunosuppressive cells in tumor microenvironment (TME), immunotherapy remains enormous challenges in colorectal cancer (CRC). Here, CRC was found to be sensitive to cuproptosis which could further evoke immune responses and mediate immune resistance. Thus, a cuproptosis-mediated immunotherapy nanoreactor (CCJD-FA) was constructed by encapsulating copper-based shell-coated CaO 2 and bromodomain-containing protein 4 inhibitor JQ-1 with DSPE-PEG-FA. Within tumor cells, CCJD-FA was disassembled under GSH environment, and the exposed CaO 2 could generate H 2 O 2 under the acidic condition, which reacted with the released Cu 2+ via Fenton-like reaction to produce O 2 for relieving hypoxia and Cu + for inducing cuproptosis. Furthermore, CCJD-FA could also inhibit intracellular glycolysis and ATP generation, then blocking the Cu + efflux protein ATP7B. Meanwhile, the IFN-γ-induced PD-L1 expression could be exactly reduced by the BRD4 suppression and oxygen supply. These effects sensitized cancer cells to cuproptosis, further evoking systemic immune responses and reshaping immunosuppressive TME to inhibit tumor growth.
研究领域:
肿瘤学
·
免疫学
·
纳米技术
·
药理学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Qiuhui Hu,Yongzhao Su,Siying Ma,Peiying Wei,Chengbin He,Di Yang,Yue Qian,Youqing Shen,Xiaoxuan Zhou,Zhuxian Zhou,Hongjie Hu
Liver fibrosis is the critical stage in the development of chronic liver disease (CLD), from simple injury to irreversible cirrhosis. Timely detection and intervention of liver fibrosis are crucial for preventing CLD from progressing into a fatal condition. Herein, we developed iron oxide (Fe3O4) nanoparticles (IONPs) and ferulic acid (FA) coencapsulated poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs), followed by surface modification with cRGD peptides (cRGD-PLGA/IOFA) for integrin-targeted clinical magnetic resonance imaging (MRI)-traceable treatment of liver fibrosis. The cRGD peptide linked on the surface of the PLGA/IOFA NPs could specifically bind to the overexpressed integrin αvβ3 on activated hepatic stellate cells (HSCs) in the fibrotic liver, enabling the high-sensitive clinical MR imaging (3 T) and precise staging of liver fibrosis. The FA encapsulated in cRGD-PLGA/IOFA showed excellent efficacy in reducing oxidative stress and inhibiting the activation of HSCs through the transforming growth factor-β (TGF-β)/Smad pathway. Notably, the IONPs encapsulated in cRGD-PLGA/IOFA NPs could alleviate liver fibrosis by regulating hepatic macrophages through the NF-κB pathway, lowering the proportion of Ly6Chigh/CD86+, and degrading collagen fibers. The FA and IONPs in the cRGD-PLGA/IOFA produced a synergistic enhancement effect on collagen degradation, which was more effective than the IONPs treatment alone. This study demonstrates that cRGD-PLGA/IOFA NPs could effectively relieve liver fibrosis by acting on macrophages and HSCs and provide a new strategy for the clinical MRI-traceable treatment of liver fibrosis.
研究领域:
纳米技术
·
生物医学工程
·
药理学
·
医学影像
·
肝病学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2023
·Vol. 21
·期 1
·1-21
·
IF 10.2
Wang Shengmei,Guo Qiuyan,Xu Rubing,Lin Peng,Deng Guoyan,Xia Xinhua
Immunotherapy has good potential to eradicate tumors in the long term. However, due to the low immunogenicity of tumor cells, current cancer immunotherapies are not effective. To address this limitation, we constructed a BSA-FA functionalized iron-containing metal-organic framework (TPL@TFBF) that triggers a potent systemic anti-tumor immune response by inducing ferroptosis and pyroptosis in tumor cells and releasing large quantities of damage-associated molecular patterns (DAMPs) to induce immunogenicity, and showing excellent efficacy against melanoma lung metastases in vivo. This nanoplatform forms a metal-organic framework through the coordination between tannic acid (TA) and Fe 3+ and is then loaded with triptolide (TPL), which is coated with FA-modified BSA. The nanoparticles target melanoma cells by FA modification, releasing TPL, Fe 3+ and TA. Fe 3+ is reduced to Fe 2+ by TA, triggering the Fenton reaction and resulting in ROS production. Moreover, TPL increases the production of intracellular ROS by inhibiting the expression of nuclear factor erythroid-2 related factor (Nrf2). Such simultaneous amplification of intracellular ROS induces the cells to undergo ferroptosis and pyroptosis, releasing large amounts of DAMPs, which stimulate antigen presentation of dendritic cells (DCs) and the proliferation of cytotoxic T lymphocytes (CD4+/CD8 + T cells) to inhibit tumor and lung metastasis. In addition, combining nanoparticle treatment with immune checkpoint blockade (ICB) further inhibits melanoma growth. This work provides a new strategy for tumor immunotherapy based on various combinations of cell death mechanisms.
研究领域:
肿瘤学
·
免疫学
·
纳米技术
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Small
·
2022
·Vol. 18
·期 12
·2106083
·
IF 15.153
Yu Gao,Wenzhan Xu,Si-Wei Zhang,Tianjie Fan,Meng Zhang,Aihua Ran,Xuan Zhang,Feiyu Kang,Guodan Wei
Nowadays, nearly 48.7% near-infrared (NIR) irradiation (>800 nm) of the full solar spectrum has actually not been fully utilized since the state-of-the-art perovskite film usually can only absorb the most UV–vis sunlight radiation. Herein, high efficiency integrated Cs 0.15 FA 0.85 PbI 3 perovskite/organic bulk (PC 61 BM:D18:Y6) heterojunction solar cells with enhanced low energy photon harvest until 931 nm and a high maintained open circuit voltage of 1.04 V is successfully obtained. In particular, the favorable double cascading charge transfer paths pave an interesting possibility to spatially separate electrons upon visible light excitation and holes upon NIR photon absorption simultaneously at interfaces, significantly suppressing non-radiative bimolecular recombination and reaching the photocurrent density as high as 27.48 mA cm −2 and power conversion efficiency of 20.31%. Besides, the strong hydrophobicity of the ternary organic film has effectively prevented ambient humidity penetration and improves the stability of the perovskite in the continuous aging test (humidity > 60%) compared with the control device. This work has opened a significantly new window to improve the NIR light harvest for next generation highly efficient solar cells with full spectrum response.
研究领域:
材料科学
·
太阳能电池
·
光伏技术
·
有机电子学
·
钙钛矿太阳能电池
·
近红外光吸收
✓ 已验证
DOI
高影响因子
Additive Manufacturing
·
2021
·
IF 10.998
Hongjie Bi,Gaoyuan Ye,Hao Sun,Zechun Ren,Tongfei Gu,Min Xu
The current work demonstrates excellent thermal, mechanical, shape memory, and self-healing properties of 3D printable, thermoreversible, cross-linked network composites. The thermoreversible cross-linked networks are composed of Diels-Alder (DA) reversible covalent and transient cross-links, which are formed by thermoplastic polyurethane (TPU) and poly(ε-caprolactone) (PCL). Also, cellulose nanocrystalline (CNC) is utilized as a cross-linking agent. The incorporated CNC, modified with furan (CNC-FA) and maleic anhydride groups (CNC-MAH), exhibits excellent compatibility with TPU/PCL matrix, forming physical and chemical cross-linking structures in the composites. Also, the mechanical properties , thermal stability, and self-healing properties are significantly improved after the addition of modified CNC. In addition, the mechanism of performance enhancement is further analyzed by molecular dynamics simulations. One should note that the mechanically robust and 3D printable self-healing composites enable the fabrication of durable conductive devices and biomimetic skin devices with high mechanical integrity, excellent electrical healing and superior strain-induced fluorescence properties, showing promise in next-generation flexible electronics, encryption devices and electronic skins, and may broaden the variety and applications of 3D-printable materials.
研究领域:
材料科学
·
聚合物科学
·
纳米技术
·
柔性电子
·
生物材料
·
3D打印
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）