BIOMATERIALS
·
2019
·
IF 10.273
Qin Zeng,Ruijing Zhang,Tao Zhang,Da Xing
A tumor-related stimuli-activatable and biodegradable nanoplatform for tumor-selective imaging and effective photodynamic therapy (PDT) towards precision medicine is highly desirable but still greatly challenging. Here, we developed a novel H 2 O 2 -activatable and biodegradable nanomedicine (BSA-MBPB) by encapsulation of a single newly synthesized pro-photosensitizer (MBPB) with its photoactivity completely annihilated within bovine serum albumin (BSA) to achieve imaging-guided tumor-targeted effective PDT. BSA-MBPB can be decomposed and activated by H 2 O 2 to not only produce the clinical photosensitizer methylene blue to recover its fluorescent, photoacoustic and photosensitizing properties for dual-modal imaging and cytotoxic singlet oxygen ( 1 O 2 ) generation, but also to simultaneously produce a GSH-depleting adjuvant quinone methide to boost the 1 O 2 yield, thus strengthening the efficacy of PDT. BSA-MBPB allows for highly efficient and accurate PDT without major side effects, offering potential as the next-generation nanomedicine towards clinical practice of precise PDT.
研究领域:
肿瘤学
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纳米医学
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生物材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYST
·
2020
·Vol. 145
·期 6
·2191-2196
·
IF 3.978
Fen-Ying Kong,Lei Yao,Xin-Yang Lu,Heng-Ye Li,Zhong-Xia Wang,Hai-Lin Fang,Wei Wang
The Au–Hg amalgam anchored on the surface of reduced graphene oxide nanosheets (Au–Hg/rGO) has been synthesized successfully and characterized by various techniques such as transmission electron microscopy, X-ray diffraction and X-ray photoelectron spectroscopy. The Au–Hg/rGO nanocomposites were found to possess excellent peroxidase-like catalytic activity and can quickly catalyze the oxidation of colorless 3,3′,5,5′-tetramethylbenzidine (TMB) to blue oxTMB in the presence of H2O2. The obvious color change offered accurate determination of the H2O2 concentration by recording the absorbance at 652 nm using a UV-vis spectrophotometer. The linear response range for H2O2 was from 5 μM to 100 μM and the detection limit was 3.25 μM (S/N = 3). Furthermore, a kinetic study indicated that the catalytic behavior of Au–Hg/rGO nanocomposites followed the typical Michaelis–Menten theory and Au–Hg/rGO nanocomposites showed good affinity for H2O2. We envision that the simple and sensitive colorimetric detection system holds great promising applications in clinical diagnostics and food and environment monitoring.
研究领域:
生物化学
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分析化学
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Zeyu Wu,Linghao Zhao,Yangkun Sun,Yufeng Zhang,Yuerong Wang,Min Zhang,Hongyang Zhang,Fanghong Ning,Ping Hu
Hydrogen peroxide (H 2 O 2 ), a type of reactive oxygen species (ROS) produced by cells, plays a significant role in various physiological processes. Its abnormal concentrations in human body are closely associated with cellular damage as well as a variety of major diseases. Consequently, sensitive and accurate detection of cellular H 2 O 2 concentration is of great significance in evaluating the degree of intracellular oxidative stress in human cells. In this study, a novel heterogeneous nanomaterial, rGO@PDA@MXene-Au@COF, was designed for electrochemical-colorimetric dual-mode detection of intracellular H 2 O 2 , which enhances both peroxidase and electrochemical activities, achieving lower detection limits and broader linear ranges. ESR spectroscopy, EIS resistance analysis and computational simulation were employed to verify the mechanism of the activity enhancement, and the detection conditions were optimized. The methods were subsequently applied to the determination of H 2 O 2 in cells, yielding results of 1.69 × 10 −14 M H 2 O 2 /cell and 1.59 × 10 −14 M H 2 O 2 /cell for electrochemical and colorimetric detection of MCF-7 cells, and 1.67 × 10 −14 M H 2 O 2 /cell and 1.58 × 10 −14 M H 2 O 2 /cell of Hela cells, respectively. These results demonstrated high sensitivity and anti-interference capabilities, enabling quantitative detection of H 2 O 2 in complex cellular environments. Furthermore, the similarity in results between the two methods confirms their mutual accuracy and reliability. This work provided a novel approach for designing multifunctional nanomaterials and detecting H 2 O 2 in cells.
研究领域:
纳米技术
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电化学
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生物传感器
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分析化学
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细胞生物学
✓ 已验证
产品关联
DOI
高影响因子
NEUROCHEMICAL RESEARCH
·
2019
·Vol. 44
·期 12
·2821-2831
·
IF 2.782
Zhai Ailing,Zhang Zeng,Kong Xiangjuan
Paeoniflorin (PF) has been reported to possess neuroprotective influences on cognitive dysfunction illness. In current research, we attempted to probe into the protective influences of PF against H 2 O 2 -induced damage and the underlying regulating mechanisms on hippocampal HT-22 cells. HT-22 cells were pretreated with PF, and then induced by H 2 O 2 . Afterwards, the influences of PF pretreatment were examined using CCK-8 assay, apoptosis assay, western blot and ROS assay, respectively. In addition, the expression of microRNA-135a (miR-135a) was analyzed and altered by qRT-PCR and cell transfection, respectively. After overexpression of miR-135a, the effects of miR-135a mimic on cell functions were detected again. Moreover, influences of H 2 O 2 , PF and miR-135a overexpression on JAK2/STAT3 and ERK1/2 signal pathways were further investigated. Further experiments verified that PF pretreatment alleviated H 2 O 2 -induced oxidative stress through increasing cell viability, inhibiting cell apoptosis, reducing ROS generation and activating JAK2/STAT3 and ERK1/2 pathways. Besides, expression of miR-135a was declined by PF pretreatment. Whereas, miR-135a mimic abrogated the protective effects triggered by PF pretreatment. These results indicated that PF can alleviate H 2 O 2 -induced oxidative stress by down-regulation of miR-135a via activation of JAK2/STAT3 and ERK1/2 pathways.
研究领域:
药理学
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神经科学
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分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2022
·
IF 9.136
Lin Chen,Xia Jiang,Wenhua Chen,Zhongde Dai,Jianping Wu,Shenggui Ma,Wenju Jiang
N-doped mesoporous carbon has been used as an efficient metal-free catalyst for hydrogen sulfide (H 2 S) removal. Traditional synthesis methods for mesopore usually are expensive, corrosive, not eco-friendly, and less N-functional groups remained, leading to the poor removal efficiency for H 2 S. This study provides a facile and green synthesis of N-doped interconnected mesoporous biochars (HNBCs) designed from waste biomass with the cross-linked lignin self-template removed by H 2 O 2 . Compared with those without H 2 O 2 (NPC), HNBCs exhibited higher mesopores volume and more basic sites, i.e., pyridinic N (PdN), pyrrolic N (PyN), -C O, and π-π*, which worked as the main active sites. As a result, adding H 2 O 2 increased the breakthrough sulfur capacity to 181 mg/g for HNBC prepared from cypress sawdust, which was about 5 times that without H 2 O 2 (37 mg/g). The desulfurization and regeneration performance were highly related to the cross-linked mesoporous structure and basic sites on the HNBC. This self-template removing method could easily extend to other waste biomass containing lignin and provide an insight into the advantages of efficient biomass self-structure utilization in the biochar designed properly.
研究领域:
环境科学
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2023
·
IF 11.4
Yanfeng Wang,Peiyun Wei,Zihan Shen,Chao Wang,Jie Ding,Wenkai Zhang,Xin Jin,Chad D. Vecitis,Guandao Gao
Hydrogen peroxide (H2O2), as a critical green chemical, has received immense attention in energy and environmental fields. The ability to produce H2O2 in earth-abundant water without relying on low solubility oxygen would be a sustainable and potentially economic process, applicable even to anaerobic microenvironments, such as groundwater treatment. However, the direct water to H2O2 process is currently hindered by low selectivity and low production rates. Herein, we report that poly(tetrafluoroethylene) (PTFE), a commonly used inert polymer, can act as an efficient triboelectric catalyst for H2O2 generation. For example, a high H2O2 production rate of 24.8 mmol gcat–1 h–1 at a dosage of 0.01 g/L PTFE was achieved under the condition of pure water, ambient atmosphere, and no sacrificial agents, which exceeds the performance of state-of-the-art aqueous H2O2 powder catalysts. Electron spin resonance and isotope experiments provide strong evidence that water–PTFE tribocatalysis can directly oxidize water to produce H2O2 under both anaerobic and aerobic conditions, albeit with different synthetic pathways. This study demonstrates a potential strategy for green and effective tribocatalytic H2O2 production that may be particularly useful toward environmental applications.
研究领域:
化学
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环境科学
·
能源
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FUEL
·
2018
·
IF 4.908
Xin Li,Yilin Xu,Chen Zhang,Hong Wang,Yongji Song,Wei Zhang,Cuiqing Li
Photocatalytic-adsorptive desulfurization of model fuel by the H 2 O 2 -assisted synthesized TiO 2 -SiO 2 (TiO 2 -SiO 2 -H) was investigated using air as the oxidant under UV irradiation. TiO 2 -SiO 2 -H was synthesized hydrothermally in the presence of H 2 O 2 and characterized by scanning electron microscopy (SEM), N 2 adsorption, X-ray diffraction (XRD), UV–vis diffuse reflectance spectroscopy (UV–vis DRS) and photoluminescence spectrum (PL). Compared to TiO 2 -SiO 2 synthesized in the absence of H 2 O 2 , Ti 0.25 SiO y -H showed greatly enhanced photocatalytic-adsorptive desulfurization performance due to its increased surface area, greatly increased UV absorption and decreased recombination of photogenerated hole/electron pairs. The Ti/Si molar ratio was optimized to 0.3 with the sulfur removal of 100% after reaction for 1 h at the fuel-to-Ti 0.3 SiO y -H weight ratio of 20, and the sulfur content could still be reduced to be <1 ppmw when the fuel-to-Ti 0.3 SiO y -H weight ratio was increased to 80. Moreover, TiO 2 -SiO 2 -H based photocatalytic-adsorptive process bears high selectivity for removing organosulfur in the toluene-containing fuel. The sulfur removal for model fuel containing 25 wt% toluene could reach 98.4% after reaction for 5 h. The photocatalytic-adsorptive selectivity of Ti 0.3 SiO y -H for organosulfur compounds in model diesel fuels followed the order of dibenzothiophene > 4,6-dimethyldibenzothiophene > benzothiophene. The desulfurization performance of TiO 2 -SiO 2 -H was basically stable after four consecutive desulfurization-regeneration cycles.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Nano Materials
·
2024
·
IF 5.3
Bin Li,Heng Liu,Xianrong Xing,Caixia Zeng,Min Zhang,Hailong Li,Na Lu
The development of sensitive and accurate glucose biosensors is significant in diabetic patient monitoring. Here, we synthesize carbon-decorated Fe3O4 nanotubes (Fe3O4@C NTs) using a rational designed template method. Through catalytic oxidation of a typical colorimetric reaction, the prepared Fe3O4@C NTs showed significantly better peroxidase-like and oxidase-like performances than other similar Fe3O4-based nanomaterials. Moreover, the optimal pH, temperature, and concentration for Fe3O4@C NTs were 4.0, 60 °C, and 40 μg/mL, respectively. We additionally investigated the steady-state kinetics of Fe3O4@C NTs, and their catalyzed reactions were found to follow the typical Michaelis–Menten model. Based on the peroxidase-like activity of Fe3O4@C NTs, they were employed for label-free, rapid, selective, and highly sensitive colorimetric detection of H2O2 and glucose, demonstrating a potential application for glucose determination.
研究领域:
生物传感技术
·
材料科学
·
医学诊断
✓ 已验证
产品关联
DOI
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2021
·
IF 19.503
Yue Yin,Ruolin Lv,Xiaoyang Li,Lu Lv,Weiming Zhang
Bimetallic Fenton catalyst has attracted widespread attention in refractory organics removal. Herein, we firstly investigated the influence of ZrO 2 structure features on H 2 O 2 activation in Zr-Fe bimetallic catalyst. The results show that the heterojunction structure will be formed after high temperature calcination , which makes the ability of Zr-Fe bimetallic catalyst to activate H 2 O 2 for bisphenol A degradation is 3.1 times higher than that of α-Fe 2 O 3 without Zr doping. Through characterization and density functional theory, it was identified that compared to (1 1 0) interface, the adsorption energy of H 2 O 2 on iron sites at (1 1 0)-(1 0 0) interface reduced by 1.27 kJ mol −1 , while the Fe–O bond length in the stable configuration of Fe-OOH increased by 0.16 Å, which was beneficial to the association and dissociation of H 2 O 2 on iron sites. Besides, the surface -OH of amorphous ZrO 2 in Zr-Fe bimetallic catalyst synthesized under low temperature conditions could promote HO 2 • /O 2 •- formation through the surface electron transfer, accelerating the Fe(III) reduction. In conclusion, this study reveals the influence of environment-friendly ZrO 2 structure features on H 2 O 2 activation, proposes a new insight into strengthening the synergistic effect between bimetals, and provides a reference for the structural optimization of bimetallic catalysts.
研究领域:
环境科学
·
催化化学
✓ 已验证
产品关联
DOI
高影响因子
PLoS One
·
2021
·Vol. 16
·期 10
·e0258483
·
IF 3.24
Wenping Dong,Chuanxi Yang,Lingli Zhang,Qiang Su,Xiaofeng Zou,Wenfeng Xu,Xingang Gao,Kang Xie,Weiliang Wang
This study investigates the degradation of nifedipine (NIF) by using a novel and highly efficient ultraviolet light combined with hydrogen peroxide (UV/H 2 O 2 ). The degradation rate and degradation kinetics of NIF first increased and then remained constant as the H 2 O 2 dose increased, and the quasi-percolation threshold was an H 2 O 2 dose of 0.378 mmol/L. An increase in the initial pH and divalent anions (SO 4 2- and CO 3 2- ) resulted in a linear decrease of NIF (the R 2 of the initial pH, SO 4 2- and CO 3 2- was 0.6884, 0.9939 and 0.8589, respectively). The effect of monovalent anions was complex; Cl - and NO 3 - had opposite effects: low Cl - or high NO 3 - promoted degradation, and high Cl - or low NO 3 - inhibited the degradation of NIF. The degradation rate and kinetics constant of NIF via UV/H 2 O 2 were 99.94% and 1.45569 min -1 , respectively, and the NIF concentration = 5 mg/L, pH = 7, the H 2 O 2 dose = 0.52 mmol/L, T = 20 ℃ and the reaction time = 5 min. The ·OH was the primary key reactive oxygen species (ROS) and ·O 2 - was the secondary key ROS. There were 11 intermediate products (P345, P329, P329-2, P315, P301, P274, P271, P241, P200, P181 and P158) and 2 degradation pathways (dehydrogenation of NIF → P345 → P274 and dehydration of NIF → P329 → P315).
研究领域:
环境科学
·
药学
✓ 已验证
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2022
·
IF 8.008
Ruijuan Zhang,Qian Ma,Gaofei Hu,Leyu Wang
The real-time tracking and efficacy evaluation of therapeutic nanoplatforms especially in deep-tissues is of great importance but faces challenges. Meanwhile, chemodynamic therapy (CDT), relying on Fenton reaction by converting H2O2 into toxic hydroxyl radicals (•OH), has drawn wide interests in the fabrication of nanozymes for tumor therapy, while endogenous H2O2 is usually insufficient for effective CDT. Here, we report the pH-responsive multifunctional nanoplatforms consisting of copper peroxide (CP) nanoparticles, paclitaxel (PTX) and perfluoro-15-crown-5-ether (PFCE), for 19F magnetic resonance imaging guided and enhanced chemo–chemodynamic synergetic therapy with self-supplied H2O2 stemmed from the decomposition of CP nanoparticles under acid conditions in tumor. The decomposition of CP nanoparticles further promotes the release of PTX for enhanced chemotherapy. Both in vitro and in vivo results indicate that the efficient generation of •OH and drug release effectively inhibits tumor growth. Furthermore, 19F MRI signal can clearly track the fate of nanoplatforms in tumor and guide tumor treatment. This work provides a promising strategy for the rational design and construction of multifunctional nanoplatforms for imaging-guided synergistic therapy of deep seated tumor.
研究领域:
肿瘤学
·
生物医学工程
·
影像医学
✓ 已验证
DOI
高影响因子
APPLIED CATALYSIS A-GENERAL
·
2021
·
IF 5.706
Yiming Chen,Wenquan Gu,Li Tan,Zhimin Ao,Taicheng An,Shaobin Wang
Photocatalytic H 2 O 2 production by O 2 reduction is an environmental-friendly process for solar light conversion to chemical energy. In this work, Ti 3 C 2 MXene was used as a non-noble metal cocatalyst to load on P25 as Ti 3 C 2 /TiO 2 (TC/TO) photocatalysts for photocatalytic H 2 O 2 synthesis. A H 2 O 2 formation rate (179.7 μmol L −1 h −1 ) of the optimized 10 %-TC/TO composite was obtained to be over 21 folds as high as that of P25 under UV light. Radical quenching experiments and superoxide radical detection confirmed the superoxide radical as the primary intermediate, suggesting the O 2 reduction in two-step single-electron indirect reaction. The higher activity of TC/TO can be attributed to the functions of Ti 3 C 2 MXene in accelerating the separation and transfer of photogenerated electron-hole pairs, suppressing their recombination, and blocking the surface Ti OOH formation. This work proves the promising roles of Ti 3 C 2 MXene in the photocatalytic reaction and further expands their new applications in photocatalysis .
研究领域:
材料科学
·
环境化学
·
光化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）