Materials Today Communications
·
2024
·
IF 3.7
Songhan Hu,Mingyuan Ma,Rui Liang,Xinxin Xu,Kai Wang,Qiang Wang
Ferrite nanoparticles are widely used in magnetic resonance imaging as T 2 contrast agent particles. In this study, we propose to utilize Mn and Zn doping into ferrite to prepare Mn-Zn doped ferrite and use it as T 2 contrast agent core particles. Also, we aim to clarify the relationship between the Mn-Zn doped ferrite nanoparticles orientation and ratio of surfactant oleic acid to oleylamine as well as different solvents. The results show that high temperature thermal decomposition method can successfully prepare uniformly doped Mn-Zn ferrite nanoparticles (Mn 0.6 Zn 0.4 Fe 2 O 4 ). And the ratio of surfactant oleic acid to oleylamine has a significant impact on the orientation of Mn 0.6 Zn 0.4 Fe 2 O 4 nanoparticles growth. As the ratio of oleic acid increases, the Mn 0.6 Zn 0.4 Fe 2 O 4 nanoparticles gradually change from growing along the [110] crystal direction to growing randomly with irregular orientation, the nanoparticles morphology and size tend from rhombohedral (37 nm) to spherical (9.84 nm). In terms of solvent, benzyl ether, 1-octadecene and hexadecylamine have no influence on the action of surfactants. The Mn 0.6 Zn 0.4 Fe 2 O 4 nanoparticles in the three solvents are grown randomly without any obvious orientation changes. All nanoparticles are spherical nanoparticles, indicating that the choice of the three solvents has little effect on the orientation of the nanoparticles. However, the three different solvents affect the crystallinity of Mn 0.6 Zn 0.4 Fe 2 O 4 nanoparticles. Nanoparticles prepared with diphenyl ether as solvent show a higher crystallinity compared to those synthesized with 1-octadecene and hexadecylamine as solvents. In contrast performance, under the optimal surfactant ratio (11:1) and solvent selection (dibenzyl ether), the transverse relaxation rate r 2 value of Mn-Zn ferrite nanoparticles reach 266.24 mM −1 s −1 , while the longitudinal relaxation rate r 1 value is 10.45 mM −1 s −1 . The r 2 / r 1 ratio is significantly larger than 10, indicating that the nanoparticles with random growth orientation serve as excellent T 2 weighted contrast agents.
研究领域:
材料科学
·
医学影像学
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DOI
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Huiru Zhu,Xiaoying Ni,Jiaxin Su,Yong Qin,Xiaoya He,Bo Liu,Shuang Ding,Haoru Wang,Xiangmin Zhang,Jie Huang,Qian Hu,Ruofei Ma,Jinhua Cai
To overcome the limited efficacy of chemodynamic therapy (CDT) caused by insufficient hydrogen peroxide (H2O2) in the tumor microenvironment, we engineered a glutathione (GSH)-responsive multifunctional nanosystem, HCTG-C, based on hollow mesoporous organosilica nanoparticles. This system integrates tirapazamine (TPZ), glucose oxidase (GOx), in situ-synthesized copper sulfide (CuS), and CT2A glioma cell membrane coating to enable dual tumor-targeted therapy and self-imaging capabilities. The therapeutic mechanism relies on three synergistic cascades: (1) GOx-mediated glucose oxidation to deplete oxygen and generate H2O2, establishing a self-sustaining H2O2 supply; (2) GSH-triggered CuS conversion to Cu(I), amplifying Fenton-like reactions for efficient H2O2-to-reactive oxygen species conversion and ferroptosis induction; and (3) hypoxia-activated TPZ to exert cytotoxic effects, synergizing chemotherapy with CDT. Experimental results demonstrated that HCTG-C achieves real-time MRI monitoring via GSH depletion-driven Cu valence transitions, while its self-replenishing H2O2 and oxygen-activation mechanisms significantly enhance antitumor efficacy against CT2A glioma in vitro and in vivo. By innovatively combining H2O2 self-supply cascades, hypoxia-activated chemotherapy, and ferroptosis-driven CDT, this work presents a paradigm-shifting strategy for self-imaging-guided combinatorial therapy, advancing ferroptosis-based approaches for precision glioma treatment.
研究领域:
纳米医学
·
肿瘤治疗
·
影像学
·
生物材料
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DOI
PubMed
高影响因子
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2025
·
IF 3
Zeng Qingbin,Wang Zhen,Guo Qianni,Song Wei,Zhao Xiuchao,Yang Yuqi,Zhou Xin
Hyperpolarized 129 Xe magnetic resonance imaging (MRI) is a powerful tool for detecting respiratory system diseases. However, 129 Xe is an inert gas and lacks specific detection capability. Entrapping xenon within molecular cages to enable specific detection is a challenging task, and numerous molecular cages have been developed and evaluated to address this challenge. Herein, we report that the aluminum-based metal-organic framework, CAU-1, can effectively entrap xenon for hyperpolarized 129 Xe MRI in aqueous solutions. This platform exhibits high water stability and good dispersibility, and shows excellent xenon entrapment capability, even at a concentration as low as 50 µg/mL. Importantly, it is responsive to pH changes across a range from 6.6 to 5.0, making it promising for monitoring the weakly acidic environment in tumors or metabolic abnormality. Furthermore, the scalable and cost-effective production of this molecular cage will facilitate future advancements in molecular imaging and chemical sensing applications.
研究领域:
医学影像学
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分子生物学
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材料科学
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产品关联
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2025
·
IF 6.7
Yuanyuan You,Wanjia Wu,Xiaoting Zheng,Hao Liu,Xiang Zhou,Ningxuan Liu,Jiajia Lu,Sike Lv,Yukang Wen,Ling Lu,Jia Tao,Bingquan Lin,Peng Zhao
Magnetic resonance imaging (MRI) contrast agents face persistent challenges in achieving target-specific activation and high signal-to-noise ratios (SNRs). To address these limitations, we developed LP-GZF, a bioresponsive nanoprobe leveraging magnetic resonance tuning (MRET) within tumor-targeting liposomes. The system coencapsulates Gd-DOTA (paramagnetic enhancer) and Zn0.4Fe2.6O4@DMSA (superparamagnetic quencher), engineered to switch between “OFF” and “ON” states via spatial separation. It has also been confirmed that the relaxivity of LP-GZF is only related to its state, instead of its concentration. In the native state, the proximity between components suppresses Gd3+ relaxivity (0.15 mM–1 s–1), while the release of Gd-DOTA restores relaxivity to 4.25 mM–1 s–1, a 28.3-fold enhancement. In 4T1 tumor-bearing mice, LP-GZF demonstrated delayed burst-enhancement kinetics, with SNR surging from 29.00 ± 1.13 to 48.88 ± 3.32 at 2 h postinjection, clearly lighting the boundary of tumor tissue. The outstanding performance of LP-GZF is attributed to the selective enrichment in the tumor and the subsequent spatial separation of the “enhancer” and “quencher”. The nanoprobe exhibited excellent biocompatibility and hepatorenal clearance. This work establishes a paradigm for stimuli-responsive contrast agents, combining spatiotemporal precision with analytical reliability for early cancer diagnosis.
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DOI
PubMed
高影响因子
RSC Advances
·
2019
·Vol. 9
·期 5
·2559-2566
·
IF 3.049
Ting Tang,Xiao Sun,Xuedong Xu,Yifeng Bian,Xiaojie Ma,Ning Chen
The development of hollow ferrogadolinium nanonetworks has not been reported for nanomedicine application until now. In this study, we developed a hollow and porous ferrogadolinium nanonetwork structure using the one-pot solvothermal method. This nanoparticle could be simultaneously used as a T1 and T2 dual-modal magnetic resonance imaging (MRI) contrast agent. In addition, the hollow lumen and abundant pores of the nanonetworks maximized the loading capacity and conferred the nanoplatforms for suitable anticancer drug loading capacity. Using these nanonetworks, MRI and anticancer experiments were conducted in vitro and satisfactory dual-modal MRI and cancer chemotherapy results were obtained. Therefore, the nanonetworks with dual-modal MRI and drug loading abilities effectively complement the ferrogadolinium composites' library and hold great promise in nanomedicine for simultaneous cancer diagnosis and chemotherapy.
研究领域:
纳米医学
·
磁共振成像
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癌症治疗
·
材料科学
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DOI
PubMed
高影响因子
MICROPOROUS AND MESOPOROUS MATERIALS
·
2013
·
IF 3.365
Aifei Wang,Wenxiu Qi,Nan Wang,Jianyun Zhao,Faheem Muhammad,Kun Cai,Hao Ren,Fuxing Sun,Liang Chen,Yingjie Guo,Mingyi Guo,Guangshan Zhu
Use of inorganic nanoparticles is expectedly improving the prospects of chemotherapy and diagnosis. Here, we report a facile approach to synthesize water dispersible, superparamagnetic manganese ferrite (MnFe 2 O 4 ) nanoparticles at relatively low temperature. Subsequently, these MnFe 2 O 4 nanoparticles are integrated with acid degradable mesoporous ZnO nanoparticles to attain a platform for simultaneous magnetic resonance imaging (MRI) and acid triggered anticancer drug delivery. Drug release was evaluated by tuning the pH of buffer solutions to mimic intracellular environment, which demonstrated a biorelevant acid sensitive release behavior. In vitro cell study congruently demonstrated an excellent concentration-dependent cytotoxicity on pancreatic cancer cells, with IC 50 of 3 μg/mL composite concentration. As far as imaging results are concerned, relaxivity value ( r 2 ) value of our system was found to be measurably higher than commercial T 2 MRI contrast agent Ferridex (63.5 mM −1 s −1 ). This smart nanosystem can be a step forward towards the realization of concurrent effective therapy, monitoring of nanocarrier distribution and disease evolution.
研究领域:
纳米医学
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生物材料
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医学影像
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肿瘤学
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产品关联
DOI
高影响因子
ACS Applied Bio Materials
·
2023
·
IF 4.7
Dan Zhao,Shibo Peng,Hanzhang Xiao,Qilong Li,Yahong Chai,Hongxia Sun,Ruping Liu,Li Yao,Lin Ma
Iron oxide nanoparticles (IONPs) have been developed as contrast agents for T1- or T2-weighted magnetic resonance imaging (MRI) on account of their excellent physicochemical and biological properties. However, general strategies to improve longitudinal relaxivity (r1) often decrease transverse relaxivity (r2), thus synchronously strengthening the T1 and T2 enhancement effect of IONPs remains a challenge. Here, we report interface regulation and size tailoring of a group of FePt@Fe3O4 core–shell nanoparticles (NPs), which possess high r1 and r2 relaxivities. The increase of r1 and r2 is due to the enhancement of the saturation magnetization (Ms), which is a result of the strengthened exchange coupling across the core–shell interface. In vivo subcutaneous tumor study and brain glioma imaging revealed that FePt@Fe3O4 NPs can serve as a favorable T1–T2 dual-modal contrast agent. We envision that the core–shell NPs, through interface engineering, have great potential in preclinical and clinical MRI applications.
研究领域:
生物医学工程
·
材料科学
·
影像医学
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产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2015
·Vol. 3
·期 45
·8832-8841
·
IF 4.726
Huihui Wang,Hao Wu,Hujun Shen,Shaote Geng,Beibei Wang,Yanfang Wang,Xiaojun Ma,Guohui Li,Mingqian Tan
The combination of complementary MRI and NIR imaging methods evolved to provide an even more powerful bioimaging tool. Herein, a novel bimodal MRI/NIR nanoprobe GCF-HDA was prepared via a facile self-assembly approach of three types of amphiphilic structures in aqueous solution. The Stokes shift of the NIR moiety increased from 30 to 150 nm and fluorescence quantum yield increased from 1.5 to 8% after conjugation with electron-rich hexadecylamine (HDA) to organic dye Cy7. The photostability of the nanoprobe GCF-HDA was dramatically improved after involving the newly synthesized dye. Molecular dynamics simulation demonstrated that the GCF-HDA is composed of 2.0–3.5 nm clusters and in each cluster the head groups of the amphiphilic molecules assemble together and the tail groups point outwards. The r1 and r2 relaxivities of GCF-HDA were found to be 11.87 and 19.91 mM−1 s−1 per Gd(III) chelate at 0.5 T, respectively. In vitro cellular imaging with human glioma U-87 MG cells showed that the GCF-HDA was able to enter the cells and accumulate in the cytoplasm. The targeted GCF-HDA resulted in higher MR contrast enhancement and stronger fluorescence intensity than the corresponding non-targeted probe GC-HDA in the tumor tissue 96 hours post injection. Ex vivo fluorescence imaging and histological analysis of the tumor tissue further confirmed the specific binding ability of the GCF-HDA.
研究领域:
医学影像学
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生物医学工程
·
纳米医学
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产品关联
DOI
PubMed
高影响因子
Frontiers in Bioengineering and Biotechnology
·
2022
·
IF 6.064
Tang Ting,Zhu Qiang,Liu Shuang,Dai Hailong,Li Yu,Tang Caihong,Chen Kexin,Jiang Mou,Zhu Lijun,Zhou Xin,Chen ShiZhen,Zheng Zitong,Jiang Zhong-Xing
As a noninvasive “hot-spot” imaging technology, fluorine-19 magnetic resonance imaging (19F MRI) has been extensively used in cell tracking. However, the peculiar physicochemical properties of perfluorocarbons (PFCs), the most commonly used 19F MRI agents, sometimes cause low sensitivity, poor cell uptake, and misleading results. In this study, a partially fluorinated agent, perfluoro-tert-butyl benzyl ether, was used to formulate a 19F MRI-fluorescence imaging (FLI) dual-modal nanoemulsion for cell tracking. Compared with PFCs, the partially fluorinated agent showed considerably improved physicochemical properties, such as lower density, shorter longitudinal relaxation times, and higher solubility to fluorophores, while maintaining high 19F MRI sensitivity. After being formulated into stable, monodisperse, and paramagnetic Fe3+-promoted nanoemulsions, the partially fluorinated agent was used in 19F MRI-FLI dual imaging tracking of lung cancer A549 cells and macrophages in an inflammation mouse model.
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DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2016
·Vol. 5
·期 4
·849-857
·
IF 4.872
Lingjie Wu,Ming Wu,Xinyi Lin,Xiaolong Zhang,Xiaolong Liu,Jingfeng Liu
Highly efficient accumulation of nanoscaled theranostic agents in a tumor site is crucial for cancer diagnosis and therapy. In this study, we designed a drug-loaded charge-switchable nanohybrid system (HNPs–DA) triggered by the low pH value of tumor microenvironment (pH 6.5) to enhance the uptake efficiency of NPs in cancer cells; the nanohybrid could exhibit T2-MR imaging enhancement and chemotherapy ability, ascribed to the loaded magnetite nanocluster (MNC) and paclitaxel (PTX), respectively. The HNPs–DA comprises two distinct functional components: (1) a biocompatible amphiphilic polymer (Pluronic F127) to act as a nanovehicle for MNC and PTX after self-assembly in an aqueous solution; and (2) a hydrophilic polymeric shell derived from stearoyl-polyethylenimine-2,3-dimethylmalefic anhydride (SC-g-PEI-DMMA). SC-g-PEI-DMMA switches the surface charge of the HNPs–DA from negative to positive by diminishing the anionic part of DMMA and sequentially recovering the cationic instinct of the PEI part at pH 6.5, which could facilitate the cellular uptake and therefore enhance the theranostic effects. In vitro studies demonstrated a darker T2-MRI image in the HNPs–DA-treated HepG2 cells at pH 6.5 as compared to that at pH 7.4. Moreover, CCK8 assay indicated that HNPs–DA exhibited a much higher cytotoxicity against HepG2 cells at pH 6.5, and flow cytometric analysis suggested that the cell death induced by HNPs–DA occurred via apoptosis, which was detected by Annexin V antibody and propidium iodide staining.
研究领域:
生物医学工程
·
癌症治疗
·
纳米医学
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DOI
PubMed
高影响因子
ANALYST
·
2023
·Vol. 149
·期 4
·1169-1178
·
IF 4.2
Chen Xu,Jie Sun,Chenhao Zhang,Lu Yang,Hong Kan,Daguang Zhang,Guan Xue,Kai Dong
With the rapid development of nanotechnology and biomedicine, numerous gadolinium (Gd)-based nanoparticle MRI contrast agents have been widely investigated. Due to the unique physicochemical properties of nanoparticles and the complexity of biological systems, the biosafety of Gd-based nanoparticle MRI contrast agents has been paid more and more attention. Herein, for the first time, we employed an ultra-high performance liquid chromatography–electrospray ionization quadrupole time-of-flight/mass spectrometry (UPLC-ESI-QTOF/MS)-based metabolomics approach to investigate the potential toxicity of Gd-based nanoparticle MRI contrast agents. In this work, NaGdF4 and PEG-NaGdF4 nanoparticles were successfully constructed and selected as the representative Gd-based nanoparticle MRI contrast agents for the metabolomics analysis. Based on the results of metabolomics, more metabolic biomarkers and pathways were identified in the NaGdF4 group than those in the PEG-NaGdF4 group. Careful analysis of these metabolic biomarkers and pathways suggested that NaGdF4 nanoparticles induced disturbance of pyrimidine and purine metabolism, inflammatory response, and kidney injury to a certain extent compared with PEG-NaGdF4 nanoparticles. These results indicated that Gd-based nanoparticle contrast agents modified with PEG had better biosafety. Additionally, it was demonstrated that the discovery of characteristic metabolomics biomarkers induced by nanoparticles would provide a new approach for biosafety assessment and stimulate the development of nanomedicine.
研究领域:
医学
·
药理学
·
纳米生物学
·
毒理学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Chang Guo,Xiaoyao Xiong,Xinxing Zhao,Yumin Li,Sijia Li,Suying Xu,Tony D. James,Leyu Wang
19F magnetic resonance imaging (19F MRI), with zero background, high tissue penetration depth, excellent spatial resolution, and nonradioactive features, has attracted considerable attention but faces tough challenges due to the shortage of sensitive and selective targetable probes. Herein, we report a biocompatible and highly sensitive 19F MRI probe with an adaptable tumor-targeting ability. The fluorine-grafted polymer (PIBMA-FSON) probes were rich with sulfoxide and carboxy groups, containing a high fluorine content (∼17 wt %). The probes exhibit superhydrophilicity, strong 19F MRI signals (enhancement of ∼95-fold), long transverse relaxation time (T2, 422 ms), and excellent 19F MRI capability. Conjugation using a targeting peptide (Arg-Gly-Asp, RGD) afforded ultrasmall soft polymer probes (PIBMA-FSON-RGD) with superhydrophilicity and tumor-targeting ability suitable for the 19F MRI of orthotopic bladder cancer. Amidification of 5% of the carboxylate units with oleylamine resulted in PIBMAOAm-FSON nanoprobes (NPs) via self-assembly, displaying different targeting toward subcutaneous tumors. Further grafting with near-infrared (NIR) dyes renders the probe suitable for NIR-fluorescence and 19F MRI dual-modality imaging. This study provides a suitable approach for designing highly sensitive and zero-background 19F MRI probes with a tunable tumor-targeting ability.
研究领域:
医学影像学
·
生物材料学
·
分子影像学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）