MATERIALS RESEARCH BULLETIN
·
2018
·
IF 2.873
Zhilai Li,Omar Johnson,Jin Huang,Ting Feng,Chaoqing Yang,Zhongxin Liu,Wei Chen
Graphene oxide/NaYF 4 : Yb, Er nanocomposites have been synthesized via hydrothermal synthesis, in which spherical cubic phase NaYF 4 : Yb, Er nanocrystals with uniformity are implanted onto the surface of graphene oxide (GO). Using a near infrared laser set to 980 nm, the light-to-heat energy transfer efficiency of GO/NaYF 4 : Yb, Er is 13.9% higher than GO by itself, revealing that the photothermal conversion efficiency of GO could be enhanced by doping NaYF 4 : Yb, Er nanocrystals. This phenomenon can be attributed to the energy transfer between the NaYF 4 : Yb, Er nanocrystals to the energy receptor in the GO substrate.
研究领域:
材料科学
·
光学
✓ 已验证
产品关联
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2019
·
IF 3.375
Yiran Jiao,Yuan Pu,Jie-Xin Wang,Dan Wang,Jian-Feng Chen
We reported the process intensified synthesis of β-NaYF4 nanorods based on the traditional hydrothermal methods. A high-gravity rotating packed bed (RPB) reactor was used to intensify the mass transfer and micromixing of the precursors for critical nuclei. The proposed high gravity RPB assisted strategy is easy-to-perform for scale-up. The influence of reaction conditions was explored and the possible mechanism of the formative of β-NaYF4 nanorods was discussed. Accordingly, over 1 g of pure β-phase NaYF4:Gd3+/Yb3+/Er3+ nanorods with well-defined morphology and structure were prepared via one batch reaction. The rare-earth doped β-NaYF4 nanorods are highly dispersible in organic solvents with intense upconversion luminescence under near-infrared (NIR) light irradiation. The translucent NIR detector card of nanocomposites of poly(methyl-methacrylate) and the nanoroads was fabricated accordingly. The photosensitive region can also be activated by illuminating the back of the card, which is useful when aligning two beams to overlap.
研究领域:
材料科学
·
纳米技术
·
化学工程
·
光学
✓ 已验证
产品关联
DOI
高影响因子
CRYSTENGCOMM
·
2022
·Vol. 24
·期 27
·4887-4898
·
IF 3.756
Mingzhou Meng,Rui Zhang,Zhenlong Cheng,Xinmeng Fa,Jianghua Yang,Anees A. Ansari,Jun Ou,Christian Wurth,Ute Resch-Genger
A solvothermal method was used to prepare a series of Yb3+/Tm3+/Ca2+ co-doped NaYF4 nanoparticles with different Ca2+ contents. Strong upconversion blue fluorescence could be observed under 980 nm laser excitation of the samples. The effect of different Ca2+ contents on the luminescence intensity was investigated, and it was found that the UV-vis upconversion luminescence increased and then decreased with an increasing Ca2+ concentration during the increase of the Ca2+ content from 0 mol% to 25 mol%, reaching the strongest fluorescence at 15 mol%, which was up to about 28 times stronger than that without Ca2+ doping. Furthermore, the mechanism was investigated, and it was found that the doping of Ca2+ disrupted the symmetry of the crystal field, resulting in a significant enhancement of the overall fluorescence. Applied to fluorescence intensity ratio thermometry, the absolute and relative sensitivities are as high as 0.0418 K−1 and 2.31% K−1, respectively, with a minimum temperature resolution of 0.0129 K.
研究领域:
材料科学
·
光学
✓ 已验证
DOI
高影响因子
CRYSTENGCOMM
·
2014
·Vol. 16
·期 25
·5650-5661
·
IF 3.858
Xiaodong Liu,Xiao Zhang,Gan Tian,Wenyan Yin,Liang Yan,Longfei Ruan,Zhiyong Yang,Debao Xiao,Zhanjun Gu
Hexagonal-phase NaYF4 nanocrystals with good uniformity and monodispersity have been successfully obtained through a thermal decomposition of rare-earth oleate complexes. By co-doping upconverters (Yb/Er, Yb/Tm or Yb/Ho) or downconverters (Eu or Ce/Tb), multicolor upconversion (UC) luminescence under 980 nm laser excitation or downconversion luminescence under UV irradiation could be obtained. For the first time, we systematically investigate the effects of various parameters including reaction temperature, time, NaF to rare-earth ions ratio and oleic acid concentration on the size, morphology, phase purity and UC emission properties using Yb/Er co-doped NaYF4 UC nanoparticles as a typical example. The results demonstrated that this strategy is a simple yet efficient route for fabrication of UCNPs with good uniformity and monodispersity, and enriches the synthetic routes for production of high quality hexagonal-phase NaYF4 nanocrystals. In addition, a mesoporous silica layer was coated onto the hydrophobic NaYF4:Yb/Er nanoparticles, converting them into hydrophilic ones, which then could be used as a potential luminescent probe for cell imaging and a promising nanocarrier for therapeutic drug delivery, making them a multifunctional platform for simultaneous imaging and therapy.
研究领域:
材料科学
·
纳米生物学
·
生物医学工程
✓ 已验证
DOI
高影响因子
MATERIALS RESEARCH BULLETIN
·
2020
·
IF 4.019
Enming Zhao,Xiaodan Liu,Dongyang Tang,Lu Liu,Guangyu Liu,Bao Zhou,Chuanxi Xing
To date, the white light lanthanide upconvertion consisting of RGB components usually originated from more than one type of emitter. Alternatively, Pr 3+ is a fascinating lanthanide ion featuring multiple visible emission bands, including RGB components that in principle enable Pr 3+ to emit white light. In this paper, we report, for the first time to our knowledge, white light upconversion through dual sensitization routes in Nd/Yb/Pr triply doped NaYF 4 microrods upon 800 nm excitation. It is found that the dual sensitization is more efficient than single sensitization for Pr 3+ upconversion. In addition, the temperature sensing behaviors of the proposed triply doped microrods are comparatively investigated using different emission bands. This work presents a novel white light emitting material upon 800 nm excitation, and further demonstrates the feasibility of multichannel thermometry using the proposed material.
研究领域:
材料科学
·
光学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
Nano Research
·
2023
·Vol. 16
·期 7
·10026-10033
·
IF 9.9
Jiang Shihui,Ke Jianxi,Li Guowei,Liu Aijun,Li Xiaohan,Ye Lixiang,Jiang Feilong,Liu Yongsheng,Hong Maochun
Hexagonal-phase NaYF 4 (β-NaYF 4 ) has been acknowledged to be one of the most efficient doping hosts to prepare bright lanthanide-doped luminescent nano-bioprobes for various biomedical applications. However, to date, it remains a great challenge to synthesize ultra-bright lanthanide-doped β-NaYF 4 nano-bioprobes under a low reaction temperature by using conventional synthetic methods. Herein, we first develop an acetic acid (HAc)-mediated coprecipitation method for the preparation of ultra-bright lanthanide-doped β-NaYF 4 nanoprobes under a low reaction temperature at 200 °C. Based on a series of comparative spectroscopic investigations, we show that the use of HAc in the reaction environment can not only promote the rapid α–β phase transformation of NaYF 4 host at 200 °C within 1 h but also boost the absolute photoluminescence quantum yield (PLQY) of NaYF 4 nanocrystals to 30.68% for near-infrared emission and to 3.79% for upconversion luminescence, both of which are amongst the highest values for diverse lanthanide-doped luminescent nanocrystals ever reported. By virtue of their superior near-infrared luminescence, we achieve optical-guided dynamic vasculature imaging in vivo of the whole body at a high spatial resolution (23.8 µm) under 980 nm excitation, indicating its potential for the diagnosis and treatment evaluation of vasculature-related diseases.
研究领域:
材料科学
·
生物医学工程
·
光学
✓ 已验证
产品关联
DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2015
·
IF 6.409
Jianguo Zhang,Shaozhen Wang,Ni Gao,Dexiang Feng,Lun Wang,Hongqi Chen
A new turn-on luminescence energy transfer (LET) system has been designed for the detection of prostate specific antigen (PSA, a cancer marker) that utilizes Mn 2+ -enhanced long wavelength luminescence NaYF 4 : Yb, Er upconversion nanorods as the donor and gold nanorods as the acceptor. The Mn 2+ -doped NaYF 4 :Yb,Er upconversion luminescence nanorods with an emission peak located in the red region were synthesized. The presence of Mn 2+ markedly increased the luminescence intensity over that of the NaYF 4 :Yb, Er upconversion nanomaterials (excited by a 980 nm continuous wavelength laser). The surfaces of Mn 2+ -doped NaYF 4 :Yb, Er upconversion nanorods were modified with poly(acrylic acid). Antibodies against prostate specific antigen were bound to the surface of the carboxyl-functionalized upconversion nanorods, which acted as the energy donor in this LET system. Gold nanorods with an absorption band at ~666 nm were synthesized by the seed growth method, acted as the energy acceptor. The emission band of the upconversion nanorods overlapped well with the absorption band of the gold nanorods. The luminescence was quenched because of the electrostatic interactions that shortened the distance between the donor (negatively charged) and the accepter (positively charged).When the PSA antigen was added into the system, the energy acceptor and the energy donors were separated because the binding affinity between PSA and anti-PSA was greater than the electrostatic interactions, and thereby the luminescence was recovered. The linear range of detecting PSA was from 0.1172 to 18.75 ng/mL ( R =0.995), with a limit of detection for PSA as low as 0.1129 ng/mL. The method was successfully applied to the sensing of PSA in human serum samples.
研究领域:
生物技术
·
纳米技术
·
分析化学
·
癌症研究
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nanoscale
·
2023
·Vol. 15
·期 26
·11179-11189
·
IF 6.7
Zhenlong Cheng,Mingzhou Meng,Jiaoyu Wang,Zhuoyue Li,Jiao He,Hao Liang,Xin Qiao,Yuanli Liu,Jun Ou
Non-contact optical temperature sensors are highly sought after by researchers due to their satisfactory temperature resolution (δ(T) < 0.1 °C), high relative thermal sensitivity (Sr > 1% °C−1), fast temporal response (t < 0.1 s), and long-term optical stability. In this study, NaYF4:Yb3+/Ho3+/Tm3+ upconversion nanoparticles were prepared by a solvothermal method, and their crystal structure, microscopic morphology, and luminescence mechanism, together with the temperature sensing properties of the specimens, were investigated. Under 980 nm laser excitation, the specimens exhibited strong upconversion luminescence, and the emission peaks corresponded to the characteristic energy level jumps of Ho3+ and Tm3+, respectively. The temperature-dependent luminescence spectra of the samples were investigated based on the fluorescence intensity ratio (FIR) technique over a temperature gradient of 295–495 K. The samples are based on thermally coupled energy levels (TCLs: 1G4(1,2) → 3H6(Tm3+)) and non-thermally coupled energy levels (NTCLs: 3F3 → 3H6(Tm3+) and 5F3 → 5I8(Ho3+), 3F3 → 3H6(Tm3+) and 1G4 → 3H6(Tm3+), 3F3 → 3H6(Tm3+) and 5F5 → 5I8(Ho3+), 3F3 → 3H6(Tm3+) and 5F4 → 5I8(Ho3+)) for temperature sensing performance. The maximum absolute sensitivity (Sa), relative sensitivity (Sr), and minimum temperature resolution δ(T) were found to be 0.0126 K−1 (495 K), 1.7966% K−1 (345 K), and 0.0167 K, respectively, which are better than those of most sensing materials, and the simultaneous action of multiple coupling energy levels can further improve the temperature precision. This study indicates that the sample has a good value for optical temperature measurement and also provides new ideas for the exploration of other high-quality optical temperature sensing materials.
研究领域:
材料科学
·
光学
·
纳米技术
✓ 已验证
DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 26
·21725-21734
·
IF 3.289
Kun Ge,Wentong Sun,Shaohan Zhang,Shuxian Wang,Guang Jia,Cuimiao Zhang,Jinchao Zhang
Applications of europium-doped NaYF4 (NaYF4:Eu3+) nanoparticles in biomedical fields will inevitably increase their exposure to humans, therefore, the assessment of toxicities must be taken into consideration. It was reported that NaYF4:Eu3+ nanoparticles could accumulate in the bone. However, the potential effect of NaYF4:Eu3+ nanoparticles on bone marrow stromal cells (BMSCs) has not been reported. In this study, NaYF4:Eu3+ particles with diameters of 50 and 200 nm (NY50 and NY200) were prepared and characterized by scanning electron microscopy, transmission electron microscopy, powder X-ray diffraction, photoluminescence excitation and emission spectra, and dynamic light scattering. The cytotoxicity of NaYF4:Eu3+ particles on BMSCs and the associated mechanisms were further studied. The results indicated that NaYF4:Eu3+ particles could be uptaken into BMSCs and primarily localized in the lysosome. NaYF4:Eu3+ particles effectively inhibited the viability of BMSCs in a size-dependent manner at 24 and 48 h. After cells were treated with 20 μg mL−1 of NY50 and NY200 for 24 h, NaYF4:Eu3+ particles could trigger cell necrosis in a size-dependent manner. The percentage of necrotic BMSCs (PI+/Annexin V−) increased to 15.93 and 14.73%. Necrosis was further verified by increased lactate dehydrogenase leakage. Meanwhile, both NY50 and NY200 induced an increased cell population in the S and G2/M phases. The following mechanism is involved in NaYF4:Eu3+ particle-induced BMSCs necrosis: the NaYF4:Eu3+ particles lead to lysosomal rupture by lysosomal swelling, permeabilization of lysosomal membranes, and increased cathepsins B and D. In addition, NaYF4:Eu3+ particle-induced BMSCs necrosis is also directly caused by the overproduction of ROS through injury to the mitochondria. This study provides novel evidence to elucidate the toxicity mechanisms for bone metabolism and may be beneficial to more rational applications of these nanomaterials in the future.
研究领域:
纳米技术
·
生物医学工程
·
细胞生物学
·
毒理学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
·
2014
·Vol. 14
·期 6
·4139-4146
·
IF 1.339
He Enjie,Zheng Hairong,Gao Wei,Tu Yinxun,Lu Ying,Tian Huani,Li Guian
NaYF4:Yb3+, Er3+, Mn2+ nanocrystals with cubic crystal phase were obtained by a facile solvothermal method through doping a proper amount of Mn2+ ions to the nanocrystals. The results of XRD and TEM showed that the as-prepared samples
were well crystallized and their average size was about 25 nm. Under excitations at 978.5 nm and at 532 nm, obvious enhancement and regulation of upconversion and downconversion fluorescence were obtained. Upconversion emission spectra indicate that these effects were independent of doped
concentrations of Er3+ and Yb3+, excitation power, and the excitation wavelength in the current study. It is concluded that the enhancement of fluorescence emissions is mainly due to the change of local symmetry around Er3+ ions, while the regulation of red-to-green
ratios was caused by efficient energy transfer between Er3+ and Mn2+ ions. This kind of upconversion material has a great potential in bioimaging and drug delivery since the excitation and emission falls into the region of “optical window” of biological tissues.
研究领域:
材料科学
·
纳米技术
·
生物医学工程
·
光学
✓ 已验证
DOI
PubMed
高影响因子
BIOMATERIALS
·
2014
·
IF 8.312
Ao Xia,Xiaofeng Zhang,Jun Zhang,Yunyun Deng,Qiang Chen,Shishan Wu,Xiaohua Huang,Jian Shen
Dual-modality imaging with magnetic resonance (MR) and upconversion luminescence (UCL) is a promising technique for molecular imaging in biomedical research. Multifunctional lanthanide-based nanoparticles have been widely investigated as agents for contrast enhanced MR and fluorescence imaging. However, the use of rare earth fluoride nanoparticles for dual-modality imaging of T2-weighted MR and UCL is rarely reported. We find that NaYF 4 :Yb 3+ ,Tm 3+ ,Co 2+ (MUC) nanorods can be applied as a high-performance dual contrast agent for both T2-weighted MR and UCL dual-modality imaging. After modification with 6-O-carboxymethyl chitosan (OCC), MUC nanorods can be endocytosed by cells without showing signs of cytotoxicity. High-quality UCL images of living cells incubated with MUC-OCC nanorods were acquired on a near-infrared (NIR) confocal microscopy under the excitation at 980 nm. Moreover, MUC-OCC nanorods display high transverse (r2) relaxivities in vitro . The application of low-dose MUC-OCC nanorods for NIR-to-NIR UCL and MR dual-modality in vivo imaging was also carried out successfully. In addition, the toxicity of MUC-OCC nanorods was evaluated by MTT assay , serological tests and histological analysis of visceral organs.
研究领域:
生物医学工程
·
分子影像学
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2021
·
IF 7.46
Wei Tang,Ruo Mi,Lun Wang,Hongqi Chen
A quantitative image analysis and separation system was designed for detection of human immunodeficiency virus (HIV) related DNAs in the red region by combining of upconversion luminescence nanoprobe and magnetic beads (MBs). Carboxyl-modified NaGdF 4 :Yb, [email protected] 4 upconversion nanoparticles (UCNPs) were connected to single-stranded DNA to form a reporter probe, while carboxyl-modified magnetic beads were connected to another single-stranded DNA to form a capture probe. In the presence of target HIV DNAs, NaGdF 4 :Yb, [email protected] 4 UCNPs and magnetic beads were conjugated to form UCNPs-DNA-MBs nanocomplexes through DNA-DNA heteroduplexes based on the principle of complementary base pairing. After magnetic separation, the upconversion luminescence intensity of UCNPs-DNA-MBs nanocomplexes was related to the concentration of the target HIV DNAs. The detection methods were investigated by fluorescence spectrometry and quantitative image analysis based on upconversion luminescence total internal reflection (TIR) imaging platform. Compared to the luminescence spectral analysis, the quantitative image analysis shows higher sensitivity (linear range of 0.02−30 nM and detection limit of 0.0102 nM). More importantly, this method only needs 10 μL sample and the analysis time is about 0.1 s. The method combines quantitative image analysis with magnetic separation technology, which has the characteristics of low background interference and high separation efficiency allowing for application to the field of biology.
研究领域:
分析化学
·
生物技术
·
纳米技术
·
病毒学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）