BIOSENSORS & BIOELECTRONICS
·
2016
·
IF 7.476
Min Cui,Zhiling Song,Yumin Wu,Bing Guo,Xiaojian Fan,Xiliang Luo
Biocompatible polymers, such as poly(ethylene glycol) (PEG), are of great significance in the development of bio-interfaces and biosensors, as they possess excellent biocompatibility and are easy for modification. A novel highly biocompatible polymer composite was synthesized herein through electrochemical polymerization of the conducting polymer poly(3,4-ethylenedioxythiophene) (PEDOT) and a PEG derivative, 4-arm PEG terminated with thiol groups . The electrodeposited conducting polymer composite of PEG doped PEDOT (PEDOT/PEG) exhibited flake-like nanostructure , large surface area and outstanding stability. In order to further immobilize antibodies, gold nanoparticles (AuNPs) were introduced to the PEDOT/PEG composite surface through their unique interaction with the thiol groups . AuNPs modified PEDOT/PEG provided a desirable support for the immobilization of various biomolecules such as antibodies for alpha fetoprotein (AFP), a vital tumor biomarker for liver cancer. The fabricated AFP biosensor demonstrated favorable selectivity, high sensitivity, and ultralow detection limit. Furthermore, owing to the presence of PEG polymers that are highly hydrophilic , such AuNPs/PEDOT/PEG based AFP biosensor also exhibited good anti-fouling ability, and it was capable of assaying target AFP in 10% (V/V) human serum samples, indicating highly feasible potential for clinical diagnosis.
研究领域:
生物医学工程
·
材料科学
·
肿瘤学
✓ 已验证
DOI
高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2017
·
IF 3.012
Ahmat Ali,Ruxangul Jamal,Tursun Abdiryim,Xueli Huang
Poly(3,4-ethylenedioxythiophene)/Gold (PEDOT/Au) hollow nanospheres with the ratio of EDOT and HAuCl 4 from 2:1 to 1:2 were synthesized by in-situ polymerization method. The synergism between the PEDOT and Au explored for detection of Dopamine (DA) and Uric acid (UA) in neutral phosphate buffer solutions (PBS 7.0). It was found that the monodispersed PEDOT and PEDOT/Au hollow nanospheres had been successfully prepared. Electrochemical experiments showed that the PEDOT/Au(1:1) modified electrode revealed excellent electrocatalytic activity with faster electron charge transfer kinetics. The results from differential pulse voltammetry (DPV) experiments revealed that the PEDOT/Au(1:1) electrode has excellent linear response with 0.15 μμ–330 μM and 1.5 μM–150 μM for the determination of DA and UA, respectively. The detection limits(S/N = 3) were found to be 0.07 μM and 0.08 μM for determination of DA and UA, respectively. The PEDOT/Au(1:1) modified electrode also had good reproducibility, repeatability and excellent stability.
研究领域:
材料科学
·
分析化学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
GREEN CHEMISTRY
·
2015
·Vol. 18
·期 6
·1731-1737
·
IF 8.02
Mengmeng Fan,Chunlin Zhu,Lin Liu,Qilu Wu,Qingli Hao,Jiazhi Yang,Dongping Sun
We have successfully prepared poly (3,4-ethylenedioxythiophene) (PEDOT)/N-doped reduced graphene oxide (N-rGO) by electrodeposition, post-reduction, and doping N atoms with a microorganism (as a green reagent) to modify PEDOT and resolve the exfoliation and fragmentation problems of pristine PEDOT. This modification greatly improves the electrochemical properties of PEDOT, showing great potential for a bio-electrode coating material, which should have excellent electrochemical properties, stability and biocompatibility. The as-prepared PEDOT/N-rGO shows lower impedance, and higher capacitive performance and cyclical stability than pristine PEDOT due to the doping of N-rGO. An MTT assay demonstrates this modified PEDOT has good adhesion, cell viability and proliferation, similar to pristine PEDOT. This indicates that the modification process does not restrain the good biocompatibility of pristine PEDOT, which results from the doping of highly biocompatible N-rGO by this green method. The wrinkled structure, residual oxygen containing functional groups and dopant N atoms of N-rGO lead to the formation of a fluctuating surface and an increase in the hydrophilicity of PEDOT, which increase the specific surface area and cell adhesion in cell culture, respectively. Consequently, this modified PEDOT improves the electrochemical properties, and resolves the exfoliation and fragmentation problems of pristine PEDOT, while still retaining the high biocompatibility of pristine PEDOT, which is promising for a bio-electrode coating material.
研究领域:
生物材料学
·
电化学
·
生物医学工程
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry A
·
2014
·Vol. 2
·期 43
·18345-18352
·
IF 0
Han Li,Minqiang Sun,Tao Zhang,Yuqian Fang,Gengchao Wang
A novel PEDOT-PSS coated sulfur@activated porous graphene composite (PEDOT/S@aPG) is prepared by the impregnation of sulfur with aPG and encapsulation with PEDOT-PSS as the cathode material for lithium–sulfur batteries. The abundant nanopores and large surface area of aPG can provide an intimate contact and strong interaction with S species. Furthermore, the conductive PEDOT-PSS layer can facilitate the charge transportation and prevent the dissolution of polysulfides. As a result, the as-prepared PEDOT/S@aPG composite cathode with a sulfur content of about 60.1% shows a higher specific discharge capacity (1198 mA h g−1 at 0.1 C) in the first cycle and good cycling stability, retaining a reversible capacity of 845 mA h g−1 after 200 cycles. Moreover, the PEDOT/S@aPG cathode also exhibits excellent rate capability, showing a high reversible capacity of 718 mA h g−1 at 2 C.
研究领域:
材料科学
·
电化学
·
能源存储
·
纳米材料
·
电池技术
✓ 已验证
DOI
MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 6
·1-12
·
IF 5.3
Zhao Zexu,Hou Yang,Zhang Hao,Guo Jiahao,Wang Jinyi
Rapid and accurate in situ determination of dopamine is of great significance in the study of neurological diseases. In this work, poly (3,4-ethylenedioxythiophene): poly (styrenesulfonic acid) (PEDOT: PSS)/graphene oxide (GO) fibers were fabricated by an effective method based on microfluidic wet spinning technology. The composite microfibers with stratified and dense arrangement were continuously prepared by injecting PEDOT: PSS and GO dispersion solutions into a microfluidic chip. PEDOT: PSS/GO fiber microelectrodes with high electrochemical activity and enhanced electrochemical oxidation activity of dopamine were constructed by controlling the structure composition of the microfibers with varying flow rate. The fabricated fiber microelectrode had a low detection limit (4.56 nM) and wide detection range (0.01–8.0 µM) for dopamine detection with excellent stability, repeatability, and reproducibility. In addition, the PEDOT: PSS/GO fiber microelectrode prepared was successfully used for the detection of dopamine in human serum and PC12 cells. The strategy for the fabrication of multi-component fiber microelectrodes is a new and effective approach for monitoring the intercellular neurotransmitter dopamine and has high potential as an implantable neural microelectrode. Graphical abstract
研究领域:
生物医学工程
·
神经科学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Catalysts
·
2019
·Vol. 9
·期 5
·407
·
IF 3.444
Bin Yang,Guoqiang Chen,Huiwen Tian,Lei Wen
In this study, oxygen vacancy modified TiO2nanorod array photoelectrode was prepared by reducing hydrogen atmosphere to increase its free charge carrier density. Subsequently, a p-type conductive poly 3,4-ethylenedioxythiophene (PEDOT) layer was deposited on the surface of oxygen vacancy modified TiO2, to inhibit the surface states. Meanwhile, a p-n heterojunction formed between PEDOT and TiO2to improve the separation of photo-induced carriers further. The photocurrent of TiO2nanorod array increased to nearly 0.9 mA/cm2after the co-modification under standard sunlight illumination, whose value is nearly nine times higher than that of pure TiO2nanorod array. Thus, this is a promising modification method for TiO2photoanode photoelectrochemical (PEC) performance improving.
研究领域:
材料科学
·
光电化学
·
纳米材料
·
半导体物理
·
能源材料
·
表面改性
✓ 已验证
DOI
高影响因子
MICROCHIMICA ACTA
·
2016
·Vol. 184
·期 2
·483-489
·
IF 4.831
Wang Junjie,Wang Yu,Cui Min,Xu Shenghao,Luo Xiliang
An electrochemical sensor for H 2 O 2 was developed based on electrochemically deposited Prussian blue (PB) nanoparticles doped poly(3,4-ethylenedioxythiophene) (PEDOT). The PEDOT/PB composite was composed of PEDOT wrapped PB nanoparticles, where the conducting polymer PEDOT not only protected the PB particles to warrant high stability, but also connected them to enhance the electron transfer. Owing to the excellent conductivity of PEDOT and unique electrocatalytic activity of PB, the PEDOT/PB modified electrode exhibited good catalytic activity toward the electrochemical reduction of H 2 O 2 , and was used for the detection of H 2 O 2 in concentrations ranging from 0.5 to 839 μM, with a detection limit of 0.16 μM. Moreover, the sensor also demonstrated excellent reproducibility, selectivity and long-term stability, showing great promise for the fabrication of electrochemical sensors and H 2 O 2 related biosensors.
An electrochemical non-enzymatic sensor for hydrogen peroxide with excellent stability was developed. It is based on conducting polymer PEDOT doped with Prussian blue nanoparticles.
研究领域:
生物医学工程
·
电化学传感
·
纳米材料应用
·
生物传感器开发
✓ 已验证
DOI
高影响因子
Biomaterials Science
·
2020
·Vol. 8
·期 11
·3173-3185
·
IF 6.183
Boguang Yang,Fanglian Yao,Lei Ye,Tong Hao,Yabin Zhang,Lei Zhang,Dianyu Dong,Wancai Fang,Yan Wang,Xiaoyang Zhang,Changyong Wang,Junjie Li
The development of three-dimensional conductive scaffolds is vital to support the adhesion, proliferation and myocardial differentiation of stem cells in cardiac tissue engineering. Herein, we describe a facile approach for preparing a poly(3,4-ethylenedioxythiophene)/alginate (PEDOT/Alg) porous scaffold with a wide range of desirable properties. In the PEDOT/Alg scaffold, chemically crosslinked alginate networks are formed using adipic acid hydrazide as the crosslinker, and PEDOT is synthesized in situ in the alginate matrix simultaneously. PEDOT exists in the alginate matrix as particles and its morphology can be modulated by adjusting the ratio of PEDOT/alginate. The results also show that the swelling properties, degradation behaviors, mechanical strength and conductivity of the PEDOT/Alg scaffold can be controlled via adjusting the PEDOT/alginate ratio. The introduction of PEDOT can overcome the brittle nature of the pure alginate scaffold. Moreover, the PEDOT/Alg scaffold exhibits excellent conductivity (as high as 6 × 10−2 S cm−1). The introduction of PEDOT improves the protein absorption capacity of the alginate scaffold. To explore its potential application in cardiac tissue engineering, brown adipose-derived stem cells (BADSCs) are seeded in the prepared PEDOT/Alg porous scaffold. The results suggest that the PEDOT/Alg porous scaffold can support the attachment and proliferation of BADSCs. Moreover, it is beneficial for the cardiomyogenic differentiation of BADSCs, especially under electrical stimulation. Overall, we conclude that the PEDOT/Alg porous scaffold may represent an ideal platform to modulate the biological behaviors of BADSCs.
研究领域:
生物材料
·
干细胞研究
·
组织工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2019
·Vol. 30
·期 15
·14007-14021
·
IF 2.195
Ahmed Arsalan,Jia Yunming,Huang Yi,Khoso Nazakat Ali,Deb Hridam,Fan Qinguo,Shao Jianzhong
We developed a high-performance electrically conductive and transparent PVDF-TrFE based electrode for piezoelectric pressures sensor using the electrospinning technique. The electrode was produced by depositing the reduced graphene oxide (rGO), multiwall carbon nanotubes (rGO-MCNTs) via spray coating. Various concentration of rGO and MCNTs were used and optimized for improved electrical performance of the resultant electrode. The deposition of poly (3,4-ethylenedioxythiophene) (PEDOT) was successfully achieved by using vapor phase polymerization (VPP). The morphological characteristics of the as-prepared hybrid composite nanofiber mats were analyzed by using field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), Fourier transforms infrared spectroscopy (FT-IR), Raman spectroscopy, X-ray diffraction (X-RD), and UV–visible spectroscopy. The electrical performance of the fabricated composite nanofibers was measured by using a four-point probe device. The results showed significant enhancement in electrical conductivity of the hybrid nanocomposite which increased up to 3916 S cm −1 and sensitivity of the developed pressure sensor was achieved 67.4 kPa −1 . This work suggests that the hybrid nanocomposite can be used for the transparent electrodes in a piezoelectric pressure sensor.
研究领域:
材料科学
·
纳米技术
·
传感器技术
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2024
·
IF 4.1
Xingrong Yin,Xiongwei Wu,Fangzhong Liu,Bei Long
The vanadium oxyhydroxide has attracted considerable attention as a cathode in aqueous zinc-ion batteries due to its changeable morphology and high theoretical capacity. However, poor conductivity and structural disintegration limit its further application. Herein, we prepare VOOH nanoparticles and apply them onto carbon cloth, followed by coating with poly(3,4-ethylenedioxythiophene) (VOOH@PEDOT). The PEDOT coating layer and carbon cloth substrate significantly mitigate volume change and enhance electrode conductivity during cycling. Benefiting from the improved charge transfer and structural stability, the optimized VOOH@PEDOT displays an excellent discharge capacity of 230 mA h/g and good cycle stability over 500 cycles at 1 A/g. Additionally, the energy storage mechanism is elucidated through ex-situ XRD analysis.
研究领域:
材料科学
·
电化学
·
能源存储
·
纳米材料
·
电池技术
✓ 已验证
DOI
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 117
·96862-96869
·
IF 3.84
Zhijie Gong,Qixing Wu,Fang Wang,Xu Li,Xianping Fan,Hui Yang,Zhongkuan Luo
Increasing the sulfur loading in the cathode of a lithium–sulfur battery is an important way to improve its capacity for practical applications. To achieve this, the present work proposes using PEDOT-PSS to encapsulate sulfur/carbon black (S/BP) by a facile solution mixing method and the formed composite is then coated on a porous carbon paper. It is believed that the formation of a core/shell structure in the PEDOT@S/BP composite can promote the electron transport and effectively impede the diffusion of polysulfides, and the porous carbon paper is able to retain the electrolyte containing the dissolved polysulfides in the cathode and alleviate the adverse effect of sulfur volumetric expansion. Due to such advantages, the proposed cathode, with a high sulfur loading of 3 mg cm−2, can yield a high reversible capacity of 1041 mA h g−1 and an excellent cycle stability with a capacity retention of 868 mA h g−1 after 100 cycles and an average coulombic efficiency of 99.4%.
研究领域:
电化学
·
能源材料
·
纳米复合材料
·
电池技术
·
功能高分子材料
✓ 已验证
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2021
·Vol. 139
·期 17
·52049
·
IF 3.125
Xiangqian Jiang,Chuncheng Ban,Ling Li,Jiandong Hao,Ningqiang Shi,Weiping Chen,Peng Gao
In recent years, the thermoelectric properties of one-dimensional boron nitride nanomaterials have gradually attracted widespread attention of researchers in the world. In this paper, boron carbon nitrogen based composite nanofiber films were prepared by electrospinning. It is found that the diameter of nanofibers decreases in BCNNTs/PVA/PEDOT composite films when electrospinning voltage rises, while diameter increases as PVA and BCNNTs concentration increase of electrospinning precursor solution. Finally, thermoelectric power factor is investigated of the composite nanofiber films. It is verified that thermoelectric properties of the films closely related to electrospinning quality. However, fiber density of single-layer BCNNTs/PVA/PEDOT nanofiber film is too low, folding increase the density and thickness of multilayer BCNNTs/PVA/PEDOT nanocomposite fiber films, and the thermoelectric characteristics are significantly improved. The Seebeck coefficient can reach 3.62 mV/K and the power factor is 29.09 nW/mK 2 .
研究领域:
材料科学
·
纳米技术
·
热电学
·
聚合物科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）