JOURNAL OF APPLIED POLYMER SCIENCE
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2015
·Vol. 132
·期 27
·
IF 1.768
Lijing Teng,Wangyan Nie,Yifeng Zhou,Linyong Song,Pengpeng Chen
The purpose of this study was to investigate the suitability of a six-arm star-shaped poly( l -lactide)s (s-PLLA) as controlled drug carriers for hydrophobic drug molecules. First, s-PLLA was synthesized by ring-opening polymerization of l -lactide using sorbitol as initiator and stannous octoate as catalyst. The structure and molecular weight ( M w ) of s-PLLA was characterized with 1 H NMR, 13 C NMR, and GPC. Second, rifampicin (RIF) used as a model drug was encapsulated within the microspheres of s-PLLA via oil-in-water emulsion/solvent evaporation technique. The morphology, drug encapsulation efficiency (EE), and in vitro release behavior of the prepared microspheres were studied in details. Results indicated that the average diameters of s-PLLA microspheres can be controlled between 8 and 20 µm by varying the copolymer's concentration or M w . The EE of RIF was mainly determined by the concentration of s-PLLA. The in vitro study showed that the burst release behavior can be depressed by increasing the M w of the s-PLLA. Present work suggests that the synthesized s-PLLA could be used as a new material for drug delivery. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132 , 42213.
研究领域:
材料科学
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药学
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生物医学工程
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产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2021
·
IF 6.707
Xiang Gao,Rui Huang,Yanpeng Jiao,Thomas Groth,Wufeng Yang,Chenlin Tu,Hailong Li,Fan Gong,Jiaqi Chu,Mingyan Zhao
The healing of wounds in diabetes mellitus patients remains a critical clinical challenge globally. To promote healing, the development of bioactive dressings that not only provide physical protection but also supply a favorable microenvironment for healing at the wound interface is urgently required. Herein, Michael addition reaction was first used for intrinsic-crosslinking of bioactive maleilated chitosan/thiolated hyaluronan (mCH/tHA) multilayer coatings on poly (L-lactic acid) (PLLA) nanofibrous mats (P-mCH/tHA) for a sustained release of insulin (IN) and compared that with pure PLLA and PLLA mats coated with native CH/HA (P-CH/HA) multilayers. The physicochemical studies showed that P-mCH/tHA have higher tensile strength, an accelerated degradation rate, more antibacterial activity and sustained release of insulin when compared to P-CH/HA and pure PLLA mats. Studies on bioactive properties of PLLA mats coated with either mCH/tHA or CH/HA indicated an improved adhesion, spreading and proliferation of mesenchymal stem cells on P-mCH/tHA_IN in comparison to the other PLLA mats. Most interestingly, in vivo investigations with a diabetes mouse model demonstrated fastest wound closure when using P-mCH/tHA_IN among all groups with facilitated re-epithelization, angiogenesis, and increased collagen deposition in the wounds, which makes this coating in combination with IN promising for development of new bioactive wound dressings.
研究领域:
生物医学工程
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材料科学
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药剂学
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组织工程
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产品关联
DOI
高影响因子
LANGMUIR
·
2021
·
IF 3.882
Lingqi Zhong,Haizheng Tao,Xiao Gong
In this work, superhydrophobic poly(l-lactic acid) (PLLA) hierarchical membranes exhibiting excellent oil-removal performance, which is of great importance in curbing the oil-pollution environment, were fabricated by a simple solvent-evaporation-induced precipitation method. PLLA membranes with hierarchical micro/nanostructures (fish scales, fibrous sheets, and petal-like morphology) can be conveniently prepared by adjusting the preparation parameters including PLLA concentration, precipitation temperature, type of solvent and nonsolvent, and the addition of nano-SiO2. The results show that the water contact angle of the fish-scale-structured PLLA membrane was 138.6°, revealing that water repellency was significantly improved compared to that of the solvent-casting PLLA membrane (∼72.8°). Moreover, the PLLA/SiO2 nanocomposite membrane with a dense hierarchical micro/nanostructure had a water contact angle greater than 167.1°, which has great potential in oil–water separation.
研究领域:
材料科学
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环境工程
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化学工程
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产品关联
DOI
PubMed
高影响因子
Advanced Fiber Materials
·
2021
·Vol. 3
·期 6
·383-393
·
IF 0
Lei Fan,Liang Minhua,Liu Yang,Huang Hanhao,Li Haofei,Dong Hua
Organ-on-a-chip (OOC) is now becoming a potential alternative to the classical preclinical animal models, which reconstitutes in vitro the basic function of specific human tissues/organs and dynamically simulates physiological or pathological activities in tissue and organ level. Despite of the much progress achieved so far, there is still an urgent need to explore new biomaterials to construct a reliable and efficient tissue–tissue interface and a general fabrication strategy to expand from single-organ OOC to multi-organ OOC in an easy manner. In this paper, we propose a novel strategy to prepare double-compartment organ-on-a-chip (DC-OOC) using electrospun poly( l -lactic acid)/collagen I (PLLA/Col I) nanofiber membrane as tissue–tissue interface. The unique features of PLLA/Col I nanofiber membrane like excellent biocompatibility, strong affinity to multiple cells, adjustable orientation, controllable thickness and porosity endow the tissue–tissue interface with excellent semi-permeability, appropriate mechanical support, inducible cell orientation, good cell adhesion and proliferation. The integration of 3D printing technology during the fabrication process enables precise size control of the tissue–tissue interface and stable bonding with microfluidic channels. More importantly, our fabrication strategy and OOC configuration makes it easy to extend from DC-OOC to multi-compartment organ-on-a-chip (MC-OOC). To show its possible application, in vitro jaundice disease model is established by constructing blood vessel/skin/liver/lung organ-on-a-chip via MC-OOC. The downward trends of the cell viability after perfusion of bilirubin, the variation in cell sensitivity to bilirubin for different type of cells and recovery of cell viability after blue light therapy prove the feasibility of this jaundice disease model. We believe this general strategy of constructing tissue–tissue interface and multi-organ OOC can be used for many other in vitro physiological and pathological models. Graphic Abstract a Schematic illustration on fabrication process of DC-OOC; b construction of blood vessel/skin/liver/lung organ-on-a-chip as in vitro jaundice disease model
研究领域:
生物医学工程
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组织工程
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药物测试
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疾病建模
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产品关联
DOI
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Jian Hu,Bo Liu,Tao Sun,Jiatao Zhang,Xueyan Yun,Tungalag Dong
The irreconcilable paradox between barrier performance and ductility is a “stumbling block” restricting the development of poly(L-lactic acid) (PLLA) films in the packaging industry. In this work, we reported the fabrication of an ultra-thin PLLA-based film with barrier properties and ductility by adjusting the polarity and conformational behavior of the polymer chains. Firstly, a novel unsaturated poly(L-lactic acid- co -butyrate itaconate) P(LA-BI) copolymer containing C C double bonds was synthesized using melt polycondensation. The results reveal that the addition of 60 % of P(LA-BI) enables PLLA film to achieve an elongation at a break of 83.6 % due to P(LA-BI) containing partially branched structures, which resulted in the polymer chains being arranged more in a high-energy gg conformer. Meanwhile, because of the large number of C O polar groups in P(LA-BI), PLLA/P(LA-BI) 60 film show CO 2 and O 2 permeability coefficients (CDP and OP) of 1.8 and 0.45 × 10 −8 g·m·m −2 ·h −1 ·Pa −1 respectively, which means that it has excellent gas barrier properties. Moreover, PLLA/P(LA-BI) 60 film shows a 33.3 % increase in CO 2 /O 2 ratio and an excellent ultraviolet (UV) barrier performance compared to neat PLLA. Preservation results suggested that the CO 2 and O 2 levels within the package could be regulated by varying the amount of P(LA-BI) added. Among them, PLLA/P(LA-BI) 40 film generated a more desirable CO 2 and O 2 atmosphere for cherry tomatoes preservation, which was reflected by the delaying of senescence, discoloration, and decay, inhibition of oxidative cell damage through reduced malondialdehyde production, and maintenance of nutritional and flavor substances in cherry tomatoes. This PLLA-based film offers the advantages of operational simplicity, environmental friendliness, and inexpensive cost, making it great promising for food preservation and other applications requiring barrier properties and ductility.
研究领域:
材料科学
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食品科学
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聚合物化学
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包装工程
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2018
·
IF 6.735
Yun Zhong,Tiantian Li,Haibo Lin,Lei Zhang,Zhu Xiong,Qile Fang,Guoying Zhang,Fu Liu
In this work, we report the continuous flowing catalysis of meso-/macro-porous microspheres confining Au nanoparticles based on Poly ( l -lactic acid)/Poly (D-lactic acid) (PDLA/PLLA) stereo-complex membrane. Plentiful meso-/macro-porous microspheres (1–2 µm diameter) were assembled inside the stereo-complex Poly(lactic acid) (PLA) membrane through the phase inversion, which were thought to play a critical role on robustly capturing and confining Au nanoparticles (30–40 nm diameter) with the loading content of 1.56 g/m 2 , as demonstrated by the SEM, TEM, EDX and XPS. The Au nanoparticles-loaded stereo-complex PLA membrane exhibits an instantaneous reduction for 4-nitrophenol in a continuous flowing operation with the dynamic reactive constant 386 min −1 under the water flux of 262.8–1440 L/m 2 ·h, which was ∼2900 fold higher than the static catalytic. Moreover, the catalytic membrane keeps above 90% conversion even after 140 min continuous flowing. In addition, The Au nanoparticles-loaded stereo-complex PLA membrane demonstrated the better bovine serum albumin (BSA) antifouling and ink colloid rejection. All results verified that the stereo-complex PLA membrane provided a feasible platform for meso-/macro-porous microspheres confining Au nanoparticles as high efficient heterogeneous catalysts. The proposed strategy could be extended to other robust heterogeneous catalysts for membrane catalytic applications.
研究领域:
材料科学
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催化化学
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环境工程
✓ 已验证
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
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2024
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IF 18.5
Jie Liao,Xiaoming Li,Huiqi Yang,Wei He,Bingbing Wang,Shuyu Liu,Yubo Fan
Postoperative adhesion (POA) has emerged as a prevalent clinical challenge in soft tissue repair, emphasizing the critical need for preventive measures. However, the complex POA development process makes POA prevention from a single aspect insufficient. Hence, a curcumin-loaded poly-L-lactic acid-poly (caprolactone) micro-nano conjugated fibrous membrane (PAPC MCFM (cur)) is engineered to synergistically prevent POA from multiple perspectives, in which poly (caprolactone) (PCL) nanofibers (118 ± 12 nm) with low orientation traverse the oriented poly-L-lactic acid (PLLA) microfibers (2.0 ± 0.3 µm). The PAPC MCFM not only significantly improves the mechanical properties of the anisotropic fibrous membrane (AIFM) that the modulus of elasticity and the tensile strength in the direction vertical to microfiber orientation increase by 4.5 and 13.0 times, respectively, but also can further enhance the “contact guidance effect” of AIFM, i.e., hindering fibroblast adhesion, proliferation, and differentiation to myofibroblast through inhibiting integrin β1 activation, vinculin expression and focal adhesion (FA) formation, and the nuclear localization activation of yes-associated protein (YAP). Except for these effects, PAPC MCFM loading with 2.5 mg mL −1 curcumin can further prevent POA by delivering anti-inflammatory, antioxidant, and antibacterial properties, and by suppressing fibrosis through decreased transforming growth factor-β1(TGF-β1) expression, showing effective POA prevention in rat abdominal cavity and rabbit dura mater models.
研究领域:
生物医学工程
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材料科学
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组织工程
·
药剂学
✓ 已验证
产品关联
DOI
高影响因子
POLYMER
·
2024
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IF 4.1
Shitong Wang,Kai Huang,Wenjing Shi,Jiajia Mo,Honghui Shi,Chuntai Liu,Baobao Chang
Stereocomplex crystal (SC) in poly( l -lactide) (PLLA)/poly( d -lactide) (PDLA) can significantly improve the heat resistance and mechanical performance of poly(lactic acid). In this work, a selective degradation method is developed to etch the PLLA/PDLA blend using proteinase K, and a two-phase co-continuous structure is observed directly using scanning electron microscope. Meanwhile, the evolution of the microphase morphology, inter-chain interaction, chains orientation, and crystallization of un-crosslinked and crosslinked blends during solid-state stretching, as well as the formation of SC during heating/annealing are comprehensively investigated. Results showed that the phase separation in the stretched blend could be drastically restricted by crosslinking; during stretching a blue-shift of 2995 cm −1 band shows up for both crosslinked and un-crosslinked blends as a result of the dipole-dipole coupling interaction between CH 3 and CH 3 , while the hydrogen bond interaction between CH 3 and C O is absent; only mesophase or homocrystal (HC) is formed in the stretching temperature range of 60∼105 °C; the critical strain for HC formation is advanced and the orientation of chains is enhanced by crosslinking under the same stretching condition. In the last, benefiting from the greatly reduced microphase size (namely enlarged interfacial area between PLLA and PDLA) and enhanced chains orientation, the crystallization rate of SC is accelerated during annealing, and the ultimate crystallinity of SC is elevated in the crosslinked blend.
研究领域:
材料科学
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 68
·63597-63606
·
IF 3.289
Shasha Zhao,Xiaoshan Fan,Xiaoyan Li,Xianglin Lv,Weiwei Zhang,Zhiguo Hu
Y-Shaped amphiphilic copolymers (zwitterionic-(PLLA2.5K)2 and MPEG-(PDLA2.5K)2) were simply synthesized through click reaction of alkyne-(PLA2.5K)2 and zwittterionic-N3 or MPEG-N3. Gel permeation chromatography (GPC) and 1H nuclear magnetic resonance (1H NMR) were employed to characterize the composition and structure of these copolymers. The stereocomplexes were prepared from pairs zwitterionic-(PLLA2.5K)2/MPEG-(PDLA2.5K)2 (molar ratio = 1 : 1), and confirmed by differential scanning calorimeter (DSC). Furthermore the aggregation behaviors for these synthesized polymers and their stereocomplexes had been proved by fluorescence spectroscopy (PL), transmission electron microscopy (TEM), dynamic light scattering (DLS) and static light scattering (SLS), and zeta potential. Their critical micelle concentration (CMC) obtained by PL was 0.0213 mg mL−1 for zwitterionic-(PLLA2.5K)2/MPEG1.9K-(PDLA2.5K)2 and 0.1265 mg mL−1 for zwitterionic-(PLLA2.5K)2/MPEG5K-(PDLA2.5K)2. The stereocomplexes could self-assemble into spherical micelles with diameters of 76 nm (zwitterionic-(PLLA2.5K)2/MPEG1.9K-(PDLA2.5K)2) and 89 nm (zwitterionic-(PLLA2.5K)2/MPEG5K-(PDLA2.5K)2) respectively. The biocompatibility of these copolymers and their stereocomplexes was evaluated with relatively low cytotoxicity. The DOX-loaded micelles of the stereocomplexes had a higher drug loading content and encapsulation efficiency, and could release DOX in a controlled manner. Therefore, the new stereocomplex zwitterionic-(PLLA)2/MPEG-(PDLA)2 has great potential as a hydrophobic drug nanocarrier.
研究领域:
生物材料
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药物递送系统
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2026
·
IF 5.4
Fangwei Qi,Mingming Xia,Zhongxing Zou,Donglan Zhang,Xiuwen Gao,Huixing Yu,Dongan Wang,Xiaojuan Guo,Huixing Li,Shuping Peng,Cijun Shuai
Conductive polymer composite scaffold displayed great advantages in nerve repair due to it could highly simulate the electrical microenvironment of natural tissues. However, the poor interfacial adhesion and the discrete distribution of conductive fillers in polymer matrix weaken its conductivity. Herein, Polydopamine (PDA) was grown in situ on PLLA microspheres, and then loaded with MXene nanosheets. Subsequently, a conductive MXene/PDA/PLLA conduit was fabricated by laser additive manufacture. During this processing, a three-dimensional continuous conductive network was constructed on the conduit utilizing its shearing-free properties. Meanwhile, PDA could form covalent and hydrogen bonds with MXene and PLLA through catechol, amino and imino groups, enhancing their interfacial compatibility. Additionally, PDA could generate photothermal for antibacterial under near-infrared radiation. DFT calculations proved the existence of favorable interfacial interactions between PDA and MXene and PLLA. Results showed that MXene was uniformly wrapped around the PLLA, forming a three-dimensional continuous conductive network in the conduit. At 7.5 wt% MXene, the permeation threshold and conductivity reach 1.81 % and 4.8 S/m, respectively. The enhanced current promoted cell nerve differentiation, as evidenced by a 2.4-fold upregulation of Nestin and a 4.3-fold increase in Ca 2 + influx. Besides, the conduit could effectively kill S. aureus and E. coli due to its excellent photothermal effect.
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产品关联
DOI
高影响因子
COMPOSITES SCIENCE AND TECHNOLOGY
·
2022
·
IF 9.879
Jipeng Guan,Wentao Luo,Shifang Lu,Yaru Yang,Xiaojun Shen,Bolin Tang,Yongjin Li
In the polymer blends , strength is usually compromised to toughness after feeding the specialty additives and/or toughening agents. Herein, the functional Janus nanosheets (JNSs) with grafting PU chains and epoxide groups on the opposite sides of the silica nanosheets have been synthesized successfully, denoted as PU-SiO 2 -epoxy JNSs. The functional JNSs as the compatibilizers are incorporated into the typical toughened polylactic acid/thermoplastic polyurethane (PLLA/TPU) blend. In the melt blending process, PLLA chains were in situ grafted onto the side of JNSs with the reaction between epoxide groups on the JNSs and the carboxyl acid groups of the PLLA. Notably, the obtained PU-SiO 2 -PLLA JNSs preferred to assembled at the interface owing to the amphiphilicity and Pickering effect. The interfacial adhesion was greatly enhanced via the selective chain entanglement between grafted chains on the JNSs and blending parts. At 1.0 wt % JNSs loading, the elongation at break increased from 31.4 ± 2.3% to 362.6 ± 19.7% and the modulus increased from 1.0 ± 0.02 GPa to 1.9 ± 0.03 GPa. The JNSs jammed at the interface can act as the stiff shell outside the TPU island which is beneficial for transferring stress under external force. The impact strength reached nearly 100% enhancement after feeding 1.0 wt% JNS. This report provides a new possibility to realize synchronously toughening and strengthening of the polymer blends with the functional Janus nanosheets.
研究领域:
高分子科学
·
材料工程
·
纳米复合材料
·
聚合物共混与相容性
✓ 已验证
DOI
高影响因子
CRYSTENGCOMM
·
2015
·Vol. 18
·期 2
·274-282
·
IF 4.034
Jun Shao,Yanmei Guo,Sheng Xiang,Dongdong Zhou,Xinchao Bian,Jingru Sun,Gao Li,Haoqing Hou
Linear and three-armed poly(L-lactide)/poly(D-lactide) (PLLA/PDLA, 3PLLA/3PDLA and 3PLLA/PDLA) specimens were prepared through a solution mixing method, and the morphology and the spherulite growth of poly(lactide) stereocomplex crystallites (PLA sc) from the melt with various structures and molecular weights were investigated. Polarized optical microscopy images revealed that regular spherulites and a visible boundary developed in all of the PLLA/PDLA blends with relatively lower molecular weights (Mn < 20 kg mol−1 for each branch), and irregular spherulites formed when the molecular weights of PLA polymers were higher than 60 kg mol−1. The growth rate of the spherulites (G) increased at first, and then decreased as the molecular weight increased in all of the PLLA/PDLA, 3PLLA/3PDLA and 3PLLA/PDLA specimens. The highest G value in all of the specimens was achieved when the average molecular weights of each branch were ∼10 kg mol−1. With similar molecular weights for each of the branches, the G reduced gradually as the three-armed PLA was added to the blend (i.e., PLLA/PDLA > 3PLLA/PDLA > 3PLLA/3PDLA).
研究领域:
材料科学
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）