Drug Delivery and Translational Research
·
2020
·Vol. 11
·期 5
·1969-1982
·
IF 2.664
Zhao Haijun,Chen Mengyuan,Zhao Zhujiang,Zhu Linjia,Yuan Shaofei
Balancing the antitumor activity and systemic toxicity of tripterine still faces a big challenge due to the narrow therapeutic window. To address this issue, we report a microemulsion system based on tripterine, brucea oil, and glycyrrhizin, and dual modified with both transferrin and cell-penetrating peptide SA-R 6 H 4 (Tf/SA-R 6 H 4 -TBG-MEs) for combinational and tumor-targeted cancer therapy. Such a microemulsion exhibited a spherical shape with a size of ~50 nm and a mildly-negative charge. The half-maximal inhibitory concentration (IC 50 ) of Tf/SA-R 6 H 4 -TBG-MEs against ovarian cancer SKOV3 cells was 0.27 ± 0.43 μg tripterine/mL, which was 5.85 times lower than that of free tripterine. The cellular uptake of tripterine after treatment with Tf/SA-R 6 H 4 -TBG-MEs was 1.56 times higher than that of TBG-MEs (non-modified microemulsion). In pharmacokinetics studies, the area under the curve of Tf/SA-R 6 H 4 -TBG-MEs increased by 1.97 times compared with that of the physical mixture group. The tumoral accumulation of tripterine was significantly improved in Tf/SA-R 6 H 4 -TBG-MEs group than TBG-MEs-treated group. In antitumor efficacy in vivo, Tf/SA-R 6 H 4 -TBG-MEs exhibited the strongest inhibition of tumor growth and the longest survival period among all the groups, which is associated with the rational combination, microemulsion system, and dual modification with tumor-targeted ligands. Importantly, Tf/SA-R 6 H 4 -TBG-MEs significantly reduced the toxicity of tripterine against the liver and kidney. Our design provides a new approach for efficient and safe ovarian cancer therapy based on a multicomponent combination.
研究领域:
药学
·
肿瘤学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF POLYMERS AND THE ENVIRONMENT
·
2023
·
IF 5.3
Lin Xiaoxia,Zhao Jie,Zhang Yongqi,Li Yuqi,Liao Yiqiang,Zhang Hui
Photocatalytic water treatment is an advanced and efficient technology for water purification. Among various photocatalysts, iron-based metal–organic frameworks (Fe-MOFs) are widely applied for mineralizing organic wastewater due to their excellent water stability and photocatalytic activity. However, their practical application is impeded by insufficient photocatalytic performance, irreversible collapse of the framework structure during repeated use, and difficulty in recovery. In this study, we fabricated a Graphene oxide (GO) structure-oriented NH 2 -MIL-88B(Fe)/graphene oxide/sodium alginate (NM88B/GO/SA) aerogel for the removal of dyes and antibiotics, using GO interface regulation and dual-network crosslinking methods. In this hybrid system, a NM88B/GO heterostructure was formed through the directional growth of NM88B on the surface of GO. The introduction of sodium alginate (SA) enhanced the robustness and stability of the matrix, and effectively avoided aerogel fragmentation. With 30 wt% catalyst loading, the composite aerogel exhibited excellent photocatalytic degradation performance towards high-concentration (50 ppm) tetracycline hydrochloride (TC-HCl), achieving over 99% removal rate in 150 min. It also effectively degraded methylene blue (MB) at 10–30 ppm with over 99% removal rate. Furthermore, the aerogel showed excellent shape recovery ability, stability, and reusability. After five repeated tests, it maintained over 95% degradation efficiency for both TC-HCl and MB. This advanced aerogel holds great promise as a highly efficient and reusable photocatalyst for removing antibiotics and dyes from wastewater. Graphical Abstract
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2023
·
IF 13.6
Chi Ma,Wenlei Fan,Wei Qin,Yafei Guo,Lichun Ma,Nelson Belzile,Tianlong Deng
Although efficient removal of Cs from wastewater is of great importance because of the nuclear energy sustainable development and public health, removing cesium is challenging for the high concentrations of sodium and potassium ions coexist. In this work, we synthesized the first novel bismuth-doped layered tin sulfide (KBS) and applied it to the efficient green adsorption of liquid cesium resources. KBS could reach the adsorption equilibrium for Cs + within only 2 min with a theoretical adsorption capacity of 425.55 mg/g. Furthermore, the adsorption performance remained reliable after 10 cycles of use. The structure and properties of KBS were explained at the molecular level by DFT calculations, and the calculated results were in sound agreement with the experimental data. Meanwhile, in this study, the material was reinforced and shaped by the electrostatic interaction of Zein and sodium alginate hydrogel, and finally, Zein@SA/KBS spherical composite adsorbent was obtained. The problem of the difficult recovery of adsorbent and the secondary contamination was solved. The adsorption performance of Zein@SA/KBS on Cs + was better than most composite adsorbents and showed reliable stability. Therefore, the new microspherical adsorbent (Zein@SA/KBS) has great potential for industrial application in removing radioactive cesium from wastewater.
研究领域:
环境科学
·
材料科学
·
核工程
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COMPOSITES PART B-ENGINEERING
·
2025
·
IF 14.2
Zhengyang Miao,Guangzheng Zhu,Lei Yang,Peng Ding,Fang Jiang
Polymer-based thermally conductive composites have garnered significant attention in recent years due to their critical applications in areas of national strategic importance. Nevertheless, the inherently limited thermal conductivity and mechanical properties of polymers pose challenges to their practical application. Recent research indicates that employing exogenous methods and facilitating molecular-level interactions between fillers and cross-linkers are effective strategies to overcome these limitations. In this study, with the aid of the ionic effect during the sol-gel phase transition of aqueous sodium alginate molecules in the presence of divalent cations and biaxial stretching, combined with the hydrogen bonding between boron nitride nanosheets (BNNS) with excellent thermal conductivity and sodium alginate (SA) molecules, the BNNS-calcium alginate (BNNS/Ca-SA/D) films were constructed by the strategy of gel reconstruction, rehydration, evaporation-assisted self-assembly and biaxial stretching. By designing anisotropic structures with closely aligned interconnected BNNS (Herman orientation parameter as high as 0.865), the BNNS/Ca-SA/D films with a BNNS loading of 40 wt% were characterized by high in-plane thermal conductivity (45.50 W•m −1 •K −1 ) and good mechanical properties. Combined with finite element analysis to simulate the heat transfer process, the “thermo-mechanical” coupled multilevel oriented structure composite films were constructed due to the densification arrangement and the increase of interfacial adhesion during multiple cross-linking processes, and the orientation arrangement of BNNS during the tensile-induced process. The potential of the BNNS/Ca-SA/D films developed in this study for thermal management applications has been demonstrated by the practical application of thermal management devices and the human body. The polymer-based thermally conductive films developed in this paper offer promising applications for thermal management systems in modern power electronics.
研究领域:
材料科学
·
热管理
·
聚合物复合材料
·
纳米材料
·
先进制造
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL PAPERS
·
2025
·
IF 2.5
Chen Yufeng,Li Yutong
A novel surface-enhanced Raman scattering (SERS) substrate was developed to determination of the pesticide carbendazim (CBZ) through the green synthesis of silver nanoparticles (SA-AgNPs-CD) using sodium alginate as a reducing agent and α-cyclodextrin as a molecular recognition stabilizer. The composite material was systematically characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD) and UV–vis spectroscopy. The analysis revealed spherical nanoparticles with an average diameter of approximately 59 nm and localized surface plasmon resonance at 412 nm. 4-aminothiophenol (PATP) was used as a SERS probe to discuss the SERS activity of the substrate and multivariate optimization of detection parameters (substrate–analyte ratio 3:1, pH 6.8, 15 min adsorption, and sequential reagent addition) via orthogonal experimental design. The linear response which extends from 5.0 × 10 −5 to 1.0 × 10 −7 mol/L for CBZ combined with principal component analysis (PCA) revealed an ideal linear relationship between CBZ concentration and principal component F 1 , achieving a limit of detection (LOD) of 1.95 × 10 −9 mol/L. It is expected that this SERS strategy will provide great value for rapid detecting pesticide residues in fruits and food products.
研究领域:
分析化学
·
纳米技术
·
环境科学
·
食品安全
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Chen Chen,Enhui He,Xiaohui Jiang,Shuwei Xia,Liangmin Yu
Biomass-based adsorbent materials are characterized by their low cost, environmental friendliness, and ease of design and operation. In this study, biomass-based hydrogel microspheres erbium alginate (SA/Er) with high stability and adsorption properties were prepared by a one-step synthesis method. The prepared materials were characterized and analyzed by SEM-EDS, XRD, TGA, FT-IR, UV–Vis, BET-BJH and XPS, and the adsorption performance of SA/Er was investigated for high concentrations of azo dyes in water. The results showed that the adsorption performance of SA/Er on the azo dyes of direct violet N (DV 1) and direct dark green NB (DG 6) with concentrations of 850 mg/L and 1100 mg/L under the optimal conditions was very high, and the adsorption amount could be up to 692 mg/g and 864 mg/g, respectively. The adsorption process was in accordance with the quasi-secondary kinetic model, which was accomplished by physical and chemical adsorption; the Langmuir isothermal model was able to better respond to the adsorption equilibrium, and the adsorption was dominated by the adsorption of surface monolayers; after seven desorption cycles, the removal of both azo dyes by the adsorbent material could reach >79.7 %. Combined with the results of FT-IR, UV–vis and XPS analysis before and after the adsorption, it was revealed that the adsorption of SA/Er with the dye molecules mainly consisted of hydrogen bonding, electrostatic adsorption and surface complexation, which resulted in the significant adsorption effect on the two azo dyes, and the above results can provide a reference for the treatment of dye wastewater.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF ENVIRONMENTAL MANAGEMENT
·
2024
·
IF 8
Zhiying Li,Lei Zhao,Qing Ao,Ge Zhang,Dongqing Kang,Yingli Li,Jian Liu,Gongtao Ding,Zhongren Ma,Yeit Haan Teow,Mohd Shaiful Sajab,Zhiqiang Li,Zifan Wang
Studying the adsorption behavior of cationic surfactants can help to develop more effective strategies to limit their dispersion in the environment. However, there have few studies on the adsorption of cationic surfactants from the perspective of critical micelle concentration (CMC). In this study, with cetyltrimethylammonium bromide (CTAB) and octadecyl trimethylammonium bromide (OTAB) serving as the model cationic surfactants, the effect of CMC on the adsorption behavior of cationic surfactant onto the surface of sodium alginate/silica (SA/SiO 2 ) microspheres was systematically revealed. The adsorption mechanism relative to CMC was investigated under different conditions, including surfactant concentration, pH, temperature, and adsorption time. The results suggest that at identical concentrations, the smaller the CMC value of the cationic surfactants, the greater the adsorption amount (q t ). q t for CTAB and OTAB were 583.2 and 678.0 mg/g respectively, with the concentration higher than their CMC value. When the concentration was lower than the CMC value of the cationic surfactants, q t for CTAB and OTAB were 123.2 and 138.7 mg/g, respectively. The CMC value of CTAB was lower than that of OTAB under identical conditions, suggesting that the adsorption of cationic surfactants is related to their CMC. These results are beneficial for the removal of cationic surfactants by adsorption methods.
研究领域:
环境科学
·
化学工程
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2025
·
IF 3.9
Zheng Yang,Jing Xiao,Wulue Xu,Qi Liu,Hongxia Gao,Min Xiao,Zhiwu Liang
The precise removal of heat-stable salts (HSS) from an amine solution remains a challenge where the current separation process can cause ineligible amine loss and decrease the CO2 capture efficiency. This work proposed an interpenetrating polymer network gel (SA-Al/PVA@ME) constructed with sodium alginate (SA), aluminum ions, and poly(vinyl alcohol) (PVA), followed by melamine encapsulation. The formulation of the adsorbent was optimized by orthogonal experiments, leading to an HSS adsorption capacity of 128.28 mg·g–1 in monoethanolamine solution. The encapsulation of melamine (ME) promoted its adsorption affinity for HSS with a slight decrease of capacity. The kinetics and isotherms studies verify the adsorption behavior, and the mechanism was revealed through Fourier transform infrared, Brunauer–Emmett–Teller, scanning electron microscopy–energy-dispersive X-ray spectroscopy, and X-ray photoelectron spectroscopy analysis, suggesting the comprehensive effect of synergistic electrostatic interaction, ion exchange, coordination bonding, hydrogen bonding, and steric hindrance. The results suggest a new strategy to formulate adsorbents with high HSS removal efficiency and good selectivity over amine.
研究领域:
环境科学
·
高分子化学
·
碳捕集与封存
·
吸附技术
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2026
·
IF 5.4
Ruofeng Yang,Haoyu Tang,Yuxuan Liu,Hao Xu,Zongyi Li,Qilong Wu,Yuli Fan,Yan Wei,Ziwei Liang,Di Huang
The high prevalence of cardiovascular diseases has generated a pressing clinical need for small-diameter vascular grafts (<6 mm). However, their clinical translation remains constrained by several challenges, such as suboptimal mechanical properties, thrombotic risks, and limited long-term patency. Moreover, conventional experimental approaches often fail to fully capture the mechanical behavior of grafts under physiologically dynamic blood flow. In this study, artificial vascular grafts with an inner diameter of approximately 2.8 mm were fabricated using coaxial 3D printing technology. We report, for the first time, the integration of gelatin into a sodium alginate (SA)/polyvinyl alcohol (PVA) composite bioink to overcome the inherently poor cell adhesion of conventional SA/PVA scaffolds. The incorporation of gelatin not only significantly enhanced the grafts' hydrophilicity and mechanical properties (including tensile strength and elastic modulus) but also provided intrinsic RGD sequences that actively promote the adhesion and proliferation of endothelial cells. The mechanical performance of the grafts was further improved through cyclic freeze-thaw treatment. Fluid–structure interaction (FSI) finite element simulations were conducted to simulate the hemodynamic environment, analyzing stress–strain distribution and structural stability under flow conditions. Experimental results indicated that the addition of gelatin improved tensile strength and elastic modulus, rendered the material superhydrophilic, and enhanced cell adhesion. Simulations demonstrated that under physiological flow velocities, the maximum wall stress and overall deformation rate of the graft complied with clinical standards. In vitro assays confirmed the material’s excellent hemocompatibility and its capacity to promote endothelial cell proliferation. Download: Download high-res image (267KB) Download: Download full-size image Preparation of the bioink and crosslinking agent; b: Setup and process of coaxial 3D printing; c: Schematic of the cell adhesion mechanism (left and right panels represent gelatin-incorporated and gelatin-free vascular graft materials, respectively).
✓ 已验证
DOI
高影响因子
MACROMOLECULAR RAPID COMMUNICATIONS
·
2025
·
IF 4.3
Jialei Wu,Ruqin Ma,Xin Ge,Miaomiao Lv,Xiaocui Huang,Hong Lin,Ning Qi,Yefeng Yang,Desuo Zhang
Moisture-enabled electric generators (MEGs) harvest environmental moisture for energy generation and environmental monitoring, showing promise in wearable electronics. Electrospinning nanofiber membranes, favored for their large surface area, micro-nano channel networks, material versatility, and facile fabrication, serve as ideal platforms for MEGs. Although sodium alginate (SA), a natural polymer rich in hydrophilic groups, is suitable for humidity-driven energy harvesting, challenges persist in its direct electrospinnability and in balancing sustained hygroscopic power output with structural stability under humid conditions. This work designed an antibacterial bilayer nanofiber membrane with a distinct hydrophilic hierarchical structure using polyvinyl alcohol (PVA), SA, and silver nanoparticles (AgNPs), cross–linked with glutaraldehyde (GA) to enhance durability. The bilayer structure, with an upper layer of PVA/SA/AgNPs and a lower layer of PVA/AgNPs, both cross–linked with 2 wt.% GA, achieved a 0.415 V open-circuit voltage, retaining 93.2% performance after 25 cycles. It exhibited 99.83% and 99.57% inhibition against S. aureus and E. coli , respectively, ensuring biostability in humid environments. These MEGs enable multifunctional integration for real-time moisture detection, respiratory health monitoring, activity tracking, and energy harvesting in self-powered wearable systems.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
DESALINATION
·
2025
·
IF 9.8
Shengqin Dai,Xiaoying Feng,Xiaoyi Wang,Jiyan Li,Weidong Liang
Solar thermal-driven interfacial evaporation technology holds significant promise for applications in sewage purification and desalination. However, challenges such as intermittent solar illumination and salt accumulation hinder its practical effectiveness. In this study, phase change materials (PCMs) were introduced to enhance the evaporation efficiency of evaporator under weak sunlight conditions. Specifically, stearic acid serves as a PCM, conductive carbon black (KBC) as a photothermal material, while chitosan and microcrystalline cellulose(MCC) are utilized as matrix materials. SA was encapsulated in a microgel derived from CS using a vacuum impregnation technique, and KBC/SA was synthesized via a bidirectional regeneration method. Experimental results reveal that the evaporation rate can reach 3.46 kg m −2 h −1 under a light intensity of 1 kW m −2 . With the light source off, the KBC/SA evaporator still sustains an evaporation rate of 1.53 kg m −2 h −1 . On semi-cloudy days, the latent heat released from SA supplies substantial thermal energy, enabling continuous evaporation and increasing total water production by 1.85 kg m −2 compared to the conventional evaporators without PCMs. In addition, the evaporation rate of the solar evaporator in 20 % salt solution can reach 2.98 kg·m −2 ·h −1 , which is only slightly different from that in pure water solution. This study presents an effective strategy to address the intermittent use of solar energy and mitigate salt accumulation in solar-powered seawater desalination systems that employ interfacial evaporation.
研究领域:
材料科学
·
环境科学
·
能源科学
✓ 已验证
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Tingxiang He,Xiang Liu,Shenghua Lv,Dequan Wei,Leipeng Liu
The abuse of antibiotics led to significant environmental pollution through persistent residues in water bodies, posing severe risks to both ecological systems and human health. Addressing this issue, recent studies highlighted the potential of carbonaceous materials as effective adsorbents for removing antibiotics from water. Despite the proven potential of various carbonaceous materials in water purification, the application of three-dimensional porous microspherical aerogels as adsorbents presented a promising yet comparatively less discussed avenue in the quest for efficient antibiotic removal from aquatic environments.This work introduced a novel KGM-GO/CS/SA composite aerogel sphere, developed via a simple sol–gel and dripping method, using konjac glucomannan (KGM) as a cross-linking agent. We extensively analyzed its adsorption efficiency against common antibiotics such as tetracycline (TC), ofloxacin (OFL), and sulfadiazine (SDZ), revealing its rapid adsorption kinetics and high capacity. The aerogel's micro-morphology, characterized by a graded porous structure with abundant microporous channels and a low bulk density of 21.2 mg/cm3, along with its enhanced mechanical properties and thermal stability due to KGM cross-linking, signified its potential as a robust adsorbent. The surface functional groups facilitated diverse interaction mechanisms, including electrostatic attraction, hydrogen bonding, and π-π interactions, contributing to the adsorbent's high performance. Furthermore, the surface charge of the aerogel varied with pH, enhancing its electrostatic adsorption capabilities. The adsorption behavior was best described by the quasi-second-order and Langmuir models, with maximum capacities of 427.63 mg/g for OFL, 374.35 mg/g for TC, and 231.09 mg/g for SDZ, thereby offering a promising solution for antibiotic pollution remediation and illustrating the utility of carbon-based aerogel microspheres in environmental applications.
研究领域:
材料科学
·
环境科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）