TALANTA
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2025
·
IF 6.1
En Han,Ting Gao,Ming Bao,Jianrong Cai
A novel strategy based on flower-like nanocomposite combined with molecularly imprinted polymers (MIP) was developed to achieve electrochemical sensing toward tert-butylhydroquinone (TBHQ) with high sensitivity and selectivity. The flower-like nanocomposite of gold nanoparticles functionalized zinc oxide nanoflowers (ZnO@Au NFs) was prepared by one-step in-situ reduction of gold nanoparticles on the exterior of zinc oxide nanoflowers. Subsequently, the electrodeposition of MIP was taken place on the surface of three-dimensional ZnO@Au NFs in the presence of monomer pyrrole and template molecule TBHQ by cyclic voltammetry, and the morphology of imprinted films could be clearly observed by scanning electron microscopy (SEM). The nanocomposite of ZnO@Au NFs provided a specific surface area of 9.94 m 2 /g for MIP electrodepositing due to a good deal of three-dimensional petal-like structures. More importantly, the obtained flower-like MIP nanocomposite increased the electroactive area and promoted the electrical signal when TBHQ was oxidized in the imprinted cavities, which significantly improved the sensitivity and selectivity for TBHQ determination. Under the optimal conditions, the proposed sensor was able to determine TBHQ within a broad linear range from 0.5 to 200 μM, with a detection limit as low as 58 nM. Besides, the practicability of this sensor was validated in real samples, obtaining well-pleasing recoveries from 95.0 % to 106.6 %. This flower-like MIP-based electrochemical sensor showed high sensitivity, good specificity and acceptable reproducibility, providing a promising platform for highly sensitive sensing of TBHQ.
研究领域:
分析化学
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材料科学
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食品科学
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DOI
PubMed
高影响因子
FOOD CHEMISTRY
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2025
·
IF 9.8
Ming Wei,Zhichao Ma,Zhuli Zhang,Ke Chi,Shulin Zhang,Wenting Tong,Wenbo Lu
Tert-butylhydroquinone (TBHQ) is a widely used synthetic phenolic antioxidant found in edible oils and other fried foods. Nevertheless, the excess use of TBHQ can reduce food quality and impact public health. In this paper, we reported the synthesis of a nanocomposite consisting of carbon and nitrogen co-doped nickel oxide (NiO-N/C-700), which was used to modify a pencil graphite electrode for the sensitive detection of TBHQ. The carbon source was biochar derived from invasive species Solidago canadensis L., combined with inexpensive pencil graphite, which reduced overall cost. The as-prepared TBHQ electrochemical sensor exhibited a linear range of 0.02–200 μM, a limit of detection of 5.53 nM. In particular, this sensor can be applied for the quantitative detection of TBHQ in edible oil, fried food and crisps, achieving a satisfactory recovery rate of 99.30 %–106.40 %, promoting TBHQ detection in actual food samples.
研究领域:
食品科学
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环境科学
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材料科学
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DOI
PubMed
高影响因子
ACS Sustainable Chemistry & Engineering
·
2025
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IF 7.3
Huilin Yi,Hongwei Zhu,Junpeng Ren,Aoqi Liu,Jie Jiang,Xiangqian Zhang,Ning Shi,Wei Xu,Bing Sun
tert-Butyl hydroperoxide (TBHP) is a crucial synthon of organic peroxides extensively used as initiators. However, the complexity of the reaction and instability of the product pose a challenge to both the efficiency and safety during TBHP production. Therefore, it is imperative to undertake a comprehensive investigation of its preparation method and reaction mechanism. In this work, the peroxidation of tert-butanol (TBA) and its regulation mechanism is systematically studied using a microreactor system. For the first time, the key process parameters and a series of olefin-related impurities are identified. The corresponding influences on product quality indices are elucidated to establish effective strategies for enhancing the final product quality. Furthermore, a reaction network is proposed and validated by Density Functional Theory (DFT) calculation and a thermodynamic equilibrium equation. TBHP, di-tert-butyl peroxide (DTBP), and a series of olefins (DDC-1–3) are generated through a carbonium ion route with maximum energy barriers ranging from 3.84 to 4.96 kcal/mol. Notably, DDC-2 is predominately formed through free radical polymerization initiated by the decomposition of DTBP with a dissociation energy of 141.98 kJ/mol. The identified key influencing factors are strongly supported by the highly consistent experimental and theoretical results, aligning well with the distinct characteristics of the microreactors. Consequently, a high TBHP concentration of 79.8% is achieved while reducing catalyst usage, shortening the residence time, and lowering liquid holdup, demonstrating significant improvements in efficiency and productivity.
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高影响因子
ENVIRONMENTAL RESEARCH
·
2025
·
IF 7.7
Yinling He,Zhendong Sun,Ning Wu,Chuanhai Li,Qunfang Zhou,Ligang Hu,Chunyang Liao,Guibin Jiang
Mounting evidence suggests that certain environmental contaminants can influence adipogenesis and function as obesogens, many of which act by activating the key regulator peroxisome proliferator-activated receptor γ (PPARγ). Synthetic phenolic antioxidants (SPAs) are ubiquitously detected in both environmental matrices and human samples, whereas their potential effects on lipid metabolism and the underlying molecular mechanisms remain largely unexplored. In this study, we aimed to assess the agonistic effects of SPAs on PPARγ, glucocorticoid receptor (GR), and retinoid X receptor α (RXRα), as well as their adipogenic potential. Luciferase reporter gene assays showed that among the ten commonly used SPAs evaluated, only 2,4,6-tri- tert -butylphenol (AO 246) exhibited efficacious agonistic activity toward RXRα. Environmentally relevant level exposure to AO 246 significantly promoted adipogenesis in 3T3-L1 cells, as evidenced by increased lipid accumulation and adipogenic gene expression, which could be alleviated by the RXRα antagonist UVI 3003. Further analysis revealed that the early stage of differentiation (Days 0–2) was the critical window for AO 246 to enhance adipogenesis and modify the gene expression profile. This study first demonstrated the adipogenic effects of AO 246 by activating RXRα but not PPARγ or GR, emphasizing its possible implications in obesity and associated health risks.
研究领域:
环境毒理学
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分子生物学
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药理学
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内分泌学
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细胞生物学
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DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2026
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IF 13.2
Linzi Huang,Xiaoqian Sun,Kunxiang Deng,Yuan Chen,Dan Guo,Xinyi Li,Yixi Xie,Pengcheng Zhao,Junjie Fei
Tert-butylhydroquinone (TBHQ), a widely used antioxidant for extending food shelf life, requires strict content control to ensure food safety. Here, we constructed a core-shell CdMoO 4 @ZnS S-scheme heterojunction via in situ growth for highly sensitive detection of TBHQ. Compared with our previously reported heterojunction sensors, this system achieves synergistic enhancement through polyvinylpyrrolidone-mediated morphology regulation and optimal shell-thickness engineering, effectively mitigating limitations in charge separation and stability. The developed photoelectrochemical sensor exhibits a wide dual-range detection capability (0.015–20 μM and 20–190 μM) with an ultralow detection limit of 1.8 nM. The exceptional sensing performance was elucidated by density functional theory calculations and redox potential analysis. Furthermore, the sensor achieves excellent recovery rates (97.05% - 104.23%) in real-sample analyses and retains more than 91.33% of its initial response after 8 weeks of storage, highlighting its strong potential for practical food-safety monitoring applications.
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高影响因子
Catalysts
·
2022
·Vol. 12
·期 9
·971
·
IF 4.501
Zewang Guo,Denghui Chen,Qi Xiong,Miao Liang,Pengfei Li,Zehui Gong,Junzhi Qiu,Liaoyuan Zhang
Leucine dehydrogenase (LeuDH) has emerged as the most promising biocatalyst for L-tert-leucine (L-Tle) production via asymmetric reduction in trimethylpyruvate (TMP). In this study, a new LeuDH namedPbLeuDH from marinePseudomonas balearicawas heterologously over-expressed inEscherichia coli, followed by purification and characterization.PbLeuDH possessed a broad substrate scope, displaying activities toward numerous L-amino acids andα-keto acids. Notably, compared with those reported LeuDHs,PbLeuDH exhibited excellent catalytic efficiency for TMP with aKmvalue of 4.92 mM and akcat/Kmvalue of 24.49 s−1mM−1. Subsequently, L-Tle efficient production was implemented from TMP by whole-cell biocatalysis using recombinantE. colias a catalyst, which co-expressedPbLeuDH and glucose dehydrogenase (GDH). Ultimately, using a fed-batch feeding strategy, 273 mM (35.8 g L−1) L-Tle was achieved with a 96.1% yield and 2.39 g L−1h−1productivity. In summary, our research provides a competitive biocatalyst for L-Tle green biosynthesis and lays a solid foundation for the realization of large-scale L-Tle industrial production.Keywords:leucine dehydrogenase;L-tert-leucine;trimethylpyruvate;reductive amination;whole-cell biocatalysis
研究领域:
生物化学
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工业微生物学
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DOI
高影响因子
MICROPOROUS AND MESOPOROUS MATERIALS
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2022
·
IF 5.876
Menglu Cai,Xiaozhong Wang,Yiming Mo,Yingqi Chen,Liyan Dai
The selectivity limitations of tert-butylation of naphthalene for obtaining 2,6-di-tert-butylnaphathalene (DTBN) was overcame (2,6-/2,7-DTBN>30) over fine-tuned mordenite . With citric acid (CA) and zirconium modification, the synergistic effect of the alkylation catalyst was promoted and the ratio of 2.6-/2,7-DTBN increased after controlling the reaction conditions. Only requires 5.0 equivalents of solvent, 3.0 equivalents of tert-butanol and 20 wt% of catalyst dosage, the ratio of 2,6-DTBN/2,7-DTBN can reach to 49, overcoming the selectivity barriers in naphthalene alkylation reaction. Present study reveals that high 2,6-selectivity can be realized with the optimized acidity, enhanced synergistic effect and fine-tuned zeolite structures.
研究领域:
化学催化
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材料科学
·
有机合成
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DOI
高影响因子
MACROMOLECULES
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2011
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IF 4.838
Bo Chen,Jianping Deng,Xin Cui,Wantai Yang
Helical substituted polyacetylenes were investigated for inducing enantioselective crystallization of racemic N-(tert-butoxycarbonyl)alanine (BOC-alanine) enantiomers. For this purpose, helical substituted polyacetylenes [(R)-PSA and (S)-PSA)] were dissolved in supersaturated racemic BOC-alanine solutions. Upon cooling the solutions, (R)-PSA preferentially induced BOC-l-alanine to crystallize, while (S)-PSA facilitated the enantioselective crystallization of BOC-d-alanine, according to the characterizations by circular dichroism, XRD, SEM, and optical rotation analyses. As expected, no enantioselective crystallization was observed in such cases: racemic BOC-alanine enantiomers in the absence of optically active helical PSA and racemic BOC-alanine enantiomers in the presence of equal amount of (R)-PSA and (S)-PSA. The present study provides the first direct evidence for the role of artificially synthetic helical polymers in inducing efficiently enantioselective crystallization.
研究领域:
高分子化学
·
晶体学
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有机化学
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DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2012
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IF 1.693
Yabo Hao,Songhong Zhang,Kejian Yao
Vapor–liquid equilibrium (VLE) data for methanol + tert-butylamine + N,N-dimethylformamide (DMF) and constituent binary systems containing tert-butylamine at 101.3 kPa were measured. A maximum boiling point azeotrope was observed at the methanol mole fraction of 0.763, corresponding to the temperature of 340.28 K for the binary system methanol + tert-butylamine. The binary equilibrium data were correlated using Wilson, nonrandom two-liquid (NRTL), and universal quasichemical activity coefficient (UNIQUAC) models, respectively. The VLE data of the ternary system were calculated with the binary interaction parameters of the NRTL model, and the average absolute deviations of the equilibrium temperature and the vapor-phase mole fractions for methanol and tert-butylamine were about 0.87 K, 0.014, and 0.018, respectively. The results show that DMF can break the azeotrope of the methanol + tert-butylamine system as a solvent.
研究领域:
化学工程
·
物理化学
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DOI
高影响因子
FLUID PHASE EQUILIBRIA
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2016
·
IF 1.846
Gan bing Yao,Zhan xiang Xia,Zhi hui Li,Chao Shao
The solid–liquid equilibrium (SLE) for ternary system of caprolactam + cyclohexanone oxime + methyl tert-butyl ether were determined at three temperatures of (278.15, 293.15 and 308.15) K under pressure of 101.2 kPa. Three isothermal phase diagrams of the system were constructed based on the measured mutual solubility data. There were two pure solids formed in the ternary phase diagram , including pure caprolactam and pure cyclohexanone oxime, which were identified by the method of Schreinemakers' wet residue. At each temperature, the phase diagram contained three crystallization regions (which corresponded to caprolactam, cyclohexanone oxime, and a mixture of caprolactam and cyclohexanone oxime), two crystallization curves, and one co-saturated point. The crystallization field of caprolactam was larger than that of cyclohexanone oxime. The NRTL model was employed to correlate and calculate the ternary phase diagram. The calculated ternary phase diagram with the NRTL model agreed well with the experimental ones. The solid–liquid phase equilibrium and phase diagram for the ternary system of caprolactam + cyclohexanone oxime + methyl tert-butyl ether could provide basis for the purification process of caprolactam.
研究领域:
化学工程
·
材料科学
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DOI
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2016
·
IF 3.926
Qiqin Wang,Peijie Zhu,Meng Ruan,Huihui Wu,Kun Peng,Hai Han,Govert W. Somsen,Jacques Crommen,Zhengjin Jiang
An O -9-( tert -butylcarbamoyl) quinidine (t-BuCQD) functionalized polymeric monolithic capillary column was prepared by the in situ copolymerization method. The physicochemical properties of the optimized monolithic column were characterized by scanning electron microscopy and micro-LC. Satisfactory column permeability, efficiency, stability and reproducibility were obtained for this monolithic column. The chiral recognition ability of the resulting monolith was also evaluated using 47 N -derivatized amino acids, eight N -derivatized dipeptides, and two herbicides. Under the selected conditions, the enantiomers of all chiral analytes were baseline separated with exceptionally high selectivity and resolution using micro-LC. It is worth noting that this chiral stationary phase (CSP) containing quinidine with a tert -butyl carbamate residue as chiral selector exhibits much higher enantioselectivity and diastereoselectivity than the previously developed O -9-[2-(methacryloyloxy)-ethylcarbamoyl]-10,11-dihydroquinidine (MQD) based CSP for N -derivatized amino acids and dipeptides. These results indicate that this novel quinidine-based polymeric monolith can be used as an effective tool for the enantioseparation of chiral acidic compounds.
研究领域:
分析化学
·
色谱技术
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产品关联
DOI
PubMed
高影响因子
Molecular Catalysis
·
2023
·
IF 4.6
Xiaozhong Wang,Jiali Hu,Cai Xu,Yingqi Chen,Liyan Dai
Herein, a series of NiCu/Al 2 O 3 catalysts were prepared by impregnation method and subsequent thermal treatment under different reduction temperatures. The catalysts exhibited excellent catalytic activity for the amination of diethylene glycol (DEG), and satisfactory yield of tertiarybutylaminoethoxyethanol (TBEE) could be obtained. XRD, N 2 adsorption-desorption, SEM, TEM, XPS, and H 2 -TPR were employed to characterize the catalysts, the interaction between Ni and Cu on the catalytic activity was studied. It was found that NiCu alloy was formed after catalyst reduction, which strengthened the reduction ability of NiO and increased the number of Ni 0 active center, contributing to the enhanced catalytic activity. Moreover, the effects of reaction parameters on catalytic activity were explored. There was no need for a solvent, only 3 molar equivalents of tert‑butylamine (TBA) and 1 wt.% catalyst was required. After 7 h of reaction at 220 °C, satisfactory conversion (89.6%) and selectivity (84.6%) were obtained over the prepared catalyst. Cycle experiment demonstrated that the prepared catalyst retained excellent stability and reusability after six runs without significant loss of catalytic activity. This work provided an efficient catalyst for the catalytic amination of diethylene glycol with tert‑butylamine to TBEE.
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高影响因子
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