CHEMISTRY OF MATERIALS
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2023
·
IF 8.6
Shuai Wei,Zeyu Lyu,Zheng Lu,Pengcheng Luo,Luhui Zhou,Dashuai Sun,Taixing Tan,Sida Shen,Hongpeng You
Trap engineering is widely applied to contend with thermal quenching of phosphors. However, the incidental detriment of the luminescent efficiency has long been neglected. Herein, we propose a paradigm for achieving a high-performing Bi3+-doped phosphor with moderate trap engineering. Through introducing appropriate traps in a neutral atmosphere and proper doping concentration, we have successfully created a novel Ba2GdAlO5:Bi3+ yellow phosphor that exhibits exceptional thermal stability (104.1%@423 K) and a high internal quantum yield (82.78%), which is the top performance among Bi3+-doped phosphors. The oxygen vacancy and Bi2+ were identified as the responsible traps through X-ray photoelectron spectroscopy, while their depth was measured to be 0.9 eV by using thermoluminescence. Notably, the phosphor exhibited photochromism upon near-ultraviolet (n-UV) excitation and could be bleached through heat treatment. These observations highlight its potential for various applications. Finally, two white lighting devices with a color rendering index exceeding 90 were prepared with n-UV LED chips by applying Ba2GdAlO5:Bi3+ as one of the phosphors. This study not only provides a high-performance Bi3+-doped phosphor suitable for high-quality white LED (WLED) lighting but also proposes a methodology for designing phosphors with high efficiency and thermal stability..
研究领域:
材料科学
·
光学工程
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DOI
高影响因子
MATERIALS & DESIGN
·
2022
·
IF 9.417
Youyun Zeng,Yiding Shen,Shuyi Wu,Lei Cai,Zhen Wang,Kexin Cai,Jiating Shen,Kendrick Hii Ru Yie,Hualin Zhang,Lihua Xu,Jinsong Liu
The lack of safety, efficacy, and specificity has made the delivery of anti-osteoporotic drugs at a proper dose a challenge. In our study, cathepsin K inhibitor loaded poly (D, L-lactide-co-glycolide) derived lipid hybrid nanoparticles (DNPs) were modified with bone-specific polyaspartic acid [(Asp) 8 -DNPs] to treat osteoporosis. (Asp) 8 -DNPs showed its hydroxyapatite binding affinity and achieved a sustained release of cathepsin K inhibitor for up to 5 days. Cathepsin K inhibitor loaded (Asp) 8 -DNPs significantly decreased the tartrate-resistant acid phosphatase (TRAP) activity and resorption-related genes in osteoclasts. Animal studies also exhibited high accumulation of (Asp) 8 -DNPs in the tibia and femur and a greater bone mass in trabecular bone and better organized three-dimensional architecture in osteoporotic rat models. Herein, the bone targeting drug delivery system show its potential in treatment of osteoporosis.
研究领域:
药理学
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纳米医学
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骨骼生物学
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药物递送系统
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DOI
高影响因子
BIOMEDICINE & PHARMACOTHERAPY
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2024
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IF 6.9
Zhongyuan Zhang,Wenshu Xu,Zhenhua Zhang,Xiaoxue Chen,Hui Jin,Ningning Jiang,Hui Xu
This study was to investigate the potential mechanisms of treatment with metformin (Met) combined with kaempferol (Kae) against postmenopausal osteoporosis. Experiments were conducted in both ovariectomy (OVX)-induced osteoporosis rats and in vitro using RAW264.7 cells, MC3T3-E1 cells, and HUVECs. Results demonstrated the therapeutic effect of Met combined with Kae on osteoporosis. In vivo, Kae alone and in combination with Met treatments enhanced tibial trabecular microstructure, bone mineral density (BMD), and mechanical properties in OVX rats without causing hepatotoxicity and nephrotoxicity. It also reduced bone resorption markers (CTX-1 and TRAP) and increased the bone formation marker (PINP) level in the serum of OVX rats. The expression of bone resorption marker TRAP was reduced, while bone formation markers Runx2 and ALP were enhanced in the bone tissue of OVX rats. Furthermore, Met combined with Kae also promoted the expression of angiogenesis-related markers CD31 and VEGF in OVX rats. In vitro, MC3T3-E1s cells treated with Met combined with Kae showed higher expression of ALP, Runx2, and VEGF. Interestingly, the treatment did not directly promote HUVECs migration and angiogenesis, but enhanced osteoblast-mediated angiogenesis by upregulating VEGF levels. Additionally, Met combined with Kae treatment promoted VEGF secretion in MC3T3-E1, and activated the Notch intracelluar pathway by upregulating HES1 and HEY1 in HUVECs. Meantime, their stimulation on CD31 expression were inhibited by DAPT, a Notch signaling inhibitor. Overall, this study demonstrates the positive effects of Met combined with Kae on osteoporotic rats by promoting osteogenesis-angiogenesis coupling, suggesting their potential application in postmenopausal osteoporosis.
研究领域:
药理学
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骨科
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分子生物学
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细胞生物学
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DOI
PubMed
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
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2025
·Vol. 23
·期 1
·1-23
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IF 12.6
Wu Shujuan,Zhou Mengqi,Zhou Huimin,Han Lu,Liu Huifan
This study explored the novel mechanism of Astragaloside IV (As) in treating sepsis and its application through a biomimetic nano-delivery system (As@ZM). Sepsis, a condition of organ dysfunction caused by an abnormal host response to infection, poses a significant threat to global health due to its high mortality rate. Our findings revealed a new mechanism for As in treating sepsis, which involved the reduction of neutrophil extracellular traps (NETs) release, potentially related to As binding with IκBα to inhibit the activation of the NF-κB pathway. As treated neutrophils also improved the immune microenvironment by crosstalk with endothelial cells and lung epithelial cells. However, the stability and bioavailability of As limited its clinical application. To address this issue, we had developed a ZIF-8-based nano-delivery system that achieved targeted delivery through neutrophil membrane coating, significantly enhancing the therapeutic efficacy of As. The innovative design of As@ZM offered a new strategy for sepsis treatment, with the potential to improve clinical outcomes. Graphical abstract
研究领域:
免疫学
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药剂学
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感染性疾病
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DOI
PubMed
高影响因子
Journal of Materials Chemistry C
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2024
·Vol. 12
·期 48
·19487-19497
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IF 5.7
Dangli Gao,Chengxue Du,Yuqiang Wang,Wenqian Xu,Wenna Gao,Qing Pang,Yuhua Wang
The management of multicolour and multimode luminescence in persistent luminescence (PersL) materials plays a crucial role in encrypting information to combat forgery. Although luminescent anti-counterfeiting has made significant progresses, anti-counterfeiting signals only exhibit typical luminescent emission colours of materials under fixed external stimuli, which makes them susceptible to be replicated. Here, we developed a series of LiReGeO4:Bi,Ln (Re = Lu, Y and Gd, Ln = Eu, Tb, Pr, Yb, Sm, Tm, Ce, Dy and Er) phosphors with multicolour and on-demand controlled PersL emission through purposeful design of the electron–hole pair trap structure. Besides the multicolour and multimode emission, these phosphors demonstrated a temporal memory function for writing information, which provides a new dimension for higher-order anti-counterfeiting. As an example, LiLuGeO4:Bi,Ln (Ln = Eu, Tb, Pr and Yb) memory phosphors display the pattern signals in the order requested by the owner, which makes any sophisticated forgery technique powerless. The study here provides not only a simplistic method for constructing a new-type persistent memory material, but also a new paradigm of artificial intelligence memory for anti-counterfeiting technology.
研究领域:
材料科学
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光学工程
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Deng Hu,Hang Luo,Yuan Liu,Fan Wang,Bo Peng,Xiaona Li,Huan Wang,Guanghu He,Dou Zhang
Dielectric capacitors are indispensable energy storage components in both civilian applications and industrial processes. Under elevated temperatures and intense electric fields, polymer dielectrics usually suffer from an inevitably increase in conductivity, leading to a significant reduction in breakdown strength, energy density and efficiency. This investigation aims to design an all-organic dielectric with enhanced high-temperature capacitive performance by introducing a small molecule P-xylene F (PF) into polyetherimide (PEI). Two mechanisms including the incorporation of deep trap energy levels via wide bandgap fillers and the electrostatic interactions by hydrogen bonding between the fillers and the polymer matrix are proposed to support the enhancement. The hydrogen bonding between PF and polyamic acid (PAA)chains induces the formation of physical cross-linking between PF and the negatively charged benzene rings in PEI after imidization. This influences benzene ring stacking within the polymer chains and enhances the film’s mechanical strength. Additionally, PF’s wider bandgap compared to PEI introduces deep trap energy levels, hindering carrier transport and reducing conductive losses at high temperatures. As results, the dielectric achieves an energy density (U d ) of 4.47 J/cm 3 with an efficiency (η) above 90 % at 200 °C. Its excellent stability is also demonstrated with over 210,000 charge–discharge cycles at 200 °C. This study promotes the development of high-performance dielectrics at high temperature.
研究领域:
材料科学
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能源工程
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DOI
高影响因子
Inorganic Chemistry Frontiers
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2022
·Vol. 9
·期 8
·1743-1751
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IF 7.779
Hao Wang,Yuruo Qi,Fangyuan Xiao,Pan Liu,Yi Li,Shu-juan Bao,Maowen Xu
The construction of highly conductive structures with excellent adsorption–catalytic properties to accelerate electron transfer and suppress polysulfide shuttle is considered as an effective strategy to achieve well-performing sodium–sulfur batteries. Herein, a self-supported tessellated N-doped carbon/CoSe2 (NCCS) is developed as a sulfur host for sodium–sulfur batteries by a simple deposition–selenization of lyophilized bacterial cellulose (BC), where NC acts as a conductive network to ensure the rapid initiation of efficient catalytic reactions at the tessellated CoSe2 interface and maintain good structural stability. The CoSe2 nanoparticles provide strong ability in anchoring, trapping and catalyzing polysulfides. As a result, the prepared tessellated NCCS@S cathode demonstrates a high initial discharge specific capacity of 871.3 mA h g−1 at a current rate of 0.1C and good electrochemical stability for up to 500 cycles at 1C.
研究领域:
材料科学
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电化学
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DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
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2022
·Vol. 46
·期 37
·17958-17966
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IF 3.925
Feng Chen,Shiming Wu,Jingjing Fu,Xiaohui Lv,Huihui Chai,Lixia Gao,Ling Yu
Polydimethylsiloxane (PDMS) gained its fame in the construction of microdevices for studying cell growth and cell–cell interaction and the assembly of organ-on-chip models because of its excellence in optical transparency, gas permeability, nontoxicity, elasticity, and well-developed soft lithography approaches. Yet, poor cell adhesion and growth on pristine PDMS drives the need to improve its cell compatibility. Herein, rough PDMS surfaces with microcavity structures were fabricated by one-step replication from a sandpaper template. The impact of physical topologies, such as microcavity size, density, and distribution, on cell anchoring and growth was systematically studied. Results show that sandpaper-templated, rougher PDMS can support significantly more cell growth than pristine, smooth PDMS. Most of the cells (80.27%) were observed at the microcavities replicated from sandpaper, suggesting the microstructure-trapped cells have increased chance of cell anchoring and growth. Moreover, the efficacy of the physical topology–enhanced cell compatibility was compared side-by-side with PDMS chemically functionalized with tannic acid (TA). The cell adhesion, growth, and apoptosis studies proved that sandpaper-templated PDMS has comparable efficacy to TA-functionalized smooth PDMS; both improved cell proliferation by ∼50% and reduced cell apoptosis. We also found that TA functionalization of the sandpaper-templated PDMS did not significantly improve the cell compatibility, suggesting that the simple one-step replication from sandpaper is a low-cost and effective way to prepare a PDMS surface for cell growth. Finally, the potential of sandpaper templating in building microdevices for cell culture is highlighted by assembling PDMS microchannels with rough surfaces for on-chip cell culture.
研究领域:
生物工程
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细胞生物学
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DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
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2024
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IF 8.4
Jingjing Zhao,Zhong Liu,Zhiyong Ji,Xiaowei An,Xiao Du,Fengfeng Gao,Xiaogang Hao,Jun Li
An electrochemically induced bismuth iodine oxide/multiwalled carbon nanotubes/polyvinyl alcohol (BiOI/MWCNTs/PVA) composite membrane electrode with iodide ion trap (I − -trap) was fabricated by prerelease of I − under reduction potential. The I − -trap BiOI/MWCNTs/PVA composite membrane with unique lattice confinement structures was used for the selective extraction of I − in an electrochemically switched ion permselective (ESIP) process. In the ESIP system, the direct uptake and release of I − were realized by applying a cell voltage-pulse potential (CV-PP) coupling circuit on the membranes to switch the oxidation/reduction state. The I − -trap BiOI/MWCNTs/PVA composite membrane exhibited a maximum flux of 8.32 mg·m −2 ·min −1 and superior electrochemical stability. The separation factors of I − /Br − , I − /Cl − , I − /NO 3 − , and I − /SO 4 2− in the mixed solutions were 2.67, 3.71, 3.82, and 6.70 respectively. Therefore, such a novel I − -trap BiOI/MWCNTs/PVA composite membrane could be used in the ESIP system for the selective extraction of I − ions from low concentration solutions.
研究领域:
材料科学
·
环境科学
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Na Zhang,Hang Zhao,Chuying Zhang,Haotong Guo,Zhi-Min Dang,Jinbo Bai
Polymer dielectrics are crucial for electrostatic energy storage and offer broad application prospects in advanced high-power electrical systems, but their energy storage performance declines considerably due to increased conductivity at elevated temperatures. This work presents a structurally-simple high-temperature composite dielectric by incorporating positively charged ultrafine UIO-66 nanoparticles into polyetherimide (PEI) matrix. Be distinguished from traditional sub-micron MOF structures that usually reported in very recently, the newly-found nanoscale effect endows the ultrafine UIO-66 (∼12.9 nm) with largely-increased active sites, surface charge density and electron affinity. These ultrafine UIO-66 nanoparticles can capture free charge through strong electrostatic interactions and introduce deeper traps in composite dielectrics, reducing conduction loss and improving energy storage property significantly at elevated temperatures. Specifically, filling only as tiny as 0.5 wt% ultrafine UIO-66 endows the PEI-based composite with ultra-high energy densities of 5.9J cm −3 and 3.7 J cm −3 accompanied by high charge–discharge efficiencies of 91.4 % and 84.1 % at 150 ℃ and 200 ℃, respectively. These obtained performance in this work surpasses those of most previously reported mono-layered composite counterparts. This study provides a straightforward and effective strategy for designing high-temperature polymer dielectrics in advanced electrical and electronic systems, offering a new route for future applications and developments.
研究领域:
材料科学
·
电气工程
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产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2026
·
IF 6.6
Zihao Guo,Zeqi Liu,Chaoxuan Wang,Lei Qian
Here, oxygen vacancy was introduced into hexagonal β-Ni(OH) 2 (NV) nanosheets to prepare poly (vinylidene fluoride-co-hexafluoropropylene)-based dielectric composites. Oxygen vacancy gradients were controlled, and the enhanced effects on energy storage performance were systematically investigated. It was found that the oxygen vacancy elevated the Ni 2+ /Ni 3+ ratio, shifted the Fermi level downward and induced formation of deep trap states. The moderate oxygen vacancies produced uniformly distributed deep strap states, which delayed the carrier migration by the capture-release mechanism. The Fermi level (E v − E f ) of NV 1.5 was 1.064 eV and showed the smallest energy separation from the valence-band, resulting in the highest interfacial potential barrier and inhibiting the charge injection. So, the oxygen vacancy obviously affected leakage current, breakdown strength and energy density. It was observed that leakage current density of the composites reduced to 3.48 × 10 −8 A/cm 2 . At the 0.3 wt% loading of NV1.5, the composite achieved a breakdown strength of 792.97 kV/mm and an energy density of 21.15 J/cm 3 (88.17 % over the matrix), with charge–discharge efficiency of 74.12 % and below 1 % performance degradation after 10 4 cycles. This work establishes a novel route based on defect engineering for dielectric storage materials at the atomic level. Download: Download high-res image (101KB) Download: Download full-size image
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DOI
高影响因子
Laser & Photonics Reviews
·
2026
·
IF 9.7
Xiyang Li,Xiahong Lin,Jie Shao,Jie Yang,Haiqin Sun,Dong Tu,Jiaqi Liu,Fuchi Liu,Qiwei Zhang
Inorganic photochromic materials (IPCs) with luminescent modulation show promising potentials in anti-counterfeiting and biological imaging. However, existing IPCs can only be effectively activated by high-energy ultraviolet (UV)/visible (Vis) light or potentially risky x-ray irradiation, often suffering from severe photobleaching, photodamage, and low penetration. Herein, we present a universal strategy to generate near-infrared light-driven trap filling and luminescent modulation behaviors in IPCs, via the energy transfer upconversion (ETU) design. Upon 980 nm irradiation, the synthesized NaNbO 3 :Er 3+ /Yb 3+ displays large luminescent modulation ratio (Δ R t > 80%) and fast response speed to NIR light (10 s, 92%), comparable to or better than those of UV/Vis light irradiation. The designed components exhibit deep-tissue penetrable luminescent imaging, which is unable to be achieved for existing IPCs. The upconversion-mediated strategy is quite robust, and can be extended to other systems, by leveraging the ETU process of up-converting ion pairs (Ln 3+ /Yb 3+ ) to fill the traps and trigger photochromic reaction. Subsequently, the excited state energy of activators is captured by trap centers via a fluorescent resonance energy transfer (FRET), then resulting in luminescent modulation. This work sheds new light on designing NIR light-driven IPCs, and will contribute substantially to high-level optical storage and biological applications.
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DOI
高影响因子
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