ANALYTICA CHIMICA ACTA
·
2014
·
IF 4.517
Xiaoyu Mu,Li Qi,Juan Qiao,Xinzheng Yang,Huimin Ma
A chiral ligand exchange capillary electrophoresis (CLE-CE) method using Zn(II) as the central ion and l -4-hydroxyproline as the chiral ligand coordinating with γ-cyclodextrin (γ-CD) was developed for the enantioseparation of amino acids (AAs) and dipeptides. The effects of various separation parameters, including the pH of the running buffer, the ratio of Zn(II) to l -4-hydroxyproline, the concentration of complexes and cyclodextrins (CDs) were systematically investigated. After optimization, it has been found that eight pairs of labeled AAs and six pairs of labeled dipeptides could be baseline-separated with a running electrolyte of 100.0 mM boric acid, 5.0 mM ammonium acetate, 3.0 mM Zn(II), 6.0 mM l -hydroxyproline and 4.0 mM γ-CD at pH 8.2. The quantitation of AAs and dipeptides was conducted and good linearity ( r 2 ≥ 0.997) and favorable repeatability (RSD ≤ 3.6%) were obtained. Furthermore, the proposed method was applied in determining the enantiomeric purity of AAs and dipeptides. Meanwhile, the possible enantiorecognition mechanism based on the synergistic effect of chiral metal complexes and γ-CD was explored and discussed briefly.
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Journal of Environmental Chemical Engineering
·
2024
·
IF 7.4
Zuopeng Guan,Fangbo Zhao,Xinyu Guo
ABSTRACT Zinc deplating waste liquid is considered hazardous due to the presence of heavy metal Zn(II) and hydrochloric acid, along with Fe(II). This study aims to develop a new adsorbent for efficient separation of zinc (II) from deplating waste liquid in a real factory. The novel adsorbent, PSCL-CQDs-NH 2 , was prepared by grafting home-made amino-rich carbon quantum dots (CQDs-NH 2 ) onto a chloromethyl polystyrene resin matrix. It has been observed that amino groups can be protonated under strongly acidic conditions, enabling them to adsorb negatively charged Zn(II)-Cl complexes while repelling positively charged Fe(II)-Cl complexes. The grafted nano-size CQDs-NH 2 can offer more adsorption positions to improve the adsorption properties. The results shown that PSCL-CQDs-NH 2 presented higher Zn(II) adsorption capacity and better performance in separating Zn(II) from Fe(II) compared to the conventional anion exchange resin (717). At 298 K, PSCL-CQDs-NH 2 showed a maximum Zn(II) adsorption capacity of 201.77 mg/g, and a selective Zn(II)/Fe(II) separation factor of 3033.72, which were 54.7% and 45.4 times higher than those of 717 resin. In the fixed bed adsorption process, PSCL-CQDs-NH 2 exhibited 61.5% higher adsorption performance than 717 resin when treating actual zinc deplating waste liquid. Moreover, the water consumption during regeneration of PSCL-CQDs-NH 2 is reduced by 10.3% compared to the 717 resin. These findings indicate that PSCL-CQDs-NH 2 is an effective material for the treatment of industrial zinc deplating waste liquid.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2017
·Vol. 410
·期 2
·349-359
·
IF 3.431
Sun Ya Kun,Jia Man,Yang Jian,Huang Yan-Ping,Liu Zhao-Sheng,Aisa Haji Akber
A method of preparing molecularly imprinted polymers (MIPs) with Zn(II) as a metallic pivot was adopted to solve the problem of imprinting compound with intramolecular hydrogen bonds by forming stronger coordination binding interaction among the template–functional monomer-Zn 2+ complex. A ternary porogenic system including dimethyl sulfoxide, dimethylformamide, and room temperature ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate was employed to fabricate imprinted monolith with high porosity and good flow-through properties, in which chicoric acid (CA), zinc acetate, 4-vinylpyridine (4-VP), and ethylene glycol dimethacrylate (EDMA) was the template, metallic ion, functional monomer, as well as crosslinker, respectively. The influence of polymerization factors including the 4-VP-CA ratio, monomer-crosslinker ratio, template-Zn 2+ ratio on imprinting factors was systematically investigated. When the ratio of 4-VP to CA was 24:1, the greatest IF value (24.81) was achieved on the CA-MIP prepared with zinc acetate. In addition, off-line SPE with the optimal MIPs monolith led to high purity of CA (98.0% ± 0.5%) from extraction of Cichorium intybus L. roots with the recovery of 77.5% ± 2.5% ( n = 6). As a conclusion, the strategy of introducing metal ions as metal pivot to prepare MIPs was a powerful method for the MIPs synthesis to the template molecules with intramolecular hydrogen bonds.
研究领域:
化学
·
材料科学
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JOURNAL OF COORDINATION CHEMISTRY
·
2023
·
IF 1.9
Xiao-Tong Song,Ying Zhou,Gui-Bao Liu,Hui-Chao Guan,Shu-Mei Yue
By single-crystal X-ray diffraction (XRD) analysis, five complexes, catena-[(µ-2,2-bis(4-carboxyphenyl)hexafluoropropane)-(2-(pyidin-2-yl)-1,3-benzothiazole)-aqua-zinc(II)] (1), catena-[(µ-2,2-bis(4-carboxyphenyl)hexafluoropropane)-(2-(pyidin-2-yl)1,3-benzothiazole)-aqua-cadmium(II)] (2), catena-[hepta(µ-2,2-bis(4carboxyphenyl)hexafluoropropane)-diaqua-bis(2-(pyidin-2-yl)-1,3-benzothiazole)-tri-manganes(II)] (3), catena-[(µ-benzene-1,2,4,5-tetracarboxylato)-(2-(pyidin-2-yl)-1,3benzothiazole)copper(II)] (4) and catena-[(µ-3-nitrobenzene-1,2-dicarboxylato)-(2-(pyidin-2-yl)1,3-benzothiazole)-aqua-zinc(II)] (5), were characterized in this research. In these five complexes, H2hfipbb = 2,2-bis(4-carboxyphenyl)hexafluoropropane, H4btec = 1,2,4,5-benzenetetracarboxylic acid, H2NPTA = 3-nitrophthalic acid and bpt = 2-(pyridin-2-yl)benzo[d]thiazole). Complexes 1 and 2 occur in the monoclinic system with space group C2/c, 4 and 5 occur in the monoclinic system with space group P21/c, and 3 occurs in the triclinic system with space group P-1. The interaction between CT-DNA (calf thymus DNA) and those complexes was examined using UV spectroscopic analysis, fluorescent spectroscopic analysis, circular dichroism spectroscopy (CD) and viscosity analysis. This research reveals that those complexes have strong ability to interact with DNA, and they all bind to DNA in an intercalation mode, thus affecting the structure of DNA. This binding mode can arise from the interaction between the benzothiazole metal complexes and DNA. Hence, we hope to provide some scientific research bases for studying benzothiazole complexes and designing new thiazole anticancer drugs.
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Journal of Materials Chemistry B
·
2017
·Vol. 5
·期 46
·9157-9164
·
IF 4.543
Long Xu,Mingying Zhao,Yidi Yang,Yan Liang,Changzhen Sun,Wenxia Gao,Sai Li,Bin He,Yuji Pu
Low molecular weight gels (LMWGs) have significant advantages in drug delivery such as high drug loading capacity, in situ delivery of drug to the lesion site, sustaining drug release with excellent bioavailability, and minimized side effects. Here, we synthesized a reactive oxygen species (ROS)-responsive gelator to prepare an injectable gel. An anticancer drug, doxorubicin hydrochloride (DOX), and a photosensitizer, Zn(II) phthalocyanine tetrasulfonic acid (ZnPCS4), were loaded into the gel for combined chemo-photodynamic therapy. The ROS-responsive gelator was characterized by proton nuclear magnetic resonance (1H NMR) and the morphology of gels was investigated by scanning electron microscopy (SEM). The rheological properties and destruction–recovery capability of both blank and drug-loaded gels were studied. The cytotoxicity of LMWGs against 3T3 fibroblasts and 4T1 breast cancer cells was tested. The in vitro drug release of both drugs was studied and the in vivo anticancer activities of DOX–ZnPCS4-coloaded LMWGs were investigated in tumor-bearing mice. The results revealed that the injectable ROS-responsive DOX–ZnPCS4-coloaded LMWGs exhibited excellent anti-tumor efficacy by a synergistic therapy.
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TRANSITION METAL CHEMISTRY
·
2015
·Vol. 40
·期 7
·769-777
·
IF 1.306
Wang Hu,Zhang Xiao-Yin,Bi Cai-Feng,Fan Yu-Hua,Meng Xiang-Min
Abstract Three complexes, Zn(C 40 H 36 N 4 O 8 )·3CH 3 OH ( 1 ), Ni(C 40 H 36 N 4 O 8 )·3CH 3 OH ( 2 ) and Co(C 40 H 36 N 4 O 8 )·3CH 3 OH ( 3 ), with a sexidentate (N 2 O 4 ) symmetric bis-Schiff base ligand (C 40 H 36 N 4 O 8 = 1,2-bis(2-methoxy-6-formylphenoxy)ethane- l -tryptophan) have been synthesized and characterized by physicochemical and spectroscopic methods. The X-ray crystal structures show that the metal atoms of three complexes are all six-coordinated by two nitrogens from C=N groups, two oxygens from ether groups and two carboxylic oxygens in the mono-ligand, forming a distorted octahedral geometry. The complexes were screened as photocatalysts for the degradation of methylene blue, rhodamine B and methyl violet. All three complexes proved to be good candidates for the photocatalytic degradation of methylene blue and complexes 2–3 are also good photocatalysts for the degradation of rhodamine B. The mechanism of these photocatalytic degradations is discussed. Graphical Abstract The main characterization and photocatalytic experiment of three complexes.
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JOURNAL OF ENVIRONMENTAL MANAGEMENT
·
2025
·
IF 8.4
Xiaoman He,Dongyang Liu,Yue Teng,Hanzhi Wang,Qirui Wu,Wei Wang,Jingzheng Ren,Liandong Zhu
The co-culture system of Chlorella sorokiniana and Aspergillus oryzae has demonstrated exceptional tolerance and efficiency in the removal of pollutants from swine manure. This study evaluates the ability of the co-culture system to remove Zn(II) and estrone, while assessing the impact of these pollutants on the system's overall functionality. Results indicated that co-cultivation achieved higher biomass accumulation, peaking at 0.88 g/L after 96 h. Increasing estrone exposure concentration reduced photosynthetic activity and chlorophyll content, whereas Zn(II) exposure initially enhanced and later inhibited chlorophyll synthesis. Co-cultivation secreted extracellular polymeric substances, including protein-like and humus-like substances, to alleviate environmental stress and form algal-fungal community. After 96 h of cultivation, the removal efficiencies reached 86.44% for 1.5 mg/L Zn(II) and 84.55% for 20 mg/L estrone. The Quantitative Structure Activity Relationship model revealed a reduction in the ecotoxicity of estrone intermediate products to varying degrees. Metabolomics analysis showed that exposure to estrone and Zn(II) significantly boosted the production of Gibberellic acid, Indole-3-acetic acid, and Zeatin riboside in Chlorella sorokiniana , while reducing Abscisic Acid levels. Furthermore, the exposure led to an increase in various metabolites in the Tricarboxylic acid cycle of the co-cultivation system, influencing the synthesis and metabolism of key biochemical components like carbohydrates, lipids, and proteins. These findings elucidate the biochemical responses of Chlorella sorokiniana - Aspergillus oryzae co-culture system to pollutants and provide insights into its potential application in the treatment of wastewater containing endocrine disrupting chemicals and heavy metals.
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INORGANICA CHIMICA ACTA
·
2017
·
IF 2.002
Hu Wang,Xia Zhang,Yu Zhao,Dongmei Zhang,Fan Jin,Yuhua Fan
Three Zn(II) complexes with a sexidentate N 2 O 4 -donor bis-Schiff base ligand, namely Zn(C 36 H 34 N 2 O 8 )·2CH 3 OH ( 1 ), Zn(C 28 H 34 N 2 O 8 S 2 )·CH 3 OH ( 2 ) and Zn(C 40 H 36 N 4 O 8 )·3CH 3 OH ( 3 ), (L 1 , C 36 H 34 N 2 O 8 = 1,2-bis(2-methoxy-6-formylphenoxy)ethane- l -phenylalanine; L 2 , C 28 H 34 N 2 O 8 S 2 = 1,2-bis(2-methoxy-6-formylphenoxy)ethane- l -methionine; L 3 , C 40 H 36 N 4 O 8 = 1,2-bis(2-methoxy-6-formylphenoxy)ethane- l -tryptophan) were synthesized and fully characterized by physico-chemical and spectroscopic methods. The X-ray crystallography shows that the metal atoms of three complexes are all six-coordinate with two nitrogen atoms from C N groups, two oxygen atoms from ether groups and two carboxylic oxygen atoms in the mono-ligand, forming a distorted octahedral geometry. Theoretical studies of the three complexes were carried out by density functional theory (DFT) Becke’s three-parameter hybrid (B3LYP) method employing the 6–31G basis set. Moreover, the antimicrobial activities of the complexes were evaluated against Escherichia coli and Staphylococcus aureus by the agar-well diffusion method. The experiment showed that complex 2 exhibited the highest antimicrobial activity. At the same time, molecular docking was investigated to determine the molecular interaction of the complexes with microbial synthase. The docking simulation exhibited that complex 2 was well embedded into the active pocket of the enzyme and showed a more stabilized structure than complex 1 and 3 . Their structure-activity relationships were further discussed.
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JOURNAL OF COORDINATION CHEMISTRY
·
2024
·
IF 2.2
Ying Zhou,Xiao-Tong Song,Hui-Chao Guan,Shu-Mei Yue
In this investigation, six new metal complexes with 2-(pyridin-2-yl)benzo[d]imidazole (bpm) were synthesized and analyzed by single-crystal X-ray diffraction (XRD), including catena-bis[(µ-2,2-bis(4-carobxyphenyl)hexafluoropropane)-(2-(pyidin-2-yl)-1H-benzimidazole)-aqua-zinc] (1), catena-[(µ-2,2-bis(4-carobxyphenyl)hexafluoropropane)-(2-(pyidin-2-yl)-1H-benzimidazole)-aqua-cadmium] (2), aqua-[2,2-bis(4-carobxyphenyl)hexafluoropropane]-bis[2-(pyridin-2-yl)-1H-benzimidazole]-manganese (3), μ-[2-nitrobenzene-1,4-dicarboxylato]-μ-[2-nitrobenzene-1,4-dicarboxylato]-bis[2-(pyridin-2-yl)-1H-benzimidazole]-di-zinc (4), catena-[bis(µ-2-nitrobenzene-1,4-dicarboxylato)-diaqua-bis(2-(pyridin-2-yl)-1H-benzimidazole)-di-cadmium] (5), aqua-[pyridine-2,6-dicarboxylato]-[2-(pyridin-2-yl)-1H-benzimidazole]-copper hydrate (6) (H2hfipbb = 2,2-bis(4-carboxyphenyl)hexafluoropropane, H2nbdc acid = Nitroterephthalic acid, and H2pda = 2,6-pyridinedicarboxylic acid). Complex 1 crystallized in a monoclinic system with space group P21/n; 2 crystallized in a monoclinic system with space group C2/c; 3 crystallized in an orthorhombic system with space group Pna21; 5 crystallized in a monoclinic system with space group P21/c; 4 and 6 crystallized in triclinic systems with space group P-1. The DNA-binding modes of the complexes were investigated by several analysis methods (e.g. viscosity analysis, circular dichroism spectroscopy, fluorescent spectroscopic analysis, as well as UV spectroscopic analysis). Complexes 1-6 bind to calf thymus DNA via an intercalative mode. The results of this study provide insights into the mechanism of DNA binding and provide a basis for rationally designing new powerful reagents for DNA detection and targeting.
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JOURNAL OF COORDINATION CHEMISTRY
·
2025
·
IF 2.1
Hou Cong Li,Ming Zhu Wang,Ye Fan Zheng,Ning An,Min Hou,Jing Hu,Wen Ge Li
Three chlorinated metal complexes [Ni2(HL)2(C2H5OH)2Cl2]·2C2H5OH (complex 1), [Co(HL)(L)] (complex 2), and [Zn2(HL)2(CH3COO)2] (complex 3) derived from 5-chlorosalicylaldehyde and 2-(2-aminophenyl)-1H-benzimidazole Schiff base ligand (H2L). The crystal structures of the three complexes were characterized by elemental analysis, infrared spectroscopy, thermogravimetric analysis, X-ray single-crystal diffraction, and UV-visible absorption spectrum. The in vitro cytotoxicity of chlorinated ligand and its metal complexes were evaluated on four different tumor cell lines (A-549 lung cancer, SMMC-7721 liver cancer, MDA-MB-231 breast cancer, and CNE-2Z nasopharyngeal carcinoma), and normal ovarian epithelial cell (IOSE 80) was determined by MTT assay. The results indicated that chloro-benzimidazole Schiff base Co (III) complex (complex 2) displayed higher cytotoxicity against MDA-MB-231 cell line than cisplatin, while the cytotoxicity on IOSE 80 was lower than that of cisplatin. The results of further study of MDA-MB-231 cells by complex 2 showed that complex 2 could inhibit MDA-MB-231 cells in the G0/G1 phase, inhibit cell proliferation and migration, promote cell apoptosis, and increase intracellular ROS level. The Western blot analysis demonstrated that complex 2 could increase Bax protein expression and decrease Bcl-2 protein expression in MDA-MB-231 cells.
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MICROCHIMICA ACTA
·
2017
·Vol. 184
·期 12
·4731-4740
·
IF 4.58
Lu Zhiwei,Zhang Junjun,Dai Wanlin,Lin Xueni,Ye Jiaping,Ye Jianshan
The authors report on a disposable sensor for the differential pulse anodic stripping voltammetric (DPASV) determination of the ions Zn(II), Pb(II) and Cu(II). Simultaneous detection is accomplished by using a screen-printed carbon electrode (SPCE) co-modified with an in-situ plated bismuth (Bi)) film and gold nanoparticles (AuNPs). The synergistic effect of the Bi film, and the large surface and good electrical conductivity of the AuNPs strongly assist in the co-deposition of the three ions. Four well-defined and fully separated anodic stripping peaks, at 540 mV for Zn(II), 50 mV for Pb(II), 140 mV for Bi(III) and 295 mV for Cu(II), all vs. Ag/AgCl, can be seen. The modified SPCE was characterized by scanning electron microscopy, X-ray diffraction, cyclic voltammetry and electrochemical impedance spectroscopy. Under the optimized conditions, the sensor has a good response to these ions. The detection limits (at an S/N ratio of 3) are 50 ng·L −1 for Zn(II), 20 ng·L −1 for Pb(II), and 30 ng·L −1 for Cu(II). The method was applied to the determination of the 3 ions in spiked lake water samples.
Schematic of screen-printed carbon electrode (SPCE) co-modified with a bismuth film and gold nanoparticles for electrochemical simultaneous determination of Zn(II), Pb(II) and Cu(II) by differential pulse anodic stripping voltammetric (DPASV).
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JOURNAL OF SOLID STATE CHEMISTRY
·
2015
·
IF 2.133
Fei Yin,Jing Chen,Yongfeng Liang,Yang Zou,Jiang Yinzhi,Jingli Xie
Two coordination polymers [Co(dnbab) 2 (bimb)](H 2 O) 4 ( 1 ) and [Zn(dnbab) 2 (bimb)](H 2 O) 5 ( 2 ) (Hdnbab=4-[(3,5-dinitrobenzoyl)amino]benzoic acid, bimb=1,4- bis (1-imidazolyl) benzene) have been solvothermally synthesized. Their structures have been determined by single-crystal X-ray diffraction analyses and further characterized by powder X-ray diffraction (PXRD) and thermogravimetric (TG) analyses. Complexes 1 and 2 are isostructures and each displays an one-dimensional (1D) zigzag chain, which further forms a 3D supramolecular architecture with 1-D channels via inter-chain π–π interactions and hydrogen bonds . Moreover, the magnetic properties of 1 and fluorescent properties of 2 have been investigated.
研究领域:
化学
·
材料科学
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