SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2024
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IF 4.3
Brian Musikavanhu,Tingting Pan,Quanhong Ma,Yongdi Liang,Zhaoli Xue,Lei Feng,Long Zhao
Fluorescent chemosensors are often preferred for tracking toxic ions because of their non-destructive measurement and ease of use in environmental real samples and biosystems. Exploring high selectivity, great sensitivity, and biocompatible fluorophores with facile, accessible and dual-responsive features is currently highly demanding. A coumarin-based naphthol hydrazone Schiff base chemosensor, NaChro , is designed and synthesized in a two-step process to detect toxic metal ions with strong emission. Fluorescence spectra analysis demonstrates that the probe binds to Hg 2+ and Pb 2+ ions with a 1:1 and a 2:1 stoichiometry, respectively, with high sensitivity, short response time and minimal interference from other metal ions. The observed reversible turn-on reaction was attributed to the inhibition of C = N isomerization and excited-state intramolecular proton transfer (ESIPT) processes once the ions were introduced. The practical applications of NaChro are successfully addressed in paper strips, various water samples, HeLa cells and Zebrafish, demonstrating that the probe can detect and track Hg 2+ and Pb 2+ ions in environmental samples and biosystems.
研究领域:
环境科学
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生物化学
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分析化学
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产品关联
DOI
PubMed
高影响因子
Food Chemistry-X
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2024
·
IF 6.5
Min He,Jinfeng Zhang,Na Li,Lu Chen,Yan He,Zhiyun Peng,Guangcheng Wang
Thirteen kojic acid-coumarin derivatives were synthesized using the principle of molecular hybridization, and their structures were characterized by 1 H NMR, 13 C NMR, and HRMS. In vitro enzyme inhibition experiments showed that all newly synthesized derivatives have excellent inhibition of tyrosinase (TYR) activity. As a mixed inhibitor, compound 6f has the strongest activity, with an IC 50 value of 0.88 ± 0.10 µM. Multispectral experiments have confirmed that the mode of action of compound 6f on TYR was static quenching. In addition, compound 6f formed a new complex with TYR, which increased the hydrophobicity of the enzyme microenvironment, reduced the content of the α-helix in the enzyme, and changed the secondary structure. The experimental results showed that compound 6f effectively inhibited the browning of lotus root slices and had low cytotoxicity. Therefore, compound 6f is believed to have great development potential as a TYR inhibitor in the food industry.
研究领域:
食品科学
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生物化学
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产品关联
DOI
PubMed
高影响因子
LUMINESCENCE
·
2024
·Vol. 39
·期 9
·e4908
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IF 3.2
Zhong Luo,Changchun Yuan,Zhichun Li,Wenbing Ma
A novel coumarin–naphthalimide-based ratiometric fluorescent probe, called XPT, was synthesized with the aim of achieving high sensitivity and anti-interference for N 2 H 4 detection. The probe XPT consists of coumarin species and naphthalimide species, which act as the energy donor and acceptor, respectively. The phthalimide group functions as the recognition unit for N 2 H 4 . Without the presence of hydrazine, the naphthalimide remains in a non-fluorogenic phthalimide mode, disrupting the FRET signal. However, the phthalimide group undergoes the Gabriel reaction to an amine, which induces FRET and consequently causes a shift in the emitted fluorescence from 468 to 528 nm when N 2 H 4 was added. The results of the study demonstrated that XPT exhibits high sensitivity with a limit of detection 2.2 μM, as well as selectivity. Furthermore, it is remarkable that the distribution of N 2 H 4 in real water samples can be monitored by XPT.
研究领域:
分析化学
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环境科学
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DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2021
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IF 4.098
Ziyu Chen,Zejia Zhao,Jiaxin Yang,Xiaoli Gao,Xu Sang,Adnan Khan,Rui Xu,Ming Feng,Lisa Liu,Qixin Liu,Feng Song
The utilization and residue of pesticides exist multifaceted non-restrictive effects on food safety and ecological protection. Exploitation of rapid and sensitive pesticide detection technology is imperative and will be helpful to better control the detriment of pesticides. Here, a novel flexible film has been prepared based on organic-inorganic composite materials (coumarin-3-carboxylic acid and GdF 3 :Sm 3+ ), which exhibits good optical performance and can well realize the timely and maneuverable detection for different pesticides. The spectra and luminescence properties of each composition in the composite have been analyzed systematically, and the coordinated fluorescence emission of Sm 3+ and coumarin-3-carboxylic acid is revealed at an excitation wavelength of 373 nm. Besides, the energy transfer mechanism is also researched by both experiment and theoretical calculation. The actual detection of different pesticides reveals differential fluorescence influence degree. Meanwhile, the flexible film still possesses sensitive recognition in the presence of micro concentration of pesticides. Results indicate that the flexible film with good optical performance can produce visual detection ability and provide a promising strategy for wider detection applications.
研究领域:
分析化学
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环境科学
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材料科学
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DOI
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
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2024
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IF 4
Yuan Zhong,Cong Huang,Jing Zhang,Liang Zhong,Rong Zeng,Yuhuan Kuang,Xinyan Ye,Ziyin Xie,Ji Zhang,Zongde Wang,Shangxing Chen,Dayong Peng
Succinate dehydrogenase inhibitors (SDHI) are widely used in plant antifungal agents. To break the barrier of resistance, a series of new coumarin-quinolinamide SDHI derivatives containing monocyclic monoterpenes were designed and synthesized using natural camphor or natural menthol as lead compounds, and their structures were characterized by FT-IR, 1 H NMR, 13 C NMR and HRMS. In vitro antifungal activity test results showed that the target compounds had inhibitory activity against most plant pathogenic fungi, especially against Rhizoctonia solani and Phytophthora nicotianae var. nicotianae , which was superior to other fungi. Among them, compounds 11t and 12t showed better inhibitory effects on Rhizoctonia solani than the commercial fungicide tricyclazole, with EC 50 of 16.90 mg/L and 27.09 mg/L, respectively. Based on this, the detached leaf assay was used to further explore the in vivo therapeutic and preventive effects of compounds 11t and 12t on rice sheath blight in plants. The results of the antifungal activity test in vivo showed that compound 11t was slightly better than the positive control, while compound 12t was close to the control effect of azoxystrobin. More importantly, the more bioactive compounds 11t and 12t did not affect the germination of cowpea seeds and also did not affect the growth of normal human hepatocytes and kidney cells. Molecular docking experiments showed that the introduction of the diethylamino group could promote the formation of hydrogen bonds between the hydrogen atom on the amide bond of the target compound and residue Tyr91, and compounds 11t and 12t had smaller free energy between the amino acid residue, which would enhance the antifungal activity of the compounds. These studies proved the potential value of this series of compounds for the study of novel amide-based SDHI fungicides.
研究领域:
植物学
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药理学
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分子生物学
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DOI
高影响因子
PLANT SCIENCE
·
2026
·
IF 4.6
Qi Zeng,Chunting Liu,Huishen Wang,Jingwen Jia,Xuemei Yan,Xifan Liu,Yuxuan Qiu,Xiaowu Wang,Baohua Li
Black spot disease causes significant yield and quality loss in Brassica vegetables. Therefore, developing effective management strategies is imperative to ensure both productivity and marketable quality in Chinese cabbage cultivation. We surveyed and isolated 396 Alternaria strains from infected Brassica vegetables, and confirmed that A. brassicae is the most pathogenic one. By screening and identifying the resistant and susceptible lines of Chinese cabbage, we performed a the widely targeted metabolomic analysis to explore the metabolic profiling of Chinese cabbage leaf samples in response to A. brassicae infection via a time course experiment. Coumarin-3-carboxylic acid and dicumarol were identified and functionally validated as effective antifungal compounds in vitro and in vivo assays, by activating the phenylpropanoid pathway. Furthermore, cinnamic acid of phenylpropanoid pathway was functionally validated to strongly inhibit the growth of the A. brassicae by in vitro assay. The extensive dataset of candidate metabolic compounds provided valuable insights for exploring A. brassicae - Brassica vegetables interactions, facilitating the for developing green pesticides and disease-resistant cultivars.
✓ 已验证
DOI
PubMed
高影响因子
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
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2021
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IF 1.082
Bin Wang,Xiangmei Ma,Xixi Zuo,Jing Ma
We report a novel diphenylsulfone-functionalized coumarin derivative with a large Stokes shift (180 nm), which was used to develop a sensor for the determination of 2,4,6-trinitrophenol（TNP) in the DMF/H2O solution based on the fluorescence quenching and the color’s change. The experimental results showed that the chemosensor can selectively detect TNP without interference from other nitroaromatic explosives and common metal ions in natural water. There was a good linear relationship between the fluorescence intensities of the chemosensor and TNP concentration (5–50) × 10−7 M, displaying a limit of detection of 2.15 × 10−7 M.
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DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2018
·
IF 2.88
Yong Tang,Yuanyuan Li,Juan Han,Yanli Mao,Liang Ni,Yun Wang
A dual-functional fluorescent probe based on coumarin fluorophore for monitoring ClO − and Cu 2+ was synthesized and characterized. The identification mechanisms for ClO − and Cu 2+ induced different colorimetric and ratiometric changes. ClO − caused a colorimetric change from yellow to colorless and 120 nm blue-shifted emission spectra from red to blue. Besides, Cu 2+ induced a remarkable fluorescence quenching behavior and 36 nm blue-shifted absorption spectra accompanied by the color change from yellow to luminous yellow. As expected, Probe 1 displayed excellent selectivity and sensitivity for detecting ClO − and Cu 2+ over other competing ions in their respective systems. The limits of detection for ClO − and Cu 2+ were 24.62 nM and 0.39 nM, respectively. The recognition mechanisms were proved by 1 H NMR, mass spectrum and theoretical calculations. More importantly, the reversibility of Cu 2+ could be applicable to rapid quantification for ClO − /Cu 2+ . Thus, the strategy for sensing ClO − /Cu 2+ was carried out, which revealed broad applications of Probe 1 in multiple actual water and biology.
研究领域:
分析化学
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生物无机化学
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荧光传感
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环境监测
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生物成像
✓ 已验证
DOI
高影响因子
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
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2019
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IF 4.027
Yu-Heng Hu,Jie Yang,Yun Zhang,Ke-Chun Liu,Teng Liu,Jie Sun,Xiao-Jing Wang
The work is focused on the design of drugs that prevent and treat Alzheimer’s disease (AD) and its complications. A series of 3–(4-aminophenyl)-coumarin derivatives designed, synthesised, fully characterised and evaluated in vitro/vivo. The biological assay experiments showed that some compounds displayed a clearly selective inhibition for acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). Among all compounds, compound 4m exhibited the highest AChE inhibition with an IC50 value of 0.091 ± 0.011 µM and compound 4k exhibited the highest BuChE inhibition with an IC50 value of 0.559 ± 0.017 µM. A zebrafish behaviour analyser (Zebrobox) was used to determine the behavioural effects of the active compound on the movement distance of the aluminium chloride-induced zebrafish. Compound 4m offered a potential drug design concept for the development of therapeutic or preventive agents for AD and its complications.
研究领域:
药理学
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神经科学
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药物设计
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DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Chuanyu Chen,Simeng Xia,Fan Chen,Ting Peng,Lin Deng,Huiying Wu,Zhou Shi
The Fe(II)/peracetic acid (PAA) process shows significant potential for the removal of organic pollutants due to the rapid reaction between Fe(II) and PAA. However, the slow reduction from Fe(III) to Fe(II) leads to the continuous or excess dosing of Fe(II) during practical application. In this study, epigallocatechin gallate (EGCG), a typical reagent extracted from green tea, was used to enhance the degradation of coumarin (COU) by Fe(II)/PAA for the first time. A complete elimination of COU (25 μM) was achieved in the presence of 50 μM Fe(II), 300 μM PAA, and 25 μM EGCG, exhibiting a k obs value of 0.108 min −1 , which was 27 times higher than that observed with Fe(II)/PAA (0.004 min −1 ). Further, Fe(II)/EGCG/PAA demonstrated remarkable pH tolerance, with a COU removal efficiency exceeding 80 % across a pH range of 3–9. Mechanisms investigations revealed that •OH played a dominant role in COU degradation by Fe(II)/EGCG/PAA (accounting for 98.2 %). The increase in EGCG concentration from 10 to 100 μM resulted in a decreased formation of •OH yield and an enhanced generation of RO•. These findings highlight the capability of EGCG to improve the oxidation capacity of Fe(II)/PAA and modulate reactive species formation. The outstanding oxidation capacity and environmental friendliness of Fe(II)/EGCG/PAA process render it a potential strategy to eliminate organic pollutants in actual water treatment.
研究领域:
环境科学
·
化学
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产品关联
DOI
高影响因子
Analytical Methods
·
2015
·Vol. 7
·期 15
·6133-6138
·
IF 1.821
Li-Qiang Yan,Yun Ma,Mei-Fang Cui,Zheng-Jian Qi
A coumarin-based “Turn-on” fluorescence chemosensor 1 containing L-histidine for Al3+ was readily synthesized and investigated, which showed high selectivity and remarkable sensitivity to aluminium(III) ions based on a photo-induced electron-transfer (PET) mechanism in aqueous solution (Tris–HCl, 0.1 mM, pH 7.2). The sensor responded rapidly to Al3+ in aqueous solutions with a 1 : 1 stoichiometry. Meanwhile, it showed excellent adaptability and also responsiveness.
研究领域:
分析化学
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生物化学
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DOI
高影响因子
JOURNAL OF LUMINESCENCE
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2017
·
IF 2.686
Yanhua Yu,Tingting Shu,Cheng Fu,Bingjie Yu,Dongdong Zhang,Huixiu Luo,Junjie Chen,Changzhi Dong
A novel colorimetric and fluorescent sensor 6 for fluoride and cyanide was developed based on BODIPY-coumarin platform and its anions sensing properties were investigated in the mixture of acetonitrile and Tris–HCl buffer (v/v = 95:5, pH = 7.5). Probe 6 could simultaneously detect F – and CN – through colorimetric method over the other competitive anions, such as Cl – , Br – , I – , NO 3 – , ClO 4 – , HSO 4 – , S 2– and H 2 PO 4 – . It exhibited a distinct color change from red to green upon addition of F – through deprotection of tert -butyldiphenylsilyl group of coumarin . Moreover, it displayed an obvious color change from red to yellow through deprotection process firstly, then with a nucleophilic displacement mechanism. Therefore, the sensor 6 provides a novel method to simultaneously detect F − and CN − with different color change in the same solvent environment. The detection limit of sensor 6 toward F – and CN – ion was determined to be 0.43 μM and 1.9 μM respectively,
研究领域:
分析化学
·
生物化学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）