NEW JOURNAL OF CHEMISTRY
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2025
·
IF 2.5
Chenyang Zhang,Xuewei Zhang,Xuerui Yang,Guangli Xiu,JM CHOVELON,Lei Zhou
The photochemical behaviors of fungicides under irradiation differ significantly between leaf surfaces and aqueous solutions. However, few studies have compared the photolysis of fungicides between these two environmental media. In this study, three typical fungicides—kresoxim-methyl (KM), pyraclostrobin (PAS), and cyprodinil (CRL)—were examined using carnauba wax to simulate leaf surfaces The photolysis kinetics, products, and pathways were systematically compared between aqueous solutions and wax films. On wax film, the photolysis rate constants of selected fungicides were observed to be significantly faster than in aqueous solution, with increases of 44, 5 and 36-fold for KM, PAS and CRL, respectively. The primary photolysis pathways on wax films involved photoisomerization and ether cleavage; while the hydroxylation process, commonly observed in aqueous systems, was absent. Toxicity assessments demonstrated that photolysis effectively reduced their ecotoxicities in both systems, with the photolysis on wax film documented as a more profound detoxification process. Moreover, wax film thickness and pesticide additives significantly influenced photodegradation kinetics of all the three fungicides. The present study highlighted the significant influence of environmental media on the photodegradation pathways of pesticides.
研究领域:
环境科学
·
农药化学
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WATER RESEARCH
·
2024
·
IF 11.4
Rongyue Geng,Baogang Zhang,Haoyi Cheng,Mengnan Wang,Zhi Dang
Microbial reduction under anaerobic condition is a promising method for remediating vanadate [V(V)] contamination in aquifers, while V(V) may be re-generated with redox fluctuations. The inability to remove vanadium after remediation has become a key issue limiting bioremediation. In this study, we proposed the use of pyrrhotite, a natural mineral with magnetic properties, to immobilize V(V) to insoluble V(IV) under microbial action and remove vanadium from the aquifer using a magnetic field, which could avoid the problem of V(V) recontamination under redox fluctuating conditions. Up to 49.0 ± 4.7 % of vanadium could be removed from the aquifer by the applied magnetic field, and the vanadium in the aquifer after the reaction was mainly in the acid-extractable and reducible states. pH had a strong effect on the magnetic recovery of V(V), while the influence of initial V(V) concentration was weak. Microbial community structure analysis showed that Thiobacillus, Proteiniphilum, Fermentimonas , and Desulfurivibrio played key roles for V(V) reduction and pyrrhotite oxidation. Structural equation model indicated the positive correlation between these genera with the magnetic recovery of vanadium. Real time-qPCR confirmed the roles of functional genes of V(V) reduction ( napA and nirK ) and SO 4 2− reduction ( dsrA ) in such biological processes. This study provides a novel route to sustainable V(V) remediation in aquifers, with synchronous recovery of vanadium resources without rebound.
研究领域:
环境微生物学
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水资源管理
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地球化学
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生物修复技术
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PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
·
2025
·
IF 4
Wei-Huan Xu,Meng-Yao Zhu,Zhi-Heng Xu,Xiao-Jie Li,Chao-Yang Peng,Xiao-Pei Fan,Yong-Qiang Li
The fall armyworm, Spodoptera frugiperda (J. E. Smith) is a notorious insect pest of poaceae and causes severe economic damage to major cereal crop. It has evolved with different levels of insecticide resistance. Insect cytosolic GSTs are a major class of detoxifying enzymes and have been implicated in metabolic resistance and protection against oxidative stress. In this study, an epsilon class GST ( SfGSTe9 ) was identified from S. frugiperda and its transcript levels were highest in the fat bodies, second instar and pupae. Furthermore, SfGSTe9 is upregulated after exposure to beta- cypermethrin, lambda -cyhalothrin, chlorpyrifos, and malathion. The kinetic analysis suggests the purified recombinant proteins exhibit CDNB conjugating activity, with the V max of 11.87 ± 0.25 μM·min −1 ·mg −1 protein and K m of 0.22 ± 0.01 mM. The peroxidase activity assays indicate that SfGSTe9 has antioxidant activity against both CHP and H 2 O 2. The inhibition assays infer that four types of insecticides have strong inhibition on the GST activity. In vitro metabolism assays with HPLC further suggest that SfGSTe9 could be able to deplete 11.2 %, 21.3 % and 19.3 % of beta- cypermethrin, lambda -cyhalothrin and chlorpyrifos within 2 h, respectively, with specific activity varying between 30 and 40 μM·min −1 ·mg −1 protein. However, no metabolites were identified in this case, indicating that SfGSTe9 probably involves in detoxification via binding and sequestration. 3D modeling and molecular docking analysis indicate that above three types of insecticide compounds fit nicely into the hydrophobic pocket in the active site of SfGSTe9 . Our results definitely demonstrate that SfGSTe9 of S. frugiperda plays pivotal role in insecticide detoxification and serves in defence against oxidative stress .
研究领域:
昆虫学
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分子生物学
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毒理学
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高影响因子
Nanomaterials
·
2024
·Vol. 14
·期 7
·559
·
IF 4.4
Yuyang Liu,Shiyin Zhao,Yujiao Li,Jian Huang,Xuheng Yang,Jianfang Wang,Cheng-an Tao
Chemical warfare agents (CWAs) refer to toxic chemical substances used in warfare. Recently, CWAs have been a critical threat for public safety due to their high toxicity. Metal–organic frameworks have exhibited great potential in protecting against CWAs due to their high crystallinity, stable structure, large specific surface area, high porosity, and adjustable structure. However, the metal clusters of most reported MOFs might be highly consumed when applied in CWA hydrolysis. Herein, we fabricated a two-dimensional piezoresponsive UiO-66-F4and subjected it to CWA simulant dimethyl-4-nitrophenyl phosphate (DMNP) detoxification under sonic conditions. The results show that sonication can effectively enhance the removal performance under optimal conditions; the reaction rate constantkwas upgraded 45% by sonication. Moreover, the first-principle calculation revealed that the band gap could be further widened with the application of mechanical stress, which was beneficial for the generation of1O2, thus further upgrading the detoxification performance toward DMNP. This work demonstrated that mechanical vibration could be introduced to CWA protection, but promising applications are rarely reported.
研究领域:
材料科学
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化学工程
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环境科学
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纳米技术
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BIORESOURCE TECHNOLOGY
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2026
·
IF 8.2
Yingjie Song,Zhangli Hu,Xuewei Yang,Yinglin Lu
Antibiotic residues in wastewater pose ecological and health risks, demanding efficient and sustainable removal strategies. A nature-based tripartite system was developed combining Spirodela polyrhiza , a sulfamethoxazole (SMX)-degrading bacterium ( Pseudomonas sp. N6), and the white-rot fungus Trametes versicolor N105 for SMX removal. In sterile batch reactors (1 mg/L SMX), the consortium reduced SMX below the quantification limit (0.05 mg/L) within 12 days, outperforming duckweed alone and duckweed with a single microbial partner. Mass balance analysis showed that biodegradation (0.90 mg/L) dominated SMX dissipation, with fungal oxidative cleavage complementing bacterial hydroxylation and duckweed-mediated deamination. Physiological assays indicated that microbial partners, particularly the fungal component, alleviated SMX-induced oxidative stress and enhanced pigment synthesis, thereby improving duckweed growth. These results demonstrate that integrating duckweed, bacteria, and fungi yields enhanced SMX removal and mitigates phytotoxicity, highlighting a promising nature-based strategy for antibiotic-contaminated wastewater.
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JOURNAL OF APPLIED ENTOMOLOGY
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2022
·Vol. 146
·期 7
·823-837
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IF 2.183
Xuanyu He,Zhaodong Hao,Hui Li,Tian Xu,Ruixu Chen,Xiaohong Xia,Shouyin Li,Dejun Hao
Understanding the mechanism of insect resistance to toxic effects of phytochemicals can provide an insight into plant–herbivore interactions. Monochamus alternatus Hope, a main vector of pine wood nematode ( Bursaphelenchus xylophilus ), prefers to infest masson pine ( Pinus massoniana Lamb) and causes huge economic and environmental losses. α-Pinene is the primary component of resin produced by masson pine and plays a crucial role in defending against herbivorous insects, but its defensive effects on M . alternatus larvae are barely known. Here, we explored the physiological metabolism in M . alternatus larvae that were fumigated with (+)-α-pinene, (-)-α-pinene, β-pinene, (R)-(+)-limonene, myrcene and (-)-α-phellandrene. (+)-α-Pinene showed the highest fumigant toxicity to M . alternatus larvae among these monoterpenes, and the fourth instar larvae possessed the highest resistance to this compound at the larval stage. Comparative transcriptome analysis detected 423 up-regulated and 311 down-regulated genes in the larvae fumigated with (+)-α-pinene, which were mainly related to detoxification, energy and protein metabolism. Among the differentially expressed genes encoding for detoxification enzymes, 14 P450s, 13 UGTs, 1GSTs and 3ABCs were dramatically up-regulated in the larvae fumigated with (+)-α-pinene. Silencing of P450s via RNA interference led to an increased mortality in the larval fumigated with (+)-α-pinene. Piperonyl butoxide exposure significantly increased the mortality and inhibited the expressions of P450s, UGTs and ABCs in the larvae fumigated with (+)-α-pinene. These results suggested an important role of P450s in the resistance of M . alternatus larvae to (+)-α-pinene fumigation, which may facilitate the understanding of terpenoid detoxification in M . alternatus larvae.
研究领域:
昆虫学
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分子生物学
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植物-昆虫互作
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高影响因子
PLOS BIOLOGY
·
2026
·Vol. 24
·期 9
·e3004013
·
IF 6.9
Huidong Wang,Yajie Kong,Xinyue Su,Yu Shi,Jianpeng Zhang,Yinjia Wang,Yajuan Xiao,Xing Geng,Jing Song,Yueru Ye,Kairan Zuo,Chris Bass,Shutang Zhou
Plants and herbivorous insects are engaged in a continuous evolutionary arms race driven by chemical defences and counter-defences. How insects integrate distinct detoxification systems to overcome diverse phytochemicals, and how such mechanisms contribute to host-range divergence, remains poorly understood. Here, we uncover a cooperative cytochrome P450–UDP-glycosyltransferase (UGT) cascade that mediates furanocoumarin tolerance in Helicoverpa armigera . Comparative genomic analyses across Helicoverpa and related noctuid species revealed that the UGT33 family is the most extensively expanded and dynamically diversified UGT lineage in Helicoverpa . Targeted CRISPR–Cas9 knockouts of UGT33 gene clusters in polyphagous H. armigera demonstrated their essential roles in detoxifying the furanocoumarins xanthotoxin and imperatorin. Combined metabolic and functional assays further established a sequential detoxification pathway, in which the cytochrome P450 CYP6AE19 catalyses either the O-dealkylation of xanthotoxin to yield xanthotoxol or the aromatic-carbon hydroxylation of xanthotoxin to form 5-hydroxyxanthotoxin, which are subsequently glycosylated by UGT33 enzymes to form their less-toxic glucosides. In contrast, impaired CYP6AE19–UGT33 coordination in the oligophagous Helicoverpa assulta was associated with reduced xanthotoxin detoxification and high sensitivity to this compound. Together, these findings provide direct evidence for coordinated Phase I–Phase II detoxification of a plant defensive compound in insects and show that functional divergence in this pathway contributes to interspecific differences in plant toxin tolerance, which are associated with contrasting dietary breadth in closely related herbivorous insects.
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PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
·
2023
·
IF 4.7
Zhenyu Li,Mengling Chen,Wenjie Bai,Shuxia Zhang,Liwei Meng,Wei Dou,Jinjun Wang,Guorui Yuan
Carboxylesterases (CarEs) are a multifunctional superfamily of enzymes and play an important role in detoxification of various insecticides in insects. The oriental fruit fly, Bactrocera dorsalis , is one of the most destructive agricultural pests and has developed different degrees of resistance to organophosphates in field. However, the involvement of BdCarEs in tolerance or resistance to other alternative insecticides are still unclear. In the present study, 33 BdCarEs genes were identified based on the genome database of B. dorsalis . Phylogenetic analysis demonstrated that they were classified into nine clades, with abundance of α -esterases. Meanwhile, the sequence characterization and the chromosome distribution were also analyzed. The spatiotemporal expression analysis of BdCarEs genes suggested that the diversity of potential function in different physiological processes . With the exception of BdCarE21 , all BdCarEs genes responded to at least one insecticide exposure, and BdCarE20 was found to be up-regulated after exposure to all five tested insecticides individually. Eight BdCarEs genes were overexpressed in MR strain when compared to that in SS strain. Subsequently, knockdown the expression of representative BdCarEs genes significantly increased the susceptibility of the oriental fruit fly to corresponding insecticides, which indicated that the tested BdCarEs genes contributed to one or multiple insecticide detoxification. These findings provide valuable insights into the potential role in respond to tolerance or resistance to insecticides with different mode of action, and will facilitate development of efficiency management strategy for B. dorsalis .
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APPLIED CATALYSIS B-ENVIRONMENTAL
·
2023
·
IF 22.1
Xuejiao Wang,Jing Yang,Ming Zhang,Qian Hu,Bai-Xue Li,Jin Qu,Zhong-Zhen Yu,Dongzhi Yang
We design a spontaneously super-hygroscopic alkaline microreactor by photoinduced integration of Zr-MOF catalyst and alkaline poly(dimethylaminoethyl acrylate) onto LiCl-salinized poly(N-isopropylacrylamide) gel, generating a microenvironment with non-volatile polymeric base and non-bulk water for detoxification of a typical nerve agent simulant, dimethyl 4-nitrophenyl phosphate (DMNP), in atmospheric environments. The super-hygroscopic gel with directional microchannels facilitates the absorption, transport and storage of water under different humidities, and exhibits fast hygroscopic efficiency with a high moisture absorption capacity of 6.4 g g −1 . The integrated microreactor achieves simultaneous water uptake and catalytic hydrolysis of DMNP in an atmospheric environment with an initial half-life of ∼1.9 h and a final conversion of 95.5%, which is attributed to the synergistic catalytic microenvironment of the exposed Zr-MOF catalyst, the polymeric base, and the water from moist air. This work provides a feasible strategy for designing spontaneously hygroscopic microreactors for detoxifying nerve agent simulants in atmospheric environments.
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JOURNAL OF HAZARDOUS MATERIALS
·
2023
·
IF 13.6
Funian Han,Liang Yu,Xinyun Mo,Lu Zhang,Jiaqi Jia,Jingmeng Dong,Shaopeng Gu
The particle size distribution (PSD), composition, morphology, and formation mechanism of particulate matter (PM) released from the combustion of spent pot lining with and without CaSiO 3 were investigated. The results showed that NaF and Na 3 AlF 6 were found to be the main compositions of PM, and the particle size distribution of PM shows a bimodal distribution. CaSiO 3 substantially inhibited the emission of PM by transforming NaF, Na 3 AlF 6 , and CaF 2 into stable Ca 4 Si 2 O 7 F 2 . Moreover, CaSiO 3 also limited the formation of high hazardous PM 0.2 by providing SiO 2 , Al 2 O 3 , and NaAlSiO 4 with high melting points as the core of promoting the growth of PM in particle size.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
·
IF 9.136
Jiangfu Zheng,Changzheng Fan,Xiaoming Li,Qi Yang,Dongbo Wang,Abing Duan,Shuaijun Pan,Baowei Zhang,Jinglin Ding,Shengxiang Rong,Haoyu Yin
Development of efficient nanomaterials for photocatalytic degradation is very important in the removal of organic pollutants from water. The oxygen vacancy-rich g-C 3 N 4 / LDH composites (g-C 3 N 4 /LDH-OVs) with a layered structure was prepared for the efficient photocatalysis degradation and mineralization of tetracycline hydrochloride (TC) under visible light irradiation. Oxygen vacancies in the composites achieved through structural induction strategy not only provide abundant active sites but also improve the separation efficiency of the photo-generated carriers, thereby enhancing the degradation and mineralization of TC, as revealed both by theories and experiments. The optimized g-C 3 N 4 /LDH-OVs have achieved excellent photocatalytic activity (i.e., 95 % degradation and 28 % mineralization of TC after 60 min of visible light irradiation), which was 2.3 and 3.5 times higher than that of the pristine g-C 3 N 4 and LDH-OVs, respectively. Furthermore, experimental results based on bio-acute toxicity show that the g-C 3 N 4 /LDH-OVs/Vis system can effectively detoxify the transformation products. This study provides an insight into the development of LDH-based photocatalysts, so as to realize photocatalytic mineralization and simultaneous detoxification through the new strategy of oxygen vacancy defect engineering.
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ACS Sustainable Chemistry & Engineering
·
2022
·
IF 9.224
Zheng-Meng Jiang,Fang-Fang Wang,Jie Liu,Tian-Qing Huang,Hu Zhang,E-Hu Liu
The conversion of diester-diterpenoid alkaloids (DAs) into monoester-diterpenoid alkaloids (MAs) is an effective method to reduce the toxicity of Aconiti Lateralis Radix Praeparata (Fuzi in Chinese, ALRP), a popular traditional Chinese medicine. In the present study, deep eutectic solvents (DESs) were first utilized to simultaneously detoxify ALRP and extract aconitum alkaloids by gas bath thermostatic oscillator-assisted extraction. The effects of extraction parameters, including the extraction time, water content of DESs, temperature, liquid/solid ratio, and pH, on the extraction of MAs were evaluated by single-factor experiments, and the optimal condition was further optimized using response surface methodology. The results indicated that betaine-urea (Bet-Ure, 1:2 mol/mol) was the most appropriate DES to hydrolyze highly toxic DAs into less toxic MAs and improve the extraction efficiency of aconitum alkaloids in one step. The detoxification mechanism study showed that alkaline DESs had an excellent efficiency for DA hydrolysis and MA extraction, and the MA-extraction efficiency enhanced with the increase in pH. Compared with the conventional extraction, the newly developed detoxification process maximized the hydrolysis of DAs and exhibited a higher MA-extraction efficiency (1.913 mg/g vs 0.155 mg/g). The DES-based method offered an ecofriendly, simple, and feasible detoxication strategy for ensuring the safe and effective use of ALRP.
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