ACS Biomaterials Science & Engineering
·
2025
·
IF 5.5
Zhongchao Wang,Jinghan Wang,Liang Shi,Haokun Yuan,Jiaqi Wu,Weiwei Xiao,Bingyang Lu,Xiao Luo,Xiao Han,Liyuan Fan
Oral health problems, particularly tooth defects, can significantly affect people’s quality of life and overall well-being. The development of titanium (Ti) dental implants has largely replaced natural tooth roots to prevent periodontal and gastrointestinal diseases. However, challenges such as postoperative bacterial infections and poor osseointegration continue to hinder progress in dental implant technology. To tackle these issues, we used hydroxypropyl trimethylammonium chloride chitosan (HACC) and gallic acid-modified gelatin (GAG) to create extracellular matrix (ECM) coatings on titanium using layer-by-layer self-assembly. GAG showed better water solubility at room temperature, being over 99.0 times more soluble than regular gelatin. In vivo and in vitro analyses of the ECM coatings revealed their antibacterial properties and their ability to promote osteogenic differentiation, resulting in over 31.5 times more calcareous deposits than Ti. This strategy shows potential for improving oral health and reducing the complications associated with dental implants in clinical settings.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOMACROMOLECULES
·
2025
·
IF 5.4
Hua Zhao,Jingmei Liu,Wenzhi Yang,Pei Cheng,Pengyuan Liu,Yuxiao He,Yongli Liu,Fangxia Guan,Minghao Yao
Effective coverage and antibacterial treatment of irregular wounds remain challenging due to complex geometries, bacterial growth, and elevated levels of reactive oxygen species, which cause prolonged inflammation and impaired healing. In this study, a gelatin–gallic acid (GGA) hydrogel was enzymatically cross-linked using horseradish peroxidase (HRP) and hydrogen peroxide (H2O2). At high concentrations (10 wt % GGA and 0.04 wt % H2O2), the oxidized gallic acid moieties formed oligomeric structures with intrinsic photothermal activity, eliminating the need for exogenous photothermal agents. The hydrogel further exhibited thermosensitive behavior, maintaining an elastic state at skin temperatures but transitioning to a viscous, reflowable state above 43.6 °C. Within the photothermal therapeutic range (40–50 °C), the hydrogel undergoes reversible deformation, enabling shape readaptation and effective coverage of irregular wound surfaces under near-infrared irradiation. This system achieves synergistic photothermal antibacterial efficacy, thermal shape adaptivity, antioxidant performance, and inflammation mitigation, leading to enhanced healing outcomes.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION
·
2021
·Vol. 36
·期 6
·934-941
·
IF 0.957
Yan Chunchao,Xiao Feng,Qiu Tong,Zhang Xueqiong,Zhan Siwen,Lu Mengli,Yang Mengjia,Zhang Juan
To synthesize three different grafting ratios of gallic acid (GA)-chitosan (CS) copolymer by a free radical mediated grafting method, which is further applied to the field of antibacterial materials, crosslinking structures of the compound GA-CS copolymer were characterized, fully indicating that gallic acid is resoundingly grafted onto chitosan. The grafting ratios of three copolymers GA-CS are 45.71% (I), 36.12% (II), and 18.96% (III) were determined by UV-Vis spectrophotometer. The minimum inhibitory concentrations of three GA-CS copolymers are 30 µg/mL against Escherichia coli and are ranged from 250 to 550 µg/mL against Staphylococcus aureus. By counting viable bacterial colonies, it can be found that antibacterial property is preferable by increasing the grafting ratio of GA-CS copolymers. Findings of investigation on aforementioned bacteria experiment indicate that the CFU/mL values of GA-CS (I, II, III) are 2.04×10 6 , 7.56×10 6 , 1.48×10 7 to Staphylococcus aureus , and 2.96×10 6 , 1.01×10 7 , 2.14×10 7 to Escherichia coli after 12 h treatment. In addition, the interaction process between GA-CS copolymer and bacteria can be observed through a transmission electron microscope. The specific manifestation is that the bacterial cell membranes are ruptured after being treated with the copolymer, which causes the cell contents to flow out, and the cell morphology is shrunk and out of shape.
✓ 已验证
DOI
高影响因子
CHEMOSPHERE
·
2022
·
IF 8.943
Yongqiang Yang,Xiongfei Rao,Qingling Fu,Xin Zhang,Jieyu Gao,Xiang Wan,Jun Zhu,Guoyong Huang,Hongqing Hu
Organic acids usually compete the immobilization of As by iron (hydro)oxides, but their oxidizing effects are ignored. Therefore, the gallic acid (GA) with strong redox activity was chosen to investigate the influence of arsenite [As(III)] oxidation on As immobilization by ferrihydrite . Our results found that the As amount adsorbed on ferrihydrite decreased with the pH rising from 5 to 9 in the presence of GA, and the adsorption amount (28.8 g kg −1 ) at pH 9 was 45.1% lower than that in the absence of GA. Meanwhile, the As adsorption amounts in treatments of GA addition before As (Fh-GA-As(III)) were significantly lower than that in their corresponding simultaneous addition (Fh-As(III)/GA). The proportions of As(V)/As total on ferrihydrite and in equilibrium suspension were increased as the pH increased in the presence of GA, and the highest oxidation efficiency of As(III) by GA at pH 9 was 90.3%, which was mainly due to the contribution of hydrogen peroxide (H 2 O 2 , 52.6%) and semiquinone radicals (SQ − , 27.1%). In general, the oxidation and competition adsorption of As by GA inhibited the As immobilization by ferrihydrite, and the oxidation of As(III) by GA was strongly dependent on pH, while H 2 O 2 and SQ − were demonstrated as the main oxidant at pH 9.
✓ 已验证
DOI
高影响因子
Food Bioscience
·
2026
·
IF 6.2
Qian Wang,Weiyuan Niu,Xiangbo Zeng,Xinmiao Wang,Dayong Zhou,Fawen Yin
Lecithin complexes enable chain-length-dependent interfacial localization of gallates. • Pre-assembled lecithin-gallate complexes form reverse micelles at oil-water interfaces. • Complexes outperform physical mixtures by overcoming the “polar paradox” in bulk oils. • L-E3:0 Com inhibited primary oxidation, whereas L-E12:0 Com limited secondary products. • L-E3:0 Com and L-E12:0 Com may be associated with distinct interfacial environments. The antioxidant performance of phenolic compounds in bulk oils depends on both radical-scavenging capacity and interfacial localization. Gallic acid esters (GA-Es) are effective radical scavengers, but their performance is limited by the polar paradox and cut-off effect, limiting their interfacial accumulation. Here, soybean lecithin (LEC) was complexed with gallic acid (GA) and GA-Es (C1-C16), and compared with free antioxidants and physical mixtures in rapeseed oil. Spectroscopy and molecular docking indicated non-covalent association between gallate hydroxyl groups and the phospholipid headgroup; DPPH and ABTS assays confirmed retained radical-scavenging capacity. During accelerated storage at 60 °C, the lecithin-propyl gallate complex (L-E3:0 Com) and lecithin-dodecyl gallate complex (L-E12:0 Com) provided the greatest protection against lipid oxidation, with L-E12:0 Com particularly limiting 4-hydroxy-2-hexenal accumulation. The apparent critical micelle concentrations of the complexes (49.71-75.05 μmol/kg oil) were 24.6-50.0% lower than that of LEC (99.47 μmol/kg oil). Cryo-TEM and SAXS revealed formation of heterogeneous association colloids, while fluorescence probing revealed chain-length-dependent differences in local interfacial hydration. Dynamic light scattering and interfacial-tension measurements exhibited corresponding non-monotonic trends: L-E3:0 Com formed the smallest assemblies (8.48 ± 0.98 nm) and produced the lowest oil-water interfacial tension (14.35 ± 0.17 mN/m), whereas long-chain complexes formed larger structures and showed stronger hydrophobic association. These results indicate that lecithin complexation modulated gallate aggregation and interfacial behavior in a chain-length-dependent manner, providing a plausible physicochemical basis for the two antioxidant optima observed for L-E3:0 Com and L-E12:0 Com.
✓ 已验证
DOI
高影响因子
FOOD HYDROCOLLOIDS
·
2026
·
IF 13.8
Yushi Wei,Hongtao Chen,Deming Gong,Xing Hu,Guowen Zhang
The study aimed to construct a microwave-modified peanut protein isolate (MPPI)–gallic acid (GA)–carrageenan (CG) (MPGC) ternary covalent conjugate, and systematically investigate the effects of glycation covalent modification on the conformation, functional properties and interfacial behavior of MPPI, with the goal of developing new emulsifiers exhibiting superior oil-water interfacial performance. Additionally, the environmental stability of emulsions formulated using the covalent conjugate was evaluated. The results showed that as the proportion of CG increased, the degree of covalent modification significantly enhanced. When the mass ratio of the MPPI-GA conjugates to CG was 1:4 (MPGC4), the grafting degree reached 28.72%. The covalent grafting of CG induced the unfolding of MPPI-GA conjugates structure (decreased β-sheet content and increased random coil content), leading to enhanced surface hydrophobicity and surface charge of the MPPI-GA conjugates. Analysis of oil-water interface characteristics revealed that the MPGC4 conjugates exhibited optimal wettability, significantly reducing the oil-water interfacial tension from 17.34 mN/m to 13.99 mN/m, and demonstrated greater rates of interfacial diffusion, penetration and rearrangement, forming a dense adsorption layer at the interface. The emulsifying activity and emulsion stability of the MPGC4 conjugates were increased to 143.98 m 2 /g and 405.60 min, respectively. When 1.5% (w/v) MPGC4 conjugate was applied to oil-in-water emulsions, the emulsion exhibited a significantly reduced particle size with a more uniform distribution, and excellent environmental stability. This study provides a theoretical basis for the development of novel high-performance plant protein-based emulsifiers.
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2026
·
IF 6.2
Wang Sun,Rui Xu,Wenshuya Li,Ziyan Chen,Mengting Yin,Haibo Liu,Feng Chen,Hai-Jian Ni,Xinyu Zhao
Infected burn wounds remain a formidable clinical challenge due to persistent oxidative stress, bacterial infection, and dysregulated inflammation. Herein, a multifunctional microneedle (MN) patch is engineered through the integration of gallic acid-iron coordination networks (GFe) onto silk fibroin microspheres (SFMSs). The resulting GFe@SFMSs are encapsulated into a dissolvable MN array, enabling direct intradermal delivery and sequential therapeutic release. Upon nearinfrared irradiation, the patch exhibits rapid and potent photothermal antibacterial activity (>99% inhibition against E. coli and S. aureus). The pH-responsive dissociation of the metal-phenolic network facilitates sustained release of gallic acid and Fe ions, conferring durable antioxidant, anti-inflammatory, and chemodynamic effects. Simultaneously, the progressive degradation of SFMSs can activate endogenous regenerative pathways, thereby promoting collagen synthesis and angiogenesis. In a murine infected burn model, the MN patch significantly accelerates wound closure, reduces pro-inflammatory cytokines (TNF-α, IL-6), and enhances tissue remodeling. This work presents a synergistic and spatiotemporally programmable strategy for infected burn healing through the combination of photothermal, chemodynamic, antioxidant, and regenerative functions.
✓ 已验证
DOI
PubMed
高影响因子
AQUACULTURE
·
2026
·
IF 4.4
Songlin Luo,Fansheng Zeng,Guohao Chen,Shunqiang Wei,Chushun Yi,Xuemin Wei,Yinghui Wang,Aiguo Huang
White Spot Syndrome Virus (WSSV) is a major viral pathogen severely threatening crustacean aquaculture. Although natural products possess antiviral potential, their application remains limited due to stability and utilization constraints. This study employed a self-assembly strategy to construct a natural product-based metal-organic nanostructure of luteolin-loaded magnesium-gallic acid (Mg-GA) metal-organic framework (LM), to enhance the anti-WSSV efficacy of luteolin. Results indicate that the prepared LM exhibits a regular prismatic nanostructure with uniform particle size distribution, stable coordination structure, and good biocompatibility. In vivo experiments demonstrated that compared to single luteolin or Mg-GA treatment groups, LM significantly reduced WSSV viral copy numbers in infected crayfish Procambarus clarkii and markedly improved host survival rates. Gene expression analysis revealed that this self-assembled nanomaterial significantly downregulated expression of key viral genes IE1 , DNApol , and VP28 , while upregulating host antioxidant-related genes CAT and SOD , apoptosis-regulating genes BI-1 , and downregulating apoptosis-regulating genes BAX , inflammation-related genes COX1 and COX2 . This indicates its ability to synergistically inhibit viral replication and enhance host defense capabilities. Histopathological results further confirmed that LM effectively alleviated pathological damage caused by WSSV to gill and intestinal tissues, with no apparent toxicity observed in healthy individuals. In summary, the self-assembled natural product metal-organic nanostructure significantly enhances the anti-WSSV efficacy of single compounds, offering a novel nanostrategy for controlling viral diseases in aquaculture.
✓ 已验证
DOI
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Xuedong Jia,Hongyuan Guo,Yifan Hao,Jingbin Shi,Runying Chai,Shurong Wang,Hao Wu,Yujue Feng,Wei Ji,Suozhu Wu
Sensitive determination of gallic acid (GA) is important for food quality control due to its numerous bioactivity. This study presented an electrochemically deposited method for constructing poly(3-aminophenylboronic acid)-poly(β-cyclodextrin)/carboxylated multi-walled carbon nanotubes-chitosan (PAPBA-Poly(β-CD)/cMWCNT-CS) nanocomposites modified electrode. The cMWCNT-CS materials and PAPBA-Poly(β-CD) copolymer were utilized for signal amplification and dual recognition of GA, respectively. Electrochemical detection of GA was achieved through the peak current change of potassium ferricyanide redox probe induced by the synergistic interaction of PAPBA-Poly(β-CD) with target molecules. The proposed method exhibited an ultra-low limit of detection of 0.16 fM and ultra-wide response range of 10 fM to 10 μM for GA with the superiorities of easy construction, rapid response, good reproducibility, and excellent selectivity. This method could be employed to test GA concentration in black teas, apples, grapes, grape beverage, and wine samples, which provided an alternative method for ultrasensitive analysis of functional components in actual samples.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Applied Food Research
·
2026
·
IF 6.2
Lihui Yang,Xian’e Ren,Yuting Wu,Feng Yang,Kunming Zhang,Yongchun Huang,Xiaolong Miao
To enhance the bioaccessibility of vitamin D3 in fortified food systems, hydrodynamic cavitation, ultrasonic cavitation, and an ascorbic acid/hydrogen peroxide system were employed to generate free radicals that mediated the formation of gallic acid-soy protein isolate (GA-SPI) conjugates. The resulting conjugates were used to stabilize emulsions. The emulsion properties and their effects on vitamin D3 delivery were investigated. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) confirmed that covalent conjugation between GA and SPI was promoted by free radical generation in all three treatments. Compared with emulsions prepared with soy protein isolate alone, significant improvements were observed for emulsions stabilized by GA-SPI conjugates, including smaller particle size, higher absolute zeta potential, higher storage modulus, and improved storage stability and antioxidant capacity. These improvements were attributed to GA incorporation and the processing methods. More importantly, when used to encapsulate vitamin D3, bioaccessibility ranged from 53.36 ± 0.57% to 80.06 ± 0.12% for GA-SPI stabilized emulsions prepared by these methods, compared with the untreated group. These findings confirm that emulsion delivery performance can be improved by the three free radical-mediated treatments through promotion of polyphenol-protein conjugation.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF THE TEXTILE INSTITUTE
·
2021
·
IF 1.88
Zhong Zhao,Chris Hurren,Liming Zhou,Lu Sun,Jihong Wu
Antioxidants can inhibit the photofading of natural dyes. However, their effects on improving the light fastness of fabrics dyed with natural dyes are still limited since no stable covalent bonds formed between their molecules and the substrate in the conventional dipping and padding method. In this study, one antioxidant, gallic acid, was grafted to chitosan via the redox reaction between ascorbic acid and hydrogen peroxide. The grafted chitosan was then cross-linked onto cotton fabric dyed with gardenia yellow. Results of colour change caused by the exposure of treated fabric to simulated sunlight irradiation show that gallic acid grafted chitosan (GA-g-CTS) inhibited photofading of gardenia yellow on cotton. Results from handle test show that although the softness of cotton fabric cross-linked with GA-g-CTS slightly deteriorated, the overall handle of the treated fabric was not distinctly affected.
✓ 已验证
DOI
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·
IF 15
Jianyu Nie,Zhongyong Wang,Haotian Tian,Yang Qiao,Menghui Liu,Xianwen Wang,Liang Xu,Xingliang Dai
Confronted with the clinical challenges of glioma treatment, including incomplete resection and therapeutic resistance, we developed an integrative bioprinting strategy. At the core of our approach is a 3D-bioprintable, photosensitive hydrogel loaded with ruthenium-gallic acid (Ru-GA) nanoenzymes. This system is designed to seamlessly combine chemodynamic therapy (CDT) with photothermal therapy (PTT) to achieve precise and synergistic treatment of glioblastoma multiforme (GBM). Ru-GA, synthesized via Ru³⁺-gallic acid coordination, has potent peroxidase-like activity to catalyze reactive oxygen species generation from H₂O₂ in the tumor microenvironment. It also efficiently depletes glutathione to disrupt tumor redox homeostasis, and exhibits excellent near-infrared absorption and photothermal conversion efficiency. Based on GelMA and HAMA, the hydrogel is liquid at 37 °C and has the ability to be injected into tumor tissue, ensuring localized retention and sustained action of Ru-GA at tumor sites. In vitro tests verified Ru-GA kills GL261 glioma cells via CDT, and combining it with PTT further inhibits tumor cell proliferation, migration, and clonogenicity while boosting apoptosis. In 3D bioprinted tumor models, the hydrogel suppresses tumor cell aggregation and viability effectively. In vivo experiments showed intratumoral hydrogel injection plus near-infrared irradiation raises tumor temperature to 55 °C, exerting synergistic PTT/CDT effects to significantly inhibit tumor growth with excellent biosafety. Mechanistically, this therapy activates inflammatory pathways and inhibits metastasis-related signaling, offering a safe, efficient GBM treatment and laying a foundation for clinical translation of nanocatalyst-based photosensitive hydrogels.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）