CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Mengqi Wang,Jiayan Feng,Jiacheng Ding,Jinru Xiao,Dingbin Liu,Yang Lu,Yaqing Liu,Xia Gao
Multiple detection based on lateral flow immunoassay (LFA) holds significant research importance across various fields. Recently, the use of multi-color surface-enhanced Raman scattering (SERS) nanotags has enabled simultaneous detection of multiple targets within a single test line (T-line) in LFA , greatly enhancing detection efficiency, reliability, and application flexibility. However, challenges regarding signal overlap in the Raman-fingerprint region (400–1800 cm −1 ) and the difficulty in determining specific targets based on typical color analysis have persisted. In this study, we developed two types of nanoprobes that encode both color and Raman information to address these challenges in simultaneous multiple detection on a single T-line in SERS-LFA. The nanoprobes were encoded with distinguishable blue and red colors, respectively, enabling colorimetric study in multiplex LFA for qualitative analysis. Additionally, they were encoded with distinctive and non-overlapping Raman signals in the Raman-silent region (1800–2800 cm −1 ), ensuring accurate and sensitive detection by effectively avoiding interference from each other as well as background signals in the sample matrix. Using carbendazim (CBZ) and imidacloprid (IMI) as model targets, the color- and Raman-encoded SERS-LFA demonstrated promising potential for the simultaneous detection of CBZ and IMI in both standard and real samples, whether in a colorimetric or a SERS mode.
研究领域:
分析化学
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食品安全检测
✓ 已验证
产品关联
DOI
高影响因子
Journal of Water Process Engineering
·
2025
·
IF 6.7
Zhiyi Lai,Kaiyong Wang,Jianning Wu,Shengchao Yang,Zhiyong Liu,Qi Li,Guihua Meng
Nitrogen-doped cotton straws biochar-loaded cobalt tetraoxide (Co 3 O 4 /N-BC) catalysts were prepared by a two-step calcination method, and the calcination temperature of nitrogen-doped biochar (N-BC) was systematically optimized with the loading temperature of Co 3 O 4 nanoparticles, which was then used to activate peroxynitrite (PMS) for the removal of imidacloprid (IMI). Under a catalyst dosage of 0.3 g/L, PMS concentration of 5 mM, and pH of 7, 98.2 % of a 30 mg/L solution of IMI was degraded in 20 min, 40 min later, the removal rate reached 100 %. The leaching rate of cobalt ions after removal is only 0.74 mg/L, which meets the national emission standard (GB 24567-2010). Nitrogen doping was mainly in the form of pyridine nitrogen, pyrrole nitrogen and graphite nitrogen, where pyridine nitrogen was the main reactive nitrogen species that enhanced the activation of PMS. Quenching experiments and electron paramagnetic resonance spectroscopy (EPR) showed that the free radical pathway represented by SO 4 − and OH was the main pathway for IMI removal with a contribution of 93.05 %. The intermediates formed during the removal of IMI were analyzed by LC- MS, and three possible degradation pathways of IMI were proposed based on nine possible intermediates. Most of the degradation intermediates were eventually converted to low or non-toxic substances as analyzed by ECOSAR software. This study introduces a sustainable approach for reusing waste cotton straw and efficiently treating pesticide production wastewater.
研究领域:
环境科学
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化学工程
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材料科学
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分析化学
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可持续化学
✓ 已验证
产品关联
DOI
高影响因子
ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2025
·
IF 11.3
Wen Xie,Yajing Zhang,Yu He,Hang Su,Jinni Zhang,Canrong Chen,Peisi Xie,Jing Chen,Zian Lin,Zongwei Cai
Imidacloprid (IMI), a neonicotinoid insecticide extensively applied in agriculture, is among the most frequently detected pesticides in food. However, the long-term impact of chronic dietary exposure to environmentally relevant IMI doses on kidney health has not been fully elucidated, particularly regarding its nephrotoxic mechanisms. To address this gap, chronic exposure to IMI was administered to mice through supplementation of their feed with environmentally relevant doses (approximately 100 and 1000 μg/kg/day) for 24 weeks to investigate its nephrotoxicity and underlying mechanisms. Toxicological analysis revealed that chronic IMI exposure led to renal dysfunction, histopathological alterations, and excessive apoptosis in mice. Mechanistic investigations suggested that IMI might inhibit AMP-activated protein kinase (AMPK) activity through both direct and indirect pathways. Direct inhibition occurred through the binding of IMI and its metabolites to AMPK, reducing its phosphorylation activity. Indirect inhibition involved excessive production of reactive oxygen species, which suppressed AMPK phosphorylation, leading to sustained purine metabolism dysregulation in the renal system. Consequently, the kidneys showed an aggravated redox imbalance, heightened inflammatory states, and increased cellular apoptosis. The results of this study are intended to raise awareness of pesticide use and food safety among agricultural workers and consumers.
研究领域:
毒理学
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环境科学
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生物化学
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药理学
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食品安全
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分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2023
·Vol. 190
·期 4
·1-11
·
IF 5.7
Yang Jing,Deng Changxi,Zhong Wei,Peng Guanwei,Zou Jin,Lu Yan,Gao Yansha,Li Mingfang,Zhang Songbai,Lu Limin
Heterostructured TiO 2 @MXene rich in oxygen vacancies defects (VO-TiO 2 @MXene) has been developed to construct an electrochemical sensing platform for imidacloprid (IMI) determination. For the material design, TiO 2 nanoparticles were firstly in situ grown on MXene and used as a scaffolding to prevent the stack of MXene nanosheets. The obtained TiO 2 @MXene heterostructure displays excellent layered structure and large specific surface area. After that, electrochemical activation is utilized to treat TiO 2 @MXene, which greatly increases the concentration of surface oxygen vacancies (VOs), thereby remarkably enhancing the conductivity and adsorption capacity of the composite. Accordingly, the prepared VO-TiO 2 @MXene displays excellent electrocatalytic activity toward the reduction of IMI. Under optimum conditions, cyclic voltammetry and linear sweep voltammetry techniques were utilized to investigate the electrochemical behavior of IMI at the VO-TiO 2 @MXene/GCE. The proposed sensor based on VO-TiO 2 @MXene presents an obvious reduction peak at -1.05 V(vs. Hg|Hg 2 Cl 2 ) with two linear ranges from 0.07 - 10.0 μM and 10.0 - 70.0 μM with a detection limit of 23.3 nM (S/N= 3). Furthermore, the sensor provides a reliable result for detecting IMI in fruit and vegetable samples with a recovery of 97.9-103% and RSD≤ 4.3%. Graphical abstract
A sensitive electrochemical sensing platform was reported for imidacloprid (IMI) determination based on heterostructured TiO 2 @MXene rich in oxygen vacancy defects.
研究领域:
材料科学
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分析化学
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环境科学
✓ 已验证
DOI
高影响因子
TALANTA
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2025
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IF 6.1
Jingjing Yan,Wen Xie,Yingxue Jin,Zongwei Cai,Zian Lin
Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) has become a robust tool for analyzing a variety of biomacromolecules. However, the strong background interference produced by conventional organic matrices hinders the detection of small molecule analytes, which restricts the widespread application of MALDI-MS in metabolomics studies. Consequently, developing new organic matrices is urgently needed to overcome these issues. In this study, 1,4-Dioxo-1,2,3,4-tetrahydrophthalazine-6-carboxylic acid (DTCA) was firstly employed as a new matrix for MALDI-MS to enhance the detection of low molecular weight compounds because of its strong UV absorption, less matrix background interference, high ionization efficiency for metabolites, and good reproducibility. Considering these advantages, DTCA was used to analyze endogenous metabolites in the serum samples of imidacloprid (IMI)-exposed mice via MALDI-MS in positive ion mode. By combining with machine learning, the differentiation between imidacloprid-exposed mice and control mice was successfully achieved, and 39 metabolites were estimated as potential biomarkers. Additionally, potentially disrupted metabolic pathways were revealed. These results indicate that DTCA, as a new and powerful matrix in positive ion mode, has great potential for applications in the detection of small molecules.
研究领域:
分析化学
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代谢组学
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毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Environmental Chemical Engineering
·
2021
·
IF 5.909
Meimei Du,Hainan Kuang,Yongqing Zhang,Xianlin Zeng,Conghao Yi,Imtyaz Hussain,Shaobin Huang,Shuaifei Zhao
Imidacloprid (IMI) removal by persulfate (PS) oxidation activated by ball-milled FeS 2 /Fe0 composite was investigated in terms of reaction conditions and mechanisms. The ball-milled FeS 2 /Fe 0 with a mass ratio of 1:9 exhibited the highest activating efficiency for PS among the investigated mass ratios of 9:1, 4:1, 1:1, 1:4 and 1:9. Increasing dosages of ball-milled FeS 2 /Fe 0 and PS promoted IMI removal. At initial pH of 4.6 and initial IMI concentration of 0.15 mol/L, the optimal dosage of ball-milled FeS 2 /Fe 0 and PS were 0.1 g/L and 2.5 mmol/L, respectively, removing 99.8% of IMI after 60-min reaction. The ball-milled FeS 2 /Fe 0 could also activate PS effectively in a wide pH range from 3 to 9. Characterizations including Scanning electron microscopy with energy dispersive spectroscopy (SEM-EDS) and X-ray photoelectron spectroscopy (XPS) revealed that the high activation efficiency was related to FeS produced on Fe 0 surface. Activation efficiency of PS was enhanced by accelerated electron transfer mediated by increased ferrous species, ultimately, the removal efficiency of IMI was improved. The released Fe 2+ activated PS to generate SO 4 -· and·OH. SO 4 -· was detected to be predominant reactive oxygen species in IMI degradation and three different pathways for IMI degradation were proposed. This study developed a efficient method to activate PS by FeS 2 modify Fe 0 prepared by ball milling a mixture of Fe 0 and FeS 2 , which can provide some new insights into the degradation of organic pollutants .
研究领域:
环境科学
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化学工程
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Nano Materials
·
2021
·
IF 5.097
Wenyan Meng,Yiyun Gao,Zhenfen Tian,Weijie Xu,Jiagao Cheng,Shengke Li,Aihua Zou
A magnetic metal–organic framework nanocomposite as a collectable pesticide delivery vehicle was developed through the incorporation of UiO-66 with polydopamine-coated Fe3O4 (Fe3O4@PDA@UiO-66). The obtained Fe3O4@PDA@UiO-66 nanocomposite was verified by X-ray diffraction, Fourier transform infrared spectroscopy, transmission electron microscopy, and zeta potential test. The magnetic collectability of Fe3O4@PDA@UiO-66 was demonstrated through a magnetic hysteresis loop study (∼2 emu/g) and magnetic collection experiment (up to a 96% collection rate). Imidacloprid (IMI) was employed as a model pesticide to be loaded into the Fe3O4@PDA@UiO-66 nanocomposite, with 15.87% drug loading. IMI was found to exhibit sustained-release behavior after being loaded into the delivery vehicle, and magnetic Fe3O4@PDA@UiO-66 can be readily collected after IMI release, which is beneficial to constrain the hazardous effects of the vehicles and the residual pesticide on the ecosystem. The insecticidal activity of IMI@Fe3O4@PDA@UiO-66 toward Aphis craccivora Koch was found to be superior to that of free IMI, and the efficacy was comparable to that of the commercial 70% IMI water dispersible granule, indicating its potential as a magnetic collectable green carrier for pesticides in agriculture.
研究领域:
材料科学
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农业科学
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环境科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF PLANT PHYSIOLOGY
·
2023
·
IF 4.3
Qinyong Dong,Dong Li,Yangliu Wu,Chunran Zhou,Yongxi Lin,Peijuan Miao,Jiaqi Li,Canping Pan
Few studies have been conducted to investigate the impact of pesticides on the secondary metabolism of traditional Chinese medicine and strategies to mitigate the toxicity of pesticide-induced oxidative stress. The current study focuses on evaluating the potential impacts of nano selenium (NSe) and imidacloprid (IMI) on the quality, physiological biochemistry, and secondary metabolites in Perilla frutescens (L.) Britt . ( P. frutescens ). The study utilized metabolome analysis to explore the toxicity mechanism of IMI. The study noted that IMI-induced stress could emerge with detrimental effects by targeting the destruction of the phenylpropanoid biosynthesis pathway. IMI-induced phenylpropanoid metabolism disorder resulted in an 8%, 17%, 25%, 10%, 65%, and 29% reduction in phenylalanine, coniferyl aldehyde, ferulic acid, cafestol, p-coumaraldehyde, and p-coumaric acid levels, respectively. Under the treatment of exogenous NSe, the levels of these metabolites were increased by 16%, 32%, 22%, 22%, 92%, and 29%, respectively. The application of exogenous NSe increased the levels of these metabolites and improved the biochemical disorder and quality of P. frutescens leaves by optimizing the phenylpropanoid metabolic pathway and enhancing the antioxidant system. Overall, the results suggest that foliar application of NSe could alleviate the oxidative stress toxicity induced by IMI and improve the quality of P. frutescens .
研究领域:
植物生理学
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药理学
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农业科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMOSPHERE
·
2023
·
IF 8.8
Lvyun Zhuang,Xiaopeng Wu,Daizhu Lyu,Mingyue Wang,Ruohao Zhou,Jia Song,Yu Rong
An investigation of the metabolism and transfer of imidacloprid (IMI) in banana plants and soil was performed using high-resolution mass spectrometry. Results indicated the presence of eight IMI metabolites in soil and leaves that resulted from hydroxylation of the imidazolidine ring, the reduction and loss of nitro groups, and oxidative cleavage of methylene bridges. Six metabolites, including 4/5-hydroxy IMI (4/5-hydroxy), IMI olefin (olefin), and 6-chloronicotinic acid (6-CNA), were detected in the fruits following leaf treatment, while only three were detected after soil treatment. Quantitative analysis showed that the total amount of imidacloprid and its metabolites transferred from leaves to fruits was higher than that transferred from soil to fruits. Therefore, leaf transfer was considered the main means by which IMI and its metabolites transferred to banana fruits. We found that adjuvants tank-mixed with IMI could reduce the total concentration of pesticide transfer from leaves to fruits, especially reducing the amount of metabolites transformed from the reduction and loss of nitro groups and oxidative cleavage of methylene bridges, thus reducing the pesticide residue in fruits and achieving the purpose of reducing the safety risk.
研究领域:
植物学
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农业科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2023
·
IF 9.9
Jushi Weng,Jun Chen,Yifei Xu,Xinru Hu,Chuangyun Guo,Yang Yang,Jingyi Sun,Lianshe Fu,Qing Wang,Jiamin Wei,Tinghai Yang
Increasing the exposure of active sites and improving the intrinsic activity are necessary considerations for designing a highly efficient photocatalyst. Herein, an In 2 S 3 /AgI stable Z-scheme heterojunction with highly dispersed AgI nanoparticles (NPs) is synthesized by the mild self-templated and in-situ ion exchange strategy. Impressively, the optimized In 2 S 3 /AgI-300 Z-scheme heterojunction exhibits superior photodegradation activity (0.020 min −1 ) for the decomposition of insecticide imidacloprid (IMD), which is extremely higher than that of pure In 2 S 3 (0.002 min −1 ) and AgI (0.013 min −1 ). Importantly, the three-dimensional excitation-emission matrix (3D EEMs) fluorescence spectra, high-resolution mass spectrometry (HRMS), the photoelectrochemical tests, radical trapping experiment, and electron spin resonance (ESR) technique are performed to clarify the possible degradation pathway and mechanism of IMD by the In 2 S 3 /AgI-300 composite. The enhanced photocatalytic performance is attributed to the highly dispersed AgI NPs on hierarchical In 2 S 3 hollow nanotube and the construction of In 2 S 3 /AgI Z-scheme heterojunction, which can not only increase active site exposure, but also improve its intrinsic activity, facilitating rapid charge transfer rate and excellent electron-hole pairs separation efficiency. Meanwhile, the practical application potential of the In 2 S 3 /AgI-300 composite is systematically investigated. This study opens a new insight for designing catalysts with high photocatalytic performance through a convenient approach.
研究领域:
材料科学
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环境科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2020
·
IF 6.306
Yirong Guo,Rubing Zou,Fangfang Si,Wenlong Liang,Tianyi Zhang,Yunyun Chang,Xvsheng Qiao,Jinhao Zhao
In this study, a fluorescence resonance energy transfer (FRET) immunoassay based on graphene oxide (GO) and up-converting nanoparticles (UCNPs) was established for rapid detection of imidacloprid, a commonly-used insecticide. Under 980 nm near-infrared light excitation, emission of UCNPs at 542 nm can be absorbed by the energy acceptor GO. The carboxyl-functionalized GO and UCNPs were coupled with competitive antigen and antibody against imidacloprid. After optimization, the FRET immunoassay showed a wide detection range of 0.08–50 ng/mL to imidacloprid, with cross-reaction toward other three neonicotinoids including imidaclothiz (74.4%), thiacloprid (36.9%) and clothianidin (31.9%). The average recoveries of spiked water, Chinese cabbage, cucumber, honey and tea samples were 76.8%-101.8%. The accuracy and reliability of the FRET immunoassay were verified by UPLC-MS/MS with a good correlation (R 2 = 0.9816). In a summary, this study provides a sensitive and one-step method for monitoring imidacloprid residue in food and environmental samples within 1 h.
研究领域:
分析化学
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环境科学
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食品科学
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农业科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2021
·
IF 7.514
Fengqin Yin,Feng Xu,Kun Zhang,Min Yuan,Hui Cao,Tai Ye,Xiuxiu Wu,Fei Xu
The double-mesoporous-layer imprinted polymer of mesoporous silica/mesoporous molecularly imprinted nanoparticles (MIP), with high specific surface area, rich porosity, excellent mass transfer rate and selectivity, were synthesized using imidacloprid (IDP) as a template. Under the optimal conditions of pH, contact time, concentration and temperature, MIP showed high adsorption capacity of 13.86 μg·mg −1 toward IDP and the imprinting factor reached 3.5. The adsorption process model including binding isotherm and kinetics was investigated. MIP exhibited excellent regeneration and its adsorption and selectivity were outstanding among its structurally pesticide analogues. The recovery of spiked IDP for MIP in fortified real samples can reach 96.0 ± 8.5% for cabbage and 105.0 ± 9.9% for apple. The limit of detection of the enrichment method can be as low as 0.037 μg·mL- 1 with a good linear relationship (R 2 = 0.996) from 0.30 to 10.0 μg·mL −1 . The results indicated that the proposed method allowed class-specific detection of IDP in food samples.
研究领域:
食品科学
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材料科学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）