RSC Advances
·
2014
·Vol. 4
·期 90
·49000-49005
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IF 3.708
Xun Song,Siwei Yang,Lin He,Shuai Yan,Fang Liao
In this paper, ultra-flyweight hydrophobic poly(m-phenylenediamine) aerogel (PmPDA) was fabricated via a simple two step approach from a poly(m-phenylenediamine) micro-spherical shell (PmPDMS). The PmPDA was first formed by freeze-drying and then cross-linked via the oxidative polymerization of surface groups following an annealing process. The PmPDA is hydrophilic before the annealing process and becomes hydrophobic (the contact angle is 103.7°) after it is annealed in air. Moreover, the obtained ultra-flyweight PmPDA (ρ = 0.8 mg cm−3) has a large surface area (338 m2 g−1), low thermal conductivity (0.0125 W m−1 K−1 at 25 °C) and excellent mechanical properties. Finally, the regenerated aerogels retain their original shape and ultrahigh absorption capability after more than 10 cycles, making PmPDA an ideal candidate for practical application in the absorption or removal of organics, particularly in environmental protection and pollution control.
研究领域:
材料科学
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环境科学
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DOI
高影响因子
CANADIAN JOURNAL OF CHEMICAL ENGINEERING
·
2017
·Vol. 96
·期 8
·1814-1819
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IF 1.356
Quanming Lyu,Wenbo Zhang,Weizhen Sun,Zhimei Xu,Ling Zhao
The solubilities of m-toluic acid (m-TA) from 313.2 to 383.2 K, as well as those of isophthalic acid (IPA) from 373.2 to 463.2 K in water, ethanoic acid, and their mixtures were measured by the steady-state method. The modified Apelblat equation was used to correlate the experimental solubilities of m-TA, as well as those of IPA. The F-test shows that the modified Apelblat equation is suitable to model the solubilities of m-TA and IPA, respectively. Based on the determined solubility data, the thermodynamic parameters including the apparent molar enthalpy and entropy concerning solute dissolution were further calculated. We hope that the solubility data and related thermodynamic parameters can provide valuable insights into the design and optimization of the industrial manufacture of IPA.
研究领域:
物理化学
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工业化学
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DOI
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
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2025
·
IF 4.7
Zengfeng Wei,Yumeng Zhang,Hu Xia,Lijie Ni,Wenhai Wu,Xiaoning Wang,Heng Quan
A novel bio-based corrosion inhibitor, hexadecyl amine-modified catechol (CA16), was synthesized, and its molecular structure was characterized. The ability of CA16 to inhibit the corrosion of carbon steel in 1 M HCl was evaluated by potentiodynamic polarization, electrochemical impedance spectroscopy and weight loss. The highest inhibition efficiency reached 96.87% at 10 −3 M. CA16 is a mixed-type corrosion inhibitor that can adsorb on the Fe surface spontaneously through chemical adsorption following the Langmuir adsorption model. The adsorption of CA16 and carbon steel occurred between catechol groups and the Fe surface, as confirmed by quantum chemical calculations and molecular dynamic simulations. This novel bio-derived high-performance inhibitor offers a sustainable alternative to conventional petrochemical-based counterparts, demonstrating significant potential for industrial-scale applications while aligning with green chemistry principles.
研究领域:
材料科学
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绿色化学
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电化学
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DOI
高影响因子
MICROCHEMICAL JOURNAL
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2019
·
IF 3.206
Guohan Sun,Shiqiao Wang,Jianfeng Zhou,Jianbin Pan,Yanli Tong,Qinghua Mei,Haiyun Zhai
In the present study, a novel and facile poly-m-amino-benzenesulfonic acid (p-m-ABSA) film on glassy carbon electrode (GCE) was developed using pulse potentiostatic method (PPM), which is employed with the oxidative polymerization of m-ABSA at anode potential. Meanwhile, a simple and sensitive sensor was fabricated to detect normetanephrine (NMN), which is one of the significant diagnostic markers for diseases. Compared with bare GCE, the p-m-ABSA film prepared on GCE surface has the advantage of increasing electrode surface area and active sites distinctly, thus obviously improving the electrocatalytic activity. The results demonstrated that the developed electrochemical sensor exhibited high sensitivity, stability, selectivity and excellent electrocatalytic activity towards NMN. The surface morphology of p-m-ABSA/GCE was characterized by scanning electron microscopy (SEM), indicating that the electrode surface had a layered structure. The preparation conditions and analysis methods of sensors were studied in detail. Under optimum conditions, peak current and concentrations of NMN were linearly related well from 0.5 to 30.0 µM with a limit of detection (S/N = =3) of 0.17 µM. Moreover, this modified sensor has also been successfully used for the detection of NMN in human serum samples.
研究领域:
生物医学工程
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分析化学
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DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2025
·Vol. 36
·期 22
·1-13
·
IF 2.8
Ma Kangrui,Wu Jiawen,Wei Derong,Chen Jin,Rong Xuanting,Ding Ruyun,Gu Jia,Ma Xuetiao,Zheng Hui
With the development and use of the electronic and electrical equipment, solving electromagnetic pollution has become a top priority for human health. In this work, ternary co-doped (Ca 2 ⁺, Cu 2 ⁺, Sn 4 ⁺) ions were incorporated into M-type hexagonal barium ferrite (Ba 1-x Ca x Fe 11.6 Cu 0.2 Sn 0.2 O 27 ), and the effects of varying Ca 2 ⁺ doping levels on the crystal structure, surface morphology, and electromagnetic characteristics were thoroughly investigated. Structural characterizations confirms that Ca 2+ substitutes Ba 2+ sites, decreasing the grain size and lattice values while increasing the lattice strain. At x = 0.15, the Ba 1-x Ca x Fe 11.6 Cu 0.2 Sn 0.2 O 27 ferrite achieves the maximum value of saturation magnetization of 67.7 emu/g, the highest RL min value of -44.2 dB@14.3 GHz and effective absorption bandwidth of 3.04 GHz, showing potential as an effective material for absorption applications.
研究领域:
材料科学
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电磁学
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固体物理学
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环境科学
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2020
·
IF 10.652
Qilin Xu,Huachun Fan,Hongmiao Yao,Duoheng Wang,Hangwei Yu,Bingbing Chen,Zhiqun Yu,Weike Su
Monoacylated symmetrical diamines are building blocks or intermediates of several well-established drugs. However, for the symmetrical diamines, the two amine groups located in a similar chemical environment make the selective monoacylation rather difficult and no kinetics study has ever been reported before. To comprehend this kind of reaction more deeply, a continuous flow microfluidic system was developed to evaluate the reaction kinetics of m -phenylenediamine and benzoic anhydride. At first, the reaction order of each reactant, pre-exponential factors and activation energies were determined in turn. The possible reaction mechanism was postulated from the reaction order. Then, a series of validation experiments were designed to show the accuracy and the applied range (concentration and temperature) of the kinetic model. Next, to obtain a controlled selectivity, the effects of initial concentration, reaction temperature and molar ratio on the selectivity were investigated through the model simulation. In the end, under the conditions optimized by the kinetic model, 96.9% selectivity and 92.5% yield were obtained in the microreactor.
研究领域:
有机化学
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药物化学
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化学工程
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
·
IF 8.5
Hongping Wan,Yunhan Yang,Zhiwen Tu,Mingrun Tang,Bo Jing,Yumei Feng,Jiulong Xie,Huile Gao,Xu Song,Xinghong Zhao
In mucosal vaccination, the targeted delivery of antigens through M (microfold) cells is essential for initiating a robust antigen-specific immune response. In the present study, we devised a nano-delivery platform to target M cells. This platform involved coating mesoporous silica nanoparticles (MSN) with a mucoadhesive chitosan-catechol (Chic) layer, incorporating a recombinant antigen to form nanoparticles that enhance the immune response. The collagenase equivalent domain (COE) of porcine epidemic diarrhea virus (PEDV) terminated with the M cell-targeting sequence RGD (COER), was initially expressed by Escherichia coli ( E. coli ) and subsequently conjugated to the surface of MSN-Chic, forming the MSN-Chic-COER nanoparticles. MSN-Chic-COER with strong mucoadhesive properties and a propensity for M cell targeting, demonstrated enhanced uptake by dendritic cells (DCs) and trafficking to lymph nodes, compared to COE/COER after intranasal administration. MSN-Chic-COER recruited more dendritic cells to the antigen-located site via stimulating chemokine CCL20 secretion was evidenced by cell co-culture model. Additionally, it enhanced antigen permeability by disrupting the distribution of the ZO-1 protein in epithelial cells. Notably, MSN-Chic-COER elicited a higher level of cellular immunity, humoral immunity, and PEDV neutralizing antibody production. These findings underscore the potential of MSN-Chic-COER as a promising intranasal vaccine delivery system.
研究领域:
免疫学
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疫苗学
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生物材料科学
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产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2017
·
IF 5.401
Haiyan Wang,Pei Liu,Wenjing Jiang,Xue Li,Huanshun Yin,Shiyun Ai
DNA methylation is one of the important epigenetics events, and it is responsible for transcription, genomic imprinting and cellular differentiation. Aberrant DNA methylation is always contacted with various diseases. Herein, a simple and low-cost photoelectrochemical (PEC) biosensing method is proposed for detection of DNA methylation, assay of DNA methyltransferase (MTase) activity and screening of MTase inhibitor, which is based on M. SssI MTase- HpaII endonuclease system. The graphite-like C 3 N 4 (g-C 3 N 4 ) and CdS quantum dots (CdS QDs) are used as photoactive materials. After the double-stranded DNA (dsDNA) was treated with M. SssI MTase in the presence of S -adenosylmethionine, the methylated dsDNA cannot be digested by HpaII endonuclease and dithiol group at the terminal of dsDNA can be retained. As a result, CdS QDs could be coupled successfully with methylated dsDNA between the reaction of CdS QDs with dithiol of dsDNA, achieving the amplification of PEC response. Thus, the photocurrent of PEC biosensor is consistent with the M. SssI activity. The increased photocurrent was in proportion to M. SssI activity in the linear range from 1 to 80 U/mL with a detection limit of 0.316 U/mL. Furthermore, the effects of atrazine and azamethipos on M. SssI MTase activity were investigated, which might provide useful information on carcinogenic mechanism of pesticide. The PEC biosensor has potential to screen of DNA MTase inhibitor, providing valuable information for anti-cancer drug research and also for cancer therapy.
研究领域:
生物化学
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分子生物学
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分析化学
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DOI
高影响因子
APPLIED SURFACE SCIENCE
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2022
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IF 7.392
Hui Li,Juan Lai,Min Yao,Yingmeng Leng,Zhengde Wu,Jian Zhang,Hailong Peng,Zumin Qiu
A new method was applied to modify TiO 2 nanoparticles. Epoxy resin (EP) and M-TiO 2 nanoparticles were used to prepare a novel superhydrophobic composite coating (M-TiO 2 @EP) by a one-step spraying method. The M-TiO 2 @EP coating surface has rough surface with hierarchical micro-/nanostructures. The M-TiO 2 @EP coating showed excellent superhydrophobicity capability with a high water contact angle (156°) and low sliding angle (6°). The M-TiO 2 @EP coating exhibited outstanding mechanical durability owing to multilayer structure of M-TiO 2 and the adhesion enhancement of EP, and the coating still retained superhydrophobicity after long-distance (10 m) mechanical wear under the weight of 200 g. Meanwhile, the M-TiO 2 @EP coating can capture stable air film to prevent the permeation of H + , Cl − , and OH − from water and simultaneously absorb more UV irradiation. Additionally, the M-TiO 2 @EP coating superhydrophobicity was also proven for various droplets and excellent self-cleaning performance. Meanwhile, the M-TiO 2 @EP coating also showed outstanding resistance to both extreme temperatures, UV resistance, corrosion resistance, and anti-icing ability. Therefore, the novel M-TiO 2 @EP coating with these excellent properties could yield a prospective candidate for promising outdoor and harsh condition applications.
研究领域:
材料科学
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表面工程
·
防腐蚀技术
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产品关联
DOI
高影响因子
CHEMOSPHERE
·
2019
·
IF 5.108
Jiayi Yao,Manqi Gao,Xiaofeng Guo,Fuxun Ai,Zunyao Wang
In the present work, we first examined the performance of zero-valent iron (Fe 0 ) activated peroxymonosulfate (PMS) for the removal of that bisphenol M (BPM). In 90 min, 95.9 ± 1.0% of BPM (initial concentration of 10 μM) could be removed in the optimal reaction conditions: [BPM] 0 :[PMS] 0 = 1:40 (molar ratio), [PMS] 0 :[Fe 0 ] 0 = 1:3 (molar ratio), pH = 8.0 (maintained by 0.1 M phosphate buffer solution), T = 35 °C. Common environmental ions like HCO 3 − , Cl − , NO 3 − accelerated BPM degradation while NH 4 + hindered it. In radical quenching tests, sulfate radicals (SO 4 − ) were found to play a dominant role in BPM degradation, while hydroxyl radicals ( OH) were also detected. By high-performance liquid chromatography–tandem mass spectrometry analysis, 13 products of BPM including small molecules, oligomers and hydroxylated derivatives were identified, and five possible degradation pathways were then proposed. The predicted acute toxicity of the reaction products was reduced after BPM was treated by Fe 0 /PMS. All these results prove that Fe 0 /PMS is an efficient, convenient, and environmentally friendly treatment method for the removal of BPM.
研究领域:
环境科学
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化学工程
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产品关联
DOI
PubMed
高影响因子
CRYSTENGCOMM
·
2020
·Vol. 22
·期 32
·5355-5362
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IF 3.117
Jianing Tan,Song Jiang,Binghui Ge,Bojia Xu,Baobao Cao
SnO2(ZnO:Sn)m is a new phase recently found in the diagram of a ZnO–SnO2 binary system in the form of a one-dimensional nanowire, which is a new group of superlattice oxide besides the widely known M2O3(ZnO)m (M = trivalent elements, such as In, Ga, and Al, and m = integer). Thereafter, more comprehensive structural and physical properties of SnO2(ZnO:Sn)m are still quite lacking due to the difficulties in high purity synthesis. In this study, we demonstrate a rational design for the growth of SnO2(ZnO:Sn)m superlattice nanowire arrays using a home-built double-tube chemical vapor deposition (CVD) system for the first time. The atomic microstructure of the nanowire array was investigated by Cs-corrected scanning transmission electron microscopy (STEM), and a phenomenon of unsaturated Sn occupation in Sn–O octahedral layers was observed. Two new vibrational modes at 276 cm−1 and 698 cm−1 were found in Raman measurement. The photoluminescence (PL) spectrum of SnO2(ZnO:Sn)m superlattice nanowires displays an interesting broad-spectrum emission in the range of around 380–570 nm. Kelvin probe force microscopy reveals that the average work function of SnO2(ZnO:Sn)m nanowires is in the range of 4.05–4.32 eV.
研究领域:
材料科学
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物理化学
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DOI
高影响因子
PHYTOMEDICINE
·
2025
·
IF 8.3
Kaixue Zhang,Guoqing Luan,Jin Zhang,Shilong Wang,Min Jiang,Gang Bai
Background Myocardial ischemia (MI) threatens the health of middle-aged and older adults by reducing cardiac oxygen supply and function. Current therapies, including vasodilation, thrombolysis, and interventions, focus on relieving symptoms and improving blood flow but do not adequately address underlying energy metabolism issues. Ligustilide exerts a protective effect on the cardiovascular system and holds the potential for ameliorating MI; however, there is currently no systematic elucidation of ligustilide's target and action mechanism for MI. Purpose This study aimed to comprehensively assess ligustilide's potential targets for improving acute MI and elucidate its underlying mechanism. Methods The therapeutic effects of ligustilide were evaluated at doses of 30, 15, and 7.5 mg/kg over 7 days in a murine model of acute MI induced by isoproterenol hydrochloride. The putative target protein was identified through target fishing, in-gel imaging, and thermal shift assay (TSA), followed by tissue and cell localization studies via a ligustilide probe. The interaction sites between ligustilide and the target protein were elucidated using protein profiling, molecular docking, and TSA at the protein level. Subsequently, knockdown and reconstruction tests were employed at the cellular level to identify the functionally active sites where ligustilide binds to the target protein. Finally, molecular docking and molecular dynamics simulations were conducted to elucidate the underlying mechanism by which ligustilide enhances creatine kinase, M-type (CKMM) protein activity. Results The covalent bonding of ligustilide in cardiac tissue enhances the therapeutic effect on acute MI in mice. For the first time, we found ligustilide specifically targets Cys254 of the CKMM protein following epoxidation. This irreversible binding effectively reduces the proximity between creatine and ATP, promoting creatine phosphorylation and ultimately increasing the creatine phosphate (CP) level by 9.50% to 19.31%. The accumulation of CP alleviates MI by enhancing energy metabolism, mitigating oxidative stress, and suppressing inflammatory responses. Conclusions Our study unveiled ligustilide as a CKMM activator, which effectively enhances the content of CP and mitigates acute MI. The findings significantly contribute to advancing our understanding of ligustilide's function for myocardial protection while proposing a novel activation mechanism of CKMM to improve MI. And the insight into the covalent regulation of the active pocket on CKMM may lead to an alternative therapeutic strategy against acute MI.
研究领域:
药理学
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心血管病学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）