JOURNAL OF MOLECULAR LIQUIDS
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2016
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IF 2.74
Muhammad Asim Akhtar,Sara Riaz,Akhtar Hayat,Muhammad Nasir,Nawshad Muhammad,Abdur Rahim,Mian Hasnain Nawaz
trans -Porphyrin containing phenyl group at both ends was synthesized via corresponding dipyrromethanes (DPM) in the presence of TFA and DDQ. The polyethyleneglycole (PEG) chains were attached at the trans positions of ABA type porphyrinic moiety. The prepared PEGylated porphyrin (with PEG arms at the periphery) P-(PEO) 2 was self-assembled into spheres of uniform diameter while their DMF solution was dialyzed into water. Furthermore, the addition of fullerene (C 60 ) to P-(PEO) 2 caused complexation between porphyrin and fullerene which lead to interesting and trenchant morphology having worm like lateral aggregates. The assembly process and the as-prepared edifices were characterized using UV–vis absorption spectroscopy and the morphology of these assemblies was investigated using transmission electron microscope (TEM). Furthermore, the DNA binding with porphyrin aggregates has been demonstrated via electrochemical (cyclic voltammetric) response of screen printed electrodes modified . The obvious increase in redox current disclosed the intermolecular interactions of the adducts with the DNA. These studies of unprecedented adducts can further be explored for potential applications in biosensors .
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Scientific Reports
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2017
·Vol. 7
·期 1
·1-8
·
IF 4.259
Su Yanbin,Ma Xiaowei,Su Yanwen,Mu Tongxing,Li Yanhe,Jiang Ning,Su Yuyun,Zhang Qi
Inappropriate use of ethanol (EtOH) had led to noticeable health problems, but a beneficial phenomenon was found that EtOH displayed unique influences for toxic trans-crotonaldehyde (TCA) derived from mitochondrial lipid peroxidation. The influences of EtOH on the structure of TCA were systematically probed by UV-vis & Raman spectroscopy in the absence and presence of mitochondria, respectively. The maximum UV-vis peak at 301 nm of TCA was red shifted by hydroxyl (-OH) and methyl (-CH 3 ) of EtOH, respectively. Raman stretching band of aldehyde (-CH=O) of TCA (TCA-CH=O) was split by the -CH 3 of EtOH. The -CH 3 increased TCA-CH=O stretching frequency while the -OH induced it. The more exposed -OH, the less stretching frequency. The ectopic -CH 3 red shifted the UV-vis peak at 301 nm and Raman band of TCA-CH=O. In mitochondria, EtOH red shifted Raman stretching band of TCA-CH=O. Raman stretching bands of C-H, C-O and C-C of EtOH were red shifted, while Raman stretching bands of -CH 2 and C-C-O of EtOH disappeared. The paper unearths the influences of EtOH to trap and transform the structure of TCA-CH=O. This discovery has an important contribution to eliminate TCA in order to protect and repair mtDNA by means of the decrease of 8-oxoG.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2017
·
IF 3.154
Hongbao Lu,Shuangyu Xu,Wenjuan Zhang,Chunmei Xu,Beixing Li,Daxia Zhang,Wei Mu,Feng Liu
Botanical nematicides have recently received increasing interest because of the high risks of some traditional nematicides to human health and the environment. This study evaluated the nematicidal activity of a plant volatile, trans-2-hexenal, against Meloidogyne incognita. This compound exhibited higher activity in a fumigation experiment than in the aqueous phase in vitro. Both in pot tests and in field trials, trans-2-hexenal showed significant efficacy against M. incognita while maintaining excellent plant growth, especially at doses of 1000 and 500 L ha–1, which were superior to that of abamectin at 180 g ha–1 via hole application treatment but not significantly different from fumigation with 400 kg ha–1 of dazomet. Furthermore, plants treated with 500 L ha–1trans-2-hexenal had fruit yields 20.2 and 45% greater than the control group. On this basis, trans-2-hexenal may be a potential alternative fumigation agent for controlling M. incognita on tomato crops.
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Food and Bioprocess Technology
·
2017
·Vol. 10
·期 10
·1844-1853
·
IF 2.576
Ye Youxin,Zhu Mingjin,Miao Keyan,Li Xinying,Li Defu,Mu Changdao
Antimicrobial activity is an attractive property for packaging materials which can extend the shelf life of products and provide microbial safety for consumers. The study aimed to analyze the physicochemical and antimicrobial properties of gelatin-based edible films containing trans -anethole as the active additive. Encapsulation with β-cyclodextrin was used as an effective way to introduce trans -anethole into gelatin matrix. The results showed that the trans -anethole/β-cyclodextrin inclusion complex could be evenly dispersed in the gelatin-based edible films with appropriate addition. The incorporation of trans -anethole conferred the edible films with good antimicrobial activity as expected, which increased with the content of trans -anethole increasing. Moreover, the addition of inclusion complex improved the tensile strength and surface hydrophobicity and reduced the moisture content of the edible films. It was interesting that the edible films presented great UV light barrier property and it was increased by the addition of inclusion complex. Overall, the antimicrobial gelatin-based edible films showed great potential as bioactive packaging materials to extend food shelf life.
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POLYMER
·
2024
·
IF 4.1
Qingtao Niu,Aihua He,Chongdian Si,Guodong Liu,Mingxuan Xiao,Guifan Chen,Manman Jin
Four TiCl 4 /MgCl 2 Ziegler-Natta catalysts (Cat-1∼Cat-4) with titanium contents in the range of 0.038–0.578 wt% were synthesized by the chemical rout and used for isoprene polymerizations. Four catalysts had similar possessed rod-like morphologies and their surface areas gradually increased as Ti contents increased. Cat-1 with the lowest Ti content (0.038 wt%) had the highest catalytic activity (28039.6 g∙P/(g∙Ti∙h)). To our knowledge, this was the highest activity achieved for isoprene polymerization using the heterogeneous TiCl 4 /MgCl 2 Ziegler-Natta catalyst. With the increasing Ti content, the catalyst activity gradually decreased in the order of Cat-1 < Cat-2 < Cat-3 < Cat-4, whereas the trans -1,4 stereoselectivity increased. Cat-4 with the highest Ti content (0.578 wt %) gave highest trans -1,4 units (97.7 mol%). The polymers were mainly composed of fraction C, D and G. C and D had high trans -1,4 structure while G fraction had low trans -1,4 structure. The plausible stereospecific transformation models of MgCl 2 -supported Ziegler-Natta catalyst with different Ti contents were discussed.
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CHEMICAL ENGINEERING JOURNAL
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2024
·
IF 13.3
Wei Luo,Song Song,Wuyu Zhao,Tong Ding,Ye Tian,Xingang Li
Bimetallic catalysts are promising materials for high-efficient conversion of lignocellulose to value-added chemicals, but synthetic methods with reasonable generality are still lacking. Herein, we report a novel method for synthesizing bimetallic catalyst PtCu@S-1(S-1, silicalite‑1) via zeolite encapsulation with the aid of protecting chelating ligands. PtCu@S-1 displays remarkable activity for the hydrogenation of furfural (FUR) to furfuryl alcohol (FOL), and its apparent turnover frequency (TOF) values reach up to 735 mmol FUR ·mmol Pt −1 ·h −1 and 88 mmol FUR ·mmol Cu −1 ·h −1 , which are ∼ 16 and ∼ 4 times higher than that of Pt@S-1 and Cu@S-1. Interestingly, we for the first time find that OO-trans FUR is a preferable adsorption configuration over OO-cis FUR on PtCu@S-1 due to the Pt sites coordinating with the carbon atom on the furan ring. More importantly, the adsorption ability of OO-trans FUR is stronger than that of OO-cis FUR, which increases the concentration of adsorbed species on PtCu@S-1 and accelerates the hydrogenation of FUR.
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JOURNAL OF DAIRY SCIENCE
·
2025
·
IF 4.4
Meng Wei,Zeqiang Zhou,Kequn Lin,Zeyuan Deng,Jing Li
Trans -palmitoleic acid (TPA), a naturally occurring trans fatty acid found in ruminant-derived products such as dairy, has been associated with various potential health benefits. However, its digestion, absorption, tissue distribution, and metabolic properties following oral administration remain insufficiently understood. Here, we conducted pharmacokinetic analyses in C57BL/6J mice to evaluate the absorption, tissue distribution, and metabolism of TPA following oral administration. Our data showed that the plasma concentration of TPA peaked at 9.1 µg • mL −1 at 15 min post-administration, with a terminal elimination half-life of 201.1 min. Moreover, TPA was efficiently distributed to the heart, lung, liver, kidney, brain and adipose tissue, reaching peak concentrations within 30 to 60 min. These results indicate that TPA is rapidly digested, absorbed, and distributed across multiple tissues in mice, while exhibiting slow metabolic clearance and an extended residence time in vivo. Within 0 to 480 min following oral administration, TPA underwent bioconversion to trans -vaccenic acid (TVA) and cis -9, trans -11 conjugated linoleic acid (9c11t-CLA), both of which are recognized for their extensive health benefits. The bioconversion rates were 71.57–72.44% for TVA and 44.05–53.23% for 9c11t-CLA. Furthermore, TPA significantly reduced triglyceride and total cholesterol levels in steatosis hepatocytes. Notably, inhibiting the bioconversion of TPA to TVA and 9c11t-CLA did not impair its ability to reduce lipid accumulation in hepatocytes, suggesting that the beneficial effects of TPA on lipid metabolism are independent of its bioconversion to TVA and 9c11t-CLA. This study provides a reference for dairy fat intake and establishes a foundation for further exploration of the physiological effects of TPA.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Xue-Feng Ma,Xue-Feng Yao,Zhi-Zhen Chi,Ming-Qiang Zhu
Eucommia ulmoides rubber (EUR) is a high-quality natural rubber resource, which can be extracted from different organs of the Eucommia ulmoides tree . In this study, EUR was isolated from the leaves, barks, and pericarps , and the structural characteristics and physicochemical properties of EUR were systematically determined. The accumulation and distribution of EUR in different tissues were assessed through in situ observations combined with cellular and subcellular scales. The preliminary analyses indicated that the variations in the physicochemical properties of EUR across different tissues were associated with its accumulation microstructure. Further analyses by SEM and TEM showed that the initial cell differentiation and fusion resulted in the formation of tubular structures without any nucleus. A limited number of rubber particles were generated within the cytoplasm, concurrent with aggregation and fusion. Eventually, rubber particles filled the entire cytoplasm, and organelles disappeared to form highly aggregated filamentous structures. In addition, the number and area of EUR-containing cells were closely related to the organization sizes of barks and leaves. This study provided valuable insights into Eucommia ulmoides histology and the rubber industry.
研究领域:
植物学
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材料科学
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植物生理学
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COLLOIDS AND SURFACES B-BIOINTERFACES
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2022
·
IF 5.999
Weinan Li,HeXin Gong,Yuhan Fu,Jialin Sun,Yanhong Wang
Developing chemotherapy with nanoparticle-based prodrugs provides promising strategies for improving the safety and delivery of anti-cancer drugs therapeutics and effective cancer treatment. Herein, we developed a pH-sensitive prodrug delivery system (All-Trans-Retinoic Acid (ATRA) grafted poly (β-amino esters) (PBAE) copolymers , ATRA-g-PBAE) for delivery of ATRA with some physicochemical and biological properties. The in vitro release of ATRA-g-PBAE prodrug nanoparticles (PNPs) was sustained-release and pH-sensitive. The cytotoxicity and uptake of different preparations in vitro were evaluated on MCF-7 cells at pH 7.4 and 5.5. The carrier PBAE had no cytotoxicity, and ATRA-g-PBAE PNPs could significantly inhibit cell growth at pH 5.5. MCF-7 cells treated with Cy5.5 grafted PBAE (Cy5.5-PBAE) showed stronger fluorescence signals at pH 5.5. Meanwhile, ATRA-g-PBAE PNPs entered the cell via a clathrin-mediated endocytic pathway. Subsequently, PBAE protonation facilitated the escape of PNPs from the lysosome and released the drug. ATRA-g-PBAE seems promising as a novel pH-sensitive prodrug to overcome the limitations of ATRA for breast cancer therapy.
研究领域:
肿瘤学
·
药剂学
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生物医学工程
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2026
·
IF 9.1
Jinhui He,Yi Wang,Yaning Zhao,Jianlian Liu,Tianyu Zhao,Liuyi Pan,Louwei Cui,Xianjie Wang,Huiyong Chen,Dong Li
UiO-66-CH 3 achieves cis/trans-1,2-DMCH separation with α = 3.55. • Methylation reshapes UiO-66 pores to enhance molecular shape matching. • Van der Waals surface engineering magnifies cis/trans differences in cycloalkanes. • UiO-66-CH 3 retains 94% regeneration efficiency after five cycles. In the field of chemical and fine chemical industries, cis/trans-1,2-dimethylcyclohexane (cis/trans-1,2-DMCH) isomers serve as vital cycloalkane intermediates, yet their efficient separation remains a formidable challenge due to their highly similar physicochemical properties. Here, zirconium-based UiO-66 was employed as a platform to construct UiO-66, UiO-66-CH 3 , and UiO-66-(CH 3 ) 2 via a ligand methylation strategy, systematically regulating pore microenvironments for shape-selective separation. Notably, UiO-66-CH 3 exhibited the highest cis/trans selectivity (α = 3.55) and the widest breakthrough separation window (Δ t = 1500 min), outperforming the pristine and over-methylated counterparts. Characterizations and molecular simulations revealed that moderate methyl introduction enhanced framework-analyte interaction energies, which were predominantly governed by van der Waals forces. Furthermore, probability density distributions elucidated that the more compact cis-1,2-DMCH approached the methyl-functionalized pore walls more closely, forming multi-site, short-range contacts that led to higher loading and more pronounced van der Waals stabilization. Overall, this work demonstrates that tailoring MOF pore microenvironments via mild ligand methylation can effectively amplify subtle molecular conformation differences without relying on strong chemical interactions, offering a promising paradigm for designing advanced adsorbents for challenging isomer separations. Ligand methylation optimizes UiO-66's van der Waals field and geometric confinement, enabling efficient cis/trans-1,2-DMCH separation by perfectly matching the compact cis-conformation while rejecting the spatially hindered trans-isomer. Download: Download high-res image (166KB) Download: Download full-size image
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Autophagy
·
2025
·
IF 14.3
Jiahui Long,Huazhong Xie,Hao Shan,Ruoqing Chen,Jialing Zhong,Jiuge Tang,Dongmei Fang,Yao Wang,Peiqing Liu,Xiao-Ming Yin,Min Li
Formation of MAP1LC3/LC3 (microtubule associated protein 1 light chain 3)-positive structures that does not require all of the core ATG (autophagy related) proteins is emerging in the process of noncanonical autophagy (NCA). While LC3 lipidation on endolysosomal membranes has been well characterized, the involvement of other membrane sources and the regulatory mechanisms governing LC3 lipidation in alternative forms of NCA remain poorly understood. Here, we demonstrate the occurrence of LC3 lipidation on the trans-Golgi network (TGN) platform. Different from canonical autophagosomes, these LC3-positive structures do not fuse with lysosomes, and fail to degrade long-lived proteins. In addition, the functional vacuolar-type H+-translocating ATPase (V-ATPase)-ATG16L1 axis is found to be essential for TGN-associated NCA. Notably, in this process, the cytosolic but not lysosomal V1 complex of the V-ATPase assembles at the TGN and plays a pivotal role in further induction of NCA. Eventually, IL1B/IL-1β (interleukin 1 beta) secretion is found to be efficiently enhanced by such TGN-associated NCA, independently of GSDM (gasdermin)-mediated pore formation. Thus, besides the known endolysosome-related NCA, we identify a distinct form of TGN-associated NCA mediated by the V-ATPase-ATG16L1 axis. Such NCA might work as a protein-transport route for the extracellular secretion of IL1B, revealing a mechanism linking Golgi-derived NCA to inflammatory cytokines release.
研究领域:
细胞生物学
·
免疫学
·
自噬研究
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炎症
·
膜运输
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ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Shibo Liu,Hao Wang,Xiaohan Mei,Zehao Yu,Dapeng Zeng,Xiangjun Pan,Boda Ying,Xinyu Xu,Chuanyao Dong,Si Pu,Xiaoming Dong,Ruiyan Li,Yanguo Qin
Rapid rehabilitation of the ligament-bone interface following anterior cruciate ligament (ACL) reconstruction remains challenging due to poor vascularization and inadequate integration between graft, bone tunnel, and scaffold. Conventional rehabilitation stimuli are limited by their shallow tissue penetration, which fails to effectively target the bone tunnel. This study proposes a synergistic strategy using a dual calcium/copper reservoir-functionalized scaffold with trans-tissue mild photothermal therapy (mPTT, 40–42 °C) to promote phase-specific healing. A 3D-printed polyetherimide (PEI) scaffold incorporating Calcium carbonate (CaCO 3 ) serves as a calcium reservoir, while it is modified with a Cupric oxide-polydopamine (CuO-PDA) coating, serving both as a copper reservoir and a photothermal agent. Upon implantation, the rapid release of Cu 2+ accelerates early-stage vascularization, while sustained release of Ca 2+ creates a calcium-enriched osteogenic microenvironment, promoting osteogenic differentiation and bone regeneration. Crucially, near-infrared light-triggered activation of the CuO-PDA coating enables trans-tissue mPTT. This upregulates heat shock protein expression, which synergistically enhances reservoir-driven osteogenesis and collagen remodeling. This study marks the first application of mPTT in ligament-bone healing. This synergistic platform facilitates direct thermal stimulation and in situ repair at the ACL reconstruction site, offering a novel therapeutic strategy to enhance post-surgical recovery following ligament reconstruction with bone–interface fixation scaffolds.
研究领域:
骨科生物材料
·
组织工程
·
再生医学
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运动医学
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生物医学工程
·
分子骨科学
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危险品化学品经营许可证（带存储）