查找使用阿拉丁产品的科研文献

Expeditious and Cost-effective Synthesis of α-Amino Nitriles Using ZnCl2/hydrotalcite as a Recyclable Heterogeneous Catalyst

Xiaogang Yin,Qiong Yang,Hang Li,Qiudi Zhu,Xinyun Liu

Cannabidiol alleviates carbon tetrachloride-induced liver fibrosis in mice by regulating NF-κB and PPAR-α pathways.

Run Ma,Na Xie,Yuanhui Shu,Yafeng Wu,Ping He,Yining Xiang,Yan Zhou,Yuping Wang

Liver fibrosis has become a serious public health problem that can develop into liver cirrhosis and hepatocellular carcinoma and even lead to death. Cannabidiol (CBD), which is an abundant nonpsychoactive component in the cannabis plant, exerts cytoprotective effects in many diseases and under pathological conditions. In our previous studies, CBD significantly attenuated liver injury induced by chronic and binge alcohol in a mouse model and oxidative bursts in human neutrophils. However, the effects of CBD on liver fibrosis and the underlying mechanisms still need to be further explored. A mouse liver fibrosis model was induced by carbon tetrachloride (CCl 4 ) for 10 weeks and used to explore the protective properties of CBD and related molecular mechanisms. After the injection protocol, serum samples and livers were used for molecular biology, biochemical and pathological analyses. The results showed that CBD could effectively improve liver function and reduce liver damage and liver fibrosis progression in mice; the expression levels of transaminase and fibrotic markers were reduced, and histopathological characteristics were improved. Moreover, CBD inhibited the levels of inflammatory cytokines and reduced the protein expression levels of p-NF-κB, NF-κB, p-IκBα, p-p38 MAPK, and COX-2 but increased the expression level of PPAR-α. We found that CBD-mediated protection involves inhibiting NF-κB and activating PPAR-α. In conclusion, these results suggest that the hepatoprotective effects of CBD may be due to suppressing the inflammatory response in CCl 4 -induced mice and that the NF-κB and PPAR-α signaling pathways might be involved in this process.

Modified ethylene/α-octene co-polymer composites based on dual toughening of hydrogen bonding network and nanospheres

Zhiyi Huang,Tingting Liao,Xiaochun Liu,Jianyu Wu,Zilun Tang,Guoyi Pan,Huameng Liu,Xiaofeng Lin,Wenjing Lin,Yong Li,Yuxin Gu,Guobin Yi

Thermoplastic elastomer ethylene/α-octene co-polymer (POE) is a special polymer material with both elasticity and thermoplasticity. However, the nonpolarity and low-tensile strength of POE limit its application in polar materials and high-strength materials fields. In this study, we synthesized a specific molecule with C═C bonds and N  H bonds, which was introduced into POE to construct hydrogen bonding network, and the prepared modified POE is further blended with carboxyl terminated polystyrene nanospheres as toughening agent to prepare modified POE elastomer composites. Based on such dual toughening strategy containing chemical modification and physical toughening, the modified POE elastomer composites possess improved mechanical properties. The composites achieve a tensile strength of 21.4 MPa, elongation at break of 1268%, fracture energy of 109.6 MJ∙m −3 and exhibit improved thermal stability. Impressively, the tensile strength of reprocessed composites is restored to more than 90% of their original tensile strength even after four times of reprocessing steps, demonstrating excellent reusability.

Composite of Ge and α-MnSe in carbon nanofibers as a high- performance anode material for LIBs

Lirong He,Peng Zhou,Liping Wang,Mingyu Zhang,Qizhong Huang,Zhean Su,Xiaodong Wang,Ping Xu,Weijie Song,Renhao Zou

Improving the performance of anode materials is of great importance for lithium-ion batteries (LIBs). Transition metal selenides compositing carbon and germanium (Ge) have attracted extensive attention. In this work, an anode material that integrates Ge and α-MnSe in carbon nanofibers (CNFs) was first synthesized by heat treatment after electrospinning. The coupling of Ge with α-MnSe and carbon can cause the growth process of α-MnSe to occur inside the CNFs, which can buffer the volume change, refine the grains and avoid particles protruding from the surface of CNFs. In addition, the interconnected conductive network of Ge/α-MnSe@CNFs can provide fast diffusion channels for Li ions and improve the electrical conductivity . Importantly, there is a synergistic effect of Ge, α-MnSe, and CNFs on the anode material for LIBs. As expected, Ge/α-MnSe@CNFs exhibited an excellent performance with a capacity of 1514.7 mAh g −1 after 200 cycles at 0.1 A g −1 and 1030 mAh g −1 after 1000 cycles even at 1 A g −1 . Therefore, this new preparation strategy of Ge/α-MnSe@CNFs offers novel ideas to develop high-performance and long-life LIBs.

Controllable Synthesis, Magnetic Properties, and Enhanced Photocatalytic Activity of Spindlelike Mesoporous α-Fe2O3/ZnO Core–Shell Heterostructures

Wei Wu,Shaofeng Zhang,Xiangheng Xiao,Juan Zhou,Feng Ren,Lingling Sun,Changzhong Jiang

Mesoporous spindlelike iron oxide/ZnO core–shell heterostructures are successfully fabricated by a low-cost, surfactant-free, and environmentally friendly seed-mediate strategy with the help of postannealing treatment. The material composition and stoichiometry, as well as these magnetic and optical properties, have been examined and verified by means of high-resolution transmission electron microscopy and X-ray diffraction, the thickness of ZnO layer can be simply tailored by the concentration of zinc precursor. Considering that both α-Fe2O3 and ZnO are good photocatalytic materials, we have investigated the photodegradation performances of the core–shell heterostructures using organic dyes Rhodamin B (RhB). It is interesting to find that the as-obtained iron oxides/ZnO core–shell heterostructures exhibited enhanced visible light or UV photocatalytic abilities, remarkably superior to the as-used α-Fe2O3 seeds and commercial TiO2 products (P25), mainly owing to the synergistic effect between the narrow and wide bandgap semiconductors and effective electron–hole separation at the interfaces of iron oxides/ZnO.

Chemical Vapor Deposition-Grown Nonlayered α-MnTe Nanosheet for Photodetectors with Ultrahigh Responsivity and External Quantum Efficiency

Luji Li,Hongda Li,Jie Li,Hao Wu,Li Yang,Wenfeng Zhang,Haixin Chang

Development of new two-dimensional (2D) materials with high performance photoelectronic properties is critical for the future multifunctional and miniaturized optoelectronic devices. α-MnTe is an room-temperature antiferromagnetic, direct band gap p-type semiconductor with unique energy band structure and may have high photoelectric conversion efficiency and excellent photoelectric properties. However, controlled synthesis of the 2D α-MnTe single crystal has rarely been achieved so far. In this paper, 2D α-MnTe nanosheets with a NiAs-type hexagonal structure, a stable 2D nonlayered p-type semiconductor, are prepared for the first time via van der Waals epitaxy chemical vapor deposition (CVD) on mica. The thickness of 2D α-MnTe can be well tuned by the reaction temperature and gas flow. The photoelectric performance of the photodetector based on the 2D α-MnTe nanosheet shows that the 2D α-MnTe nanosheet based photodetector has an ultrahigh photoresponsivity (2599 A/W), external quantum efficiency (EQE, 8.065 × 105%), and excellent photodetectivity (3.32 × 1012 jones) at an illumination of 400 nm @ 0.062 mW/cm2 at 3 V, which is one of best performances of 2D material based photodetectors. Our work provides a new avenue to high performance 2D optoelectronic devices.

Effect of 30Bi2O3–55B2O3–15ZnO glass content on sintered copper paste for metallization of α-Al2O3 ceramics

Sun Qin,Yang Wanchun,Hu Zhongyu,Jia Gaozhi,Wang Yangyang

Copper pastes are widely used in metallization of ceramic surfaces but are limited by poor oxidation resistance, high resistivity, and low bonding strength. In this work, the 30Bi 2 O 3 –55B 2 O 3 –15ZnO glass powder was prepared by the melt-quenching method. A copper paste containing the glass powder and formic acid-treated copper microparticles was used for metallization of α -Al 2 O 3 ceramic surface. The copper thick films were obtained by low-temperature sintering after screen printing. The effects of the glass powder contents on resistivities and shear strengths of the copper films on α -Al 2 O 3 ceramic substrate were analyzed. The microstructures of the copper thick films and the interfacial bonding mechanism on the α -Al 2 O 3 ceramic surface were investigated in detail. The copper thick film with 10-wt% 30Bi 2 O 3 –55B 2 O 3 –15ZnO glass and sintered at 650 °C for 20 min exhibited a low resistivity (3.38 ± 0.94 µΩ cm) and a high shear strength (35.24 ± 1.2 MPa). ZnAl 2 O 4 and Bi 2 B 4 O 9 were detected on the edges of the copper film near the interface, which enhanced interfacial binding between the copper thick films and the α -Al 2 O 3 ceramic substrate. These results demonstrated that the low-temperature sintering copper paste containing 30Bi 2 O 3 –55B 2 O 3 –15ZnO glass was effective for α -Al 2 O 3 ceramic surface metallization.

Hollow nanosphere fabricated from β-cyclodextrin-grafted α,β-poly(aspartic acid) as the carrier of camptothecin

Junping Zeng,Haitao Huang,Shiyuan Liu,Haibo Xu,Jin Huang,Jiahui Yu

This research is aimed to develop a kind of hollow nanosphere based on β-cyclodextrin-grafted α, β-poly(aspartic acid) (β-CD- graft -PAsp) as drug carrier to enhance the stability of camptothecin (CPT) in aqueous media. Firstly, mono(6-(2-aminoethyl) amino-6-deoxy)-β-cyclodextrin (β-CDen) was synthesized by a substitution reaction between mono-6-deoxy-6-(p-tolylsulfonyl)-β-cyclodextrin (6-OTs-β-CD) and ethylenediamine; and then, the five-member rings in poly( l -succinimide) (PSI) were successively opened by β-CDen to obtain β-CD- graft -PAsp. The synthesized β-CD- graft -PAsp was found to form the unique hollow nanosphere with the internal hole of about 17   nm and many β-CD cavities of 0.7   nm interspersed on the shell. The drug-loading behavior of the hollow nanosphere was also evaluated by using CPT as guest molecule of β-CD. It was worth of note that the β-CD- graft -PAsp hollow nanosphere as carrier enhanced the stability of CPT in aqueous media, and the CPT from the β-CD- graft -PAsp hollow nanosphere displayed a sustained release profile and hence resulted in the essential decrease of cytotoxicity to L929 cell line. Furthermore, almost no cytotoxicity of the β-CD- graft -PAsp is desirable for the application of drug carrier. As a result, the β-CD- graft -PAsp hollow nanosphere showed a great potential as the carrier of CPT.

4, 9-dihydroxy-α-lapachone as a potent antiproliferation agent for triple-negative breast cancer via ferroptosis

Zhong He,Hui Long,Hongyue Ma,Wanrong Ran,Yinhong Song,Wenjuan Shang,Junhui Wang,Ye Qin,Zhangshuang Deng

Triple-negative breast cancer (TNBC) is the most aggressive and malignant breast cancer. Ferroptosis is an oxidative, iron-dependent form of regulated cell death. Ferroptosis-targeted therapies is a promising approach to improving treatment outcomes of TNBC. Combining death pathway inhibitors with relevant indices for ferroptosis and LipROS, this study uncovered that a natural product of 4, 9-dihydroxy- α -lapachone (DLN) from Catalpa bungei “jinsi” exhibited in vitro and in vivo inhibitory activity against TNBC via ferroptosis. The molecular mechanism is an activation of the FTH1 led to iron overload, and then inhibition of cysteine-glutamate antiporter (system Xc − ) and GPX4, which further sensitized TNBC cells to ferroptosis. This study clarified the pathway of DLN-induced cell death in TNBC treatment and exhibited its potential as therapeutic agent for TNBC.

Superconductivity in the Medium-Entropy/High-Entropy Re-based Alloys with a Non-Centrosymmetric α-Mn Lattice

Kuan Li,Longfu Li,Lingyong Zeng,Yucheng Li,Rui Chen,Peifeng Yu,Kangwang Wang,Zaichen Xiang,Tian Shang,Huixia Luo

Medium/high-entropy alloys (MEAs-HEAs) and rhenium-based compounds with a non-centrosymmetric (NC) structure have received a lot of attention for offering a fertile soil in search for unconventional superconductivity. Here, five previously unreported NC Re-based MEA-HEA superconductors with an α-Mn lattice are successfully synthesized, with their superconducting transition temperatures (Tcs) ranging from 4 to 5 K. An increase in the superconducting transition temperature (Tc) can be achieved by modulating the valence electron count (VEC) through compositional adjustments. Magnetization measurements confirm that all the synthesized Re-based MEA-HEAs are bulk type-II superconductors. Specific heat analysis reveals that the superconducting state of these HEAs can be well described by a single-gap s-wave model. Our results show that the Kadowaki-Woods ratio (KWR) of these α-Mn MEA/HEA superconductors are close to the typical value of heavy fermion compounds, suggesting the existence of strong electronic correlation. These findings provide promising material platforms to study the role of high disorder in the origin of superconductivity in the NC MEAs-HEAs.

An amphoteric and hydrogen-bond-rich artificial α-amino acid for highly durable aqueous redox flow batteries

Zhang Pengbo,Liu Yuzhu,Wei Jie,Wu Zuoao,Song Xinmei,Ding Guochun,Wang Huaizhu,Liang Junchuan,Tie Zuoxiu,Jin Zhong

Aqueous organic redox flow batteries offer promising prospects for large-scale, high-safety, and cost-effective energy storage systems with no reliance on scarce mineral resources. However, challenges such as limited water solubility and poor stability hinder the practical application of organic redox molecules in aqueous organic redox flow batteries. Herein, we report the design and synthesis of an artificial redox-active α-amino acid molecule by functionalizing 1,5-dihydroxyanthraquinone with natural cysteine side group, which exhibits enhanced aqueous solubility and redox reversibility in alkaline aqueous organic redox flow batteries. Owing to its unique zwitterionic structure and abundant hydrogen bonds, the negolyte based on artificial α-amino acid molecule exhibits a very low capacity decay rate of 0.00025% per cycle (equivalent to 0.011% per day) under 1 M electron transfer. Theoretical simulations and spectroscopic analyses underscore the importance of the symmetric distribution and abundant hydrogen-bonding interactions of amphipathic amino acid side chains in enhancing the stability of the anthraquinone redox core and reducing its dimerization, as well as enhancing its water solubility and redox reversibility. This study presents the promising potential of nature-inspired principles in designing electrochemically stable, redox-active organic molecules, contributing to the advancement of large-scale, biocompatible, and sustainable aqueous organic redox flow batteries.

A strategy of extracting and purifying the α-terpineol obtained from the Penicillium digitatum biotransformation of limonene

Zehao Li,Zixuan Wang,Lulu Zhang,Feng Yingjie,Jinchu Yang,Haoliang Li,Weimin Song,Qiuling Wang,Yongfeng Yang,Zhenzhen Huang,Yongming Xu,Yufeng Fu,Meizhou Ding,Gang Fan,Jingnan Ren,Aiqun Yu,Jian Feng,Guijie Li,Linhua Huang,Yujiao Cheng

α-Terpineol, an abundant oxygenated monoterpene compound, shows a varied range of beneficial bioactivities. This study focused on the efficient extraction and purification of α-terpineol from the biotransformation of limonene using Penicillium digitatum DSM 62840 mutant (PdTP1-overexpressed OE2 strain). The α-terpineol was primarily distributed in the supernatant, with minimal association with the biomass. And the optimal extraction was achieved using ethyl acetate as the extractant, which can directly obtain the highest recovery of α-terpineol without sequential extractions. The equilibrium of mass transfer was quickly reached (≤20 s in vortex). Additionally, the purification method of α-terpineol using column chromatography was described, further improving the purity of product to 96.86% in gas chromatography. Structural identification of purified α-terpineol was confirmed using gas chromatography-mass spectrometry, Fourier-transform infrared spectroscopy, and nuclear magnetic resonance. This simplified and efficient strategy for the extraction and purification of α-terpineol not only provides a solid theoretical basis for the final step in the relevant study of microbial synthesis of α-terpineol but also is of great significance for its industrial application.