Nature Communications
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2026
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IF 18.1
Zhang Wen,Liu Wei,Zhao Xiaoyu,Chen Yuanfang,Bi Changfen,Li Shuqin,Zou Bingwen,Liu Luntao,Fan Saijun
Topical treatment remains the standard for radiation-induced dermatitis, which affects approximately 95% of radiotherapy patients. However, the robust skin barrier significantly restricts transdermal drug permeability, compromising therapeutic efficacy. Here we show a NIR-Ⅱ light and endogenous H 2 O 2 dual-propelled Janus nanomotor (Au-hSiO 2 -Pt-TA), which enhances skin permeability by a factor of 12.8 compared with passive nanoparticles. By leveraging the synergistic advantages of self-thermophoresis and self-electrophoresis, these motors enable non-invasive, deep penetration through directional movement. Intriguingly, we find that NIR-II-induced hyperthermia (~ 45 °C) triggers neuro-immune regulation via the CGRP-RAMP1 axis, which suppresses inflammatory cell recruitment and migration while polarizing macrophages toward a pro-repair phenotype, thereby alleviating radiation-induced systemic inflammatory responses. Additionally, tannic acid loaded on the nanomotors functions as an efficient ROS scavenger, further mitigating radiation-induced oxidative stress. Overall, the movable nanomotors offer a potent strategy for RD and demonstrate high efficacy through combined neuro-immunoregulation and ROS scavenging.
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MICROCHIMICA ACTA
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2026
·Vol. 193
·期 7
·501
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IF 5.4
Wang Yunan,Zhang Qiang,Cheng Yue,Shi Chenglong,Wang Yong,Ma Xiaofei
A micro-nano structure enhanced chiral separation strategy is proposed by integrating biomimetic liposome assemblies with cyclodextrin (CD) derivatives as composite chiral selectors in capillary electrophoresis (CE). The self-assembly of weakly chiral, poorly soluble phospholipids into liposomes markedly amplifies chiral discrimination when coupled with CD-based molecular recognition, enabling highly efficient separation of multiple 9-fluorenylmethoxycarbonyl (Fmoc)-amino acid enantiomers. This enhancement is proposed to be associated with the formation of interfacial pre-enrichment microzones on liposome surfaces, where locally concentrated selectors and analytes may engage in synergistic hydrogen bonding, hydrophobic interactions, and steric effects, collectively strengthening chiral recognition. The composite system exhibits good selectivity and compatibility in mixed-sample separations, supporting simultaneous enantioseparation of multiple amino acids with high reproducibility. Beyond establishing an effective CE-based approach for amino acid enantiomer separation, this work demonstrates a proof-of-concept for transforming poorly soluble, weakly chiral substances into efficient chiral selectors through micro-nano assembly, offering preliminary insights for synergistic chiral separation systems. Graphical abstract
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JOURNAL OF SOLID STATE ELECTROCHEMISTRY
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2026
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IF 3.1
Zhang Jun,Liu Boyu,Luo Laizheng,Liang Pingjuan,Li Jinzhi,Jiang Lingying,Chen Xingyi,Tang Huan,Chen Longxiang,Jin Meng,Wu Weimin,Lu Shi-Yu
The development of cost-effective, highly active and durable Pt-based electrocatalysts for oxygen reduction reaction (ORR) remains a major challenge to advancing proton exchange membrane fuel cells (PEMFCs). Hollow nanoarchitecture loaded with metal alloys has been widely used as a nanoreactor to regulate electronic structure of active sites and enhance reactant enrichment. In this study, PtCo alloy nanoparticles are uniformly dispersed on both outer and inner surfaces of hollow TiN spheres and carbon composite support (Pt 3 Co/H-TiN-C). The optimized Pt 3 Co/H-TiN-C nanoreactor delivers a mass activity of 64 mA mg Pt −1 and a specific activity of 0.122 mA cm Pt −2 at 0.90 V vs. RHE in 0.1 M HClO 4 solution. Furthermore, the Pt 3 Co/H-TiN-C nanoreactor enables an effective four-electron transfer pathway with high selectivity and low H 2 O 2 yield (less than 3%) toward ORR process. After accelerated durability tests, the half-wave potential of Pt 3 Co/H-TiN-C shows a decay of only 24 mV after 10,000 cycles, markedly smaller than Pt/C catalyst (74 mV). The enhanced durability and ORR kinetics of Pt 3 Co/H-TiN-C are attributed to the synergistic effect of strain effect in PtCo alloy, strong interactions between PtCo and H-TiN-C, and nanoreactor architecture. These features not only regulate the Pt electronic structure, increasing the Pt 0 content, but also expose more accessible active sites on the outer/inner surfaces to accelerate charge/mass transport. Moreover, alloyed Co atom suppress the dissolution of Pt, endowing an improved durability. This work provides a new strategy for designing efficient and durable Pt-based ORR catalysts for PEMFCs.
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Cell Death & Disease
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2026
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IF 12.2
Sun Zhiming,Deng Yunfang,Liu Yue,Zeng Liyuan,He Chujing,Liu Ye,Liu Zhaohui,Li Jiabing,Sheng Ying,Cai Yuqiao,Xue Yuyao,Zhao Yu
Temozolomide (TMZ) resistance in glioblastoma (GBM) is often linked to high MGMT protein levels, but MGMT-deficient tumors can still acquire resistance, implicating MGMT-independent repair pathways. Here, we identify an oxidative stress-responsive LMO7–ALKBH2 ubiquitination mechanism that regulates ALKBH2 stability and modulates alkylation damage tolerance in GBM. The E3 ligase LMO7 directly binds ALKBH2 and promotes K48-linked polyubiquitination and proteasomal degradation of ALKBH2, with Lys7 serving as a major ubiquitin acceptor site. Oxidative stress enhances LMO7-dependent ALKBH2 ubiquitination through NEDD8-dependent cullin neddylation, reducing TMZ-induced ALKBH2 accumulation and increasing TMZ sensitivity. The K7R substitution attenuates LMO7- and oxidative stress-induced ALKBH2 polyubiquitination and degradation and weakens LMO7-dependent TMZ sensitization. Functionally, ALKBH2 depletion sensitizes MGMT-deficient GBM cells to TMZ and methyl methanesulfonate, whereas ALKBH2 re-expression restores alkylator tolerance. In patient datasets, ALKBH2 protein levels are elevated in GBM and inversely associated with MGMT protein levels, an association not detected at the mRNA level. High ALKBH2 expression in chemotherapy-treated IDH-wild-type glioma and low LMO7 expression in the CGGA astrocytoma cohort are each associated with shorter overall survival. Together, these results indicate that oxidative stress-coupled LMO7-dependent polyubiquitination of ALKBH2 modulates TMZ sensitivity in GBM, particularly in MGMT-deficient tumors.
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Nature Communications
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2026
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IF 18.1
Wang Xu,Li Shuangyu,Shi Wenzhuang,Xue Beiru,Wang Xu,Liu Miao,Lu Binjuan,Xu Zhouye,Gao Ye,Liu Jiachang,Ji Xingyue,Li Jia-Tang,Wang Yipeng
Antimicrobial peptides (AMPs) are essential components of the innate immune system in animals, playing crucial roles in defending against microbial infections. Hydrogen sulfide (H 2 S), a vital gasotransmitter, is involved in regulating a wide array of physiological functions. However, the role of H₂S in the anti-infective actions of AMPs remains poorly understood. Here, we demonstrate the crucial role of H 2 S in mediating the anti-infective functions of AMPs across diverse animal species. LL-37/CRAMP, the human cathelicidin family AMP and its mouse homolog, induce H 2 S production predominantly through 3-mercaptopyruvate sulfurtransferase (3MST) in Escherichia coli and Clostridium perfringens . The generated H₂S further participates in reactive oxygen species (ROS) accumulation, leading to bacterial death by oxidative damage. Additionally, LL-37 activates the Akt signaling pathway, upregulating cystathionine γ-lyase (CSE) expression to generate H 2 S in macrophages. This process plays a potential role in facilitating the immunomodulatory activity of LL-37/CRAMP and we confirmed that H 2 S is involved in their in vivo anti-infective activity of LL-37. Moreover, besides LL-37/CRAMP, we reveal that AMPs from various animal species also induce H 2 S production in bacteria and macrophages. Overall, our findings highlight a previously unrecognized role of H 2 S in AMP anti-infective function, which is ubiquitous across AMPs from different animals.
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Journal of Food Measurement and Characterization
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2026
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IF 3.6
Wang Yu,Wang Yueping,Zhao Wenli,Li Yan,Zhang Qipeng,Liang Wenjuan
To understand the chemical markers and their xanthine oxidase (XO) inhibitory activities in the pulp, shreds and inflorescence axis of A. heterophyllus , an investigation guided by UHPLC-OE-MS tracking, in vitro activity screening and molecular docking was carried out. The inflorescence axis exhibited an XO inhibition rate of 31.87%, significantly higher than that of the pulp (6.69%) and shreds (3.75%), which was closely associated with its abundant content of flavonoids. Further analysis identified flavonoids such as luteolin ( Fl2 ), kaempferol ( Fl3 ), quercitrin ( Fl4 ) and 8-prenylluteone ( Fl16 ) serve as potential contributors to the XO inhibitory activity. Molecular docking with XO revealed binding energies below − 5.0 kcal/mol for above compounds. 8-Prenylluteone ( Fl16 ) showed the strongest interaction, with the lowest binding energy of -8.8 kcal/mol, suggesting its enhanced activity was attributed to the isopentenyl side chain attached to the flavonoid skeleton. This study provided a new perspective for discovering XO inhibitors from A. heterophyllus by-products.
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Microsystems & Nanoengineering
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2026
·Vol. 12
·期 1
·241
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IF 11.1
Ou Qiuqian,Chu Hongwei,Liu Yujian,Cai Liangling,Huang Zhenhe,Li Dan,Lin Jiating,Hu Yue,Li Jiyu,Li Peng,Yang Jiao,Yu Xinge,Li Yingchun
Scientific exercise monitoring is significant for injury risk prevention and training outcome promotion. Wearable biosensing technologies have emerged as transformative tools for real-time, in-situ physiological state profiling through dynamic biomarker detection during exercise activities. However, current studies remain suboptimal for practical exercise management due to inherent constraints including single-analyte detection paradigms, limited permeability and breathability, and inadequate thermoregulatory performance. Here, we present a novel wearable composite fabric system engineered for multiplex sweat biomarker monitoring while delivering unprecedented wear comfort. The hierarchical architecture was achieved through strategic integration of interwoven fiber-based sensor arrays with conventional textiles, augmented by bilateral deposition of microbead-enhanced polyvinylidene difluoride (PVDF) and polyacrylonitrile (PAN) electrospun nanofiber membranes. The porous matrix, Janus hierarchical gradient, and microbead-mediated interfacial engineering render this fabric system with excellent breathability of 13 mm/s, water vapor transmission rate of 468.9 g/m 2 /h, and solar reflectance of 96.2%. Systematic validation revealed the system’s capabilities in multiplex biomarker tracking during diverse exercise scenarios, machine learning-powered fatigue assessment, and scientific exercise regimen evaluation. This work establishes a universal framework for developing wearable platforms with reliable sensing functionality and wear comfort, facilitating effective personalized exercise healthcare management.
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Scientific Reports
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2026
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IF 4.9
Zhong Meigong,Wu Meimei,Chen Ruizhen,He Jiadi,Qiu Yulan,Huang Jing,Mai Yanyang,Lu Wenjie,Wu Wanting,Zheng Mingzhu,Huang Xiaoxue,Ling Jie,Ren Liangliang,Li Minxian,Lin Peifeng,Chen Minli,Zhang Qin,To KwanNin,Wang Yu,Ren Dong,Chai Xingxing,Wang Lili,Xue Zhonglin,Zhang Xin
We evaluated the therapeutic effect of psoralidin combined with cisplatin in a mouse model of breast cancer by H&E, immunohistochemistry and TUNEL staining. Transcriptome analysis, bioinformatics analysis and molecular docking analysis were used to explore the mechanism of psoralidin and cisplatin in improving breast cancer. The results showed that psoralidin could synergistically enhance the inhibitory effect of cisplatin on the proliferation of 4T1 breast cancer cells, promote the apoptosis of 4T1 cells, increase DNA damage and ROS expression. It also inhibited the expression of breast cancer cell proliferation-related molecules and energy metabolism factors related to tumor cell growth. Psoralidin could also synergistically enhance its inhibitory effect on tumor growth in breast cancer mice. Further molecular docking analysis revealed that psoralidin enhanced the killing effect of cisplatin on tumor cells by binding to Nr1i2 . These findings provide a clear scientific basis for the enhancement of anticancer sensitivity to cisplatin by psoralidin.
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CELLULOSE
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2026
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IF 4.6
Zhou Hong,Zheng Shuzhen,Zhou Chunhua,Ma Jianfeng
The practical application of cement-based materials is often constrained by their inherent brittleness and low flexural strength. Although both microcrystalline cellulose (MCC) and graphene oxide (GO) show potential as reinforcing agents, achieving synergistic enhancement of compressive strength and flexural strength of cement-based materials remains an urgent problem to be solved. This study developed a novel GO-MCC composite (GOMCC) via a combined ultrasonic and chemical modification approach, aiming to achieve a synergistic reinforcement effect. Characterization techniques (FTIR, TEM, XRD, DLS) confirmed the successful formation of the composite between MCC and GO, which effectively inhibited agglomeration and enhanced interfacial bonding. When incorporated into cement paste at a dosage of 1.0 wt.‰, the GOMCC-2 composite (GO: MCC = 3:100) significantly improved the flexural strength, with increases of 18.2%, 14.6%, and 26.4% at 3, 7, and 28 days, respectively. Microstructural and hydration analysis (BET, SEM, XRD, isothermal calorimetry) revealed that the oxygen-containing functional groups of GO and the hydroxyl groups of MCC acted synergistically to strengthen the interfacial bonding with cement hydration products (C–S–H gel). Furthermore, the GOMCC composite served as a nucleation site for hydration products, promoting the formation of a denser microstructure with a refined pore structure, and contributed to crack-bridging effects, thereby effectively enhancing the mechanical properties of the cement-based material.
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NATURE STRUCTURAL & MOLECULAR BIOLOGY
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2025
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IF 10.1
He Zhaoxiang,Teng Fei,Yang Yanqing,Guo Ruiyang,Wu Mengchen,Han Fangzhu,Tian Hongtao,Wang Jiawei,Hu Yiqi,Jiang Yangwei,Zhang Leili,Xu Chenyang,Yang Fan,Zhou Jiancang,Zhang Shan,Letts James A.,Zhou Ruhong,Zhou Long
Metformin is the only antihyperglycemic biguanide targeting type 2 diabetes mellitus with proven safety. Although a mechanism of action involving tight inhibition of the respiratory complex I has been proposed for hydrophobic biguanides, it remains elusive for the hydrophilic metformin, whose excellent pharmacological tolerance depends on weak complex I inhibition without competitive nature. Here we solved cryo-electron microscopy structures of the metformin-bound porcine respirasome. Our structural and kinetic data are consistent with a model in which metformin enters complex I only in its open state and becomes trapped at the ubiquinone redox site by ubiquinone-induced conformational closing of the enzyme. By contrast, the hydrophobic proguanil alone occupies both the entrance and the redox site of the ubiquinone channel in open and closed complex I and is kinetically consistent with competitive inhibition with conformation-dependent affinities. Our data provide the molecular basis for metformin’s well-known superior properties, such as a wide therapeutic window and positive ubiquinone cooperativity, leading to its clinical success and facilitating future therapeutic developments.
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Scientific Reports
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2026
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IF 4.9
Köksaldı Seher,Kayabaşı Mustafa,Işık Muhammet İkbal,Taçyıldız Celal,Paşa Onur,Karataş Ezgi,Yergin Tacyıldız Suna,Oruç Yavuz
This study aimed to investigate retrobulbar biomechanical and microvascular changes associated with increasing axial length in myopic eyes using shear wave elastography and a quantitative vascularity index. In this prospective cross-sectional study, 99 eyes from 99 adults were classified into three groups according to axial length: <24.00 mm (Group 1), 24.00–25.99 mm (Group 2), and ≥ 26.00 mm (Group 3). All participants underwent comprehensive ophthalmologic and ultrasonographic evaluations. Shear wave elastography was used to quantify the stiffness of the optic nerve and adjacent retrobulbar fat tissue. Retrobulbar microvascularity was assessed using ultra-microangiography, with color pixel percentage measured as a vascularity index. No significant differences in tissue stiffness were observed among axial length groups (all p > 0.05). However, the vascularity index differed significantly between groups ( p = 0.026) and remained independently associated with axial length after adjusting for age and sex ( p = 0.041), suggesting progressive reduction in retrobulbar microvascularity, reflected by lower vascularity index values, with increasing axial elongation. Optic nerve diameter significantly decreased with increasing axial length ( p = 0.010). These findings indicate that axial elongation in myopic eyes is associated with significant retrobulbar microvascular changes without corresponding alterations in tissue stiffness.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2026
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IF 4.1
Yu Wanting,Wu Di,Ao Zhongjie,He Yu,Tang Dianping
Methods based on photo-heat conversion materials have been developed for the immunoassays, but most involve low sensitivity or complex procedures and are unsuitable for routine use. Herein, a portable photothermal immunoassay was designed for point-of-care (POC) testing of disease-related biomarker (carcinoembryonic antigen (CEA)) in biological fluids on a digital near-infrared (NIR) thermometer with smartphone readout. Initially, the photothermal materials with manganese (Mn) and iron (Fe) bimetallic oxide (MnFe 2 O 4 ) were synthesized via a typical hydrothermal method, and then functionalized with polyclonal anti-human CEA detection antibody (pAb 2 ). In the presence of target CEA, a sandwich-type immunoreaction was implemented on monoclonal rabbit anti-human CEA capture antibody-coated microplate with MnFe 2 O 4 -pAb 2 . Under an 808-nm laser irradiation, the labeled MnFe 2 O 4 on the detection antibody converted the light into heat, thereby causing the increasing temperature of the detection solution in the microplate. The variation in the temperature was collected on a portable NIR thermometer with smartphone readout. Under optimal conditions, the MnFe 2 O 4 -based immunoassay exhibited good photothermal responses for the detection of target CEA with a dynamic linear range of 0.01–150 ng mL −1 at a low detection limit of 0.56 pg mL −1 . Good reproducibility, intermediate precision, and high specificity were acquired. No significant differences at the 0.05 significance level were encountered for the analysis of human serum samples between the developed photothermal immunoassay and the commercially available enzyme-linked immunosorbent assay (ELISA) for the determination of CEA. Importantly, this immunoassay offers promise for simple and cost-effective analysis of biological samples in diagnostics. Graphical
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