BIOLOGICAL RESEARCH
·
2023
·Vol. 56
·期 1
·1-14
·
IF 6.7
Dai Bing,Liu Si,Shen Wenxin,Chen Li,Zhou Qianlan,Han Lina,Zhang Qinzhen,Shan Lishen
Background Asthma is a heterogenous disease that characterized by airway remodeling. SYVN1 (Synoviolin 1) acts as an E3 ligase to mediate the suppression of endoplasmic reticulum (ER) stress through ubiquitination and degradation. However, the role of SYVN1 in the pathogenesis of asthma is unclear. Results In the present study, an ovalbumin (OVA)-induced murine model was used to evaluate the effect of SYVN1 on asthma. An increase in SYVN1 expression was observed in the lungs of mice after OVA induction. Overexpression of SYVN1 attenuated airway inflammation, goblet cell hyperplasia and collagen deposition induced by OVA. The increased ER stress-related proteins and altered epithelial-mesenchymal transition (EMT) markers were also inhibited by SYVN1 in vivo. Next, TGF-β1-induced bronchial epithelial cells (BEAS-2B) were used to induce EMT process in vitro. Results showed that TGF-β1 stimulation downregulated the expression of SYVN1, and SYVN1 overexpression prevented ER stress response and EMT process in TGF-β1-induced cells. In addition, we identified that SYVN1 bound to SIRT2 and promoted its ubiquitination and degradation. SIRT2 overexpression abrogated the protection of SYVN1 on ER stress and EMT in vitro. Conclusions These data suggest that SYVN1 suppresses ER stress through the ubiquitination and degradation of SIRT2 to block EMT process, thereby protecting against airway remodeling in asthma.
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PubMed
高影响因子
Nano Research
·
2023
·
IF 9.9
Mao Xue,Li Zhen-Zhen,Hao Dong-Lian,Han Wei-Dong,Li Gao-Peng,Wang Yao-Yu,Zhang Kun
Developing free-standing and mechanical robust membrane materials capable of superior enrichment of phosphopeptides for analyzing and identifying the specific phosphoproteome of cancer cells is significant in understanding the molecular mechanisms of cancer development and exploring new therapeutic approaches, but still a significant challenge in materials design. To this end, we firstly constructed highly flexible ZrTiO 4 nanofibrous membranes (NFMs) with excellent mechanical stability through a cost-effective and scalable electrospinning and subsequent calcination technique. Then, to further increase the enrichment capacity of the phosphopeptide, the biomimetic TiO 2 @ZrTiO 4 NFMs with root hair or leaf like branch microstructure are developed by the hydrothermal post-synthetic modification of ZrTiO 4 NFMs through growing unfurling TiO 2 nanosheets onto the ZrTiO 4 nanofibers. Importantly, remarkable flexibility and mechanical stability enable the resulting TiO 2 @ZrTiO 4 NFMs excellent practicability, while the biomimetic microstructure allows it outstanding enrichment ability of the phosphopeptide and identification ability of the specific phosphoproteins in the digest of cervical cancer cells. Specifically, 6770 phosphopeptides can be enriched by TiO 2 @ZrTiO 4 NFMs (2205 corresponding phosphoproteins can be identified), and the value is much higher than that of ZrTiO 4 NFMs (6399 phosphopeptides and 2132 identified phosphoproteins) and commercial high-performance TiO 2 particles (4525 phosphopeptides and 1811 identified phosphoproteins). These results demonstrate the super ability of TiO 2 @ZrTiO 4 NFMs in phosphopeptide enrichment and great potential for exploring the pathogenesis of cancer.
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JOURNAL OF APPLIED ELECTROCHEMISTRY
·
2023
·
IF 2.9
Li K. P.,Liu Z. Z.,Wang C.,Zhang Y. Q.,Yang X. B.,Zhou B.,Xie Z. X.,Duan Z. Q.,Hu Y. M.
Nanocrystalline Cu 2 Cu 1− x Fe x SnS 4 (CCFTS) was prepared by a simple liquid-phase method. Physiochemical properties of the CCFTS powder as well as the CEs fabricated thereby were investigated using XRD, Raman spectroscopy, SEM, UV–Vis absorption, electrochemical impedance spectroscopy (EIS), etc. Conduction band shifts as well as the bandgap increases in the as-prepared CCFTS as a function of the Fe content were observed. For the dye-sensitized solar cells (DSSCs) with CCFTS counter electrodes (CEs), charge transfer impedance ( R ct1 ) and short-circuit current ( J sc ) were reduced by 64.54% and improved by 14.64%, respectively, compared with that with Fe-free Cu 3 SnS 4 (CTS) CE. The enhancement of electron transfer through the CE/electrolyte interfaces stems from the optimal energy level alignment and the surface morphology tuned by the Fe alloying and hence improve the electrocatalytic activity of the CEs for the reduction from I 3 − to I − . As a consequence, photovoltaic conversion efficiency (PCE) of 6.95% was obtained which is 1.25 times that of the cell with Fe-free CTS CE. This work confirmed that element alloying into nanocrystalline transition metal compounds is effective for catalytic activity improvement. Material preparation reported herein is feasible, has high efficiency and low cost, and believed beneficial to high DSSCs development. Graphical abstract
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RARE METALS
·
2023
·Vol. 42
·期 12
·4189-4200
·
IF 8.8
Xie Yong-Shuai,Peng Ying,Deng Zhe-Zhe,Zhu Ze,Cheng Yuan,Ma De-Hua,Zhu Lu-Yi,Zhang Xing-Hong
ZrO 2 fiber is a promising high-temperature resistant and heat-insulating fiber material. However, the decrease in mechanical properties caused by grain growth at high temperatures seriously affects its application. How to achieve the synergy of its temperature resistance and the thermal insulation performance is still the focus of the current industry. In this work, we started with doping inequivalent elements and studied the phase composition, temperature resistance, and thermal insulation properties of Y 2 O 3 -ZrO 2 ceramic fibers by adjusting the Y/Zr molar ratio. The results showed that Y 2 O 3 could enter the crystal lattice of ZrO 2 and form a solid solution. With the increase in Y 2 O 3 content, the structure of fibers changed from a tetragonal phase to a cubic phase, and the configurational entropy of the system increased. The larger configuration entropy in the sample could produce a robust steric hindrance effect, inhibiting grain growth. After heat treatment at 1300 °C, the grain size of Y 2 Zr 2 O 7 (Y5Z5) fibers was only 61.8% that of Y 0.1 Zr 0.9 O 1.95 (Y1Z9) fibers. The smaller grain size made the Y5Z5 fibers still have excellent flexibility and deformation recovery performance after heat treatment at 1300 °C and could still return to the original state after 85% compression or folded in half. In addition, due to the larger configurational entropy, the mean free path of phonon scattering was shortened, thereby improving the thermal insulation performance of the fiber. In short, this work achieves the synergistic effect of temperature resistance and thermal insulation properties of zirconia-based fiber materials only through simple inequivalent element doping. Graphical abstract
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Advanced Composites and Hybrid Materials
·
2023
·Vol. 6
·期 6
·1-10
·
IF 20.1
Zou Tao,Zhang Dongqiao,Shen Kuangyu,Huang Zhenduo,Xu Tao,Peng Xiaohong,Zhang He,Du Yanliang,Sun Luyi
Recently, many efforts have been devoted to studying early-stage fire-warning materials (EFWMs). Among those, thermoelectric effect-based EFWM (TE-EFWMs) are particularly attractive because they are self-powered and intrinsically sensitive to temperature. However, none of the reported fire-warning response times of TE-EFWMs can reach 1.0 s. Herein, flame-retardant composite cotton fabrics with speedy and repeatable fire warning function (denoted as CF-TE-FR) were constructed by in-situ polymerized polypyrrole (PPy) doped with P-toluenesulfonic acid (PTSA) and a flame retardant composite layer composed of sodium montmorillonite (MMT) and ammonium polyphosphate (APP). The fire warning performance of CF-TE-FR was effectively enhanced through PTSA doping, and the fire warning response time was shortened with an increasing concentration of PTSA. The fire warning indicator could be triggered as fast as 0.8 s when the molar ratio of PTSA to pyrrole monomer reached 1:3. Meanwhile, all the CF-TE-FR samples could release the fire-warning signals repeatedly. This work proposes a facile approach to the fabrication and application of organic thermoelectric polymer-based materials with ultrafast fire-warning response, repeatable fire-warning capability, and excellent flame retardancy. Graphical abstract Flame-retardant cotton fabrics based on the thermoelectric effect of polypyrrole demonstrate speedy and repeatable fire warning function.
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高影响因子
CELLULOSE
·
2023
·Vol. 30
·期 17
·10733-10748
·
IF 5.7
Zhang Jing-Fang,Tang Ren-Cheng
Reducing the flammability of kapok fiber (KF) is an important strategy to increase its applicability. In this work, the phosphorylation of KF with ammonium dihydrogen phosphate (ADP) was used to reduce its flammability, the conditions of phosphorylation reaction were studied in detail, and the chemical groups, crystalline structure, thermal stability, heat release capability, flammability and charring ability of phosphorylated KF were analyzed. KF showed significantly higher phosphorylation level than cotton, and its phosphorylation greatly depended on ADP and urea dosage, reaction temperature and time, and pH. Urea addition, pH 6, 150 ℃ and 1 h rendered high phosphorylation with acceptable whiteness. Phosphorylated KF exhibited good char-forming, low heat release and excellent flame retardant performances during thermal degradation and combustion as evidenced by thermogravimetric, microcalorimetric, vertical combustion and combustion residue morphology analyses. The residue rate of phosphorylated KF subjected to thermal degradation exceeded 50% in nitrogen, and 25% in air. This investigation demonstrates that phosphorylated KF is an intrinsically flame retardant material. Graphic abstract
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FISH PHYSIOLOGY AND BIOCHEMISTRY
·
2023
·
IF 2.9
Xu Xuhui,Zhou Mengyuan,Xie Kunmei,Zhang Shuai,Ji Xiaomeng,Sun Ying,Li Qiulu,Dong Zibo
Avermectin is widely used as an important insecticide in agricultural production, but it also shows strong toxicity to non-target organisms. Quercetin is a natural flavonoid that is widely used due to its good anti-inflammatory and antioxidant effects. We believe that quercetin may have a potential therapeutic effect on avermectin poisoning. This experiment was proposed to observe the effect of quercetin on the toxic response to avermectin by observing the toxic response caused by avermectin in the brain of carp. In this project, 60 carp were studied as control group (Control), quercetin administration group (QUE), avermectin exposure group (AVM) and quercetin treatment avermectin exposure group (QUE + AVM) with different interventions to study the effect of quercetin on avermectin. The carp brain tissues were stained and simultaneously analyzed for blood–brain barrier (BBB), oxidative stress indicators, inflammatory factors, and apoptosis using qPCR technique. The results of the study indicate that avermectin exhibits a neurotoxic mechanism of action in fish by decreasing the transcript levels of tight junction protein-related genes, which in turn leads to the rupture of the BBB in the carp brain tissue. Avermectin induced apoptosis in carp brain tissue by increasing oxidative stress response and promoting inflammatory cell infiltration. Quercetin could reduce the accumulation of reactive oxygen species (ROS) in the brain tissue of carp caused by avermectin exposure toxicity, maintain redox homeostasis, reduce inflammatory response, and protect brain tissue cells from apoptosis. The present study confirmed the therapeutic and protective effects of quercetin on neurotoxicity in carp caused by avermectin exposure.
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高影响因子
IONICS
·
2023
·Vol. 29
·期 12
·5183-5193
·
IF 2.8
Du Fang-Xiao,Liu Song-Li,Li Yang,Wang Jian-Kang,Zhang Peng
The scalable synthesis of MoS 2 /N-doped carbon (MoS 2 /NC) nanosheets was accomplished using a facile salt template–assisted synthesis method. The MoS 2 nanosheets were uniformly encapsulated in nitrogen-doped carbon frameworks. As an anode for sodium-ion batteries (SIBs), the electrochemical performance of the MoS 2 /NC electrode was significantly improved compared to pure MoS 2 , which demonstrated a reversible capacity of 334.6 mAh g −1 after 100 cycles at 0.2 A g −1 ; even after 250 cycles of 1 A g −1 , the capacity could still be maintained at 252.9 mAh g −1 . This excellent sodium storage performance was mainly due to the coupling of nitrogen-doped carbon with MoS 2 and the uniform distribution of the nanosheets, which improved the reaction kinetics. Besides, the electrochemical reconstruction ensured the integrity of the electrode. This work was of great significance for the large-scale synthesis of MoS 2 anode material with enhanced stability SIBs.
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Electrocatalysis
·
2023
·
IF 3.1
Hu Xuemei,Zhou Jianping,Bao Jianqin,Zhang Yadong,Qiao Junqiang
In this work, hierarchical Cu 2 ZnSnS 4 electrocatalysts with different morphologies and stoichiometries were synthesized via the hydrothermal method and their electrocatalytic performances in hydrogen evolution reaction were evaluated. The morphologies of Cu 2 ZnSnS 4 electrocatalysts were modulated by adjusting the content of surfactants during the hydrothermal process. The stoichiometries of as-prepared Cu 2 ZnSnS 4 were found to be Cu 2 Zn 0.8 Sn 0.7 S 2.9 , Cu 2 Zn 0.7 Sn 1.2 S 4.7 and Cu 2 Zn 0.5 Sn 0.7 S 3.2 for the absence of surfactant and the addition of polyethylene glycol-(400) (PEG 400) and octylphenol polyoxyethyleneether-10 (OP 10) respectively. The Cu 2 ZnSnS 4 synthesized with the addition of PEG 400 displayed superior electrocatalytic activity in acid medium with an overpotential of 295 mV obtained at 10 mA cm − 2 and a Tafel slope of 133 mV dec − 1 . This work reveals that the stoichiometry and microstructure of Cu 2 ZnSnS 4 are critically important for its electrocatalytic activity while have less impact on the electrocatalytic durability, and provides useful information to explore the utilization of chalcogenides as the attractive electrocatalysts.
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RESEARCH ON CHEMICAL INTERMEDIATES
·
2023
·Vol. 49
·期 12
·5361-5374
·
IF 3.3
Du Chuanqing,Huang Yeyin,Tang Wanjun,Sun Lang,You Qingliang,Li Tingcheng,Xie Guangyong
Formulation and shaping of heterogeneous catalysts are vital in the successful industrial application. Here micro-sized vanadium chromium composite oxides catalysts with the spherical shape were prepared via spray drying with colloidal silica as a binder material. The physicochemical properties of catalysts with different Cr/V molar ratios were characterized by XRD, XPS, FT-IR, TPR, and particle size distribution analysis. It was revealed that the addition of Cr inhibited the formation of the crystalline phase V 2 O 5 and decreased the reduction temperature of pentavalent vanadium species, and also resulted in the formation of monoclinic CrVO 4 and a highly dispersed state of vanadia species. VCrO/SiO 2 particles with various Cr/V atomic ratio were studied as catalysts for p -chlorotoluene ammoxidation to p -chlorobenzonitrile, in which the catalyst with Cr/V ratio of 1 exhibited the best catalytic performance. When the Cr/V ratio was less than 1, mixed phases of orthorhombic CrVO 4 and monoclinic Cr 2 V 4 O 13 were formed and resulted in a low catalytic activity. With the increase of Cr/V ratio, the content of monoclinic CrVO 4 in the catalysts increased, resulting in the catalytic activity of the catalysts improved. However, too large an amount of Cr led to the formation of highly oxidizing hexagonal-Cr 2 O 3 phase, which reduced the selectivity of the catalytic reaction. Graphic abstract
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TRIBOLOGY LETTERS
·
2023
·Vol. 71
·期 4
·1-13
·
IF 3.2
Fu Jingguo,Fan Liyang,He Yuhang,Yu Zhiwei,Ma Dengqing,Yin Huabing,Zhang Hongpeng
The combination of surface dimples and solid lubricant can improve the friction state between moving parts. However, the presence of surface dimples also leads to surface stress concentration, and the influence of these stresses on tribological properties is also worth studying. In this work, solid lubricant mixture polyimide and tungsten disulfide were firstly encapsulated in the dimples on the cylinder liner surface. The influence of surface stress concentration on the anti-friction performance of moving parts was then investigated through surface stress simulation and reciprocating friction and wear experiments. The results indicated that during reciprocating friction movement, surface stress concentration caused by the dimples mainly appeared at their edges. Moreover, as the diameter of the dimples increased, there was a gradual decrease in maximum surface stress on the cylinder liner. However, higher contact pressure and shear stress generated by edge-induced stress concentration could promote tribochemical reactions between Fe matrix and mixed solid lubricants polyimide and tungsten disulfide, resulting in formation of a solid lubrication film as well as iron–carbon and iron–nitrogen compounds that enhanced anti-friction effects.
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MEDICAL ONCOLOGY
·
2023
·Vol. 40
·期 11
·1-11
·
IF 3.4
Li Jun,Lin Chenyu,Zhu Yuqian,Shao Chengwei,Wang Tiegong,Chen Bingdi
The research of nanomaterials for bio-imaging and theranostic are very active nowadays with unprecedented advantages in nanomedicine. Homologous targeting and bio-imaging greatly improve the ability of targeted drug delivery and enhance active targeting and treatment ability of nanomedicine for the tumor. In this work, lycorine hydrochloride (LH) and magnetic iron oxide nanoparticles coated with a colorectal cancer (CRC) cell membrane (LH-Fe 3 O 4 @M) were prepared, for homologous targeting, magnetic resonance imaging (MRI), and chemotherapy. Results showed that the LH-Fe 3 O 4 @M and Fe 3 O 4 @M intensity at HT29 tumor was significantly higher than that Fe 3 O 4 @PEG, proving the superior selectivity of cancer cell membrane-camouflaged nanomedicine for homologous tumors and the MRI effect of darkening contrast enhancement were remarkable at HT29 tumor. The LH-Fe 3 O 4 @M exhibited excellent chemotherapy effect in CRC models as well as LH alone and achieved a high tumor ablation rate but no damage to normal tissues and cells. Therefore, our biomimetic system achieved a homologous targeting, bio-imaging, and efficient therapeutic effect of CRC.
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