FUEL
·
2025
·
IF 7.5
Yuanyuan Li,Xiaoling Xu,Ran Zhang,Xingbao Yang,Kun Jia
Traditional coal mine fire suppression methods face critical limitations, including short-term efficacy, poor penetration in concealed coal seams, and environmental risks from chemical residues. To address these challenges, this study developed a biomaterial-based composite inhibitor integrating physical isolation, free radical quenching, and antioxidant slow release for sustainable prevention of spontaneous coal combustion. A novel antioxidant-loaded composite was synthesized using hollow mesoporous TiO 2 nanoparticles (HM-TiO 2 ) as carriers, which were functionalized via layer-by-layer self-assembly (LBL) of chitosan (CS) and phytic acid (PA) to encapsulate tea polyphenol (TP). This design enables the TP antioxidant activity and low release while leveraging CS/PA’s catalytic char-forming capacity. The chemical composition and micromorphology of the composite were systematically characterized through FTIR, XRD, SEM, and TEM analyses. Programmed temperature oxidation experiments combined with thermogravimetric (TG) and thermogravimetric-Fourier Transform Infrared Spectroscopy (TG-FTIR) measurements were conducted to evaluate inhibition performance by tracking mass loss, characteristic gas emissions, and radical intermediates. Key findings demonstrate that the composite inhibitor: Prolongs coal ignition delay by 48 % compared to untreated coal, attributed to the synergistic barrier effect of the TiO 2 @CS-PA framework and TP’s radical scavenging activity; Reduces CO, CO 2 , CH 4 and H 2 O emissions during low-temperature oxidation; Maintains structural stability above 400 °C, with TiO 2 catalyzing dense char layers to isolate oxygen diffusion. This multifunctional composite overcomes the trade-off between inhibition longevity and environmental compatibility observed in conventional inhibitors (e.g., MgCl 2 , KMnO 4 ), offering a scalable solution for fire prevention in high-level mining areas. The bio-based components (CS, PA, TP) further ensure ecological safety, aligning with green mining initiatives.
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CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Jiaqi Zhou,Jingyi Li,Yu Wang,Kaiwen Liang,Jingjing Yu,Cuicui Ding,Hui Wu,Lihui Chen,Min Zhang
In abdominal wall hernia repair, current mainstream polypropylene (PP)-based patches face challenges such as chronic inflammation, mismatched degradation rates, and insufficient anti-deformation properties. While natural biomaterials offer good biocompatibility and degradability, their clinical application is limited by insufficient mechanical strength. To overcome this challenge, we engineered a chitosan (CS) and cellulose nanofiber (CNF)-reinforced collagen membrane. This design leveraged dual polysaccharide functionalities: CNF provided nanoscale reinforcement, while CS enabled multi-point cross-linking with collagen, synergistically enhancing the membrane's structural stability. To further enhance performance, a sequential approach involving the layer-by-layer blade-coating and induced assembly was employed, producing stacked and oriented lamellar structures. The optimized membrane exhibited raised tensile strength (49.00 MPa) and fracture energy (121.22 MJ/m 3 ), prolonged degradation period (52.7 % weight retention at 28 days), and reduced swelling rate (135.5 %). In vitro biocompatibility assays confirmed the material's non-cytotoxicity and excellent blood compatibility. Moreover, in vivo rat abdominal defect models demonstrated superior tissue regeneration, minimized inflammation, and effective mechanical support when using the developed membrane compared to PP meshes and pure collagen membranes (COL). These findings highlight the potential of this green strategy to provide a balanced solution for hernia repair, addressing both mechanical and biological requirements.
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PubMed
高影响因子
Current Drug Delivery
·
2023
·Vol. 21
·期 8
·1142-1150
·
IF 2.4
Fang Ruiyue,Liao Yiqi,Qiu Huishuang,Liu Yuxin,Lin Shiyuan,Chen Hui
Introduction: With the rapid development of nanotechnology, the research and development of nano-drugs have become one of the development directions of drug innovation. The encapsulation of the nanoparticles can change the biological distribution of the drug in vivo and improve
the bioavailability of the drug in vivo. Naringenin is poorly soluble in water and has a low bioavailability, thus limiting its clinical application. The main purpose of this study was to develop a nano-sized preparation that could improve the oral bioavailability of naringenin.
Methods: Chitosan oligosaccharide modified naringenin-loaded bovine serum albumin nanoparticles (BSA-COS@Nar NPs) were prepared by emulsification solvent evaporation and electrostatic interaction. The nanoparticles were characterized by HPLC, laser particle size analyzer, transmission electron
microscope and X-ray diffraction analysis. The release in vitro was investigated, and the behavior of nanoparticles in rats was also studied. The caco-2 cell model was established in vitro to investigate the cytotoxicity and cellular uptake of nanoparticles. Results: BSA-COS@Nar
NPs were successfully prepared, and the first-order release model was confirmed in vitro release. In vivo pharmacokinetic results indicated that the area under the drug concentration- time curve (AUC) of BSA-COS@Nar NPs was 2.37 times more than free naringenin. Cytotoxicity and
cellular uptake results showed that BSA-COS@Nar NPs had no significant cytotoxic effect on Caco- 2 cells and promoted cellular uptake of the drug. Conclusion: BSA-COS@Nar NPs could improve the in vivo bioavailability of naringenin.
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高影响因子
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
·
2015
·Vol. 15
·期 1
·600-605
·
IF 1.556
Jiang Ping,Li Duxin,Xiao Ya,Yang Xingxing,Liu Yuejun
The biodegradable microcapsules based on chitosan for a controlled delivery of clove oil were prepared by the single coagulation process. The effect of chitosan concentration, core to shell ratio, types of emulsifier, flocculating agent and hardening agent on the microcapsule diameter
and the particle size distribution of microcapsule were investigated. The optimized conditions for the preparation of microcapsules with well-defined structure and narrow dispersibility were under that (1) the concentration of chitosan was 1.0 wt%, (2) clove oil to chitosan ratio was 75:25,
(3) OP-10 and 10 wt% sodium sulfate were used as emulsifier and flocculating agent respectively, and (4) the concentration hardening agent glyoxal was 1 wt% based on the weight of chitosan. The uniform spherical structures with smooth surfaces with a particle size distribution of 1–15
μm were evidenced by SEM images of microcapsules. Core–shell, hetero-structures were confirmed by optical micrograph. The chemical component of the microcapsules was determined by FTIR. Thermal analysis showed the microcapsules were thermally stable below 150°C. It was
found that the pH value and temperature play important roles on the release rate of clove oil from the microcapsules. The release volume of clove oil from microcapsules at pH = 7, and pH = 10 were smaller than that at pH = 2. And the release volume of Clove oil from microcapsules at 60°C
was smaller than that at 20°C and 40°C, which showed a sustained and prolonged release.
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2018
·Vol. 42
·期 21
·17740-17749
·
IF 3.201
Panpan Wang,Lihua Wang,Shujun Dong,Guohui Zhang,Xuejuan Shi,Chunhui Xiang,Lili Li
Chitosan/poly(ethylene oxide)/permutit (CS/PEO/PT) composite nanofibers were prepared via electrospinning and their potential application in the removal of hexavalent chromium (Cr(VI)) from aqueous solutions was studied in detail. SEM results showed that the nanofibers were homogeneous and bead-free. XRD and DSC results demonstrated that there were strong interactions among CS, PEO and PT. The solubility test showed that the CS/PEO/PT composite membrane had excellent durability in water. The CS/PEO/PT-1% nanofibers exhibited the best adsorption performance for Cr(VI) ions in acidic solution (pH = 3) and at a low Cr(VI) concentration of 50 mg L−1. The maximum adsorption capacity reached 208 mg g−1. The adsorption kinetics and equilibrium data were well described by pseudo-second-order kinetic and Langmuir isotherm models, respectively. According to the results of FTIR and XPS analyses, protonation, ion exchange, electrostatic interactions and redox reactions were involved in the adsorption process. All the results indicated that the electrospun CS/PEO/PT nanofibers could be used as promising absorbents for the removal of Cr(VI).
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高影响因子
MOLECULES
·
2025
·Vol. 30
·期 20
·4067
·
IF 4.6
Yaping Cheng,Haimin Liao,Huimei Shan,Yunquan Liu,Huinan Mo
Antimony (Sb), as a toxic heavy metal, has drawn worldwide attention, and its efficient removal from water has become increasingly urgent. In this study, an iron-modified alkaline lignin chitosan (Fe-ALCS) gel bead is prepared by the freeze-drying method to remove Sb(III) from the aqueous solution. The static adsorption experiment discusses the various environmental influences on the adsorption performance of Fe-ALCS for Sb(III) removal. The adsorption mechanism is explored by combining adsorption kinetics, isothermal adsorption, and characterization methods (such as FTIR, XRD, XPS, etc). The results show that the equilibrium adsorption capacity of Sb(III) decreases with the increase in pH and mass–volume ratio. With the increase in the initial Sb(III) concentration,Qeshowed a rapid increasing trend in the range of 50–100 mg/L and continued to rise with the extension of contact time (t), reaching the maximum value at 3540 min. Under the optimal conditions of pH = 3,m/v= 1.0 g/L, andC0= 20 mg/L, the removal efficiency (Re) value is 95.07%, which is still approximately 86.8% after five adsorption–desorption cycles. The maximum adsorption capacity is 266.58 mg/g fitted by the Langmuir model. The adsorption mechanism is mainly related to the iron-based active site of Fe–O(OH), where the O–H on its surface undergoes ligand exchange with Sb(OH)3to form a stable Fe–O–Sb coordination structure. Additionally, C–OH, C–O, and other functional groups in ALCS also contribute to Sb adsorption. Fe-ALCS is an environmentally friendly, renewable, and convenient biomass adsorbent with good potential for wastewater treatment.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Lian-Jie Zhao,Jia-Ran Li,Yu Li,Li-Li Sun,Shao-Ni Sun,Xue-Fei Cao
The development of low-cost and high-performance water purification adsorbents has attracted increasingly attentions. In this work, corn stalk pith (CSP) and chitosan rich in amino groups were treated with ZnBr 2 ·4H 2 O to prepare lignocellulosic aerogels (LAs) and lignocellulose-chitosan composite aerogels (LCAs) for wastewater treatment. The effects of the ZnBr 2 ·4H 2 O treatment time and the addition of chitosan on the structure and adsorption performance of the aerogels were evaluated. The results showed that the lignocellulosic aerogel LA 15 had a three-dimensional porous structure and the optimal adsorption capacity of which reached 489.4 mg/g for Congo red. After the addition of chitosan, the adsorption performance and the adsorption behavior of LCA 10 for Congo red were evaluated in detail. The maximum adsorption capacity of the prepared LCA 10 for Congo red was up to 641.5 mg/g, which was 31 % higher than that of LA 15 . Adsorption kinetics suggested that the adsorption of Congo red on LCA 10 followed the pseudo-second-order kinetic and the Langmuir isotherm model, indicating that the adsorption was dominated by chemical adsorption and the adsorption of Congo red was mainly occurred on the surfaces of LCA 10 . This study provides a simple method for preparing high-performance dye adsorbents under mild conditions.
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高影响因子
Chemistry-An Asian Journal
·
2013
·Vol. 9
·期 1
·319-327
·
IF 4.572
Xiaoxi Hu,Yun Wang,Bo Peng
Graphical Doff my cap : pH-Responsive chitosan-capped mesoporous silica nanoparticles were synthesized by using a facile strategy and served as nanocapsules for site-specific drug loading and release. Herein, we present a straightforward synthesis of pH-responsive chitosan-capped mesoporous silica nanoparticles (MSNs). These MCM-41-type MSNs could be used as nanocapsules to accommodate guest molecules. Subsequently, (3-glycidyloxypropyl)trimethoxysilane was grafted onto the surface of the MSNs, which served as a bridge to link between MSNs and chitosan, which is ubiquitous in nature and commercially available. Owing to the pH-responsive and biocompatible features of chitosan, the loading and release of an anti-cancer drug, doxorubicin hydrochloride, were carried out in vitro, in which the composite chitosan-capped MSNs (CS-MSNs) showed excellent environmental response. As the pH value of the media decreased, the degree of drug release correspondingly increased. Moreover, thanks to the perfect biocompatibility of chitosan, the CS-MSNs exhibited lower cytotoxicity than that of the naked MSNs in an MTT assay. In addition, the in vitro kill potency against MCF-7 breast-cancer cells was enhanced over time, as well as with increasing concentration of the drug-loaded CS-MSNs. These results indicate that CS-MSNs are promising candidates for pH-responsive drug delivery in cancer therapy.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2018
·
IF 6.735
Jinxin Liu,Runrun Wu,Runxin Gu,Fengxian Qiu,Jianming Pan
Fabrication of chitosan-based composites without tedious procedures and significant biological hazard arising from using glutaraldehyde in the Schiff base reaction is highly needed. An environmentally friendly chitosan tablet is fabricated using Fe 3+ -mediated chitosan complexes via metallo-supramolecular chemistry. The structural properties of the material were investigated by SEM, FTIR, Raman and XRD, and the results indicated that Fe 3+ could chelate with chitosan via a “hide-and-seek” strategy to form well crosslinked polymer network. Moreover, the swelling behavior of the chitosan tablet showed that maximum swell ability achieved at pH 7.4. In addition, the chitosan tablet displayed pH-stimulated release properties, and its construct (i.e. chitosan-Fe 3+ complexes) was released efficiently at pH 1.0. Furthermore, the cytotoxicity experiments confirmed that chitosan tablet was compatible with human cell. Based on these results, we demonstrate here that the obtained chitosan tablet would be an oral iron supplementation potentially for treatment of iron deficiency anemia (IDA).
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
·
IF 8.025
Xinxian Dai,Si Li,Shuhan Li,Keqin Ke,Jie Pang,Chunhua Wu,Zhiming Yan
In this study, chitosan (CS) film containing covalent organic frameworks (COFs) immobilized silver nanoparticles (AgNPs) were developed for food packaging with improved antibacterial activities and film properties. COFs-AgNPs were fabricated via in-situ synthesis of immobilizing AgNPs on COFs. Transmission electron microscope, Zeta potential, X-ray diffraction, element mapping and Fourier transform infrared spectroscopy confirmed the successful fabrication of COFs-AgNPs, and COFs-AgNPs showed superior antibacterial activity against S. aureus and E. coli . Furthermore, the as-prepared COFs-AgNPs composite was further used to fabricate CS composite films (CS/COFs-AgNPs) by a solution casting method. The findings showed that the tensile strength of the nanocomposite films enhanced dramatically with the increase of the COFs-AgNPs content, while the UV–visible light barrier property, water swelling and solubility properties, and water vapor permeability (WVP) decreased significantly. Not only that, the CS/COFs-AgNPs nanocomposite films also showed outstanding antibacterial activity and effectively prolonged the storage time of white crucian carp ( Carassius auratus ). As a result, CS/COFs-AgNPs nanocomposite films show great potential in active food packaging.
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2022
·Vol. 46
·期 48
·23386-23393
·
IF 3.925
Zhongmin Feng,Chuanyu Zhu,Yupu Meng,Zhuqing Wang
Poly(m-phenylenediamine) has a wide range of applications in adsorption due to its high amino content; however, its nanoparticles tend to aggregate in water and are not easily separated from aqueous solutions. In this research, a soft and easily separable adsorbent material was successfully prepared by cross-linking poly(m-phenylenediamine) and chitosan through hydrogen bonding. Experimental results showed that the prepared chitosan and poly(m-phenylenediamine) hybrid membrane (CS/PmPD) could selectively reduce Au(III) from a mixture of multiple metal ions (Cu2+, Zn2+, Ni2+, Cd2+, and Au(III)). The maximum treatment capacity of Au(III) reached 410 mg g−1 under optimal adsorption conditions (pH = 3.0 and adsorption time of 120 min). The CS/PmPD membrane can be regnerated after rinsing with sodium bisulfite solution, and its performance remains stable after multiple cycles. In addition, the membrane has achieved satisfactory results in treating the actual CPU gold-containing leachate. Therefore, the CS/PmPD membrane has a promising application in gold recovery from electronic wastes.
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MATERIALS & DESIGN
·
2019
·
IF 5.77
Pengbo Sun,Lijing Zhang,Shengyang Tao
The processing method of natural polymers is one of the critical factors affecting their application. As commonly used biomass, chitosan was usually shaped by a wet chemical method which dissolves chitosan in a solvent and then fabricated into the membrane, fiber or other forms. This process often needs a large number of solvents and acids, which are harmful to the environment. In this paper, we mixed chitosan powder and thermoplastic polyurethane to form membrane by selective laser sintering. This method has advantages of simple operation, fast membrane formation, and low preparation cost. No solvents were applied in the whole progress. The hybrid membrane had an adsorption performance for heavy metal ions, the maximum adsorption capacities to Cu(II) and Pb(II) reached 19.6 mg g −1 and 30.4 mg g −1 , respectively. Palladium ions could also be adsorbed by the membrane to form palladium-loaded composite materials, which could be used as a catalyst for reducing p-nitrophenol, and the conversion rate could reach 96% in 20 min.
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高影响因子
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