INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2024
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IF 3.8
Chuangye Wang,Jintang Xue,Ruixue Sun,Xinrong Song,Xinyi Zhang,Xufeng Lin,Longli Zhang
The purpose of this paper is to report an efficient templating synthesis of hierarchically porous SAPO-11 molecular sieves. Poly(vinyl alcohol) was phosphorylated to get different phosphorus contents, and those designedly modified polymers were employed as mesoporous template in the hydrothermal synthesis of SAPO-11. Consequently, the prepared hierarchical molecular sieves exhibited higher BET areas, regular mesopore structures, and better acidity than their conventional counterpart. The catalysts with SAPO-11s as support had improved catalytic conversion and selectivity in hydroisomerization of n-hexane. The templating mechanism of the designed mesoporogens as well as the effects of their phosphorus content on the properties of hierarchical SAPO-11 molecular sieves were well discussed. This work provides an effective approach to template intracrystal mesopores in hierarchical silicoaluminophosphate molecular sieves.
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Small Methods
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2025
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IF 9.1
Xinlong Liu,Yimeng Li,Xinhua Liu,Yangyang Huang,Fujun Wang,Jiafeng Li,Yuqi Guo,Xinyuan Zhu,Lijuan Zhu,Chuan Zhang
Plasmids are widely used gene vectors in gene therapy, yet their efficient delivery remains a major challenge for achieving optimal therapeutic outcomes. Recently, poly(β-amino esters) (PBAEs) have emerged as promising carriers for non-viral gene delivery due to their tunable structures and high delivery efficiency. Nonetheless, the cationic nature of PBAEs raises toxicity concerns, and their lack of tissue-specific targeting capability limits their clinical application. Herein, a novel PBAE for efficient plasmid delivery is constructed, which contains disulfide bonds in the backbone and N-acetylgalactosamine (GalNAc) moieties at the terminals (GalNAc-PBAEs). To address the potential reduction in nucleic acid condensing capacity caused by end-capping PBAE with GalNAc, the commonly used end-capping amines in conventional PBAE are employed as monomers to create GalNAc-PBAEs with tertiary amine side chains. Through side-chain screening, the optimized GalNAc-PBAE exhibits enhanced transfection efficiency, surpassing that of the conventional top-performing PBAE, C28-E7, and rivaling the commercial transfection reagent Lipo2000. Importantly, the GalNAc moieties enable the plasmid-PBAE polyplex to efficiently target the liver. In a mouse model with acute liver fibrosis, the efficient delivery and expression of a representative plasmid encoding HGF significantly mitigate liver fibrosis and improve liver function, demonstrating the potential of the designed PBAE in gene therapy.
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PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
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2025
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IF 4
Wei-Huan Xu,Meng-Yao Zhu,Zhi-Heng Xu,Xiao-Jie Li,Chao-Yang Peng,Xiao-Pei Fan,Yong-Qiang Li
The fall armyworm, Spodoptera frugiperda (J. E. Smith) is a notorious insect pest of poaceae and causes severe economic damage to major cereal crop. It has evolved with different levels of insecticide resistance. Insect cytosolic GSTs are a major class of detoxifying enzymes and have been implicated in metabolic resistance and protection against oxidative stress. In this study, an epsilon class GST ( SfGSTe9 ) was identified from S. frugiperda and its transcript levels were highest in the fat bodies, second instar and pupae. Furthermore, SfGSTe9 is upregulated after exposure to beta- cypermethrin, lambda -cyhalothrin, chlorpyrifos, and malathion. The kinetic analysis suggests the purified recombinant proteins exhibit CDNB conjugating activity, with the V max of 11.87 ± 0.25 μM·min −1 ·mg −1 protein and K m of 0.22 ± 0.01 mM. The peroxidase activity assays indicate that SfGSTe9 has antioxidant activity against both CHP and H 2 O 2. The inhibition assays infer that four types of insecticides have strong inhibition on the GST activity. In vitro metabolism assays with HPLC further suggest that SfGSTe9 could be able to deplete 11.2 %, 21.3 % and 19.3 % of beta- cypermethrin, lambda -cyhalothrin and chlorpyrifos within 2 h, respectively, with specific activity varying between 30 and 40 μM·min −1 ·mg −1 protein. However, no metabolites were identified in this case, indicating that SfGSTe9 probably involves in detoxification via binding and sequestration. 3D modeling and molecular docking analysis indicate that above three types of insecticide compounds fit nicely into the hydrophobic pocket in the active site of SfGSTe9 . Our results definitely demonstrate that SfGSTe9 of S. frugiperda plays pivotal role in insecticide detoxification and serves in defence against oxidative stress .
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CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Qiliang Zhu,Wenxuan Huang,Jianhua Shen,Haibo Jiang,Yihua Zhu,Chunzhong Li
Metal halide perovskite nanocrystals have garnered significant attention in the realm of photocatalytic CO 2 reduction in recent years owing to their remarkable reducing properties and high selectivity. However, the issue of low photocatalytic activity due to severe carrier recombination phenomena in perovskite has posed a significant challenge. To address this, a one-pot in-situ preparation strategy was employed to create a BiOBr/Bi-doped perovskite nanocrystal S-scheme heterojunction, resulting in a significant improvement in the CO 2 photoreduction performance. The heterojunction material exhibited a CO yield of 151.56 μmolg -1 h −1 , with a selectivity for CO of 93.6 %. The molar ratio of the components was modulated using an in-situ water aging strategy, yielding a photocatalyst performance that exceeded that of pure BiOBr. The synthesis strategy of one-step in-situ preparation of heterojunctions overcomes the problem of insufficient bonding caused by two-step methods. And various characterizations and DFT calculations strongly support the S-scheme mechanism of the photocatalyst. The active site effectively reduces the energy barrier for the transition from *COOH to *CO intermediate, thereby significantly improving photocatalytic activity.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2024
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IF 9.4
Ning Li,Jiafeng Ma,Wenlong Wang,Qing Chang,Lei Liu,Caihong Hao,Huinian Zhang,Huayang Zhang,Shengliang Hu,Shaobin Wang
The layered chalcogenide ZnIn 2 S 4 (ZIS) exhibits photo-stability and a tunable band gap but is limited in photocatalytic applications, such as hydrogen (H 2 ) production, due to rapid carrier recombination and slow charge separation. To overcome these limitations, we have synthesized a ternary MoS 2 /ZIS/graphene quantum dots (GQDs) heterojunction, wherein MoS 2 and GQDs are strategically attached to ZIS interlaced nanoflakes, enhancing light absorption across the 500–1500 nm range. This heterojunction benefits from dual S-scheme interfaces between MoS 2 -ZIS and ZIS-GQDs, establishing directed internal electric fields (IEFs). These IEFs accelerate the transfer of photoinduced electrons from the conduction bands of MoS 2 and GQDs to the valence band of ZIS, promoting rapid recombination with holes and facilitating efficient catalytic reactions with plentiful photoinduced electrons stemmed from the conduction band of ZIS. As a result, the photocatalytic H 2 production rate of the MoS 2 /ZIS/GQDs heterojunction is measured at 21.63 mmol h −1 g −1 , marking an increase of 36.7 times over pure ZIS. This research provides valuable insights into designing novel heterojunctions for improved charge separation and transfer for solar energy conversion applications.
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Journal of Materials Chemistry C
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2024
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IF 5.7
Sheng Ding,Wei Gan,Jun Guo,Ruixin Chen,Run Liu,Ziwei Zhao,Jianrou Li,Zhaoqi Sun,Miao Zhang
In this study, the S-scheme heterostructure photocatalyst of SnS2/TiO2 (denoted as ST) ultrathin nanosheet-nanorod arrays with high efficiency for the degradation of tetracycline hydrochloride (TC-HCl) was successfully prepared by a two-step hydrothermal method. By expanding the light absorption area and hindering the reorganization of light-generated e--h+ pairs, the binding of TiO2 to SnS2 prepared photocatalysts with highly efficient photocatalytic activity and long-term stability. The results showed that the optimized photocatalyst samples all contributed to the degradation efficiency of tetracycline hydrochloride within 90 min than the photocatalytic degradation of pure TiO2 (41.1%). Among them, the ST loaded with 30 mM SnS2 exhibited the highest photocatalytic degradation efficiency of TC-HCl (93.4%). The reaction rate constant K is 0.02597 min-1, and the transient photocurrent density of ST-30 was up to 34.35 A/cm2, which were 5.78 and 10.54 times higher than that of unmodified TiO2. At the same time, the effects of photocatalysts on the degradation efficiency of TC-HCl under different conditions (pH values, inorganic anions and antibiotic concentrations) were systematically investigated. The inhibition of the degradation efficiency of tetracycline hydrochloride by SnS2/TiO2 heterojunction with the addition of different free radical scavengers indicated that ·O2- and ·OH were the main active substances involved in the degradation process. In addition, two environmentally friendly degradation pathways were proposed based on the analysis of liquid chromatography-mass spectrometry (LC-MS) results and the toxicity assessment of various intermediates in the degradation process. Finally, the photocatalytic mechanism of SnS2/TiO2 heterojunctions was proposed based on the optical and electrochemical properties of the photocatalysts as shown in the tests. These results indicate that the synthesized S-scheme heterostructure photocatalyst SnS2/TiO2 can significantly improve the light trapping ability and reduce the photoelectron-hole complexation rate, which is a promising approach to enhance the degradation efficiency of photocatalysts.
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APPLIED SURFACE SCIENCE
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2024
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IF 6.3
Yiru Chen,Dongying Zhu,Shikai Xue,Haiyan Wang,Qiujun Lu,Guihua Ruan,Chenxi Zhao,Fuyou Du
Constructing heterogeneous photocatalysts to enhance the visible light absorption and photo-generated charge carrier separation for efficient degradation of organic pollutants in water samples remained a significant challenge. An S-scheme BiOCl/ZnCrZr-layered bimetallic oxide (LBMO) heterojunction was constructed by depositing BiOCl nanoparticles on ZnCrZr-LBMO. The characterization of material samples were by XRD, SEM, TEM, XPS, FTIR, UV–Vis-DRS, transient photocurrent response, and electrochemical impedance spectroscopy. The photocatalytic efficiency of BiOCl/ZnCrZr-LBMO heterojunction was obviously improved, about 3.95 and 1.68 folds higher than that of pristine BiOCl and ZnCrZr-LBMO, respectively. The fast separation and migration and the prolonged lifetime of photo-generated carriers in the BiOCl/ZnCrZr-LBMO heterojunction were validated by photoelectrochemical tests. The influence factors, versatility, and reusability of the heterojunction were also evaluated. Free radical scavenging test and ESR experiment revealed that ·O 2 – and h + active radicals were the dominant active radicals in the BPA degradation. Additionally, BPA degradation intermediates were detected by LC-MS, and the possible degradation pathway of BPA was deduced using density functional theory. This novel S-scheme model heterojunction was expected to provide new ideas for the study of the photocatalytic mechanism and the BPA removal.
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MATERIALS SCIENCE IN SEMICONDUCTOR PROCESSING
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2024
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IF 4.2
Min Yuan,Ke Huang,Dongqing Dai,Hongfei Yin,Wei Zhao,Yixin Jiang,Yahui Feng
The integration of heterogeneous photocatalysts has emerged as a promising approach to boost the effectiveness of photocatalytic reactions for hydrogen evolution. In this study, we explore the synergistic effects of Ti 3+ -TiO 2 /P-doped g-C 3 N 4 heterojunctions on the enhancement of visible light-induced hydrogen generation efficiency. The photocatalytic hydrogen evolution performance of the as-prepared TPCN100 (280.38 μmol g −1 h −1 ) surpasses that of pristine P-doped g-C 3 N 4 (34.89 μmol g −1 h −1 ) and Ti 3+ -TiO 2 (39.71 μmol g −1 h −1 ) by factors of 8.0 and 7.1 respectively. Through a comprehensive investigation of the structural, electronic, and photocatalytic properties, the underlying mechanisms accountable for the observed enhancement in efficiency within the heterojunction system were elucidated. Based on the in-situ X-ray photoelectron spectrometer (XPS) examination, measurement of band edge, and electron paramagnetic resonance (EPR) analysis, the S-scheme photocatalytic mechanism was proposed. The integration of Ti 3+ -TiO 2 and P-doped g-C 3 N 4 offers new insights into the design of advanced photocatalytic materials for sustainable energy applications.
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DYES AND PIGMENTS
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2024
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IF 4.1
Xiaochen Zhu,Haiyan Qi,Tao Jing,Jun Li,Ming Zhao,Jiayu Zhang,Chao Luo,Maoxia Ran
4-Hydroxybenzoic acid is one of the important metabolism biochemical markers of the urine in gastric cancer patients. In this work, a fluorescence sensor based on N,S-doped carbon dots conjugated molecular imprinting polymers (N,S-CDs@SiO 2 @MIPs) was prepared to detect4-hydroxybenzoic acid. The novel fluorescence sensor in response to 4-hydroxybenzoic acid ranged from 0 to 100 μmol/L, with a detection limit of 1.27 μmol/L. Furthermore, 4-hydroxybenzoic acid demonstrated strong fluorescence quenching capability on our fluorescence sensor, with the fluorescence quenching mechanism involving a combined effects of dynamic quenching and electron transfer. Lastly, the N,S-CDs@SiO 2 @MIPs were applied to analyze 4-hydroxybenzoic acid inhuman urine samples with high accuracy. The findings showed that N,S-CDs@SiO 2 @MIPs sensor might have high potential for effectively, selectively, accurately diagnosing gastric cancer patients.
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TOXICOLOGY
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2025
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IF 4.6
Hua Zhang,Fei Lin,Bo-Han Lin,Xiong-Lin Sun,Qing-Shui Zheng,Rui Gao,Yong Wei,Shao-Hao Chen,Xue-Yi Xue
Bisphenol S (BPS) is widely used in the production of food containers and children's toys and is known to have endocrine-disrupting effects linked to various cancers; however, its role in renal cell carcinoma (RCC) development remains unclear. This study investigates the mechanisms by which BPS may promote RCC progression. The effects of BPS on proliferation and migration were evaluated in HK-2 and 786-O cells using CCK-8, scratch, and Transwell assays. A LASSO regression model and functional analysis were employed to identify candidate genes involved in BPS-related renal cancer progression and to construct a prognostic model, which was validated using Kaplan-Meier and ROC curves. Additionally, the impact of BPS on epithelial-mesenchymal transition (EMT)-related markers was examined. Results showed that BPS did not significantly affect the proliferation of HK-2 and 786-O cells at concentrations of 0-10 μM but significantly enhanced cell migration and invasion, inducing EMT. The LASSO model identified nine key genes associated with BPS-related renal cancer progression, with WNT5A expression positively correlated with BPS concentration. Knockdown of WNT5A significantly inhibited BPS-induced migration of HK-2 and 786-O cells and disrupted the EMT process. These findings demonstrate that BPS promotes HK-2 and 786-O cell migration through the WNT5A-dependent EMT pathway, and inhibition of WNT5A expression can suppress this process. This study provides novel insights into the role of BPS in renal cancer progression and highlights potential therapeutic targets for RCC.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2024
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IF 8.1
Hongquan Fu,Jinhua Wang,Juan Zhang,Dan Liu,Hejun Gao,Yunwen Liao,Hao Yu
Though the different exposed crystal facets of cadmium sulfide (CdS) catalysts have been demonstrated to enhance their photocatalytic activity , the mechanism behind H 2 evolution on these diverse facets remains elusive. Here, we synthesized CdS photocatalysts with co-exposed (101) and (002) crystal facets, incorporating S vacancies via a hydrothermal method within the temperature range from 80 to 240 °C. The resulting CdS nanorods exhibited exposed (002) and (101) crystal facets, demonstrating abundant S vacancies, and showcased a notable photocatalytic hydrogen (H 2 ) evolution activity of 467.67 μmol g −1 ·h −1 —approximately 144 times higher than that of CdS nanoparticles . Both experimental results and density functional theory (DFT) calculations showed the significance of co-exposed (101) and (002) crystal facets as self-constructed crystal homojunctions on CdS, facilitating efficient spatial separation of photogenerated charges. Additionally, co-exposed (101) and (002) crystal facets with S vacancies, stemming from the mismatched lattice, were observed to enhance the adsorption of water (H 2 O) molecules. This, in turn, reduced the energy required for H 2 dissociative adsorption , providing thermodynamic advantages. The understanding of the synergistic effect between self-constructed (101) and (002) facet junctions and S vacancies on CdS for boosting photocatalytic H 2 evolution holds promise for expanding the applications of CdS-based materials in various photocatalytic processes.
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JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
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2024
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IF 11.2
Shuang Zhou,Da Wen,Wei Zhong,Jianjun Zhang,Yaorong Su,Aiyun Meng
The effective adsorption of oxygen (O 2 ) molecules over photocatalysts is a critical step in promoting the performance of photocatalytic H 2 O 2 production. However, g-C 3 N 4 usually features a Yeager-type (side-on) adsorption configuration of O 2 molecules, which causes the breaking of O–O bonds and severely hinders the H 2 O 2 production activity. Herein, we synthesized an oxygen-vacancy-rich TiO 2– x /g-C 3 N 4 step-scheme (S-scheme) heterojunction to regulate the oxygen adsorption configuration and improve the 2e – ORR selectivity of H 2 O 2 production. In-situ X-ray photoelectron spectroscopy (in-situ XPS) and density functional theory (DFT) calculations reveal that the S-scheme heterojunction is formed between TiO 2– x and g-C 3 N 4 . The difference between their Fermi levels leads to the electron flow from g-C 3 N 4 to TiO 2– x , which increases the electron-deficient sites in g-C 3 N 4 . As a result, the cleavage of O–O bonds on the surface of g-C 3 N 4 is avoided and the oxygen adsorption configuration is tuned from Yeager-type to Pauling-type (end-on). Consequently, the photocatalytic H 2 O 2 production rate is dramatically improved to 1780.3 μmol h –1 , which is about 5 times higher than that of pristine g-C 3 N 4 . This work paves a new way to tailor the oxygen adsorption configuration by rationally designing S-scheme heterojunction photocatalysts.
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