POLYMER BULLETIN
·
2026
·Vol. 83
·期 10
·549
·
IF 4.2
Du Jiajie,Chen Sixian,Ding Rui,Wang Yingpeng,Shi Qisong
Traditional rigid sensors often lack sufficient flexibility, while pure poly(vinylidene fluoride) (PVDF) piezoelectric materials suffer from limited β-phase content and suboptimal mechanical properties. To address these challenges, we synthesized WO₃@UiO-66-NH₂ heterojunction materials via a hydrothermal method and integrated them with electrospinning technology to fabricate flexible TPU/PVDF composite piezoelectric sensor films. Characterization and performance evaluation identified an optimal PVDF-to-TPU mass ratio of 8:2. Moreover, incorporation of 0.5 wt% WO₃@UiO-66-NH₂ yielded the highest β-phase content in PVDF, along with enhanced dielectric properties, energy storage density, and piezoelectric output. The resulting flexible piezoelectric sensor demonstrates a sensitivity of 1.87 V/N, with response and recovery times of 40 ms and 140 ms, respectively. It reliably monitors diverse human activities and physiological signals, including wrist and knee joint flexion, vocalization, swallowing, respiration, and grasping. Combining excellent flexibility, high sensitivity, and rapid response, this sensor shows considerable promise for applications in human health monitoring and motion detection.
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npj Materials Degradation
·
2026
·
IF 7.5
Xue Hanzhe,Guo Wenxi
With the rapid development of renewable energy technologies, droplet electricity generators (DEGs) have emerged as a promising approach to harvest low-frequency and random mechanical energy from falling droplets. However, conventional triboelectric PDMS suffers from a low dielectric constant and charge leakage, limiting charge storage, separation, and output performance. Inspired by the skin structure of planthoppers, we develop a self-powered biomimetic pyramidal-structured DEG based on a fluorinated TiO 2 nanoparticle-decorated pyramid-structured PDMS film (F-TiO 2 @P-PDMS). The resulting micro/nano hierarchical superhydrophobic film exhibits an increased dielectric constant and enhanced electrical output compared with pure PDMS. The device maintains stable performance under both low- and high-frequency droplet impacts. When integrated into a self-powered cathodic protection system, it shifts the corrosion potential of 304 stainless steel from −180 to −390 mV, demonstrating effective corrosion protection. This work offers a strategy for efficient droplet energy harvesting and green anticorrosion applications.
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Advanced Biotechnology
·
2026
·Vol. 4
·期 2
·14
·
IF 8.8
Huang X,Jia Q,Li G,Yang X,Xu S,Liu J,Li W,Liu Y,Xie W,Cao L.
Enzymatic depolymerization of polyethylene terephthalate (PET), the world's most widely used polyester, in seawater at ambient temperature offers a promising and energy-efficient route for freshwater-free plastic recycling. While a number of PET hydrolases have been reported in recent years, their potential under saline conditions remains largely unexplored. Here, we screened eight enzymes in artificial seawater at 30 °C and engineered the most active one, IsPETase, using a semi-rational strategy focused on rigidifying flexible sites. The resulting variant M8 showed simultaneous enhancementsin thermostability (ΔT m = + 27.3 °C), activity (1.14-fold increase) and soluble expression yield (14.3-fold increase). The overall depolymerization efficiency of M8 surpassed that of the thermostable benchmark enzymes DuraPETase and LCC-ICCG by 32.2- and 10.4-fold, respectively. Notably, M8 achieved continuous and efficient depolymerization of 15% (w/v) PET powder in natural seawater at 37 °C, yielding monomers at a rate of 15.4 mM/day, a concentration sufficient to support downstream bacterial assimilation. This work provides an efficient enzymatic platform and paves the way for fully integrated, seawater-based plastic bioconversion processes.
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Scientific Reports
·
2026
·
IF 4.9
Liu Wenjing,Cong He,Wang Xin,Jiao Yawen,Meng Rui,Liu Shan,Zhang Kaijin
The distinct conditions of the marine habitat drive microorganisms to synthesize exopolysaccharides possessing unique structural features and a broad spectrum of bioactive properties. An extracellular polysaccharide (AVP1) was obtained from the fermented liquid of a marine Aspergillus versicolor CS13 from the Yellow River Delta sediment. AVP1 was characterized as a mannogalactan with a molecular weight of approximately 16.2 kDa and a mannose-to-galactose molar ratio of 1.0: 2.4. The polysaccharide AVP1 was constituted by a backbone of →2)-α- d -Man p -(1→ and →5)-β- d -Gal f -(1→ units, and branch at C-6 of →5)-β- d -Gal f -(1→ units. The side chains contained →6)-α- d -Man p -(1→ and α- d -Man p -(1→ units. AVP1 possessed an obvious α‑amylase inhibitory activity in vitro. AVP1 significantly enhanced insulin sensitivity and glucose consumption in insulin-resistant (IR)-HepG2 cells, and alleviated sodium palmitate (PA)-induced insulin resistance. Moreover, AVP1 effectively reduced total cholesterol (TC) and triglyceride (TG) levels, while increased the activities of superoxide dismutase (SOD), catalase (CAT) and reduced glutathione (GSH). It also decreased malondialdehyde (MDA) content and reactive oxygen species (ROS) levels, thereby improved lipid metabolism and mitigated oxidative stress in IR-HepG2 cells. These results demonstrated that AVP1 exhibited notable restorative effects in IR-HepG2 cells and possessed strong activity to alleviate insulin resistance in vitro. This study provides a basis for the development of novel marine-derived hypoglycemic agents.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·
IF 15
Decai Wang,Tong Zhou,Yalan Cui,Chen Bao,Shuaiqi Yuan,Chengchen Wu,Qian Liu,Chao Liu,Jiannan Hu,Mingrong Liu,Ziling Li,Xinyue Ma,Yunfei Zhu,Jingjing Sun,Shuyun Xu,Yuzhou Wu
The persistent opening of the mitochondrial permeability transition pore (mPTP) plays a critical role in bronchial asthma pathogenesis. The ATP synthase c subunit (c subunit) constitutes a core component of mPTP. A novel c subunit inhibitor, 1,3,8-triazaspiro [4.5] decane derivatives (PP10), effectively suppresses pathological mPTP opening without impairing ATP synthesis. Although intraperitoneal PP10 administration mitigates airway inflammation in asthmatic mice, its hydrophobicity hinders inhaled delivery to airway epithelial mitochondria, requiring penetration of the mucus layer, cell membrane, and mitochondrial outer membrane. To overcome this, we developed inhalable human serum albumin-triphenylphosphine-polyethylene glycol-PP10 nanoparticles (HSA-TPP-PEG-PP10 NPs). These NPs demonstrated efficient mucus penetration, high drug loading, mitochondria-targeting capability, and biosafety. They suppressed house dust mite/lipopolysaccharide (HDM/LPS)-induced mPTP opening, inhibited the mitochondrial DNA (mtDNA)-cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway, reduced inflammation in human bronchial epithelial (HBE) cells, and alleviated airway inflammation in asthmatic mice upon inhalation.
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CELL DEATH AND DIFFERENTIATION
·
2026
·
IF 13.6
Luan Jing,He Jiyuan,Wu Dantong,Duan Yaning,Hou Guoyuan,Ma Shuang,Qin Jianhua,Sun Na,He Yuanzheng,Zhang Wei,Gao Minghui
Ferroptosis is a type of regulated necrosis driven by iron-dependent lethal accumulation of lipid peroxides. Selenoprotein thioredoxin reductase (TrxR) plays crucial roles in cellular redox homeostasis. However, its role in ferroptosis remains unclear. Here, we report TrxR1 positively regulates ferroptosis. The selenocysteine of TrxR1 is required for its regulation of ferroptosis. Mechanistically, the CRL4A CRBN E3 complex ubiquitinates KEAP1 at K84 and K312, driving KEAP1 degradation. Overexpression of TrxR1 increases KEAP1 stability by suppressing CRL4A CRBN E3 complex mediated KEAP1 ubiquitination and degradation, enhances the interaction between NRF2 and KEAP1, promotes NRF2 ubiquitination and drives NRF2 degradation, which results in downregulation of GPX4 expression, thereby sensitizing cells to ferroptosis. Furthermore, high level of TrxR1 sensitizes cancer cells to ferroptosis in vivo. CRBN inhibitor thalidomide and IKE combination treatment results in markedly retarded tumor progression. Our study reveals a crucial pro-ferroptotic role for TrxR1 and nominates it as a potential biomarker for guiding future ferroptosis-inducing therapies in select cancers.
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Nature Communications
·
2026
·
IF 18.1
Yang Sixie,Chang Bo,Wang Chang,Wang Yigang,Wen Zhang,Liu Yiwen,Zhou Haoshen,He Ping
The global shift to renewable energy has intensified demand for lithium-ion batteries. Conventional lithium sources and extraction methods—such as brine evaporation and ore roasting—are time- and resource-intensive, geographically constrained, and environmentally damaging, underscoring the need for more sustainable resources and extraction strategies. Here we report an electrodialysis-based approach for direct lithium carbonate extraction from seawater, using ambient carbon dioxide as the carbon source. The method integrates a solid-state lithium-conducting membrane with Li–air chemistry, enabling lithium enrichment and carbonate formation in a single step without added precipitants. The Li–air configuration imparts intrinsic ion selectivity via thermodynamically driven displacement reactions. Experimental results confirm the production of lithium carbonate (93.8% purity) with an applied voltage below 2 V, while reducing chemical input and energy consumption compared to conventional processes. This work has the potential to provide a low-impact route for accessing lithium resources and contributes to the sustainability of future battery supply chains.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2026
·Vol. 37
·期 18
·1392
·
IF 3.2
Liu Fangyu,Gui Kaixuan,Zheng Yuhao,Dong Shun
The development of high-performance microwave-absorbing materials from renewable resources is a crucial pathway toward achieving green electromagnetic protection. In this work, biomass-derived porous carbon with a terrace-like pore structure was successfully fabricated from potato via a synergistic pyrolysis-chemical activation strategy. The influence of KOH concentration on microstructural evolution and microwave absorption performance was systematically investigated. The results demonstrate that at an optimal KOH concentration of 2 mol/L, the material exhibits a honeycomb-like architecture composed of terrace‑like pores, exhibiting excellent microwave absorption performance: a minimum reflection loss of −64.97 dB at a matching thickness of 2.1 mm and an effective absorption bandwidth of 6.82 GHz (11.18–18.00 GHz) at a thickness of 2.53 mm. The excellent performance originates from the synergistic effects of conductive loss provided by the terrace-like conductive network, polarization relaxation loss induced by multi-level interfaces and broadband impedance matching enabled by the gradient pore structure. This study offers a feasible preparation strategy and theoretical support for synthesizing lightweight, high-efficiency and broadband microwave-absorbing materials from agricultural waste.
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International Journal of Minerals Metallurgy and Materials
·
2026
·Vol. 33
·期 6
·1870-1885
·
IF 8.8
He Baili,Kou Jue,Sun Chunbao,Li Yue,Li Xiaolin,Temirov Uktam,Chang Ziyong
The development of effective adsorbents is crucial for the sustainable recovery of noble metals from secondary resources. In this study, MIL-101(Cr)-Tu, a Cr-based metal–organic framework (MOF) modified with thiourea, was successfully prepared by double-phase encapsulation followed by post-synthetic modification. At 298 K, the largest adsorption capacities of Au(III), Pd(II), and Pt(IV) by MIL-101(Cr)-Tu were (1230.83 ± 8.72), (330.41 ± 7.29), and (315.58 ± 13.67) mg·g −1 , respectively. The uptakes of Au(III), Pd(II), and Pt(IV) increased with temperature. The adsorption data fit well to both the Langmuir and pseudo-second-order kinetic models, indicating that the adsorption process conformed to monolayer adsorption and chemisorption. Mechanistic analysis revealed that the amino and thiourea groups facilitated the adsorption of noble metals through coordination and electrostatic attraction. Notably, Au(III), Pd(II), and Pt(IV) interacted strongly with the thiourea groups owing to their “soft–soft” interactions. Moreover, Au(III) was reduced to Au(I) and Au(0), Pt(IV) was reduced to Pt(II), and the amino groups were oxidized to NO 2 . The adsorption of Pd(II) did not involve redox reactions. Additionally, MIL-101(Cr)-Tu exhibited strong selectivity for noble metals and excellent reusability, demonstrating its great potential for the extraction of noble metals from secondary resources.
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Cell Death Discovery
·
2026
·
IF 10.4
Li Chengxun,Gu Dantong,Li Yingzhu,Wang Li,Yu Hongmeng
Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-driven malignancy, making the viral protein EBNA1 a pivotal therapeutic target. This study evaluates VK-2019, a clinical-stage EBNA1 inhibitor, for its potential to sensitize NPC cells to chemotherapy. We report that VK-2019 synergistically enhances gemcitabine efficacy, reducing the IC50 by nearly 30-fold in EBV-positive C666-1 cells. Transcriptomic profiling combined with in vitro and in vivo models reveals a distinct mechanism: VK-2019 inhibition of EBNA1 downregulates c-MYC, thereby derepressing its downstream target, Proline Dehydrogenase (PRODH). Furthermore, we demonstrate that gemcitabine independently upregulates PRODH via p53 pathway activation. This dual induction of PRODH drives enhanced anti-tumor cytotoxicity. These results provide a prominent preclinical rationale for evaluating VK-2019 in combination regimens and offer a potential therapeutic strategy for patients with EBV-associated nasopharyngeal carcinoma.
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Nano-Micro Letters
·
2026
·Vol. 18
·期 1
·415
·
IF 38.5
Zhang Donghao,Wang Xiaodan,Pan Na,Fan Wenxin,Sui Kunyan
The diffusion-complexation strategy enabled the synchronous construction of both an in-plane oriented MXene network and a longitudinal charge gradient structure within the hydrogel.
An advanced ionic skin with an integrated architecture has been developed, which exhibits exceptional electromagnetic interference shielding performance along with outstanding self-powered sensing capability.
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Journal of Inorganic and Organometallic Polymers and Materials
·
2026
·
IF 6
Wang Pengjie,Xu Hang,Liao Hean,Zhu Kefei,Zhang Xiaorui,Dai Qiran,Li Chenhao,Weng Ling,Feng Yu,Yue Dong,Liu Jialin
In this work, network regulation and reactive flame-retardant reinforcement were integrated by introducing BBA (2,2’-diallyl bisphenol A) and TAIC (triallyl isocyanurate) to tailor the ene/Diels-Alder, together with HECP (hexakis(4-allyl-2-methoxyphenoxy)cyclotriphosphazene) to build a copolymerized P-N cyclomatrix network via melt blending and staged curing. The flame-retardant action is mainly attributed to the synergism of phosphorus-promoted condensed-phase charring/barrier formation and nitrogen-assisted release of inert volatiles that dilute combustible pyrolysis species, thereby suppressing heat and mass transfer. At 3–4 wt% HECP, the resin achieved a flexural strength of 140 MPa and a T g of 179.4 °C, while the dielectric constant/loss decreased to 2.60/0.007 and the characteristic breakdown strength increased to 29.70 kV/mm. The flame-retardant performance was simultaneously improved, with LOI rising to 36.8%, UL-94 reaching V-0, and THR (Total Heat Release) decreased by 44.1% at 5 wt% HECP. Excessive HECP induced network heterogeneity due to self-ring-opening polymerization, leading to partial property regression. These results demonstrate a scalable route to multifunctional BMI insulating matrices for high-reliability electronic packaging.
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