JOURNAL OF CHROMATOGRAPHY A
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2012
·
IF 4.531
Lin-feng Zhou,Xu-gan He,Jun-qin Qiao,Hong-zhen Lian,Xin Ge,Hong-yuan Chen
A simple and facile needle-adapter was designed for constructing manual on-line polymer monolith microextraction-high performance liquid chromatography (PMME-HPLC). A capillary poly(4-vinylpyridine- co -ethylene glycol dimethacrylate) [poly(VP- co -EGDMA)] monolith was prepared by in situ polymerization, using 4-vinylpyridine (VP) and ethylene glycol dimethacrylate (EGDMA) as functional monomer and cross-linker, respectively. The synthesized monolith was used as the extraction medium for concentrating four EPA priority pollutants, 2-chlorophenol, 2,4-dichlorophenol, 2,4,6-trichlorophenol and pentachlorophenol, from water samples. The effect of the dosage of porogen polyethylene glycol 6000 (PEG) on back pressure and extraction performance of the capillary monolith was also investigated. Moreover, the influences of several parameters (such as extraction time, desorption time, content of MeOH in sample solution and sample pH) were examined to obtain the optimal PMME conditions. As a result, the established on-line PMME-HPLC protocol, with good extraction efficiency (80.6–91.7%), satisfactory recovery (94.7–106% and 76.8–86.3% for water and serum samples, respectively) and low detection limit (0.3–1.4 μg/L), exhibited potential applicability for the analysis of chlorophenols in environmental and biological samples.
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高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2022
·
IF 4.326
Bingxue Huang,Yi Zhou,Lingfei Wei,Rui Hu,Ximu Zhang,Phil Coates,Farshid Sefat,Wei Zhang,Canhui Lu
Continuous liquid interface production (CLIP) has been regarded as a revolutionary three-dimensional (3D) printing technology capable of continuously creating complex structures with both high resolution and fast speed. However, it highly relies on the UV light source, which is costly and not applicable for some end uses. Herein, a novel photocurable ink containing biocompatible poly(ethylene glycol) diacrylate (PEGDA) and graphene oxide (GO) was demonstrated in successful CLIP 3D printing with a cheap visible light source. GO not only works as a photoabsorber for significant enhancement of visible light absorbance to realize high-resolution CLIP printing but also reinforces the polymer matrix to achieve high mechanical properties of the final products. Of note, the CLIP-printed microlattices with a microtexture as thin as 100 μm exhibited fantastic superelastic features coupled with outstanding mechanical performance. Remarkably, the microlattice prints with custom geometries could survive from 90% compressive strain, indicating their stunning superelasticity.
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高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2022
·
IF 3.119
Yingmin Yu,Xiaocheng Zhang,Lingxiao Yi,Min Li,Fangyu Zhang,Jiajun Wei
Liquid–liquid equilibrium (LLE) data of ternary systems {2-ethyl-1-hexanol + ethylene glycol + water/n-heptane} were measured at 298.2, 308.2, and 318.2 K under 101.3 kPa. The distribution coefficient (D) and selectivity coefficient (S) of the systems were calculated to analyze the extraction ability of the two extractants that separate 2-ethyl-1-hexanol and ethylene glycol. Meanwhile, the NRTL and UNIQUAC activity coefficient models were used to correlate the experimental data and the different model parameters were obtained by data regression. The root-mean-square deviation (RMSD) between the calculated and experimental values was less than 0.96%, indicating that both models have a reasonable correlation with the experimental data of the ternary system and can accurately predict the experimental data. GUI-MATLAB has validated the binary interaction parameters.
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高影响因子
ACS Omega
·
2021
·
IF 3.512
Jun Yu,Jiezhen Liang,Xiaopeng Chen,Linlin Wang,Xiaojie Wei,Youqi Li,Yanmin Qin
Nickel and tungsten, combined with copper, were incorporated into a magnesium aluminum spinel to form a multifunctional catalyst (Ni–W–Cu/MgAl2O4). Characterization results suggested that the adjacent Cu not only facilitated the reduction of W6+ to W5+ with substantial oxygen vacancies but also promoted the reducibility of the Ni species. Besides, the incorporation of Ni, W, and Cu into the support enhanced the catalytic acidity, as well as the L acid sites. The catalyst exhibited a strong synergistic effect between the three metals and the support, resulting in higher catalytic activity for the one-pot hydrogenolysis of cellulose to ethylene glycol. High cellulose conversion (100%) and ethylene glycol yield (52.8%) were obtained, even under a low H2 pressure of 3 MPa.
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高影响因子
JOURNAL OF MOLECULAR LIQUIDS
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2016
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IF 2.74
Tianxiang Zhao,Xianshu Qiao,Qiang Xu,Xiaohong Xie,Xionghui Wei,Jianbin Zhang
Isothermal gas-liquid equilibrium (GLE) data were measured for dilute SO 2 in the binary system polyethylene glycol 600 (PEG) + H 2 O at T = 298.15 K and p = 122.66 kPa, in which SO 2 partial pressures were calculated in the range of (0 to 140) Pa. Based on the fitting GLE data, Henry’s law constants ( H x ) of dilute SO 2 in various PEG (1) + H 2 O (2) mixtures were obtained. Meanwhile, densities, viscosities, and surface tension of the binary system PEG (1) + H 2 O (2) were also measured over the whole concentration range at T = (298.15 to 323.15) K. From density and viscosity data, the excess molar volumes ( V m E ) and viscosity deviations (Δ η ) were calculated. Based on kinematic viscosity data, the enthalpy of activation for viscous flow (Δ H *) and entropy of activation (Δ S *) for the viscous flow were also obtained. Additionally, the important intermolecular interaction among PEG, H 2 O and SO 2 were investigated using UV-Vis, FTIR, and 1 H NMR spectroscopic techniques. Spectral results showed that the interaction between PEG and H 2 O resulted from hydrogen bonding , and the interaction of PEG with SO 2 resulted from both the O → S charge-transfer interaction and intermolecular hydrogen bonding.
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高影响因子
Polymer Chemistry
·
2018
·Vol. 9
·期 33
·4343-4353
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IF 4.927
Yanyan Zhou,Lei Li,Wei Chen,Dian Li,Nianchen Zhou,Jinlin He,Peihong Ni,Zhengbiao Zhang,Xiulin Zhu
A tadpole-shaped amphiphilic copolymer containing cyclic hydrophobic poly(ε-caprolactone) (PCL) and two hydrophilic poly(ethylene glycol) (PEG) tails, PEG-b-(c-PCL)-b-PEG, was rationally designed and prepared by a combination of ring-opening polymerization (ROP), chain end modification and intermolecular Cu-catalyzed azide–alkyne cycloaddition (CuAAC) “click” reaction. Firstly, cyclic PCL with two pendent alkynyl groups (c-PCL-2alkynyl) was prepared via successive ROP, a bimolecular CuAAC “click” reaction and transformation of pendent hydroxyl groups to alkynyl groups. Subsequently, a tadpole-shaped amphiphilic copolymer PEG-b-(c-PCL)-b-PEG was fabricated by the CuAAC “click” reaction between c-PCL-2alkynyl and azido-terminated PEG (PEG-N3). For the comparison purpose, a linear triblock copolymer [PEG-b-(l-PCL)-b-PEG] and a 4-arm star copolymer (2PEG-b-2PCL) with comparable molecular weights and compositions were also synthesized. All these polymers were fully characterized by size exclusion chromatography (SEC), nuclear magnetic resonance (NMR) spectroscopy, Fourier transform infrared (FTIR) spectroscopy, and matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. In addition, the self-assembly behavior, drug loading capacity and in vitro cytotoxicity of the tadpole-shaped amphiphilic copolymer and its linear and 4-arm star analogues were preliminarily investigated. It was found that the assemblies of PEG-b-(c-PCL)-b-PEG showed a similar spherical morphology but a smaller size compared with those of PEG-b-(l-PCL)-b-PEG and 2PEG-b-2PCL. The in vitro cytotoxicities against L929 fibroblast cells and HeLa cells evaluated by MTT assays revealed that the copolymers, especially PEG-b-(c-PCL)-b-PEG and 2PEG-b-2PCL, exhibited favorable biocompatibility, which might be potentially used as nanoscale drug delivery systems.
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高影响因子
JOURNAL OF SOLUTION CHEMISTRY
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2022
·Vol. 52
·期 1
·91-104
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IF 2
Yu Yingmin,Yi Lingxiao,Wei Jiajun,Guo Hongyue,Li Min
The liquid–liquid equilibrium (LLE) data for ethylene glycol + 2-ethyl-1-hexanol + { n -hexane, 1-hexene, 2-propyl-1-heptanol, and isopropyl ether} were measured at 298.2 K under 101.3 kPa. The distribution constant ( D ) and selectivity ( S ) of 2-ethyl-1-hexanol in the systems were calculated to analyze the extraction ability of the four extractants. The Bachman and Othmer–Tobias equations were chosen to examine the experimental LLE data. The linear correlation coefficient R 2 is greater than 0.98, indicating that the linear fitting of the experimental data is good. The data were regressed by thermodynamic models NRTL and UNIQUAC. The deviation between experimental data and simulated data was calculated by the root mean square deviation (RMSD) and the absolute average deviation (AAD). The RMSD is less than 0.79% and the AAD is less than 0.46%. It indicates that the two models are suitable for the regression of the system.
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高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Yixun Zhang,Xin Zhou,Wenlian Zheng,Jianwei Chen,Qianfeng Xu,Zhenguo Liang,Hongli Zhang,Jundong Lin,Wenjie Xie,Yangjia Zhuo,Muqi Chen,Fen Zou,Biyan Wen,Zeheng Tan,Weide Zhong,Huikang Yang,Ronghua Yang
Melanoma is highly dependent on cellular metabolism, but current treatments show limited effectiveness. Despite the promising antitumor properties of curcumin, its clinical utility is limited by its poor bioavailability and potential systemic toxicity. To address these challenges, we formulated curcumin-loaded polyethylene glycol–polycaprolactone (PEG–PCL) nanoparticles, denoted as PEG–PCL@Cur. We employed omics technologies to investigate their impact on melanoma at the molecular level. In vitro studies revealed that PEG–PCL@Cur notably suppressed the growth, movement, and invasiveness of A375 melanoma cells in a dose-dependent manner. Untargeted metabolomics identified 347 metabolites that were significantly altered. A decrease in fumaric acid levels indicated the suppression of oxidative phosphorylation and a shift in metabolism. Proteomics further confirmed the downregulation of key mitochondrial proteins, such as SDHA, pointing to mitochondrial dysfunction. Mechanistically, PEG–PCL@Cur increased reactive oxygen species (ROS) production by raising NADH levels and inhibiting SDHA expression. This led to a reduction in the level of fumaric acid production and a disruption of the tricarboxylic acid (TCA) cycle. Additionally, PEG–PCL@Cur hindered the generation of inorganic phosphate (Pi), resulting in a decreased level of ATP production. These metabolic changes promoted apoptosis and enhanced melanoma cell death. In vivo, PEG–PCL@Cur significantly curtailed tumor growth in a melanoma xenograft model and displayed an enhanced biocompatibility. Histological analysis showed extensive tumor necrosis, diminished proliferation markers, and elevated levels of apoptosis indicators. Overall, our integrated metabolomic and proteomic approach highlights how PEG–PCL@Cur targets SDHA-mediated metabolic reprogramming and mitochondrial dysfunction. This discovery positions PEG–PCL@Cur as a promising nanoplatform for melanoma therapy and offers valuable insights into the development of targeted nanomedicines.
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高影响因子
RSC Advances
·
2014
·Vol. 4
·期 78
·41588-41596
·
IF 3.708
Lixin Yang,Xiuli Hu,Weiqi Wang,Shi Liu,Tingting Sun,Yubin Huang,Xiabin Jing,Zhigang Xie
Y-shaped amphiphilic block copolymers, (methoxy-poly(ethylene glycol))2-block-poly(L-glutamic acid) ((mPEG)2-PGA) and its precursor (methoxy-poly(ethylene glycol)2-block-poly(γ-benzyl-L-glutamate) ((mPEG)2-PBG), were prepared in three steps: (1) macroinitiator (methoxy-poly(ethylene glycol))2-NH2 ((mPEG)2-NH2) was synthesized by coupling two methoxy-poly(ethylene glycol)s with serinol and diisocyanate. (2) (mPEG)2-PBG was synthesized by ring opening polymerization of γ-benzyl-L-glutamate-N-carboxyanhydride initiated with the macroinitiator ((mPEG)2-NH2); (3) the protective benzyl groups in (mPEG)2-PBG were removed to obtain (mPEG)2-PGA. The properties of both (mPEG)2-PBG and (mPEG)2-PGA were characterized by 1H NMR, FT-IR, GPC, and DLS. In aqueous solution (mPEG)2-PBG tends to form more stable micelles compared to linear mPEG-PBG copolymer. The size of (mPEG)2-PBG decreases with increasing length of hydrophobic PBG in (mPEG)2-PBG. Paclitaxel and cisplatin were grafted onto (mPEG)2-PGA to form (mPEG)2-PGA-PTX (MPTX) with a grafting ratio of near 90% and (mPEG)2-PGA-Pt (MPt) conjugates with a loading efficacy of 15% (w/w). MPTX can greatly improve the solubility of PTX. Both conjugates can self-assemble into micelles with a mean diameter of about 50 nm and show enhanced anti-cancer activity against MCF-7, HeLa, and SMMC cell lines. The in vivo anticancer evaluation in mice shows MPt showed a desirable antitumor activity and allowed us to deduce the system toxicity. Therefore, both MPTX and MPt have a great potential as a polymer drug in cancer chemotherapy.
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高影响因子
Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Jingwen Ma,Ruiting Wang,Jinhao Liu,Ying Tian,Junbin Li
Electrocatalytic nitrate-to-ammonia reduction (NO 3 RR) offers a sustainable alternative to fossil-fuel-dependent Haber-Bosch processes. However, limited NH 3 yield and unsatisfactory faradaic efficiency hindered the development of NO 3 RR. Herein, a unique Ru/V o -NiCo 2 O 4 heterostructure is reported as an effective NO 3 RR catalyst, in which the NiCo 2 O 4 site preferentially adsorbs nitrate, while the Ru site provides active H species for the subsequent reduction process. Structural characterization reveals that enrichment of ruthenium on the surface of nickel-cobalt oxide catalysts by electrochemical deposition not only promotes the generation of abundant oxygen vacancies, but also promotes the charge redistribution and the formation of built-in electric field inside the catalysts, which improves the electrical conductivity as well as promotes the generation of a large number of active sites in the NO 3 RR and EGOR processes. Ru/V o -NiCo 2 O 4 exhibits excellent bifunctional catalytic activity for NO 3 RR and ethylene glycol oxidation reaction (EGOR). Specifically, in the electrocatalytic nitrate reduction for ammonia production, the Faraday efficiency reached up to 95.14 % with an ammonia yield of 17.20 mg h −1 cm −2 at - 0.3 V. The catalyst also performed well for the oxidation of ethylene glycol, with a voltage of only 0.469 V required to achieve a current density of 50 mA cm −2 . After continuous electrolysis for 12 h at a current density of 100 mA cm −2 , the formate Faraday efficiency reaches as high as 88 %. Moreover, utilization EGOR instead of OER to form NO 3 RR||EGOR full cell not only realize energy-saving NH 3 production, meanwhile achieving value-added formate product. For the constructed NO₃RR||EGOR full cell, its formate Faraday efficiency reaches up to 94 % after continuous electrolysis for 12 h at a current density of 100 mA cm −2 . This work provides a strategy to achieve highly efficient, energy-saving ammonia synthesis via rational design of bifunctional electrocatalysts and construction of a co-electrolysis system, which carries substantial significance for both energy and environmental sectors.
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高影响因子
Polymer Chemistry
·
2012
·Vol. 4
·期 5
·1430-1438
·
IF 5.321
Longlong Chang,Jinjian Liu,Jianhua Zhang,Liandong Deng,Anjie Dong
A novel pH-sensitive, amphiphilic and biodegradable copolymer brush, methoxy poly(ethylene glycol)-block-(polycaprolactone-graft-poly(methacrylic acid)) (mPEG-b-(PCL-g-PMAA)), was developed for NPs for the oral delivery of hydrophobic drugs. The copolymer brush was synthesized by combining ring-opening polymerization (ROP) and atom transfer radical polymerization (ATRP), followed by selective hydrolysis. The structure and composition of the copolymer and its precursors were characterized by 1H-NMR, FT-IR and GPC. The critical micelle concentrations (CMC) of mPEG-b-(PCL-g-PMAA) in aqueous medium were determined to be 6.8 × 10−4 and 9.6 × 10−4 mg mL−1. The copolymer could self-assemble into NPs in aqueous solution with an average size of 104–129 nm, determined by DLS. The morphology of the NPs was spherical, as observed by TEM. The zeta potentials of the NPs were about −25 mV, measured by zeta potential measurements. Ibuprofen (IBU), a poorly water-soluble drug, was chosen as the model drug and encapsulated into the core of the NPs via a nano-precipitation method. The drug loading content (DLC) of the NPs prepared from mPEG-b-(PCL-g-PMAA) reached about 13%, with a drug loading efficiency (DLE) of above 75%. The in vitro release behavior of IBU from the NPs was pH-dependent. Typically, at pH 3.0 (0.01 M), the cumulative release percentage of IBU was about 40% over 12 h, whereas at pH 7.4 (0.01 M), more than 95% was released within 12 h for NPs prepared from mPEG113-b-(PCL91-g-PMAA155). The MTT assay indicated that blank NPs prepared from mPEG-b-(PCL-g-PMAA) did not show significant toxicity against NCL-H460 cells. These results indicated that this new type of pH-dependent polymeric NPs prepared from mPEG-b-(PCL-g-PMAA) has great potential to be used as a drug carrier for the oral administration of hydrophobic drugs.
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高影响因子
JOURNAL OF CATALYSIS
·
2026
·
IF 6
Lin Wang,Yu-Xi Ni,Xin-Yu Peng,Yue Liu,Yu-Nan Yi,Yao-Yue Yang
Electrocatalytic ethylene glycol oxidation reaction (EGOR) is a sustainable technique for production of value-added C2 chemicals, but it suffers from the large dosage of noble metals and poor stability of electrocatalysts. Herein, we designed a PtPdCuSnBi multi-principal element alloy nanoparticles (PtPdCuSnBi MPEA NPs), the incorporation of Cu, Sn and Bi not only modulated electronic structure and coordination environment of Pt and Pd, but also enhanced the generation of active *OH ad species during EGOR, thus it exhibits superior EGOR performance with high mass activity ( 1 0 . 2 5 A m g − 1 N M ) and Faradaic efficiency of glycolate (∼95.1%) at 0.8 V vs. RHE, and enhanced catalytic stability. The in-situ electrochemical infrared reflection absorption spectroscopy (IRAS) results confirmed the C2 pathway and enhanced ability of EG-to-GA electroconversion on PtPdCuSnBi MPEA NPs. Further combined with the density functional theory (DFT) calculations, it is demonstrated that Pt and Pd exhibit significant electron-enrichment effect, and d -band center of Pt moves upward close to the Fermi level in MPEA structure, thus exhibiting a stronger adsorption of reaction intermediates to achieve a lower energy barrier of rate-determining step (*OCH 2 -CH 2 OH → *OHC-CH 2 OH). This study provides a new paradigm for rationally modulating the structure of Pt-group metals to fabricate low-cost electrocatalyts for electrocatalytic upgrading of EG and other small-molecule alcohols.
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危险品化学品经营许可证（带存储）