LANGMUIR
·
2018
·
IF 3.789
Xiaochong Li,Chuan Xie,Hesheng Xia,Zhanhua Wang
A pH- and ultrasound dual-responsive drug release pattern was successfully achieved using mesoporous silica nanoparticles (MSNs) coated with polydopamine (PDA). In this paper, the PDA shell on the MSN surface was obtained through oxidative self-polymerization under the alkaline condition. The morphology and structure of this composite nanoparticle were fully characterized by a series of analyses, such as infrared (IR), transmission electron microscopy, and thermogravimetric analysis. Doxorubicin hydrochloride (DOX)-loaded composite nanoparticles were used to study the performances of responsive drug storage/release behavior, and this kind of hybrid material displayed an apparent pH response in DOX releasing under the acidic condition. Beyond that, upon high-intensity focused ultrasound exposure, loaded DOX in composite nanoparticles was successfully triggered to release from pores because of the ultrasonic cavitation effect, and the DOX-releasing pattern could be optimized into a unique pulsatile fashion by switching the on/off status. From the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, it was observed that our blank nanoparticles showed no toxicity to HeLa cells, but DOX-loaded nanoparticles could inhibit the growth of tumor cells. Furthermore, these composite nanoparticles displayed an effective near-IR photothermal conversion capability with a relatively high conversion efficiency (∼37%). These as-desired drug delivery carriers might have a great potential for future cancer treatment that combine the chemotherapy and photothermal therapy.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Lingqi Deng,Ziqi Xu,Fang Wang,Jiaqi Liu
Natural polysaccharide polymer hydrogels have garnered significant attention in biomedical applications due to their exceptional biocompatibility and biodegradability. However, their practical utility is constrained by inherent limitations such as inadequate mechanical strength and poor toughness. These deficiencies often result in premature drug release and reduced functional longevity when applied in drug delivery systems. To address these challenges, the incorporation of self-healing systems based on dynamic covalent or non-covalent bonds has emerged as an effective solution. In this study, chitosan (CS) was first quaternized (marked as QCS) and then compounded with gelatin and polyacrylamide, using 5-fluorouracil (5-Fu) as the model drug. The Fe 3+ @ TA system, formed by adding Fe 3+ and TA, served as a redox initiator to enable free radical polymerization of acrylamide and shorten the preparation time of hydrogel. Ultimately, a smart hydrogel with an interpenetrating network structure was successfully prepared. By adjusting the concentrations of CS and TPP, the regulation of the microstructure and physicochemical properties of the hydrogel was achieved. The results showed that the hydrogel, as a candidate multifunctional dressing, possessed excellent tensile and compressive properties, self-healable capability, and appropriate repeatable adhesion performance. In vitro drug release and antimicrobial assays demonstrated that the hydrogel exhibits pH-responsive release characteristics and effective antimicrobial properties against Staphylococcus aureus and Escherichia coli . Comprehensive biocompatibility assessments, including cytotoxicity and hemolysis testing, confirmed the material's biological safety profile. These findings collectively establish the strong and flexible composite hydrogel as a promising platform with extensive potential for drug delivery applications.
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高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2026
·
IF 8.3
Yuanyuan Zhang,Xin Du,Xuechun Wang,Xuanzhi Li,Liuqing He,Jiahui Li,Xiaohu Wang
Microfluidic chip monitors 1.9 μL urine pH from 4.0 to 9.0. • Fiber-collimated optics and ML resist urine pigment, turbidity, hemolysis. • GBDT-LRGB model is optimized and verified with over 2000 groups of data. • 92.5% samples show pH residuals < 0.2, within clinical 0.5 deviation. • Adaptable for organ-on-a-chip, single-cell culture, and IVD devices. The demand for stable and accurate continuous pH monitoring of trace liquids in microfluidic chips keeps rising, yet existing methods fail to balance five core indicators: stability, accuracy, measurement range, anti-interference and low cost. This work constructs a microfluidic pH detection system via optimized optical layout, 3D microfluidic structure and machine learning. Fiber coupling and collimating lenses homogenize light inside the micro-cuvette. Combined with 3D mixing channels and matched indicators, GBDT and logarithmic RGB features realize stable pH detection (4.0–9.0) for liquid volumes as low as 1.9 μL. Models are trained with 1890 measurements obtained from 6 replicate measurements of 265 clinical urine samples and 50 simulated samples. In random testing, 92.5% of samples have residuals below 0.2 pH units, and all samples fell within the total allowable error (TEa) of 0.5 pH units for the dipstick method. The maximum SD obtained from the measurements was 0.066 in the 48 h continuous stability test. Under the experimentally tested conditions, the system tolerated urine yellow background up to G4, turbidity up to 200 NTU, mild hematuria/hemolysis up to R3, and variations in ionic strength down to 10 −6 . This method demonstrates potential for certain clinical urine pH testing applications and could be applicable to trace pH measurement in selected life science scenarios, including cell culture, organoid culture, continuous-flow microfluidics, and POCT. Download: Download high-res image (174KB) Download: Download full-size image The pH monitoring system for trace urine analysis in microfluidic chips
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2022
·Vol. 46
·期 10
·4724-4733
·
IF 3.925
Chaohua Li,Cong Chang,Xuelian Wang,Qingni Xu,Yuqi Chen,Yueli Zhang,Mengqi Yi,Yuyang Li,Bei Xiong,Bo Lu
The application of intelligent responsive nanoparticles in combination therapy has become an emerging issue in cancer therapeutics. In this work, we have constructed a dual-responsive targeted nanoparticle for multi-modal combination therapy (ICG/DOX@HMSNs-SS-NC-HA or simplified to ID@HMSNs-SNH). The chemotherapeutic doxorubicin (DOX) and the photosensitizer indocyanine green (ICG) are loaded into hollow mesoporous silica nanoparticles (HMSNs) by physical embedment. These HMSNs are coated with oxidized hyaluronic acid (OHA) by a pH-sensitive Schiff base bond and a redox-sensitive disulfide bond to prevent the drugs from leaking. They not only showed intelligent controlled drug release properties, but also can fully integrate photothermal/photodynamic therapy (PTT/PDT) to develop synergistic anti-tumor efficacy as confirmed by in vitro evaluations. Cell uptake experiments proved that they could selectively target tumor cells overexpressing CD44 receptors, thus reducing their uptake by normal cells. Moreover, cytotoxicity experiments displayed their satisfactory anti-tumor (HepG2) effect with an IC50 value of 0.09 μg mL−1. In conclusion, the obtained ID@HMSNs-SNH concurrently releases drugs that respond to a slightly acidic and reducing tumor microenvironment (TME), displaying great performances of chemotherapy with PTT/PDT in vitro for tumor ablation.
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RSC Advances
·
2015
·Vol. 5
·期 13
·9546-9555
·
IF 3.84
Zhe Lin,Jizhen Li,Hongyan He,Huihui Kuang,Xuesi Chen,Zhigang Xie,Xiabin Jing,Yubin Huang
A pH-sensitive drug release system using acetalated-dextran as valves was designed to manipulate smart intracellular release of anticancer drugs. Dextran was grafted onto the exterior of MSN through a click reaction, and followed by acetalation to generate the final carriers of MSN–Dex-Ac. The hydrophobic Dex-Ac would act as valves on the MSN surface to block the entrapped drugs inside the MSN pores. While under acidic conditions mimicking the micro-environment of endosomal/lysosomal compartments, the valves could be opened by acetal hydrolysis to recover the acetalated-dextran to its hydrophilic state, resulting in fast drug release. In vitro drug release profile clearly showed that DOX release was restricted at pH 7.4 by the valves, while it was accelerated under acidic conditions. Fast endocytosis and intracellular DOX release was observed by confocal laser scanning microscopy (CLSM). Cytotoxicity evaluation showed good biocompatibility with the carriers. In vitro MTT assays revealed that the DOX-loaded particles exhibited comparable antitumor activity with free DOX towards HeLa cells.
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高影响因子
RSC Advances
·
2016
·Vol. 6
·期 94
·91940-91948
·
IF 3.289
Haozhe He,Yanrong Ren,Zhanfeng Wang,Zhigang Xie
An effective strategy was developed to fabricate pH-responsive poly(ether amine) hollow nanoparticles for the controllable loading and release of anticancer drugs. The amphiphilic poly(ether amine) containing coumarin groups (gPEAC) was first synthesized, which was further modified with myristic acid to form comb-like poly(ether amine) (acPEAC). The nanoscale micelles formed by acPEAC in aqueous solution were cross-linked through the photo-dimerization of coumarin groups. Then hollow micelles were obtained by removing their hydrophobic cores of myristic ester. The anticancer drug doxorubicin (DOX) was directly loaded into the micelles without any organic solvent. The DOX-loaded micelles displayed desirable pH-sensitive release behaviours. Moreover, the hollow micelles exhibit great potential for loading drugs and controllable release, and drug-loaded micelles indicate comparable anticancer efficacy as free DOX. This work highlights the potential for the rational design of functional polymers as smart drug carriers.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2017
·
IF 5.401
Xin Zhang,Ke Jiang,Huajun He,Dan Yue,Dian Zhao,Yuanjing Cui,Yu Yang,Guodong Qian
A fluorescent pH sensor based on post-synthetically modified nanoscale UiO-67-bpydc by encapsulating Eu 3+ cations in the pores was fabricated. The Eu 3+ incorporated sample (Eu 3+ @UiO-67-bpydc) shows excellent luminescence due to the sensitization and protection provided by the parented framework. Subsequently, Eu 3+ @UiO-67-bpydc was developed as a pH sensor. Eu 3+ @UiO-67-bpydc shows good chemical resistance to both acidity and alkalinity solutions with pH ranging from 1.06 to 10.99, which makes it potentially useful for wide-range pH sensor. In addition, cycling experiments have demonstrated the utilizability of the sensor. The MTT analysis shows that Eu 3+ @UiO-67-bpydc possesses favourable biocompatibility. Furthermore, fluorescence imaging of Eu 3+ @UiO-67-bpydc in PC12 cells was also performed to test its feasibility in vivo. Given its exceptional stability and pH-dependent fluorescent intensity, the fluorescent probe should be a promising candidate for application in fluorescent pH sensing in vitro and in vivo.
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Soft Matter
·
2012
·Vol. 8
·期 23
·6364-6370
·
IF 4.39
Fenggui Chen,Chunliang Li,Xiaoyan Wang,Guangming Liu,Guangzhao Zhang
In the present study, by use of the atom transfer radical polymerization (ATRP) method, we have prepared well-defined 6-arm star-shaped poly[2-(dimethylamino)ethyl methacrylate] (PDEM) and poly(acrylic acid) (PAA) containing a fluorescent triphenylene core and have studied the pH and ion-species sensitive fluorescence properties of such two star polyelectrolytes. The results obtained by analytical ultracentrifugation indicate that the star PDEM molecules will aggregate together as the pH increases over the pKa but the star PAA molecules will keep a monomeric state over the whole pH range. For both PDEM and PAA, the fluorescence intensity decreases with increasing pH, indicating that the fluorescence intensities of PDEM and PAA are dominated by aggregation induced fluorescence quenching and the chain conformation controlled nonradiative relaxation, respectively. This suggestion is further confirmed by the fact that the star PDEM molecules can form excimers at high pHs and no excimer emission peak can be observed for the star PAA molecules. In the studies of ion-specific fluorescence properties at different pH, for both of the two polyelectrolytes, the ion specificity is determined by the counterion condensation for the charged chains, whereas nonelectrostatic ion adsorption governs the specific ion effect for the uncharged chains.
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ELECTROCHIMICA ACTA
·
2022
·
IF 7.336
Shuairu Zhu,Deyu Liu,LinZhe Lv,Jiabo Le,Yang Zhou,Jianming Li,Yongbo Kuang
Cheap, durable, and efficient oxygen evolution reaction (OER) catalysts applicable in near-neutral electrolytes are highly desired in various energy conversion applications for establishing carbon neutrality . However, it is very challenging for noble metal-free materials to be efficiently operated in such conditions, and the screening of new compounds has reached a bottleneck for this purpose. Herein, we show that significant stability enhancement can be achieved via novel interfacial interactions through rational integration of components, which opens up a new opportunity to meet this challenge. We realized a mixed oxides film of Co 3 O 4 and CoNb 2 O 6 with a unique heterogeneous architecture, where the Co 3 O 4 active site receives strong protection against dissolution from niobate phases via Coulombic interaction. Moreover, the cobalt niobate phase also promotes the overall charge transport, as suggested by the impedance study. As a result, the heterogeneous catalyst exhibits attractive stability and activities in neutral and even weak acidic electrolytes. This work indicates that the screening criteria of novel ternary oxides OER catalysts should not be limited to the intrinsic property of new phases, and that controlled phase separation can be a convenient tool and a new paradigm for future works.
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JOURNAL OF MOLECULAR LIQUIDS
·
2022
·
IF 6.633
Shengfeng Ye,Zhaolan Zhai,Shibin Shang,Zhanqian Song
Rosin-based surfactants exhibit unique superiority in self-assembly; however, pseudo-Gemini surfactants derived from rosin are rare. Herein, A new pH-responsive surfactant, N-decyl-maleimidepimaric acid N, N-dimethylenediamide (C 10 MPAN) was synthesized from rosin, and its structure was characterized by NMR and MS. Additionally, a novel pseudo-Gemini surfactant was prepared by mixing C 10 MPAN and maleic acid (MA) at a molar ratio of 2:1. Hydrogels at pH 5.35–5.00, viscoelastic solutions at pH 5.00–2.00, and hydrogels at pH ≤ 2.00 formed sequentially in the C 10 MPAN/MA aqueous solutions. The properties of these hydrogels and viscoelastic solutions were investigated using rheology, cryogenic transmission electron microscopy (cryo-TEM), differential scanning calorimetry (DSC), polarized optical microscopy (POM), and small-angle x-ray scattering (SAXS). The aggregates in the C 10 MPAN/MA aqueous solution underwent a transition from unilamellar vesicles to multilamellar vesicles, to wormlike micelles , and finally to enormous lamellar micelles as the pH was decreased from 5.35 to 1.00. The exponent between the zero-shear viscosity of the wormlike micelles and concentration reached 23.1. The sizes of the unilamellar vesicles at pH 5.35 varied from 10 to 100 nm, while those of the multilamellar vesicles at pH 5.00 reached 500 nm. Moreover, a Maltese crosses liquid crystal phase was formed by the lamellar micelles. 1 H NMR and surface tension methods were further used to investigate the aggregation mechanism induced by the pH. The large rigid skeleton of rosin acts as the backbone for the formation of diverse aggregates. This study shows the superior properties of rigid groups in the self-assembly of surfactants and provides a new insight for the applications of rosin.
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SURFACE & COATINGS TECHNOLOGY
·
2024
·
IF 5.3
Shurong Zheng,Guangyao Dai,Qimei Xue,Ruiqi Liang,Wancheng Zhu,Changhao Wang,Yashao Chen
Biodegradable magnesium alloy (MgA) is a promising candidate material for orthopedic implants due to its excellent biocompatibility and mechanical properties. However, its poor corrosion resistance, susceptibility to infection, and differences in mechanical properties with human tissues always hinder its application in biomedical fields. Therefore, the construction of MgA surface with good corrosion resistance, excellent antimicrobial properties, and suitable mechanical properties is highly desired for its clinical applications. Herein, we have designed micro/nano composited structures containing pH-responsive hydrogel micropatterns and inorganic nanomaterials onto the surface of MgA (MgA-MgO-HANRs-Micropatterns) to improve its biological activities. Firstly, a MgO film was prepared on the surface of MgA using micro-arc oxidation method. Then, hydroxyapatite nanorods (HANRs) were grown on the MgO film using microwave-assisted hydrothermal method. Further, using UV light and photomasking technique, 2-hydroxyethyl methacrylate (HEMA) and 2,2-dimethylacryloyloxy-1-ethoxypropane (DMAEP) were polymerized on the surface of HANRs with loading of antibacterial agent carvacrol to construct pH-responsive hydrogel-carvacrol micropatterns at different sizes. The hydrophilicity, antimicrobial, antifouling and biocompatibility of MgA-MgO-HANRs-Micropatterns are significantly enhanced in comparison with MgA. In bacterial infections and inflammatory environments at pH = 5.0, the micropatterned hydrogel coating releases carvacrol due to ketone bond cleavage, which enhances the antimicrobial capacity of the MgA samples. Compared with MgA, the corrosion current density of MgA-MgO-HANRs-5 μm is reduced by four orders of magnitude and could be maintained even immersing in the simulated body fluids for 30 days. In addition, the bactericidal rates of MgA-MgO-HANRs-5 μm against S. aureus and E. coli are 96 % and 89 %, respectively, and the sample shows long-term and stable antimicrobial performance with the ability to kill nearly 75 % of S. aureus and 82 % of E. coli after 14 days of immersion.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2024
·
IF 4.3
Zhe Li,Xiaohui Wang,Xiuli Fu,Jinhua Liu,Yuanan Liu,Hongxin Zhang
The pH and O 2 are the two important parameters to evaluate environmental conditions, healthcare, and industrial processes. Herein, we developed a ratiometric fluorescent capillary-based dual-functional sensor for simultaneous monitoring of pH and O 2 fluctuations. The fluorescent sensor consists of a pH sensing unit and an O 2 sensing unit on both ends of the capillary inner wall. The ratiometric fluorescent pH sensing unit includes pH-sensitive probe HPTS and the reference dye Ce6, while the O 2 sensing unit is composed of O 2 -sensitive probe RuDP and the reference dye C6. Under single-wavelength excitation at 430 nm, the ratiometric fluorescent dual-functional sensor exhibits highly sensitive, selective and reproducible responses to both pH and O 2 . As for practical aqueous samples, the results about pH and O 2 levels obtained by our sensor are considerable consistent with commercial devices. Meanwhile, the dynamic changes of pH and O 2 levels during glucose catalysis by glucose oxidase can be detected in real-time and accurately. The dual-functional ratiometric fluorescent capillary transducer provides a significant potential platform for environmental monitoring and medical diagnosis.
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