SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2019
·
IF 2.931
Jing Zou,Yixin Huang,Lirong Zhu,Zheng Cui,Baoling Yuan
A spectrophotometric method using 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonate) (ABTS) as the indicator was proposed for measuring persulfates, i.e., peroxymonosulfate (PMS) and peroxydisulfate (PDS). This method was based on the direct oxidation of the colorless ABTS by PMS/PDS to generate the green-colored ABTS + at neutral pH and room temperature . The generated ABTS + had four different characteristic absorption peaks at 820 nm, 732 nm, 650 nm and 415 nm. The absorption values at these wavelengths increased with the increase of PMS/PDS concentration, and there were well linear relationships (R 2 > 0.998) between the corresponding absorption values and the concentrations of PMS/PDS in the range of 3–500 μM. Monitoring the change of PMS/PDS concentration by the proposed ABTS method was in good agreement with that monitored by the common spectrophotometric method using potassium iodide as the indicator. The green-colored waste solutions produced after PMS/PDS analysis with the ABTS method showed no bactericidal effect towards Escherichia coli . The proposed multi-wavelength spectrophotometric method using ABTS as the indicator could be employed as a candidate method for the accurate and convenient measurement of PMS/PDS in water.
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高影响因子
Nano Research
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2019
·Vol. 12
·期 8
·1937-1942
·
IF 8.515
Sun Hongxia,Du Haoran,Yu Mengkang,Huang Kuangfu,Yu Nan,Geng Baoyou
Vesicular lithium vanadium phosphate/carbon hollow mesoporous microspheres were fabricated using a facile polyvinylpyrrolidone-assisted aerosol-spray-assisted method and subsequent heat-treatment. While changing the content of polyvinylpyrrolidone, we found that carbon content was adjustable on the surface of lithium vanadium phosphate. By optimizing the carbon content among the composites, the electrochemical performance can be enhanced significantly. The results of electrochemical performance tests suggested that the samples exhibited good cycle performance and high discharge capability in the voltages between 3.0–4.8 V. The observed excellent electrochemical performances could be attributed to the proper content of carbon coating and the vesicular hollow mesoporous microsphere structure, increasing the transmission rate of lithium ions and reducing the structural change during charging and discharging effectively.
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JOURNAL OF BIOTECHNOLOGY
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2019
·
IF 3.163
Xiao-Ling Tang,Nan-Nan Zhang,Guo-Yan Ye,Yu-Guo Zheng
( R )-3-amino-1-butanol is a key intermediate of Dolutegravir for the treatment of HIV/AIDS and its green and efficient biosynthesis has attracted a great deal of attention. Transaminases are currently used as promising biocatalyst for the synthesis of chiral amines. However, many transaminases have ( S )-specificity and ( R )-selective transaminases were less exploited and studied, making the production of ( R )-amines remain challenging. In this study, a novel transaminase from Actinobacteria sp. ( As -TA) was obtained and applied for the biosynthesis of ( R )-3-amino-1-butanol by transferring the amino group from isopropylamine to 4-hydroxy-2-butanone. After optimization of the reaction condition and using a substrate fed-batch strategy, the conversion of 100, 200, 300, 400 and 500 mM 4-hydroxy-2-butanone reached 100%, 94.9%, 86.1%, 76.1% and 70.9%, respectively. ( R )-3-amino-1-butanol with a maximum yield of 29.6 g/L and 99.9% e.e. value was obtained. This was the first time demonstrating the successful biosynthesis of ( R )-3-amino-1-butanol with transaminase as biocatalyst and the obtained As -TA enriched the enzyme pool of transaminase with ( R )-specificity.
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JOURNAL OF ETHNOPHARMACOLOGY
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2019
·
IF 3.414
Peter Yaro,Jing Nie,Mingcheng Xu,Kui Zeng,Houhong He,Jianbiao Yao,Ruwei Wang,Su Zeng
Ethnopharmacological relevance The major terpene lactones of ginkgo biloba extract (GBE) include ginkgolide A , B, C and bilobalide are used for the protection of cardiovascular, cerebrovascular and neurodegenerative diseases. Terpene lactones are orally bioavailable and predominantly eliminated via the renal pathway. However, information on the transporters involved in the pharmacokinetics (PK) and renal excretion of terpene lactones is limited. Aim of the study The objective of this study is to assess the role of OAT1/3 which are important transporters in the human kidney in the PK and renal excretion ginkgolide A, B, C and bilobalide. Materials and methods Uptake of ginkgolide A, B, C and bilobalide in Madin-Darby Canine Kidney (MDCK) and human embryonic kidney 293 (HEK293) cells overexpressing OAT1 or OAT3, respectively were studied. To verify the result from in vitro cell models, the studies on PK, kidney accumulation and urinary excretion of ginkgolide A, B, C and bilobalide were carried out in rats. Results The result showed that ginkgolide A, B, C and bilobalide are low-affinity substrates of OAT1/3. Following co-administration with probenecid , a typical inhibitor of OAT1/3, the rat plasma concentrations of ginkgolide A, B, C and bilobalide increased significantly. AUC showed a significant increase in the probenecid-treated rats compared to control rats (893.48 vs. 1123.85, 314.91 vs. 505.74, and 2724.97 vs. 3096.40 μg/L*h for ginkgolide A, B and bilobalide, respectively), while the clearance of these compounds significantly decreased. The accumulation of ginkgolide A, B and bilobalide in the kidney of the probenecid-treated rats was reduced by 1.8, 2.4, and 1.5-fold, respectively; further reducing the cumulative urinary recovery of these compounds. Conclusion The findings indicated that ginkgolide A, B and bilobalide are excreted via OAT1/3-mediated transport in the kidney and OAT1/3 inhibitor significantly influence the PK ginkgolides and bilobalide.
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高影响因子
HIGH PERFORMANCE POLYMERS
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2019
·
IF 1.584
Huabo Huang,Renpeng Chen,Shuaiyi Yang,Liang Li,Yulan Liu,Juan Huang
To obtain the promising pseudocapacitance of MnO2, the composite hydrogel of MnO2 and polyaniline (PANI) was fabricated using in situ polymerization of aniline hydrochloride in the aqueous solution containing commercial MnO2 nanoparticles and additives. Both scanning electron microscopy and transmission electron microscopy results indicated that the composite hydrogel exhibited a 3-D porous structure, within which MnO2 nanoparticles were uniformly embedded. The investigations of cyclic voltammetry, galvanostatic charge−discharge, and electrochemical impedance spectroscopy demonstrated superior supercapacitor (SC) performance of the hydrogel electrode even with high loading. The electrode with loading of 1.5 mg cm–2 showed a favorable specific capacitance (293 F g–1, 10 mV s–1), which only decreased to 258 F g–1 when the loading of the electrode was seven times higher (10.8 mg cm–2). Furthermore, the hydrogel electrode displayed good cycle stability in the acidic solution (81% capacitance retention after 1000 charge/discharge cycles). The favorable electrochemical performance of the composite hydrogel should be attributed to the fast electron/ion transport and good protection for MnO2 in the 3-D porous structure. Due to the facile one-pot synthesis and optimized nanostructure, it could be expected that MnO2-embedded 3-D porous PANI composite hydrogels have great application in the field of high-performance electrode with high loading for SCs.
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ULTRASONICS SONOCHEMISTRY
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2019
·
IF 7.279
Weijun Chen,Ruiling Lv,Aliyu Idris Muhammad,Mingming Guo,Tian Ding,Xingqian Ye,Donghong Liu
This study investigated the effect of glycation on the binding of whey protein isolate (WPI) with (−)-epigallocatechin-3-gallate (EGCG), and the physicochemical stability and bioaccessibility of the formed complex. The WPI-gum Acacia (GA) conjugate was prepared by ultrasound-assisted Maillard reaction. Results indicated that conjugated WPI showed stronger binding and entrapping ability to EGCG than that of WPI. The protein aggregation induced by EGCG was partly inhibited by glycosylation, presumably due to the steric hindrance of polysaccharide chains. The greatest protection of EGCG and its antioxidant activity were also obtained by complexing it with WPI-GA conjugate. The in vitro bioaccessibility analysis demonstrated that the bioaccessibility of EGCG cloud be significantly ( p < 0.05) enhanced by complexing it with WPI, especially WPI-GA conjugate. These findings are important to design promising and effective EGCG carriers for its wide application in food industry.
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CHEMISTRY-A EUROPEAN JOURNAL
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2018
·Vol. 24
·期 52
·13830-13838
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IF 5.16
Xiangming Li,Yihe Zhang,Zequn Ma,Meng Fu,Qi An
Graphical The heat is on : A facile and efficient approach for the preparation of pH responsive self-assembled (electrostatic interactions) rGO-polymer-DOX nanocomposites for photothermal and chemical therapy is reported (see figure). The development of well-controlled drug carriers that are stable and highly effective for the delivery of anticancer agents is challenging. Herein, we report a novel pH-controlled drug delivery system, utilizing reducing graphene oxide (rGO)-polymer self-assembly films as carriers, for the preparation of effective drug nanorods and nanoparticles. In this system, the rGO-polymer carriers were constructed by the alternating assembly of poly- l -lysine (PLL) and polyaspartic acid (PASP) around the rGO sheets. Furthermore, the rGO-polymer cores, which possess a positively charged surface as the desired template, could assemble with negatively charged doxorubicin (DOX) via electrostatic interactions. The DOX embedding efficiency and the morphology of the drug nanocomposites could be controlled by the number of rGO-polymer bilayers and concentration of the rGO-polymer bilayers and the initial DOX concentration. Importantly, the release of DOX could be regulated by controlling the pH and by using a NIR laser. Under acidic conditions, the interactions between the PASP layer and DOX molecules can be broken, resulting in gradual release of the DOX molecules. Upon NIR irradiation, the release of DOX could be further accelerated and a photothermal effect from rGO induced. Cellular uptake and cytotoxicity experiments indicate that the drug nanocomposites possess effective anticancer activity. Thus, in this work, we present a useful strategy for the fabrication of pH-responsive drug nanocomposites for combined photothermal and chemical therapy. The nanocomposite can be used as a potential drug delivery system for practical cancer treatment.
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Materials Science & Engineering C-Materials for Biological Applications
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2018
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IF 5.08
Juan Zhang,Xiao-Tong Guo,Jun-Ping Zhou,Guang-Zhou Liu,Shu-Yong Zhang
A nanocomposite with multi-walled carbon nanotubes (MWCNTs) coated with surface molecularly imprinted polymers (MIPs) poly(3-aminophenylboronic acid) (PAPBA) was successfully prepared via potentiodynamic electropolymerization and tested as an effective electrochemical material for epinephrine (EP) detection. The morphology and properties of the sensing material were characterized with scanning electron microscopy and electrochemical impedance spectroscopy. Compared with MWCNTs or non-imprinted polymers PAPBA modified MWCNTs electrodes, the PAPBA(MIPs)/MWCNTs modified electrode showed a lower charge transfer resistance and enhanced electrochemical performance for EP detection. The improved performance can be attributed to the large amount of specific imprinted cavities with boric acid group which can selectively adsorb EP molecule and the synergistic effect between MWCNTs and PAPBA(MIPs). The effects of pH, the molar ratio between monomer and template molecule, the cycle number of electropolymerization, and the accumulation time of the modified electrode on the sensing performance were investigated. It was found that under the optimal conditions, the PAPBA(MIPs)/MWCNTs sensor could effectively recognize EP from many possible interferents of higher concentration within a wide linear range of 0.2–800 μmol·L −1 , with low detection limit of 35 nmol·L −1 , high sensitivity and good discrimination. The detection of EP in human serum and real injection samples using the PAPBA(MIPs)/MWCNTs sensor also gave satisfactory results.
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JOURNAL OF NANOPARTICLE RESEARCH
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2018
·Vol. 20
·期 6
·1-9
·
IF 2.127
Wu Xiang-Feng,Li Hui,Su Jun-Zhang,Zhang Jia-Rui,Feng Yan-Mei,Pan Jun-Cheng,Zhang Ying,Sun Li-Song,Zhang Wei-Guang,Sun Guo-Wen
The In 2.77 S 4 microspheres had been firstly fabricated by using polyethylene glycol (PEG) as the morphological modifier and then used to hybridize with In(OH) 3 nanocubes by a simply depositional method. The structure, optical properties, morphology, chemical compositions, and charge carrier behaviors of the as-prepared In 2.77 S 4 /In(OH) 3 composites were characterized, respectively. The methyl orange, tetracycline, rhodamine B, and Cr(VI) dilute solution were selected to evaluate their photocatalytic activities. Experimental results showed that In(OH) 3 nanocubes could improve the photocatalytic activity and recyclability of the In 2.77 S 4 microspheres under the visible light irradiation. With the usage of In(OH) 3 increased, the photocatalytic efficiency of the hybrids was firstly increased and then decreased. When the mass ratios of In 2.77 S 4 to In(OH) 3 were 6:2, it reached the maximum of 100% in 15 min for methyl orange, obviously higher than 67.4% of In 2.77 S 4 and 1.1% of In(OH) 3 . Meanwhile, it could also oxidize 85.6% of tetracycline in 20 min, 97.8% of rhodamine B in 7.5 min, and reduce 92.9% of Cr(VI) in 30 min under the visible light irradiation. Moreover, it could still degrade 91.7% of methyl orange solution after 3 cycles, which was much higher than 40.7% of In 2.77 S 4 microspheres. In addition, the possible mechanism of enhancing photocatalytic properties was proposed.
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JOURNAL OF THE AMERICAN CERAMIC SOCIETY
·
2018
·Vol. 102
·期 3
·1414-1424
·
IF 2.956
Yaowu Wei,Tao Zhang,Qi Zhang,Bingqiang Han,Nan Li
Improving the hydration resistance of CaO aggregates is the key to successful application of lime-based refractories in metallurgical industry. Additive Zr(OH) 4 and Al(OH) 3 were introduced in the preparation of CaO granules using granulation equipment and calcination method in this study. The results showed that the hydration resistance of CaO granules was improved significantly, especially for granules with 0.6 wt.% Zr(OH) 4 and 0.9 wt.% Al(OH) 3 , respectively. The shell of CaO granules was relatively dense after calcination and the volume of open pores of CaO granules decreased from 3.56 × 10 −2 to 1.80 × 10 −2 cm 3 /g when additive was introduced. Zr(OH) 4 and Al(OH) 3 have the opposite effect on the closed porosity of CaO granules, the closed porosity of CaO granules was decreased with Zr(OH) 4 addition, but increased with Al(OH) 3 addition.
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Journal of Cleaner Production
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2018
·
IF 5.651
Peng Liu,Yining Gao,Fazhou Wang,Lu Yang
Heavy metal contamination is an important environmental issue . Heavy metal removal by cementitious materials would be an efficient method because of their large-scale exposure to rainwater and groundwater. In this study, 3-thiocyanatopropyltriethoxysilane (TCPS)-modified Fly ash (T-FA) beads were prepared and incorporated into pervious concrete . The functionalized pervious concrete was used to sequester Cd (II) from solution, utilizing the chelating property of the thiocyanate on TCPS. TCPS molecules were chemically bonded onto FA beads after alkali activation , which was confirmed by IR spectroscopy. IR shows the vibration of Si OH and the asymmetric vibrations of CH 2 and CN on TCPS. In addition, 29 Si NMR spectroscopy identifies a new peak at −47.22 ppm assigned to T 2 [RSi(OSi) 2 OH]. T-FA beads can efficiently remove Cd (II) when immersed and stirred in a CdCl 2 solution. An equally significant sequestration capacity was demonstrated when T-FA beads were incorporated in pervious concrete. Cd (II) concentrations were reduced from 300 to 15.86 ppm when a 100 × 100 × 100 mm 3 T-FA-loaded concrete specimen was exposed to a 5 L CdCl 2 solution.
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2018
·Vol. 135
·期 46
·46764
·
IF 1.901
R. Zhang,L. Wang,C. Zhang,R. Yang,X. Sun,B. Song,C.-P. Wong,Y. Xu
A novel kind of conductive self-assembled colloid particles (CPs) was prepared from poly(3-thiophenecarboxylic acid) (PTPCA) and chitosan (CS) via electrostatic interaction and π–π interaction. The resultant CPs were then cast on the electrode surface to provide a platform for fabricating high-sensitive biosensor. It should be noted that the good conductivity of PTPCA can accelerate the electron transfer and facilitate the signal transduction from the CP film to the underlying electrode. This advantage endowed the biosensor with high sensitivity for H 2 O 2 detection. Under the optimal conditions, a linear range from 1 × 10 −11 to 1 × 10 −5 mol L −1 with a detection limit of 3 × 10 −12 mol L −1 was obtained for H 2 O 2 detection. The biosensor can be used to detect H 2 O 2 in commercial disinfector with satisfactory results. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018 , 135 , 46764.
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