ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2023
·Vol. 415
·期 27
·6771-6783
·
IF 4.3
Ma Wanwan,Chen Huan,Hou Hongwei,Hu Qingyuan,Bai Yu
Phosphatidylcholine (PC) and lysophosphatidylcholine (LPC), two types of phospholipids (PLs), have been reported to be closely correlated with head and neck cancers of laryngeal cancer (LC) and thyroid cancer (TC), which make their analysis crucial. TiO 2 @COF-based solid-phase microextraction (SPME) coupled to UHPLC-MS/MS was developed for the rapid and accurate detection of seven potential PL biomarkers from small amounts of serum in this work. The combination of TiO 2 and COF proves to be effective for the extraction of the target analytes. Under optimal conditions, the developed TiO 2 @COF-based SPME-UHPLC-MS/MS method revealed good linearity ( R 2 ≥ 0.997) with LODs ranging from 0.05 to 0.38 ng/mL for PLs, the extraction recoveries and matrix effects ranging from 83.09–112.03% and 85.38–113.67%, respectively. As a high-throughput pretreatment method, satisfactory probe-to-probe reproducibility rates of 2.7–10.1% were obtained. Finally, the TiO 2 @COF-based SPME-UHPLC-MS/MS method was applied to analyze LPC 14:0, LPC 16:0, LPC 18:0, LPC 18:1, LPC 19:0, PC 16:0/18:1, and PC 18:0 in serum samples from early LC patients ( n = 15), early TC patients ( n = 15), and healthy volunteers ( n = 15). The results indicated that cancer patients could be effectively differentiated from healthy controls using orthogonal partial least squares discriminant analysis (OPLS-DA). In conclusion, the established TiO 2 @COF-based SPME-UHPLC-MS/MS method is reliable for the rapid determination of the seven PLs in serum samples, which is promising for early diagnosis of head and neck cancers. Graphical abstract
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高影响因子
CELLULOSE
·
2023
·Vol. 30
·期 17
·11261-11272
·
IF 5.7
Wang Junsheng,Zhuang Jie,Jin Wanhui,Yu Qian,Yu Jing,He Li,Wang Qiuhan,Cheng Deshan,Cai Guangming,Wang Xin
Textile-based wearable electronics have drawn increasing attention in recent years, but stable and durable conductive mechanism on textiles has been the challenge. In this study, we propose to fabricate a liquid metal circuit on textile substrates for flexible antennas and wearable sensors via screen printing method. The breakage of liquid metal circuit on cotton/lycra elastic fabrics can be repaired by pressing or heating, and the patterned liquid metal circuits can be removed using sodium hydroxide solution. Furthermore, the liquid metal circuit was designed as a pressure switch for thermal management system with the temperature precisely controllable by tuning the applied pressure. The liquid metal circuit was further designed as a flexible near field communication (NFC) antenna, providing identification capacity such as replacing campus card and protecting children. The maximum bending angle and effective distance of the NFC tag are determined to be 150 and 17.8 mm, respectively. In addition, the as-prepared liquid metal-based fabric sensors can accurately human motion detection in real time, exhibiting great potential in flexible wearable electronics.
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Nano Research
·
2023
·
IF 9.9
Qu Haijing,Chen Han,Cheng Wei,Pan Yuqing,Duan Zhiran,Wang Yanjun,Liang Xing-Jie,Xue Xiangdong
Although anti-cancer nanotherapeutics have made breakthroughs, many remain clinically unsatisfactory due to limited delivery efficiency and complicated biological barriers. Here, we prepared charge-reversible crosslinked nanoparticles (PDC NPs) by supramolecular self-assembly of pro-apoptotic peptides and photosensitizers, followed by crosslinking the self-assemblies with polyethylene glycol to impart tumor microenvironment responsiveness and charge-reversibility. The resultant PDC NPs have a high drug loading of 68.3%, substantially exceeding that of 10%–15% in conventional drug delivery systems. PDC NPs can overcome the delivery hurdles to significantly improve the tumor accumulation and endocytosis of payloads by surface charge reversal and responsive crosslinking strategy. Pro-apoptotic peptides target the mitochondrial membranes and block the respiratory effect to reduce local oxygen consumption, which extensively augments oxygen-dependent photodynamic therapy (PDT). The photosensitizers around mitochondria increased along with the peptides, allowing PDT to work with pro-apoptotic peptides synergistically to induce tumor cell death by mitochondria-dependent apoptotic pathways. Our strategy would provide a valuable reference for improving the delivery efficiency of hydrophilic peptides and developing mitochondrial-targeting cancer therapies.
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Tissue Engineering and Regenerative Medicine
·
2023
·
IF 3.6
Zhang Ying,Li Chuan,Wei Qiushi,Yuan Qiang,He Wei,Zhang Ning,Dong Yiping,Jing Zhenhao,Zhang Leilei,Wang Haibin,Cao Xiangyang
BACKGROUND: This study aimed to explore the effect of a nanomaterial-based miR-320a inhibitor sustained release system in trauma-induced osteonecrosis of the femoral head (TIONFH). METHODS: The miR-320a inhibitor-loaded polyethylene glycol (PEG)- Poly(lactic-co-glycolic acid) (PLGA)- Poly-L-lysine (PLL) nanoparticles were constructed using the double emulsion method. The TIONFH rabbit model was established to observe the effects of miR-320a inhibitor nanoparticles in vivo . Hematoxylin–eosin staining and microcomputed tomography scanning were used for bone morphology analysis. Bone marrow mesenchymal stem cells (BMSCs), derived from TIONFH rabbits, were used for in vitro experiments. Cell viability was determined using the MTT assay. RESULTS: High expression of miR-320a inhibited the osteogenic differentiation capacity of BMSCs in vitro by inhibiting the expression of the osteoblastic differentiation markers ALP and RUNX2. MiR-320a inhibitor-loaded PEG-PLGA-PLL nanoparticles were constructed with a mean loading efficiency of 1.414 ± 0.160%, and a mean encapsulation efficiency of 93.45 ± 1.24%, which released 50% of the loaded miR-320a inhibitor at day 12 and 80% on day 18. Then, inhibitor release entered the plateau. After treatment with the miR-320a inhibitor nanoparticle, the empty lacunae were decreased in the femoral head tissue of TIONFH rabbits, and the osteoblast surface/bone surface (Ob.S/BS), osteoblast number/bone perimeter (Ob.N/B.Pm), bone volume fraction, and bone mineral density increased. Additionally, the expression of osteogenic markers RUNX2 and ALP was significantly elevated in the TIONFH rabbit model. CONCLUSION: The miR-320a inhibitor-loaded PEG-PLGA-PLL nanoparticle sustained drug release system significantly contributed to bone regeneration in the TIONFH rabbit model, which might be a promising strategy for the treatment of TIONFH.
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高影响因子
FIBERS AND POLYMERS
·
2023
·Vol. 24
·期 12
·4279-4286
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IF 2.5
Zhou Jianhua,Niu Zhuanli,Xiao Anguo,Li Xiang
Materials with passive daytime radiative cooling (PDRC) have drawn more attention as a result of their potential for energy savings. We prepared SiO 2 -encapsulated ZnO@ZIF-8 (ZZS) particles and a radiative cooling coating containing ZZS particles. Owing to the polyhedron structure and the phonon-polarization resonance of ZZS particles, the ZZS fabric coating could reflect sunlight with 83% and radiate heat to outer space with 0.96. Compared with the ambient air, its average temperature decreased by 6.4 °C, and the human body under direct sunlight could avoid overheating 3.9 °C. In addition, the ZZS coated fabric after rubbing still had good PDRC and its average temperature increased by 1.38℃ higher than the original ZZS coated fabric. Owing to good PDRC property, hydrophobicity, mechanical properties and simple methods, the widespread usage of ZZS coated fabric for personal thermal management appears to be promising.
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JOURNAL OF MATERIALS SCIENCE
·
2023
·
IF 4.5
Liu Xinkai,Jing Kang,Peng Shaohua,Shi Qianru,Liu Hui
With acrylamide (AM), methacryloxyethyltrimethyl ammonium chloride, polyethyleneimine ethoxylated (PEI), and graphene oxide (GO) as the raw materials, an amino-functionalized GO-based recyclable composite aerogel (CPAM/PEI/GO, CPAM = cationic polyacrylamide) was constructed by a mild method. In order to verify successful preparation of the composite aerogel, it was characterized by Fourier infrared spectroscopy, Raman spectroscopy, scanning electron microscopy, and X-ray photoelectron spectroscopy. Since CPAM/PEI/GO had negative charge on the surface, methyl orange (MO), an anionic dye, was chosen as the adsorption molecule to study adsorption performance of the aerogel. The results showed that CPAM/PEI/GO possessed efficient adsorption performance toward MO, and the equilibrium adsorption capacity could attain 677.55 mg/g at 303 K. The adsorption process for CPAM/PEI/GO toward MO could be well simulated by pseudo-second-order kinetic and Langmuir adsorption model, and the adsorption was a spontaneous process. The main driving forces of adsorption process were hydrogen bonding, π – π conjugate interaction, and electrostatic interaction. Even after six adsorption–desorption cycles, the equilibrium adsorption capacity of CPAM/PEI/GO aerogel still could retain 536.99 mg/g, which indicated that the aerogel exhibited good regenerability. The composite aerogel might provide a new inspiration for the preparation of amino-functionalized GO-based aerogels and broaden their application field in wastewater treatment.
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高影响因子
JOURNAL OF SOLID STATE ELECTROCHEMISTRY
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2023
·
IF 2.5
Chen Lezi
Aqueous zinc ion batteries have shown great prospects in large-scale energy storage. However, severe dendritic growth and unrestrained side reactions have limited the high speed development of aqueous zinc ion batteries due to the instability of zinc anodes in aqueous electrolytes. Here, butanediol additive is introduced into ZnSO 4 electrolyte to improve the stability of zinc anode by adjusting the solvation structure of zinc hydration layer. This leads to a long cycle life (1000 h), which is more than 8 times greater than that of ZnSO 4 basic electrolyte, for Zn||Zn symmetric batteries utilizing 2 M ZnSO 4 and 15% butanediol additions. The butanediol additive can also achieve high Coulombic efficiency with an average value of 99.58% in Zn||Cu batteries. The Zn||V 2 O 5 full battery exhibits a maximum capacity of 205 mAh g −1 , and even after 1000 cycles at 1.0 A g −1 , it still has a high reversible specific capacity of 177 mAh g −1 .
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JOURNAL OF PLANT GROWTH REGULATION
·
2023
·
IF 4.8
Ayyaz Ahsan,Zhou Yingying,Batool Iram,Hannan Fakhir,Huang Qian,Zhang Kangni,Shahzad Khurram,Sun Yongqi,Farooq Muhammad Ahsan,Zhou Weijun
Plant yield is severely hampered by drought, affirming the urgent need to develop strategies to improve plant growth and drought tolerance. The synergistic application of ABA and calcium nanoparticles (Ca-NPs) has emerged as a promising approach for sustainable crop production and improved resistance to abiotic stress, although the underlying mechanism for foliar application of growth regulator ABA and Ca-NPs in regulating plant growth and drought tolerance in rapeseed ( Brassica napus L.) remains poorly understood. To address this knowledge gap, the current study was conducted to investigate the protective role of 100-µM ABA and 100 ppm Ca-NPs in alleviating the drought stress (15% PEG-6000) in B. napus following further application with 100 µM solution of photosynthesis inhibitor 3-(3,4-dichlorophyllorophenyl)-1,1-dimethylurea (DCMU). Foliar application of 100 ppm Ca-NPs and 100-µM ABA significantly reduced the drought stress by increasing chl a, chl b, total chlorophyll, carotenoids, xanthophyll by 86, 63, 78, 56, 68%; nutritional profile Ca, K, P, Mg, Mn, B by 131, 108, 98, 111, 82, 67% of B. napus plants, respectively. Moreover, under drought condition the combined treatment of Ca-NPs + ABA along with the DCMU increased the Pn, Gs, Ci, Tr by 30, 24, 37, 22% and transcript abundance of transcription factors and ROS homeostasis genes ( CDPK5, MYC2, TGA1, CAS , and POD ), and photosynthetic proteins expressions ( NCED3, PsbB, CP29, CP24, PCaA, CP26 and cytochrome f) . Overall, this study provides the evidence of effectiveness of combined application of Ca-NPs and ABA in alleviating drought stress in rapeseed.
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高影响因子
MICROCHIMICA ACTA
·
2023
·Vol. 190
·期 10
·1-10
·
IF 5.7
Dai Shuyu,Guo Yun,Mao Hongyan,Wei Xiaohui,Zhang Wenfen,Chen Xin,Zhao Wuduo,Zhang Shusheng
A new nano-scale spherical vinyl-functionalized covalent organic polymer (TAPT-DVA-COP) with uniform sizes around 300 nm was initially constructed using 2,5-divinyl-1,4-benzaldehyde (DVA) and 2,4,6-tris(4-aminophenyl)-1,3,5-triazine (TAPT) as monomers. Then, a sulfonic acid (-SO 3 H) modified COP termed COP-SO 3 H was developed based on post-sythesis method employing TAPT-DVA-COP as precursor. Capillary electrochromatography (CEC) monolithic columns were fabricated using the physical doping technique to exhibit the application potential of TAPT-DVA-COP and COP-SO 3 H. Compared to the TAPT-DVA-COP monolithic column, the COP-SO 3 H monolithic column achieved a highly selective separation between analytes with different properties, including monosubstituted benzenes, alkylbenzenes, hydroxybenzoates, nucleoside bases, and biogenic amines. Non-covalent interaction (NCI) analysis and experimental data show that the synergism of the sulfonic acid group and aromatic moieties on COP-SO 3 H endows the new stationary phase with diverse interactions, including ion exchange, hydrophobic, π-π and hydrogen bonding. In addition, the COP-SO 3 H monolithic column exhibited good reproducibility and excellent potential for the determination of hydroxybenzoates in compact powders and alkylbenzenes in effluent samples. Graphical abstract
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高影响因子
Nature Chemistry
·
2023
·
IF 21.8
Yu Baoqiu,Lin Rui-Biao,Xu Gang,Fu Zhi-Hua,Wu Hui,Zhou Wei,Lu Shanfu,Li Qian-Wen,Jin Yucheng,Li Jing-Hong,Zhang Zhenguo,Wang Hailong,Yan Zier,Liu Xiaolin,Wang Kang,Chen Banglin,Jiang Jianzhuang
Single-crystal X-ray diffraction is a powerful characterization technique that enables the determination of atomic arrangements in crystalline materials. Growing or retaining large single crystals amenable to it has, however, remained challenging with covalent organic frameworks (COFs), especially suffering from post-synthetic modifications. Here we show the synthesis of a flexible COF with interpenetrated qtz topology by polymerization of tetra(phenyl)bimesityl-based tetraaldehyde and tetraamine building blocks. The material is shown to be flexible through its large, anisotropic positive thermal expansion along the c axis ( α c = +491 × 10 –6 K –1 ), as well as through a structural transformation on the removal of solvent molecules from its pores. The as-synthesized and desolvated materials undergo single-crystal-to-single-crystal transformation by reduction and oxidation of its imine linkages to amine and amide ones, respectively. These redox-induced linkage conversions endow the resulting COFs with improved stability towards strong acid; loading of phosphoric acid leads to anhydrous proton conductivity up to ca. 6.0 × 10 −2 S cm −1 .
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高影响因子
Plasmonics
·
2023
·
IF 3
Dong Jun,Li Chenlu,Wang Yan,Cao Yi,Fan Yimeng,Han Qingyan,Gao Wei,Wang Yongkai,Qi Jianxia
Surface-enhanced Raman scattering (SERS) is widely employed because it offers quick, microscopic, and traceless detection. This study used high-voltage and low-voltage ultrasonic oscillation to embed gold-silver nanoparticles (Au-Ag NPs) into the pores of chemically modified ultrathin anodic alumina (AAO) films, resulting in a highly sensitive three-dimensional SERS substrate. We improved the substrate’s stability and Raman activity by adjusting the particle alloy ratio. For the substrate in this alloy ratio, the Raman signal of probe molecules (Rh6G) adsorbed on the substrate surface is enhanced. the enhancement factor (EF) was as high as 1.40 × 10 7 , the relative standard deviation (RSD) of 10.6%, and the concentration of Rh6G shows a linear relationship with Raman intensity, with a linear correlation coefficient of 0.961. In addition, we evaluated the substrate’s detection effect on thiram molecules. It has been proven that this structure has good practicality and high sensitivity as a Raman enhanced substrate.
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高影响因子
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
·
2023
·Vol. 148
·期 21
·12311-12320
·
IF 4.4
Fang Jia,Yi Chengcheng,Pu Ping,Chen Chen,Yang Yi,Wang Jiaxin,Lin Bin
Ag/CeO 2 catalyst is synthesized by hydrothermal method, which has been studied under the effects of different catalyst content, ash and Ag load through activity and characterization tests. Ag loading increases the catalytic activity of CeO 2 , and the peak combustion temperature of soot decreases by 74 °C. The catalytic effect of Ag/CeO 2 is affected by catalyst content, Ag load and ash content. The optimum mass ratio of soot/catalyst is 1/10, and 10 mass% is the saturation value of Ag loading at CeO 2 . Ash inhibits the promoting effect of Ag/CeO 2 in the oxidation process of soot. This study provides a theoretical basis for the industrial application of Ag/CeO 2 catalyst in gasoline engine and also provides a research idea for the low-temperature oxidation of soot.
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