CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Yuxuan Dai,Shenghan Gao,Zhi Zhang,Wan-Jie Du,Xinyu Bao,Yun Xu
Alzheimer's disease (AD) has displayed complex pathological features, in which oxidative stress and ferroptosis play important roles. The development of collaborative treatment methods aimed at multiple pathological factors is particularly important for effective alleviation of AD. In our research, a multifunctional delivery system (CART-CeO 2 )@HA was developed for the co-delivery of neuroprotective Cocaine- and amphetamine-regulated transcript (CART) peptides and antioxidant CeO 2 nanozymes encapsulated within an ROS-responsive nanogel. Under the stimulation of Aβ, (CART-CeO 2 )@HA exhibited effective relief for cell apoptosis, mitochondrial dysfunction and synaptic loss on account of ROS removal and ferrous ions chelation. With sufficient accumulation and sustained drug release in the brain of APP/PS1 mice, (CART-CeO 2 )@HA significantly reduced the levels of oxidative stress and ferroptosis, which facilitate the reduction of Aβ deposition and the repair of neuronal damage, jointly rescuing the cognitive impairment in APP/PS1 mice. These results verified the clinical potential of the multi-target delivery system in AD synergistic therapy.
研究领域:
神经科学
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纳米技术
·
药剂学
·
生物医学工程
·
病理学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Qi Xin,Shaofang Zhang,Si Sun,Nan Song,Yadong Zhe,Fangzhen Tian,Shu Zhang,Meili Guo,Xiao-Dong Zhang,Jianning Zhang,Hao Wang,Ruiping Zhang
Sepsis, a life-threatening condition caused by a dysregulated immune response to infection, leads to systemic inflammation, immune dysfunction, and multiorgan damage. Various oxidoreductases play a very important role in balancing oxidative stress and modulating the immune response, but they are stored inconveniently, environmentally unstable, and expensive. Herein, we develop multifunctional artificial enzymes, CeO2 and Au/CeO2 nanozymes, exhibiting five distinct enzyme-like activities, namely, superoxide dismutase, catalase, glutathione peroxidase, peroxidase, and oxidase. These artificial enzymes have been used for the biocatalytic treatment of sepsis via inhibiting inflammation and modulating immune responses. These nanozymes significantly reduce reactive oxygen species and proinflammatory cytokines, achieving multiorgan protection. Notably, CeO2 and Au/CeO2 nanozymes with enzyme-mimicking activities can be particularly effective in restoring immunosuppression and maintaining homeostasis. The redox nanozyme offers a promising dual-protective strategy against sepsis-induced inflammation and organ dysfunction, paving the way for biocatalytic-based immunotherapies for sepsis and related inflammatory diseases.
研究领域:
纳米技术
·
免疫学
·
炎症
·
治疗学
·
生物催化
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Gang Xing,Xuan Liu,Yazhen Jia,Jialin Wu,Liming Chai,Wenjie Zhai,Zhaojun Wu,Jing Kong,Jianbin Zhang
Synthesis of catalysts with high catalytic degradation activity for formaldehyde (HCHO) at room temperature is highly desirable for indoor air quality control. Herein, a novel K-Mn 3 O 4 @CeO 2 catalyst with excellent catalytic oxidation activity toward HCHO at near room temperature was reported. In particular, the K addition in K-Mn 3 O 4 @CeO 2 considerably enhanced the oxidation activity, and importantly, 99.3 % conversion of 10 mL of a 40 mg/L HCHO solution at 30 °C for 14 h was achieved, with simultaneous strong cycling stability. Moreover, the addition of K species considerably influenced the chemical valence state of Mn from +4 ( ε -MnO 2 ) to +8/3 (Mn 3 O 4 ) on the surface of CeO 2 , which obviously changed the tunnel structure and the number of oxygen vacancies. One part of K species is uniformly dispersed on K-Mn 3 O 4 @CeO 2 , and the other part exists in the tunnel structure of Mn 3 O 4 @CeO 2 , which is mainly used to balance the negative charge of the tunnel and prevent collapse of the structure, providing enough active sites for the catalytic oxidation of HCHO. We observed a phase transition from tunneled KMnO 2 to Mn 3 O 4 to tunneled MnO 2 with the decreasing K + content, in which K-Mn 3 O 4 @CeO 2 exhibited higher HCHO oxidation activity. In addition, K-Mn 3 O 4 @CeO 2 exhibited lower oxygen vacancy formation and HCHO adsorption energies in aqueous solution based on density functional theory calculations. This is because the K species provide more active oxygen species and richer oxygen vacancies on the surface of K-Mn 3 O 4 @CeO 2 , promote the mobility of lattice oxygen and the room-temperature reduction properties of oxygen species, and enhance the ability of the catalyst to replenish the consumed oxygen species. Finally, a possible HCHO catalytic oxidation pathway on the surface of K-Mn 3 O 4 @CeO 2 catalyst is proposed.
研究领域:
环境科学
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催化化学
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMOSPHERE
·
2024
·
IF 8.1
Linxin Zheng,Ningchao Zheng,Zhizeng Pan,Guang Gao,Chao He,Xinran Mou,Xiangbiao Yin,Shunyan Ning,Mohammed F. Hamza,Yuezhou Wei
Efficient recovery of uranium from wastewater and seawater provides an important guarantee for the sustainable growth of nuclear energy. Herein, we skillfully use the alkali etching method to construct CeO 2 hollow spheres rich in Ce–OH groups for the removal and recovery of uranium from water matrixes. It is found that the CeO 2 exhibits fast adsorption kinetics (equilibrium time within 10 min) and moderate adsorption capacity (143.1 mg/g), and the removal efficiency of low concentration uranium (0.1 g/L and 1 g/L) reaches 100% within 1 min of adsorption. Moreover, the adsorption of uranium by CeO 2 is almost unaffected by common anions and cations in the environment, even if the concentration of anions is 1000 times that of uranium. More importantly, the CeO 2 can enrich uranium concentration in seawater by 167.9 times and the recovery rate reaches 83.9%. Mechanistic studies reveal that the adsorption of uranium by CeO 2 is mainly attributed to the rich Ce–OH groups on the surface of CeO 2 , resulting in the rapid adsorption of U(VI) and mainly forms a single-bridge model. The findings of this study provide a green and efficient path for the removal and recovery of uranium from wastewater and seawater.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Catalysts
·
2020
·Vol. 10
·期 6
·681
·
IF 3.52
Qian Zhang,Yiwen Jiang,Jingheng Gao,Mingli Fu,Sibei Zou,Yanxia Li,Daiqi Ye
A series of CeO2–MnOXcatalysts with different Ce contents was prepared using Mn–BTC MOF as a sacrificial template for toluene oxidation. Interestingly, the performance of CeO2–MnOXincreased rapidly only when the Ce content lower than 5%. The 1%-, 3%- and 10%-Ce-content samples exhibited the T90value of 325 °C, 291 °C and 277 °C, respectively. XRD shows that the catalyst phase changes significantly before (Mn3O4only) and after (Mn2O3, Mn3O4and CeO2) 3% Ce loading. All other results indicated that the Ce–Mn interface properties of different Ce content composite oxides was quite distinguishable in terms of removal and energy efficiency. XRD and XPS results further showed that there a Ce monolayer dispersion threshold existed on the interface of MnOX(3.2 wt%, confirmed by XPS), which caused the difference in performance increment. The dispersed Ce could be divided into a monolayer dispersion state (1–3%) and a crystalline phase state (>3%), according to the existence form, which corresponded to the significant and minor enhancements of toluene conversion rate. Importantly, the Ce in monolayer dispersion state obviously improved the redox properties of catalysts interface, while the Ce in crystal state not. The interfaces with monolayer dispersion Ce result in more abundant metal ion states, oxygen vacancies, better electron transfer performance and catalytic activity.
研究领域:
催化化学
·
材料科学
✓ 已验证
DOI
高影响因子
Nanomaterials
·
2025
·Vol. 16
·期 1
·53
·
IF 4.3
Yaohui Xu,Yu Hu,Nengwei Zeng,Haimei Wang,Yuan Zhang,Zongjie Liu,Xinrui Chen,Zhao Ding
To overcome the limitations of template-dependent and anion-assisted methods, this work presents a solvent-controlled strategy for the one-step solvothermal synthesis of octahedral CeO2. Using only Ce(NO3)3·6H2O in methanol/water (MeOH/H2O) mixtures without the addition of auxiliary templates or surfactants, phase-pure cubic CeO2was obtained. Well-defined octahedra were exclusively formed in a 15 mL MeOH/5 mL H2O system at 180 °C for 12 h, whereas other alcohols (including ethanol (EtOH),n-propanol (n-PrOH), and iso-propanol (i-PrOH)) yielded irregular aggregates. Time-dependent evolution revealed continuous crystallinity optimization between 3 and 24 h, beyond which surface dissolution occurred. The solvothermal mother liquor could be recycled four times without compromising phase purity or octahedral morphology, as confirmed by XRD and SEM. This work provides a green and practical route for morphology-controlled oxide synthesis while significantly reducing solvent consumption.
研究领域:
材料科学
·
纳米材料合成
·
绿色化学
·
无机化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RARE METALS
·
2025
·
IF 11
Dong Yu-Guo,Kong Wen-Jing,Ma Zhuang,Yang Yong,Wang Ping,Sheng Shi-Xiong,Dong Lin,Gu Xiao-Li,Chen Zu-Peng
The oxidation of lignin model compounds to esters via C–C bond cleavage has attracted considerable attention, as esters could be used as important polymer precursors and pharmaceutical intermediates. However, most studies focus on designing homogeneous or noble metal catalysts and conducting the reactions under basic conditions. Here, we report an efficient process for the C–C bond cleavage of lignin model compounds and selectively producing esters over different shaped CeO 2 (i.e., nanospheres (S), nanorods (R), nanoparticles (P), and nanocubes (C)) under base-free conditions. Specifically, the yield of methyl anisate from the aerobic oxidation of 1-(4-methoxyphenyl)ethanol reaches 77.6% over CeO 2 -S in one hour (91% in 9 h), exhibiting higher performance compared to other evaluated CeO 2 catalysts (6.4%–40.2%). Extensive characterizations and experimental investigations reveal that the density of weak base sites and oxygen vacancies on the CeO 2 surface is positively correlated with the yield of methyl esters. Furthermore, the reaction pathway is investigated, which confirms that 1-(4-methoxyphenyl)ethanol first undergoes two reactions (i.e., etherification and dehydrogenation) to produce intermediates of 1-methoxy-4-(1-methoxy-ethyl)-benzene and 1-(4-methoxyphenyl)ethanone, respectively, followed by a series of functional group transformations to generate the targeted methyl anisate ultimately. Graphical abstract
研究领域:
催化化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
CHEMISTRY-A EUROPEAN JOURNAL
·
2024
·
IF 3.9
Dongping Fan,Jinyu Zheng,Xin Xiang,Dongdong Xu
Graphical The hybrid of PdCuAg and CeO 2 nanowires with structural (abundant heterojunction/interfaces and ultrathin nanowire structure) and compositional advantages were facile prepared by one-pot method, thus embracing enhanced electrocatalytic performance for ethylene glycol oxidation reaction. Introducing CeO 2 into Pd-based nanocatalysts for electrocatalytic reactions is a good way to solve the intermediate toxicity problem and improve the catalytic performance. Here we reported a simple strategy to synthesize the PdCuAg and CeO 2 nanowires hybrid via a one-pot synthesis process under strong nanoconfined effect of specific surfactant as templates. Owing to the structural (ultrathin nanowires, abundant heterojunction/interfaces between metal and metal oxide) and compositional (Pd, Cu, Ag, CeO 2 ) advantages, the hybrid showed significantly enhanced catalytic activity (6.06 A mg Pd −1 ) and stability, accelerated reaction rate, and reduced activation energy toward electrocatalytic ethylene glycol oxidation reaction.
研究领域:
化学
·
材料科学
·
电化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Sustainable Chemistry & Engineering
·
2025
·
IF 7.3
Shiling Zhao,Kaizhi Wang,Shaoqi Mao,Beibei Yang,Yu Zhao
In the pursuit of high-selective oxidation of 5-hydroxymethylfurfural (HMF) to valuable derivatives such as 5-hydroxymethylfuroic acid (HMFCA), 5-formyl-2-furanoic acid (FFCA), and furan-2,5-dicarboxylic acid (FDCA), we have developed a diethylenetriamine pentaacetic acid (DTPA)-assisted strategy to construct a highly effective photothermal catalyst with maximized Ag–CeO2 interfaces and rich oxygen vacancies. Under optimal reaction conditions, this catalyst achieves remarkable yields of 99% for HMFCA, 99% for FFCA with a turnover frequency (TOF) of 163 h–1, and 98% for FDCA. Combined theoretical calculations and a series of characterization analyses reveal that the superior performance is due to the unique properties of the maximized Ag–CeO2 interfaces and the rich oxygen vacancies, which enhance electron transport and synergistically enhance the catalytic activity of silver clusters. In contrast to other photocatalytic oxidation systems for HMF, this work showcases high selectivity in the oxidation of HMF to HMFCA, FFCA, and FDCA. These findings not only elucidate the mechanisms behind selective oxidation but also offer a promising approach for the directional photosynthesis of high-purity chemicals in related applications.
研究领域:
材料科学
·
催化化学
✓ 已验证
产品关联
DOI
高影响因子
ENVIRONMENTAL RESEARCH
·
2026
·
IF 8.2
Junjie Zhang,Jiayuan Xu,Jijun Ding,Haixia Chen
High-efficiency oil-water separation membranes based on low-mesh copper mesh offer advantages in cost-effectiveness, scalability, and adaptability to complex separation scenarios. However, their inherently large pore size usually results in insufficient separation precision. In this work, the Cu/PVDF/CeO 2 composite membrane is fabricated on the copper mesh substrate by combining the non-solvent induced phase separation method with spraying and immersion techniques. By adjusting the porogen content, the pore size of the composite membrane is effectively regulated, leading to enhanced separation efficiency. This strategy aims to simultaneously achieve superhydrophobicity and high-precision oil-water separation on low-mesh-number copper mesh substrates. The Cu/PVDF/CeO 2 composite membrane achieves a maximum water contact angle of 158.7°, exhibiting superhydrophobicity. In oil-water separation tests, the membrane demonstrates a separation efficiency exceeding 98.5% for all tested oil-water mixtures. Optimal performance is observed in the separation of the immiscible mixture of dichloromethane and water, where the membrane achieves a separation efficiency of 99.83% alongside a high separation flux of 79138.4 L m −2 ·h −1 . Additionally, the composite membrane exhibits excellent long-term stability and cycling stability. This study provides a feasible method for the preparation of high-efficiency oil-water separation composite membranes based on copper mesh substrates, with potential applications in industrial wastewater treatment and environmental remediation.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CERAMICS INTERNATIONAL
·
2026
·
IF 6
Kui Ding,Anqi Sheng,Jing Song,Shuyan Song,Hongjie Zhang,Lang Zhao
To address the low removal rate, severe surface damage, and unclear mechanism of A-plane sapphire during chemical mechanical polishing, a novel Al 2 O 3 -CeO 2 mixed-abrasive slurry was developed by integrating the mechanical abrasion of Al 2 O 3 with the chemical reactivity of CeO 2 . The optimal formulation, containing 2 wt% Al 2 O 3 , 0.2 wt% CeO 2 , 0.15 wt% sodium hexametaphosphate, 0.7 wt% isooctanol polyoxyethylene ether, and 0.5 wt% sodium D-gluconate with aminomethyl propanol as pH regulator, yields an atomically smooth surface (Ra = 0.079 nm) and a high removal rate (MRR = 905 nm/h). XPS analysis reveals that a hydrated Al-OH layer and a CeAl x O y soft phase form on the sapphire via interfacial solid-state reaction, and are removed by mechanical shearing of the mixed abrasives.
✓ 已验证
产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2026
·
IF 9.1
Haihuan Sun,Xiaoyan He,Zongcheng Yang,Xiaoqing Dou,Wenhan Fan,Chengqing Yuan,Xiuqin Bai
Biofilm formation on material surfaces is a persistent challenge in aquatic environments, creating an urgent need for sustainable catalytic antimicrobial strategies. Although ceria nanozymes with haloperoxidase (HPO)-like activity have attracted increasing attention, their practical application is limited by the low density of surface Ce 3+ sites and oxygen vacancies. Herein, defect-engineered Cu-doped CeO 2 nanozymes were developed to enhance HPO-like catalytic activity and antibacterial performance. Cu incorporation regulated the Ce 4+ /Ce 3+ redox equilibrium and promoted oxygen-vacancy formation, resulting in enhanced catalytic activity, while controlled Cu 2+ release contributed to synergistic antibacterial effects. As a result, the optimized Cu-CeO 2 nanozymes achieved approximately 99% bacterial inactivation against E. coli and 97% inhibition against Bacillus sp. at a low nanoparticle concentration of 10 mg/L, demonstrating broad antibacterial activity against representative Gram-negative and Gram-positive bacteria. Combined experimental characterization and density functional theory calculations revealed the defect-mediated mechanism underlying the enhanced catalytic performance. This work provides a defect-engineering strategy for developing ceria-based nanozymes with enhanced catalytic antibacterial performance for potential catalytic antifouling applications.
✓ 已验证
产品关联
DOI
高影响因子
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