CARBOHYDRATE POLYMERS
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2025
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IF 12.5
Longfei Wang,Jingyi Hu,Meng Zhou,Huaen Yuan,Huan Lu,Jingyi Chen,Mengyu Zhao,Menglan Xiao,Mingqin Zhao,Miao Lai
Heterocyclic fragrance compounds possess unique aromas that can enhance flavor of products, but their applications are limited due to high volatility, short storage durations, and thermal instability. This paper used porphyrin grafted carboxymethyl chitosan (CMCS) as wall material and selected four heterocyclic fragrance compounds as core materials to develop an effective controlled release system of photothermal-responsive microcapsules. The optimal preparation process for microcapsules was determined through response surface methodology (RSM). The Scanning electron microscopy (SEM), Transmission electron microscopy (TEM) and Flourier transform Infrared Spectroscopy (FTIR) results confirmed the successful preparation of microcapsules. Photo-release performance and thermo-gravimetry (TG) demonstrated excellent photothermal-responsive behavior. The results of MD indicated that the system of microcapsule exhibited enhanced stability and superior convergence, with van der Waals forces being the primary interaction between hosts and guests. Notably, the 3-acetylpyridine/5-( p -aminophenyl)-10,15,20-triphenylporphyrin-carboxymethyl chitosan (ATPD/AC) displayed strongest intermolecular force among the other microcapsules, which performed the highest complexation strength with guest and the highest stability. This study provided a theoretical foundation for constructing stable controlled release systems for heterocyclic fragrance microcapsules.
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高影响因子
NEW JOURNAL OF CHEMISTRY
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2025
·
IF 2.5
Sheng Gong,Fangsheng Xu,Haiyan Liao,Heyang Sun,Chaoqiang Huang,Xinhua Zhou,Murtaza Hasan,Sundaram Gunasekaran
Despite the promising application, the facile and controllable preparation of zinc-loaded microcapsules is compulsory, especially for biosafety and high bioavailable as well.Here, calcium alginate microcapsules loaded with vanillin-chitosan Schiff base zinc (VCSB-Zn(II)@CA) were successfully primed via emulsification exogenous for Zn2+ continuously sustained release. The microcapsules were characterized by FT-IR, SEM, and TGA. The best preparation condition was obtained by a multi-factor(MF) orthogonal experiment, which was 50 g/L of CaCl2, 1.5% of Span 80 of the oil phase, 20 g/L of SA, and 1 g/75 g of vanillin-chitosan Schiff base zinc (VCSB-Zn(II)) to SA ratio, and the encapsulation efficiency (EE) was about 65.21%. In comparison to chitosan-Zn(II) (Chs-Zn(II)) and VCSB-Zn(II) released Zn2+ only at simulated gastric fluid, VCSB-Zn(II)@CA microcapsule showed a more continuous release in the whole release process. The cumulative release rate (Ri) of VCSB-Zn(II) and VCSB-Zn(II)@CA was close and much higher than that of Chs-Zn(II), which were 82.81%, 79.15%, and 57.33%, respectively. The release curve met the first-order and the Korsmeyer-Peppas model, which followed the Fick diffusion mechanism. In the future, this Zn2+ sustained released system will lead to a new horizon of more efficient applications in trace element supplements for human beings and animals.
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ACS Omega
·
2025
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IF 4.3
Huibin Yu,Hongqin Ke,Tu Chen,Jia Huang,Lei Zhou,Shenqi Wang
This study aimed to develop a novel adsorbent, Zn2+-loaded hexanediamine–chitosan (HDA-CS) beads, for the selective removal of human testosterone from plasma. The preparation involved synthesizing chitosan beads, modifying them with hexanediamine to enhance adsorption capacity and subsequently loading them with zinc ions. The effects of the HDA spacer, Zn2+ concentration, and adsorption time on the adsorption percentage for testosterone were systematically investigated through a series of adsorption experiments. Results indicated that the Zn2+-HDA-CS beads achieved a maximum adsorption capacity of approximately 35% within 90 min. The analysis of plasma concentrations of Zn2+, albumin, and sex hormone-binding globulin (SHBG) indicated that the adsorption process involved a complex interaction between testosterone-bound SHBG and albumin for Zn2+ binding sites on the beads. Additionally, the adsorbent demonstrated good storage stability and selectivity for testosterone, with minimal impact on total protein content in plasma. These findings highlight the potential of Zn2+-HDA-CS beads as an effective therapeutic option for managing testosterone levels in clinical settings, particularly in patients undergoing androgen deprivation therapy for prostate cancer.
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PACKAGING TECHNOLOGY AND SCIENCE
·
2024
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IF 2.8
Lin Lin,Xu Liu,Ce Shi,Xiaochen Chen,Tariq Aziz,Fahad Al-Asmari,Amal A. Mohamed,Haiying Cui
The objective of this research was to develop and analyse a chitosan- Tremella fuciformis polysaccharide (CS-TFP) edible film using chitosan (CS) and Tremella fuciformis polysaccharide (TFP) as the primary raw materials. The findings revealed significant improvements in the thickness, solubility, opacity, mechanical properties and barrier properties (water vapour and oxygen permeability) of the chitosan film upon the addition of TFP, but water content and hydrophobicity were reduced. Moreover, TFP addition markedly enhanced the antibacterial and antioxidant activities of the chitosan films. Structural analysis of the CS films and CS-TFP edible films indicated that the formation of hydrogen bonds and high compatibility between CS and TFP. Specifically, TFP increased crystallinity, reduced roughness and improved the compactness of the edible film. This increase in compactness was directly linked to enhanced physical properties, whereas increased crystallinity contributed to better thermal stability. Furthermore, the application of CS-TFP-3 edible films in chicken preservation proved that they could significantly delay the deterioration of chicken. Findings in this study suggested that CS-TFP edible film as a bioactive packaging material showed great potential to preserve chicken meat and extend the shelf life.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Yuhe Dong,Tong Wu,Tao Jiang,Wanying Zhu,Linyan Chen,Yuantong Cao,Ying Xiao,Ye Peng,Ling Wang,Xi Yu,Tian Zhong
As an anti-infection antibiotic delivery route, a drug-controlled release system based on a specific condition stimulus response can enhance drug stability and bioavailability, reduce antibiotic resistance, achieve on-demand release and improve targeting and utilization efficiency. In this study, chitosan-coated liposomes containing levofloxacin (Lef@Lip@CS) were prepared with lysozyme in body fluids serving as an intelligent “switch” to enable accurate delivery of antibiotics through the catalytic degradation ability of chitosan. Good liposome encapsulation efficacy (64.89 ± 1.86 %) and loading capacity (5.28 ± 0.18 %) were achieved. The controlled-release behavior and morphological characterization before and after enzymatic hydrolysis confirmed that the levofloxacin release rate depended on the lysozyme concentration and the degrees of deacetylation of chitosan. In vitro bacteriostatic experiments showed significant differences in the effects of Lef@Lip@CS before and after enzyme addition, with 6-h inhibition rate of 72.46 % and 100 %, and biofilm removal rates of 51 % and 71 %, respectively. These findings show that chitosan-coated liposomes are a feasible drug delivery system responsive to lysozyme stimulation.
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Acta Biomaterialia
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2018
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IF 6.383
Huan Yang,Cui Tang,Chunhua Yin
Estrone-modified glycol chitosan nanoparticles (GCNP-ES) based on the mechanisms of ES-mediated endocytosis and intracellular pH-responsive drug release were developed for the treatment of breast cancer. GCNP-ES were prepared by grafting copolymerization of glycol chitosan with 2-(diisopropylamino)ethyl methacrylate to generate GCNP prior to ES conjugation. The particle size, zeta potential , and paclitaxel (PTX) encapsulation efficiency of GCNP-ES were characterized. In particular, GCNP-ES exhibited pH-responsive dissociation properties while maintaining stability under long-term storage and lyophilization. The drug release of PTX-loaded GCNP-ES (PTX/GNCP-ES) was modestly prolonged with considerable pH sensitivity. GCNP-ES promoted internalization in breast cancer MCF-7 cells by approximately 5-fold as compared to GCNP, and the internalized GCNP-ES was mainly localized in the endosomes of MCF-7 cells. PTX/GNCP-ES exhibited higher cytotoxicity and cell apoptosis ratio than GCNP. In mice with MCF-7 breast cancer xenograft, PTX/GCNP-ES showed higher accumulation at the tumor site, which resulted in a higher tumor inhibition ratio (81.4%) than that achieved by PTX/GCNP (69.4%) and PTX solution (48.8%). Furthermore, no histological and hematological toxicity was detected in in vivo studies of PTX/GCNP-ES. Overall, these results suggested the potential applicability of GCNP-ES as a drug delivery system for breast cancer therapy. Statement of Significance Most breast cancers are hormone dependent. Herein, we developed a estrone-modified glycol chitosan nanoparticles (GCNP-ES) as a drug delivery system to overcome the drawbacks of chemotherpeutic drugs, including poor water solubility and lack of specifity. GCNP-ES could provide efficient drug delivery in breast cancer cells. The study demonstrated that GCNP-ES could dissociate under mildly acidic conditions, leading to the timely payload release of the drug in target tumor cells following internalization. The conjugated estrone of the nanoparticles could significantly increase drug accumulation in the tumor site and result in enhanced therapeutic effect. Thus, the potential applicability of GCNP-ES was suggested.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
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IF 5.4
Tangjun Ren,Junyu Meng,Mengke Sun,Qi Zhang,Chenyang Yao,Haonan Wu,Xinting Wang,John Osilama Thomas,Liuliu yang,Enpeng Gu,Xi Wang,Jian Yang
As a physiological process maintaining skin integrity, wound healing is often disrupted by complex microenvironments, infection, and abnormal pH levels, leading to delayed healing. Additionally, irregularly shaped wounds are complex enough to cover adequately with traditional dressings. To address these issues, we developed a functional hydrogel via the Schiff base reaction between chitosan (CS) and difunctional telechelic-polyethylene glycol (DT-PEGn) of varying molecular weights, which was subsequently loaded with ciprofloxacin (CIP) to form a CS@DT-PEGn@CIP composite system. The results demonstrate that DT-PEGn of different molecular weights effectively modulate the hydrogel's swelling ratio, mechanical properties, injectability, self-healing capacity, and drug release characteristics, thereby conferring tunable functional advantages in wound repair. In vitro antibacterial assays and a rat full-thickness wound model further confirmed the outstanding efficacy of CS@DT-PEGn@CIP in significantly inhibiting bacterial growth and accelerating wound healing. Notably, the CS@DT-PEG6000 hydrogel containing only one-third of the free CIP dose exhibited superior therapeutic outcomes compared to free CIP alone, highlighting the high efficiency and safety of the composite system. In summary, this study systematically demonstrates the unique advantages of CS@DT-PEGn hydrogel in promoting wound healing, including its responsiveness to microenvironmental pH, antibacterial properties, and excellent conformability to wound surfaces. These findings provide novel strategies and potential applications for clinical wound management.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Junyan Guo,Mohammad Rizwan Khan,Naushad Ahmad,Wanli Zhang,Lanhuan Meng
Chitosan (CS) films functionalized with cinnamaldehyde (CIN)-derived Schiff base and Fe 3+ coordination were developed for pH-responsive antimicrobial food packaging. The Schiff base-Fe 3+ crosslinking system enhanced tensile strength by 39.59% and reduced water vapor permeability by 11.25%, while imparting pH-triggered CIN release via acid-hydrolyzable imine bonds. Scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, and thermogravimetric analysis confirmed uniform dispersion of CIN/Fe and improved crystallinity. The films demonstrated bactericidal activity against foodborne pathogens (89.52% for Escherichia coli ATCC 25922, 82.98% for Staphylococcus aureus ATCC 25923) combined with moderate 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) scavenging (37.41% at 30 min), suggesting primary application in antimicrobial packaging. In fruit preservation trials, strawberries and passion fruit coated with CS/CIN/Fe films showed 33.17% and 29.36% lower weight loss, respectively, extending shelf life by suppressing respiration-driven spoilage. Cytotoxicity (<0.21% hemolysis) and biocompatibility (>80% cell viability) validated safety. This work presents a sustainable strategy for intelligent packaging by integrating dynamic Schiff base-metal coordination, addressing both food waste and plastic pollution.
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MOLECULES
·
2022
·Vol. 27
·期 24
·8832
·
IF 4.927
Shengyou Ge,Xiaoyi Zhu,Chuanlong Zhang,Dongchen Jia,Wei Shang,Chao Ding,Jianping Yang,Yuanyong Feng
The strategy of incorporating bioactive inorganic nanomaterials without side effects as osteoinductive supplements is promising for bone regeneration. In this work, a novel biomass nanofibrous scaffold synthesized by electrospinning silica (SiO2) nanoparticles into polycaprolactone/chitosan (PCL/CS) nanofibers was reported for bone tissue engineering. The nanosilica-anchored PCL/CS nanofibrous bioscaffold (PCL/CS/SiO2) exhibited an interlinked continuous fibers framework with SiO2nanoparticles embedded in the fibers. Compact bone-derived cells (CBDCs), the stem cells derived from the bone cortex of the mouse, were seeded to the nanofibrous bioscaffolds. Scanning electron microscopy and cell counting were used to observe the cell adhesion. The Counting Kit-8 (CCK-8) assay was used. Alkaline phosphatase (ALP), Alizarin red staining, real-time Polymerase Chain Reaction and Western blot tests were performed to confirm the osteogenesis of the CBDCs on the bioscaffolds. The research results demonstrated that the mechanical property of the PCL together with the antibacterial and hydrophilic properties of the CS are conducive to promoting cell adhesion, growth, migration, proliferation and differentiation. SiO2nanoparticles, serving as bone induction factors, effectively promote the osteoblast differentiation and bone regeneration. This novel SiO2-anchored nanofibrous bioscaffold with superior bone induction activity provides a better way for bone tissue regeneration.Keywords:silica;polycaprolactone;chitosan;bioscaffold;osteogenesis;bone tissue engineering
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Advanced Materials Interfaces
·
2025
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IF 4.4
Li Xu,Chen Chen,Zishan Li,Jie Zhang,Shufei Hu,Shuyue Ren,Peng Luo,Zhixian Gao
This study presents the development of a novel material capable of efficiently enriching and recovering pathogenic bacteria from food matrices without requiring surface modification of biological components or complex chemical conjugation. A nanocellulose-based chitosan aerogel (CNF-CS) is synthesized via cross-linking of nanocellulose, extracted from pulp, with chitosan. The CNF-CS aerogel enables selective adsorption of negatively charged bacterial cells through electrostatic interactions. When integrated with a custom-designed micro-injection extrusion enrichment device, the system achieves rapid and efficient enrichment and recovery of foodborne pathogens. The CNF-CS aerogel-based system demonstrated a high enrichment efficiency of (96.30 ± 1.01)% and an elution rate of (89.16 ± 3.08)% for target pathogens. The entire enrichment and elution process is completed within (6.16 ± 0.05) min using 800 mL liquid samples or complex real-food matrices, including milk, watermelon, and oyster. Furthermore, the constituent materials of the CNF-CS aerogel are environmentally benign, biodegradable, and derived from sustainable sources. The aerogel can be tailored in terms of size, shape, and thickness to meet specific application requirements, highlighting its adaptability and strong potential for practical implementation and widespread adoption.
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JOURNAL OF THE TEXTILE INSTITUTE
·
2025
·
IF 1.5
Na-won Baek
Enzyme-based dyeing processes have demonstrated the efficacy of synthetic templates; however, research on natural templates remains limited. This study explores the feasibility of enzyme dyeing processes for cellulose and protein fibers and verifies the potential of chitosan (CS) as a template to replace chemical templates. The dyeing mechanism of textiles was thoroughly analyzed using liquid chromatography-tandem mass spectrometry. The dyeability and functionality of dyed textiles were examined through Fourier-transform infrared spectroscopy, thermogravimetric analysis, and scanning electron microscopy. The color and colorfastness of textiles were evaluated using color depth analysis and various fastness tests. The results demonstrated that applying CS templates in the dyeing process increased K/S values and improved colorfastness for both silk and cotton fabrics. The K/S value of the dyed silk fabric increased from 5.6 to 7.8 following the application of the chitosan template, with color fastness improving by approximately one grade. For the dyed cotton fabric, the K/S value rose from 2.2 to 3.1, and color fastness improved by one or two grades on average.
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MICROPOROUS AND MESOPOROUS MATERIALS
·
2025
·
IF 4.7
Jing Zhang,Yifei Pu,Baichuan Zhuang,Jifei Zhuo,Xiaoli Xie,Shuang Xie,Tengfei Qu,Guangjun Gou
To address the challenge of removing heavy metal ions from industrial effluents, chitosan-based adsorbent materials have been extensively reported, particularly in terms of composite materials and the introduction of groups. In this paper, β- cyclodextrin ( β -CD) and amidoxime (AO) were simultaneously chemically cross-linked with chitosan (CTS) for the first time, resulting in amidoxime functionalized chitosan/ β- cyclodextrin composite (CTS-g-AO- β -CD) which was primarily applied to remove toxic metal ions. The adsorption capacities of CTS-g-AO- β -CD were 35.66, 31.28, 16.46 mg/g for Cu 2+ , Pb 2+ and Zn 2+ . The adsorption of Cu 2+ and Pb 2+ followed the pseudo-second-order kinetic and the Langmuir isotherm model, whereas the adsorption of Zn 2+ adhered to the pseudo-second-order kinetic and Freundlich isotherm model more closely. After five regeneration cycles, CTS-g-AO- β -CD still retained a certain adsorption performance, demonstrating its potential for application as a novel adsorbent.
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