ACS Biomaterials Science & Engineering
·
2025
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IF 5.5
Juan Huang,Mingjing Yang,Xingyu Zhou,Jigang Luo,Xiaoxia Yan,Guanghui Lin,Shijie Li,Shihui Liu,Zhuoyue Song,Chunzhi Tang,Nenggui Xu,Tao Liu,Jian Liang
Drug repurposing has received increasing attention in the field of oncology drug development as an alternative strategy to de novo drug synthesis. Disulfiram (DSF) has a long history of clinical application in alcohol withdrawal, and recent studies have revealed that its metabolite diethyldithiocarbamate (DDTC) can be coordinated with copper ions in vivo to form Cu-DDTC complexes with anticancer activity. However, the insufficient in vivo stability of DSF remains a challenge. In this study, the nanomedicine Cu-BTC@DDTC with DDTC-Cu(I) chemical valence and polycrystalline structure was prepared by incorporation of DDTC into the nanosized metal–organic framework (MOF) Cu-BTC. The in vitro cellular evaluation results showed that Cu-BTC@DDTC exhibited high inhibition of tumor cell growth, migration, and invasion. Animal experiments on the xenograft tumor model further demonstrated the excellent antitumor activity and biosafety of Cu-BTC@DDTC, and the antitumor activity was found to be closely related to the regulation of the SLC7A11/GPX4 signaling pathway to induce ferroptosis. This study provides a feasible option for antitumor drug development based on a drug repurposing strategy.
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Carbohydrate Polymer Technologies and Applications
·
2025
·
IF 6.5
Yu Yao,Yuchen Lin,Hongwei Xi,Ruhao Han,Liangjie Tian,Yusheng Yang,Chonghe Cui,Yuhui Chen,Huimin Zhang,Ruixiong Chen,Wangan Li,Qingrong Lin,Rong Zeng,Yanjun Hu
s Currently, large segmental bone defects due to accidents, osteomyelitis debridement surgery, and other conditions, the treatments remain difficult. Large segmental bone defects are characterized by long treatment times, poor prognoses, and infectious complications. Although metal ions play crucial roles in directing bone tissue engineering, limited research has concentrated on ion-doped bacterial cellulose’s immunomodulatory properties. Therefore, we developed a mineralized bacterial cellulose (ZnCu-CaP-BC) biomaterial loaded with zinc and copper ions to enhance the bone immune environment and improve bone regeneration, as well as achieve anti-infection effects. The successful preparation of a mineralized bacterial cellulose biomaterial doped with Zn/Cu ions was confirmed by material characterization and biocompatibility experiments. Moreover, in vitro experiments demonstrated that the developed biomaterial has strong antimicrobial properties and can stimulate macrophages to improve the bone immune microenvironment by both reprogramming macrophages from the M1 to M2 phenotype and increasing the expression of alkaline phosphatase (ALP) and osteoclastogenic protein (OCN). The study performed in vivo experiments to further validate the bone-enhancing and antimicrobial properties of this biomaterial by using a rat femoral condylar defect and subcutaneous infection model. Overall, owing to the excellent antimicrobial, immunomodulatory, and bone-enhancing effects of ZnCu-CaP-BC, this material has great potential in the future.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
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IF 6.3
Liang Yan,Weiwei Men,Yujing Zhang,Yanqi Wu,Xuan Yang,Yilin Zhang,Chuyang Liu,Jun Liu,Feng Xu
To address the challenges of impedance mismatch and limited absorption bandwidth in ferrite-based microwave absorbers, a one-step oxygen-deficient sintering process was employed to fabricate Zn 0.35 Ni 0.65 Fe 2 O 4 /Ni-Cu multiphase composites. This approach effectively regulates Cu 2+ substitution for Ni 2+ /Zn 2+ in the ferrite lattice while modifying the Ostwald ripening process, synergistically enhancing dielectric and magnetic losses. The pure Zn 0.35 Ni 0.65 Fe 2 O 4 exhibits a broad low-frequency absorption of 5.6 GHz (3.4–9.0 GHz, covering the entire C-band). Notably, the Zn 0.35 Ni 0.65 Fe 2 O 4 /Ni-Cu composite achieves a remarkable minimum reflection loss (RL min ) of −35 dB along with an effective absorption bandwidth (EAB) of 4.7 GHz. Consequently, this work provides both a facile synthesis methodology and mechanistic insights for designing high-performance electromagnetic materials with multiband operability.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2026
·
IF 9.6
Yi Zhou,Peike Cao,Shuo Chen,Hongtao Yu,Xie Quan
Selectively converting carbon dioxide (CO 2 ) to ethanol via photocatalysis offers a sustainable means of storing solar energy in chemical bonds. However, its efficiency is limited by an inadequate proton supply from water oxidation to drive the carbon‑carbon (C C) coupling step. This inefficiency leads to poor ethanol selectivity and promotes a competing hydrogen evolution side reaction, ultimately restricting overall system performance. Here, we designed a ternary In(OH) 3 -Cu 2 O/PCN heterojunction as a functionally partitioned catalyst: Polymeric carbon nitride (PCN) acts as the photoelectron donor, cuprous oxide (Cu 2 O) acts as the CO 2 reduction center, and trace indium hydroxide (In(OH) 3 ) is dedicated to water oxidation. Density Functional Theory (DFT) calculations reveal that water dissociation on In(OH) 3 generates active hydrogen species (*H), which are subsequently transferred to adjacent Cu sites with a low migration barrier. This interfacial proton relay mechanism avoids the accumulation of high-energy *H intermediates on the active sites, which suppresses the competing hydrogen evolution reaction. Correspondingly, the energy barrier for the crucial adsorbed carbon monoxide (*CO) dimerization step is lowered from 0.93 eV to 0.78 eV. The catalyst demonstrates superior activity to most documented photocatalysts for CO 2 -to-ethanol conversion, operating under sacrificial agent-free conditions, achieving an ethanol production rate of 125.4 ± 5.1 μmol g −1 h −1 and a selectivity of 90.4% ± 2.8%. These findings highlight the promise of functionally partitioned architectures in steering complex multi-step photocatalytic transformations toward valuable multi‑carbon products.
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WATER AIR AND SOIL POLLUTION
·
2026
·Vol. 237
·期 14
·791
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IF 3.5
Yu Lian,Lu Jiarui,Yu Meng,Duan Yajing,Zhang Baofeng,Zhang Xuan,Wang Xiaoyue,Liang Cunzhen
Cu(I) doped Fe 3 O 4 nanoparticles was loaded onto graphene oxide, Cu-Fe 3 O 4 /GO with binary active sites and accelerated Fe(III)/Fe(II) cycle showed higher tetracycline hydrochloride oxidation efficiency than Fe 3 O 4 and Cu-Fe 3 O 4 , the influences of initial H 2 O 2 concentration, reaction pH, catalyst dosage, reaction temperature and radical scavengers on catalytic performance of Cu-Fe 3 O 4 /GO were investigated. The heterogeneous Fenton reaction over Cu-Fe 3 O 4 /GO surface contained Fe(III)/Fe(II) and Cu(II)/Cu(I) active sites, Fe species were the dominant active centers. Cu-Fe 3 O 4 nanoparticles and GO combined via C–O–Fe bond and formed a stable Cu-Fe 3 O 4 /GO conductive structure, which promoted electrons transfer between Cu-Fe 3 O 4 and H 2 O 2 , thus accelerating Fe(III)/Fe(II) and Cu(II)/Cu(I) cycles. GO significantly improved specific surface area, Cu-Fe 3 O 4 nanoparticles dispersibility, and adsorption performance of catalyst. Furthermore, the strong interaction between GO and Cu-Fe 3 O 4 prevented ions from leach, GO captured the soluble Fe(III) which was efficiently reduced to Fe(II) surf by surrounding H 2 O 2 and Cu(I) surf . The degradation efficiency maintained 80.7% after six cycles, the excellent stability can be ascribed to the strong interaction between Cu-Fe 3 O 4 and GO. Reactive oxygen species scavenging results indicated that surface-bound • OH surf played a dominating role, followed by aqueous • OH aq and superoxide radicals (O 2 •− ).
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JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
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2026
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IF 4.4
Congyang Zou,Yujie Wang,Jie Tian,Ruijie Liu,Minjie Yang
The Ag 2 CO 3 /Cu-BiVO 4 (ACCB) Z -scheme heterojunction photocatalyst was synthesized via a combined hydrothermal and deposition method to activate peroxydisulfate (PDS) for efficient degradation of norfloxacin (NOR). Compared with conventional photocatalysts, the as-prepared Z -scheme heterojunction effectively promotes the separation of photogenerated carriers via a Z-scheme charge transfer pathway. Systematic characterizations including XRD, SEM, and XPS verified the successful preparation of the ACCB Z -scheme heterojunction and the incorporation of Cu, both of which play key roles in enhancing PDS activation and NOR degradation. Photocatalytic degradation experiments demonstrated that ACCB-100 exhibited optimal performance among the ACCB catalyst series under visible light irradiation, achieving a NOR degradation efficiency of 95.68% within 120 min, which was significantly superior to those of the pristine single-component materials. Further cyclic degradation experiments showed that ACCB-100 still retained a degradation efficiency of 88.62% after five cycles, indicating its excellent photocatalytic stability. Simultaneously, radical trapping experiments and ESR analyses demonstrated that h + , ·O 2 − , ·OH and SO 4 ·- were the active species involved in the photocatalytic degradation of NOR.
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ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Xian-Ze Meng,Xin-Ran Li,Yang Li,Hong-Ji Wan,Hao-Jie Yan,Lian-Kui Wu,Fa-He Cao
The deployment of potassium ion (K+) sensors in demanding environments, such as marine resource utilization, energy storage systems, and industrial processes, is severely limited by the thermal instability of state-of-the-art sensing materials. Traditional ionophores like valinomycin and crown ethers irreversibly lose activity above 50 °C, rendering them unsuitable for applications involving significant temperature fluctuations. Herein, we report a breakthrough all-solid-state K+ sensor engineered to overcome this fundamental limitation. The sensor architecture integrates a Cu2O semiconductor as an ion-electron transduction layer and a potassium–copper hexacyanoferrate (CuHCF(K)) active layer, forming a robust Cu–Cu2O–CuHCF heterojunction. First-principles density functional theory (DFT) calculations guided the rational design, predicting superior K+ selectivity over Na+ based on adsorption energetics and d-band center analysis. A one-step electrochemical synthesis protocol was developed to fabricate this heterostructure with comprehensive characterization (EIS, XPS, XRD, SEM) confirming its successful formation and interfacial properties. The sensor demonstrates exceptional analytical performance, operating reliably within a wide temperature range of 25–100 °C and maintaining high selectivity for K+ in high-salinity seawater matrices. Furthermore, to bridge the gap between laboratory data and field deployment, we developed and open-sourced a Potential–Temperature–Concentration (PTC) machine learning model based on a back-propagation neural network. This work provides a new paradigm for designing robust electrochemical sensors for harsh environments, combining theoretical material design with intelligent data processing for practical industrial applications.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2026
·
IF 6.7
Haixia Wu,Sai Li,Dongyuan Yang,Yuhang Wang,Shuoshuo Wang,Yameng Ma,Zekai Ma,Na Liu,Kui Zhang,Haiyan Zhu,Shaobo Jia,Peng Ren,Qing Feng,Rui Tan,Zhiming Feng
Flexible zinc-air batteries (FZABs) hold great promise for powering next-generation wearable electronics, yet their advancement is hindered by sluggish oxygen electrocatalysis and poor cycling stability. Here, we employ a dielectric barrier discharge (DBD) plasma-assisted approach to modify CuO x /activated carbon (CuO x /AC) composite catalysts, offering a facile and scalable route to simultaneously tailor surface chemistry and nanostructure. The plasma treatment generates abundant oxygen vacancies and stabilizes mixed Cu + /Cu 2+ valence states, thereby accelerating both oxygen reduction and evolution reaction (ORR/OER) kinetics. It also produces a three-dimensional porous architecture of vertically aligned nanosheets with uniformly dispersed CuO x nanoparticles, enabling rapid electron/mass transport. When applied in FZABs, the CuO x /AC-DBD catalyst achieves a high peak power density (226 mW cm −2 ), an open-circuit voltage of 1.37 V, and remarkable cycling stability with 95% capacity retention. Compared with untreated catalysts, it exhibits a much lower charge-transfer resistance (12 Ω cm 2 ) and superior durability. This study demonstrates that DBD plasma engineering is an effective and low-cost strategy for designing high-performance bifunctional catalysts, paving the way for flexible and wearable energy storage devices.
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Catalysts
·
2026
·Vol. 16
·期 5
·402
·
IF 4.5
Lewa Zhang,Joseph Cao,Bowen Liu,Rongze Li,Bangwei Deng,Chenyuan Zhu
Electrocatalytic nitrate reduction to ammonia (NH3) offers a sustainable alternative to the Haber–Bosch process while enabling remediation of nitrate-contaminated water. However, the mechanistic origin of performance differences among bimetallic catalysts remains poorly understood, particularly regarding the metal-dependent evolution of reaction intermediates. Here, we construct a series of phase-pure tandem Cu–M catalysts (M = Co, Ni, Fe, Sn) by physically integrating commercial nanoparticles to examine the role of the secondary metal. In this architecture, Cu governs nitrate adsorption and its initial reduction to nitrite, whereas M dictates downstream hydrogenation toward NH3. Operando ATR–FTIR spectroscopy reveals that NH3FE is determined by the hydrogenation kinetics of nitrite-derived intermediates rather than nitrate activation itself. Among the examined systems, Cu–Co achieves optimal kinetic matching, enabling rapid nitrite consumption and continuous hydrogenation, delivering an ammonia Faradaic efficiency of 91.2% with minimal nitrite accumulation (~1.0%) and a yield rate of 0.86 mmol h−1cm−2at −0.5 Vvs. RHE. In contrast, Ni and Fe exhibit sluggish hydrogenation, while Sn induces pronounced intermediate buildup. These findings identify nitrite hydrogenation as the selectivity-determining step in tandem nitrate reduction and establish the chemical nature of the secondary metal as a decisive descriptor for rational catalyst design.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Zhihan Hu,Tong Wang,Huimeng Feng,Zhipeng Zhao,Xiao Sun,Shougang Chen
Core-shell Cu-BTC@ZIF-8 enhanced hydrophobicity without sacrificing ethylene adsorption. • ZIF-8 shell provided water blocking while enabling ethylene transport. • HMDS/PDMS integration improved water resistance, filler dispersion and membrane processability. • Active packaging membrane with ethylene-scavenging, antibacterial activity, and improved water stability. Ethylene accelerates postharvest ripening and quality loss of fruits and vegetables even at ppm levels. Copper-based MOFs, such as Cu-BTC, can capture olefins via open metal sites (OMS) through π-complexation, yet water sensitivity and powder form limit their use in humid, air-based transport. Here, we report an ethylene-scavenging composite membrane developed through a processable material-design strategy involving structural protection, surface engineering, and membrane integration. A ZIF-8 shell is grown in situ on Cu-BTC to form a microporous protective interface that suppresses water ingress and mitigates water-induced OMS deactivation, while its known aperture flexibility associated with 2-methylimidazolate linker motion is incorporated into the design to maintain ethylene transport through the shell under humid air. In air at 25 ± 2 °C and 50 ± 5% RH, Cu-BTC@ZIF-8 exhibited an ethylene uptake of 35.97 cm 3 (STP) g −1 over 72 h, exceeding pristine Cu-BTC. An ultrathin HMDS-derived siloxane layer was subsequently introduced, and the particles were embedded in PDMS to further improve water resistance and convert the powder adsorbent into a processable membrane form with improved engineering applicability. In an 80 L sealed chamber under real air, the Cu-BTC@ZIF-8 + HMDS|PDMS membrane showed an ethylene removal capacity of 34.71 cm 3 (STP) g −1 over 72 h based on MOF mass and retained approximately 80% of its initial performance after ten 72 h cycles. In a 10-day banana storage experiment at 25 ± 2 °C, the composite membrane delayed visible browning by 3–4 days compared with blank and pure PDMS controls and showed inhibitory activity against E. coli and S. aureus . This work proposes a feasible material-oriented strategy to enhance the water resistance and processability of Cu-BTC-based MOF materials, while avoiding compromising ethylene adsorption performance under real-air conditions.
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Journal of Materials Chemistry C
·
2026
·
IF 5.1
Wenbo Wu,Tianyi Liu,Yaqun Han,Yue Wu,Suli Wu
Structural colors are generated by some different mechanisms. Here, we prepared a kind of large-area structural color films using Cu₂O@SiO₂ microsphere as the coloring units. The film is prepared by infusing PDMS into a disordered structural template assembled from Cu₂O@SiO₂ microsphere, followed by thermal curing and peeling. The disordered Cu₂O@SiO₂ thin layers embedded in the film are obtained by a spraying method, which can generate vivid noniridescent structural colors due to the strong Mie scattering of Cu₂O@SiO₂ microsphere. Meanwhile, Cu₂O@SiO₂-polydimethylsiloxane composite films show excellent chemical stability and mechanical properties. Dynamic tuning of the structural color is achieved by covering the film surface with a liquid layer, which modulates the interfacial medium environment and alters the relative refractive index contrast between the medium and the scattering units. Notably, when applied as structural color writing paper, the film demonstrates good reversible writing and erasing performance. The simple color-changing mechanism and ease of large-area fabrication make it a promising candidate for rewritable colored paper applications.
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FULLERENES NANOTUBES AND CARBON NANOSTRUCTURES
·
2016
·
IF 0.812
Liyuan Zhang,Yanfang Tai,Changpeng Lv,Chuanhu Wang
In this study, the water-soluble magnetic-multi-walled carbon nanotubes nanocomposites were fabricated via a facile and efficient approach and were characterized by X-ray diffraction, energy-dispersive X-ray, and transmission electron microscopy in detail. The nanocomposites could be employed as an effective adsorbent for removal of heavy metal ions, Cu(II) ions, from aqueous solution. It is noteworthy that the novel adsorbent displayed good water-dispersibility, rapid absorption rate, high absorption capacity, and convenient magnetic separation. Furthermore, the nanocomposites could be recovered and recycled for 10 consecutive trials without significant loss of its activity.
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