TALANTA
·
2026
·
IF 6.7
Xin Zhou,Jingyao Zhang,Wencong Li,Xiangdong Xu
An organic material 4-(4-dimethylaminostyryl) methylbenzothiazole 4-methylbenzenesulfonate (DABT) with a D-π-A structure was prepared, and its luminescent properties and pH-driven fluorescence switching were investigated. The dimethylamino group in its cation contains a nitrogen (N) atom with a lone pair of electrons, serving as the electron donor for sensing H + ions. Protonation of this N atom under acid stimulation modulates the intramolecular charge transfer (ICT) effect and the resultant light absorption and photoluminescence of DABT, thereby realizing the recognition and detection of H + . These characteristics endow DABT with photochromism in both liquid and solid states, and the feasibility of sensing ultra-acidic pH: (i) Both acid (trifluoroacetic acid, TFA) and base (triethylamine, TEA) additions can be efficiently sensed by three forms of reversible conversions, including color, light absorption, and fluorescence response of DABT in its dichloromethane (DCM) solution; (ii) TFA or TEA vapor in air can also be rapidly sensed by solid DABT powders or DABT−polyvinyl alcohol (PVA) composite films; (iii) In the strong acidic pH range of 1.0−3.5, a good linear relationship between the fluorescence emission of DABT and pH value was measured, with a high fitting R 2 of 0.9925. This work reveals the peculiar reversible photochromism of organic DABT under acid or base treatment, and particularly, it discloses novel highly-sensitive fluorescent organic probes for efficiently sensing ultra-acidic pH.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2026
·
IF 9.6
Chenxi Gao,Changcun Han,Hao Xiang,Zhuo Peng,Yinbo Tong,Chengyi Zhang,Hui Lv,Yizhong Huang
Precise control of the photogenerated charge dynamics and the electronic configuration of active sites is key to enhancing the performance of photocatalytic hydrogen-producing materials. Here, we report an efficient one-pot strategy to prepare sulfur-doped g-C 3 N 4 (SCN). Furthermore, a PtNd/SCN composite photocatalyst was successfully fabricated by loading a platinum (Pt)‑neodymium (Nd) alloy onto the SCN surface via an H 2 reduction method. Using trithiocyanuric acid as a single precursor to supply C, N, and S enables uniform S doping within the g-C 3 N 4 framework, broadening the light absorption range and optimizing the band structure. Pt serves as the primary hydrogen-evolving active site, while Nd acts as an “electronic co-catalyst” for Pt, forming strong electronic interactions through its unique 4f orbital structure. HRTEM and XPS analyses confirm the formation of a Pt Nd alloy interface and directional electron transfer from Nd to Pt, effectively modulating the Pt d-band center and optimizing the adsorption free energy of hydrogen intermediates, thereby significantly enhancing hydrogen evolution reaction (HER) kinetics. The experimental results show that the optimized PtNd/SCN composite photocatalyst exhibits a markedly enhanced photocatalytic hydrogen production rate under simulated sunlight, reaching 5468 μmol·g −1 ·h −1 —5 times higher than Pt/CN (1074 μmol·g −1 ·h −1 ) and 1.3 times that of Pt/SCN (4076 μmol·g −1 ·h −1 ). PL, TRPL, and photoelectrochemical measurements confirm that the introduction of Nd promotes the migration of photo-generated electrons from SCN to Pt, thereby significantly suppressing carrier recombination. This study reveals the unique mechanism by which the rare earth element Nd acts as an electronic regulator for the d-band center of Pt, providing new insights into the design of photocatalytic systems with low Pt loading. Download: Download high-res image (144KB) Download: Download full-size image
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2026
·
IF 9.1
Shuo Zhang,Chenxi Chang,Tong Xu,Qingyuan Zhang,Wenxia Zhao,Xiuling Cai,Zidan Li,Bin Zhu
An interface-engineered S-scheme BiOBr/CoFe-LDH heterojunction photocatalyst was fabricated via a facile one-pot hydrothermal method to boost CIP degradation. The crystal structure, morphology, optoelectronic properties and interfacial charge transfer behavior were systematically characterized by XRD, TEM, XPS, photoelectrochemical measurements and density functional theory (DFT) calculations. The optimized 5-BOB/LDH/PMS/Vis system achieved ∼90% CIP removal within 60 min for 20 mg L −1 CIP solution, with an apparent rate constant 1.7-fold and 11.3-fold higher than those of pristine CoFe-LDH and BiOBr, respectively. The catalyst exhibited excellent practical applicability: it retained 81.5% activity after 5 consecutive cycles, maintained high degradation efficiency over a broad pH range (4–11) and showed universal degradation capability toward tetracycline, rhodamine B, acetaminophen and sulfadiazine. Mechanistic studies revealed that the constructed S-scheme heterojunction not only suppressed charge carrier recombination but also upshifted the d-band center of Fe species, enhancing PMS adsorption and accelerating the synergistic redox cycle between Co and Fe active sites. This work provides a rational design strategy for high-performance PMS-activating photocatalysts and demonstrates great potential for the advanced treatment of antibiotic-containing wastewater.
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Sensing and Bio-Sensing Research
·
2026
·
IF 4.7
Ahmad Movahedpour,Omid Sheydaei,Arash Asfaram,Sajedeh Karami,Hassan Ghasemi
This study presents the design and electrochemical characterization of a highly sensitive and selective sensor for the determination of D−/L- kynurenine (D−/L- KYN), based on a carbon paste electrode (CPE) modified with multi-walled carbon nanotubes (MWCNTs). The electrocatalytic oxidation of D−/L-KYN at the MWCNT-modified CPE was systematically investigated using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The Structural and morphological characteristics of the MWCNTs were characterized by Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and X-ray diffraction (XRD). The combined characterization results confirmed the successful functionalization, morphological integrity, and crystalline structure of the MWCNTs, supporting their suitability as an efficient electrode modifier. At physiological pH (7.0) in phosphate buffer solution (PBS), D−/L-KYN exhibited a well-defined oxidation peak at +0.85 V (vs. Ag/AgCl). The electrochemical behavior of the analyte followed a diffusion-controlled mechanism involving a two-electron/two-proton transfer process. Key analytical parameters including solution pH and scan rate were optimized to enhance sensor performance. The fabricated sensor exhibited a linear concentration range of 0.06–40.0 μM, with an impressive limit of detection 3 nM (S/N = 3). Furthermore, the sensor demonstrated excellent reproducibility and repeatability, with relative standard deviations (RSDs) of 3.8% and 3.3%, respectively. The developed platform was successfully applied to the quantification of D−/L-KYN in spiked human plasma samples, demonstrating its potential for clinical and biomedical applications.
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Scientific Reports
·
2026
·
IF 4.9
Zhou Kun,Yuan Wei,Zhang Fan
Radix Bupleuri-Radix Paeoniae Alba (RB-RPA) has the potential to ameliorate the immune microenvironment in hepatocellular carcinoma (HCC). The interactions between various cells influence the immune microenvironment. However, the effects of the active components (saikosaponin D (SSD) and paeoniflorin) of RB-RPA on HCC and the cell interactions within its microenvironment warrant further investigations. We established orthotopic mouse models of HCC using Hepa 1–6 cells (a hepatoma cell line) to investigate the infiltration of cancer-associated fibroblasts (CAFs). Following this, we knocked down CLCF1 in the CAFs to explore their interactions with Hepa 1–6 cells. We subsequently treated CAFs with SSD-paeoniflorin. In T-cell activation assays, we overexpressed PD-L1 in Hepa 1–6 cells and co-cultured these cells with T cells. Additionally, we treated HCC mice with SSD-paeoniflorin and induced the overexpression of CLCF1 in vivo. In mice with HCC, tumors were characterized by substantial infiltration of CAFs, which displayed elevated levels of the protein CLCF1. These CAFs play a role in suppressing the HCC immune microenvironment and elevating PD-L1 levels through the production of CLCF1. At the cellular level, SSD-paeoniflorin inhibited the growth of CAFs and the expression of CLCF1 and also suppressed the PD-L1 level in Hepa 1–6 cells through CAF-derived CLCF1. Mechanistically, CLCF1 may promote PD-L1 expression via the JAK/STAT3 signaling pathway. Furthermore, the overexpression of PD-L1 in Hepa 1–6 cells suppressed T cell proliferation and activation. In animal studies, SSD-paeoniflorin improved the HCC immune microenvironment by enhancing the interaction between CAFs and Hepa 1–6 cells through CLCF1. Collectively, SSD-paeoniflorin inhibits CLCF1 secretion in CAFs to downregulate PD-L1 expression in Hepa 1–6 cells and may reactivate the anti-tumor immune microenvironment in HCC.
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高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2026
·
IF 5.4
Siyi Liu,Mingqin Kang,Zhongping Dong,Shuyan Xiao
Single-atom nanozymes exhibit high catalytic efficiency, which is strongly determined by the coordination environment of metal centers and the structure of the supporting carbon matrix. Herein, a series of sulfur-coordinated copper single-atom nanozymes with atomically dispersed Cu-N x sites was synthesized via pyrolysis of zeolitic imidazolate framework-8 precursors co-encapsulating sodium copper chlorophyllin (SCC) and L -cysteine. SCC provided Cu-N 4 motifs, stabilizing atomically dispersed Cu sites during pyrolysis. L -cysteine plays a multifaceted role by introducing Cu-S coordination, regulating carbon framework size, and generating defect-rich structures, collectively enhancing oxidase-like activity. The optimized nanozyme exhibited a Michaelis-Menten constant of 0.28 mM and a maximum reaction rate of 6.73 × 10⁻ 8 M·s⁻ 1 , indicating strong substrate affinity and rapid catalytic turnover. Using this nanozyme, a colorimetric sensor for D -penicillamine ( D -PA) was developed, achieving an ultra-wide detection range from 0.5 to 3000 μM through a segmented detection strategy, with a low detection limit of 0.279 μM and recoveries of 92.7–107.4% in river water samples. This work demonstrates a robust sulfur-coordination strategy for high-performance single-atom nanozymes and provides a practical platform for monitoring pharmaceutical pollutants over an ultra-wide concentration range.
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Materials Today Energy
·
2026
·
IF 8.1
Hui Lu,Shuai Zhang,Tao Sun,Wei Wang,Wei Sun,Li Yan,Xueying Cheng,Chunbo Liu
The photocatalytic two–electron oxygen reduction reaction (2e - ORR) for hydrogen peroxide (H 2 O 2 ) production offers a green and sustainable alternative to the energy–intensive anthraquinone process. Donor–π–acceptor (D–π–A) conjugated polymer photocatalysts are suitable for this reaction because their electronic structures and visible–light absorption can be readily tuned. However, inefficient charge separation and limited ORR selectivity remain major challenges. Here, we regulate the donor unit in a D–π–A polymer comprising an alkynyl triazine acceptor and an alkynyl π–bridge by replacing the fluorenone (DBF) donor with thienothiophene (DBTT). The stronger electron–donating character of DBTT promotes spatial separation of the highest occupied and lowest unoccupied molecular orbitals, facilitating charge separation and suppressing carrier recombination. Consequently, TEPT–DBTT achieves an H 2 O 2 production rate of 2273 μmol g -1 h -1 under visible light, approximately six times higher than that of TEPT–DBF. This study demonstrates that donor–unit engineering effectively modulates spatial charge separation and enhances photocatalytic H 2 O 2 production, providing a molecular design strategy for efficient triazine–based D–π–A polymer photocatalysts.
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XENOBIOTICA
·
2026
·
IF 1.5
Jiexin Qiu,Beibei Yao,Qing Yu,Jiajie Wang,Lingling Huang,Jiale Chen,Yufeng Lu,Chunying Wang
Cis-2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside (cis-THSG), a photoisomer of the major bioactive component in Polygoni Multiflori Radix Praeparata (He-Shou-Wu), has enhanced hypolipidemic activity but is associated with idiosyncratic hepatotoxicity. Its metabolic fate under pathological conditions and key clearance enzymes remain unclear.This study aimed to compare metabolite profiles of cis-THSG in normal and hyperlipidemic rats in vivo and in vitro, identify metabolites, and characterise enzyme kinetics in rat liver microsomes (RLMs) and major CYP450 isoforms. Metabolites in plasma, urine, faeces, bile, and intestinal bacteria incubation fluids were analysed by UHPLC-Q-TOF-MS/MS. Enzymatic kinetics and CYP450 isoforms were investigated via chemical inhibition assays.A total of 27 metabolites were characterised; cis-THSG underwent rapid glucoside hydrolysis, and its aglycone underwent phase I and II reactions. Hyperlipidaemia reduced metabolites to 20 and markedly increased plasma cis-THSG and aglycone abundance. Kinetic parameters were Km 32.86 μmol/L, Vmax 0.7285 μmol/(min·mg protein), CLint 0.02217 L/(min·mg protein). Rat liver microsomal CYP isoforms analogous to human CYP3A4 and CYP2C9 mediated cis-THSG oxidative metabolism.This study provides the first comprehensive metabolite map of cis-THSG, identifies its aglycone as a potential bioactive form, and reveals a disease-related metabolic shift. CYP phenotyping offers a mechanistic basis for predicting clinical drug–drug interactions.
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高影响因子
ChemistrySelect
·
2025
·Vol. 10
·期 22
·e05941
·
IF 2
Yiyi Qiao,Jian Cao,Yanan Li,Chuanxiao Wang,Jiayu Gao,Linlin Wang,Xiao Zhang,Le Wang,Yuanhao Li,Zhicheng Zuo
Graphical “Donor-Acceptor” structural molecules with ICT and AIE properties were constructed. The sensor Nap-B1 was able to specifically recognize HSA by modifying with pyridinium and quinolinium. In the H2O-EtOH system or highly viscous and solid phase environment, the fluorescence of sensor was turned on in an aggregated. Elevated levels of human serum albumin (HSA) serve as an early indicator of cardiovascular and renal diseases in diabetic and hypertensive patients. This study focuses on the design and synthesis of two fluorescent probes, Nap-B1 and Nap-KL, which were developed by functionalizing the “D–A” structural framework consisting of naphthalimide derivatives (A) and triphenylamine (D) with pyridine/quinoline cations. These sensors are intended for the quantitative detection of HSA in urine, specifically recognizing HSA and inducing fluorescence “turn-on” upon binding. Both Nap-B1 and Nap-KL is demonstrated high selectivity for HSA, stability independent of environmental factors, and sensitivity for rapid detection. Changes in Zeta potential, dynamic light scattering (DLS), fluorescence lifetime, and fluorescence intensity were observed, which result from alterations in HSA conformation before and after sensor binding. Molecular docking experiments further confirmed that the probes bind to HSA via hydrophobic interactions and electrostatic adsorption, forming a probe-HSA complex and triggering the fluorescent response.
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RARE METALS
·
2026
·Vol. 45
·期 3
·e70185
·
IF 12.1
Chenyang Shu,Yimin Chen,Chuanlan Xu,Xinru Xu,Lingtao Sun,Jiayi Niu,Cherkasova Tatiana,Chaozhong Guo,Yuan Niu,Quan Xu
en This link goes to a English section zh This link goes to a Chinese section Platinum (Pt)-based catalysts are crucial for the commercialization of hydrogen/metal air batteries, but they suffer from Pt scarcity, high cost, and nanoparticle dissolution/agglomeration, mainly leading to performance degradation. We address this by synthesizing a PtFe alloy catalyst (PtFe–PA–NC) via a phytic acid (PA) assisted pyrolysis strategy, featuring Pt-skin-coated PtFe alloy nanoparticles on hierarchically porous N-doped carbon (NC). PA treatment simultaneously enhances the support's surface area and pore structure for better mass transport, and incorporates P into the carbon framework via P–C bonds. It can induce charge delocalization, regulating the electronic structure of PtFe alloys and strengthening Pt–Fe coupling. The Pt-skin suppresses Fe dissolution, whereas the PtFe core optimizes oxygen reduction reaction (ORR) intermediate adsorption (e.g., *OH). Theoretical calculations confirm that the Fe atom adjusts the d-band center of the Pt atom, intensifying oxygen binding and shifting the rate-determining step. Electrochemically, PtFe–PA–NC achieves a half-wave potential of 0.85 V and retains 95.8% of specific energy density after more than 140 h in zinc-air batteries. In alkaline fuel cells, it delivers a peak power density of 508 mW cm −2 at an ultralow Pt loading (0.017 mg cm −2 ), approximately twice that of 5 wt% Pt/C (0.025 mg cm −2 ). This work showcases synergistic electronic and interfacial regulation through heteroatom doping and alloying, promoting high-performance hydrogen/metal air batteries. 摘要 en This link goes to a English section zh This link goes to a Chinese section 铂基催化剂是氢/金属空气电池商业化的关键,但铂资源稀缺、成本高昂且纳米颗粒易溶解/团聚 , 是导致其性能衰减的主要原因。为此 , 本论文通过植酸(PA)辅助热解策略合成了一种 PtFe合金催化剂(PtFe–PA–NC) , 其结构为: Pt 壳层包覆的PtFe合金纳米颗粒负载于分级多孔氮掺杂碳(NC)载体上。通过植酸处理过程可同时实现了两个效果 : 一是提升了载体的比表面积与孔结构, 优化了传质效率 ; 二是通过 P–C 键将磷引入碳骨架,诱导电荷离域 , 从而调控 PtFe 合金的电子结构、强化 Pt–Fe 耦合作用。其中, Pt 壳层可抑制 Fe 的溶解, 而 PtFe 核则能优化氧还原反应(ORR)中间产物(如 * OH)的吸附行为。理论计算表明: Fe 原子可调节 Pt 原子的 d 带中心, 增强氧的结合作用并改变反应的决速步。电化学测试表明: 在锌空气电池中, PtFe–PA–NC 的半波电位达 0.85 V, 且在 140 h 以上的运行后仍保持 95.8% 的能量密度; 在碱性燃料电池中, 当 Pt 载量低至 0.017 mg cm −2 时, 其峰值功率密度达 508 mW cm −2 , 约为商用 5 wt% Pt/C (载量为 0.025 mg cm −2 ) 的两倍。本研究工作通过杂原子掺杂与合金化实现了电子结构与界面的协同调控, 为高性能氢/金属空气电池的开发提供了新思路。
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CHEMISTRY-A EUROPEAN JOURNAL
·
2022
·Vol. 29
·期 16
·e202203524
·
IF 5.02
Liang Yan,Yongqi Ke,Yu Wang,Jingkui Yang,Yujian He,Li Wu
Graphical A series of mini-PEGs modified D-amino acid-containing peptides were synthesized. It was determined that the polyethylene glycol (PEG) modification promoted the enzymatic cleavage of the D-amino acid-containing peptides under the action of serine-like proteases. It was previously reported that D-amino acid-containing peptides exhibited the ability to resist enzymatic hydrolysis. This study investigated the influence of mini-PEGs modification on enzymatic hydrolysis ability of D-amino acid-containing peptides. The results showed that PEGylation promoted enzymatic hydrolysis of the D-amino acid-containing peptide, especially, the cleavage rate of the D-amino acid-containing peptide 6-w with PEG 3 modification at the N-ends was up to 17 times higher in the presence of proteinase K (PROK) compared to those without PEG 3 modification. Moreover, analysis of the enzymatic cleavage sites demonstrated a similar cleavage pattern of the PEGylated D-amino acid-containing peptide to that of the unmodified peptide. The computational simulations further showed that the enhanced enzymatic hydrolysis ability can be attributed to the strong interaction between PROK and the peptide after PEG 3 modification and the resulting formation of a mature catalytic triad structure.
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FOOD RESEARCH INTERNATIONAL
·
2022
·
IF 7.425
Zuoyong Zhang,Shudong He,Luji Zhang,Xinjiang Li,Risheng Jin,Qian Liu,Shuguan Chen,Junhui Wang,Hanju Sun
Vegetable oils with different unsaturated degrees (corn > peanut > olive > palm > coconut) and corresponding enzymatic hydrolysis-thermal oxidation (ENTH) oils were added into D-xylose and L-cysteine Maillard reaction (MR) system, respectively, for potential meaty aroma production. Results indicated that coconut oil and palm oil had lower peroxide, p -anisidine, total antioxidant values, and malondialdehyde content after ENTH and MR. Corn, peanut, and olive oils after ENTH could significantly promote MR because they caused the lower pH, higher reactants depletion, and higher browning degree in the water phase separated from the oil-Maillard reaction system. Additionally, the volatiles were mainly formed from oil phase. Corn, peanut, and olive oils were beneficial to volatiles formation in the oil-MR system due to fatty acid oxidation, especially oleic acid and linoleic acid. Meanwhile, compared to raw oils, adding ENTH oils to the MR system could reduce the content of oxygen, nitrogen, and sulfur-containing heterocycles.
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高影响因子
危险品化学品经营许可证（带存储）