JOURNAL OF MATERIALS SCIENCE
·
2015
·Vol. 51
·期 3
·1344-1353
·
IF 2.371
Yang Xia,Meng Nannan,Zhu Yuanchao,Zhou Yifeng,Nie Wangyan,Chen Pengpeng
In this work, molybdenum disulfide (MoS 2 ) nanosheets were employed to enhance the mechanical and thermal properties of chitosan (CS), which was one of the most promising biomaterials. In order to promote a homogeneous dispersion of MoS 2 and improved interface interactions between CS and fillers, carboxyl functionalization was subjected to the exfoliated MoS 2 nanosheets by chemical conjugation with thioglycolic acid before compositing with CS. Afterward, the CS/MoS 2 – g –COOH composite films were prepared by a simple solution blending method. Micromorphology characterizations showed that MoS 2 – g –COOH nanosheets dispersed much better than unmodified MoS 2 nanosheets, which was considered to be quite beneficial for the enhanced properties of CS nanocomposites. DMA results indicated that the mechanical properties of CS were improved by incorporating with MoS 2 – g –COOH nanosheets compared with neat CS and unmodified MoS 2 -filled CS. The thermal stability of CS/MoS 2 – g –COOH was also improved. This work demonstrated a promising route to prepare MoS 2 -based polymer nanocomposites with excellent performances.
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RSC Advances
·
2015
·Vol. 5
·期 49
·38810-38817
·
IF 3.84
Yeping Li,Jingbo Xu,Yun Xu,Liying Huang,Junli Wang,Xiaonong Cheng
The objective of the study is to describe a new approach of combining quantum dots into chitosan as an anti-cancer drug carrier. Novel chitosan–ZnSe/ZnS (CS–ZnSe/ZnS) nanoparticles were synthesized by a one-step ionic gelation technique, with ZnSe/ZnS quantum dots (ZnSe/ZnS QDs) as cross-linking agent and for fluorescent labeling. The approach not only avoids the use of emulsifiers and chemical cross-linking agents but also prevents the possibility of damage to drugs. The fluorescent CS–ZnSe/ZnS nanoparticles were about 100–500 nm in size and stable in a physiological environment. Low cytotoxicity was ensured by investigation with mouse lung carcinoma cells. The cell viability remained 99% when the concentration of CS–ZnSe/ZnS nanoparticles increased to 200 μg mL−1. In the in vitro drug release experiment, 5-fluorouracil (5-Fu) loaded within CS–ZnSe/ZnS nanoparticles had more preferable sustained-release performance and longer equilibrium time compared with that of the pure 5-Fu. The fluorescent CS–ZnSe/ZnS nanoparticles are expected to be used for biological fluorescent labeling and drug carriers.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
·
IF 8.025
Zhe Li,Xiaoxia Jiang,Hao Huang,Ao Liu,Hongning Liu,Naeem Abid,Liangshan Ming
The purpose of this study was to prepare chitosan/zein (CS/Zein) edible films reinforced with Mosla chinensis essential oils (EOs) nanoemulsions (NEs) and nanoparticles (NPs) in order to compare their properties. NEs and NPs containing EOs could be used to fabricate films with functional properties, and the films were prepared using a casting method. The influence of EO concentration and mixing methods on the physical, mechanical, and functional properties of the films was investigated. The results indicated that the films formulated with EO NEs generated favorable fundamental and functional characteristics with excellent mechanical properties, moisture barrier capacity, and significant antioxidant and antibacterial activity . In addition, the use of NEs-based films improved the release of bioactive compounds, and the mechanism of EO release was found to follow a first order model. In summary, EO NEs were more effective in preserving the fundamental and functional properties of CS/Zein nanocomposite edible films than NP-based films. These differences may reflect different forms and methods of dispersing EOs in NEs and NPs. This study demonstrated that NEs reinforced films could be used to enhance the effectiveness of EOs in food products and develop new strategies for their delivery and application.
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Journal of Functional Biomaterials
·
2022
·Vol. 13
·期 3
·141
·
IF 4.901
Jingxin Zhou,Na Li,Ping Liu,Zhiwei Liu,Lili Gao,Tifeng Jiao
In recent years, quercetin plays an increasingly important role in the medical field. However, the absorption and effect of quercetin as a drug in vivo are limited due to its extremely poor solubility in water. In addition, chitosan nanoparticles can deliver poorly soluble drugs as drug delivery carriers. Herein, chitosan nanoparticles were prepared by oxidative degradation and ionic cross-linking technology to study the drug loading properties of quercetin. On the other hand, the application of chitosan for fluorescent materials can improve the biocompatibility of fluorescent materials and increase the adsorption of fluorescent materials. Fluorescently labeled chitosan nanoparticles, especially chitosan microsphere fluorescent probes prepared using the abundant amino groups on chitosan chains to react with fluorescein isothiocyanate (FTIC), have been widely used as fluorescent probes in biomarkers and medical diagnostics. Therefore, chitosan–quercetin (CS–QT) drug-loaded nanoparticles are labeled with FITC, and the drug-loaded rate, encapsulation efficiency, and antioxidant properties were investigated. The drug-loaded rate of the sample reaches 8.39%, the encapsulation rate reaches 83.65%, and exhibits good antioxidant capacity. The fluorescence aperture of the obtained sample was consistent with the inhibition zone, which could realize the visualization of the antibacterial performance of the sample. The fluorescent-labeled nano-system exhibit superior antibacterial properties, which provide a strategy for observing the release and function of drugs.
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Journal of the Mechanical Behavior of Biomedical Materials
·
2016
·
IF 2.876
Jingjing Wu,Jiaoyan Liu,Yanmei Shi,Ying Wan
Silk fibroin (SF) and hydroxyapatite (HA) were incorporated into chitosan/glycerophosphate (GP) system to prepare new types of hydrogels. The formulated chitosan/SF/GP and chitosan/SF/HA/GP solutions were found to be injectable at room temperature, and able to form into hydrogels at near-physiological temperature and pH. Rheological measurements showed that elastic modulus of certain chitosan/SF/GP and chitosan/SF/HA/GP gels could reach around 1.8 and 15 kPa, respectively, and was much higher than their respective viscous modulus. Compressive measurements revealed that some chitosan/SF/GP and chitosan/SF/HA/GP gels had 8 and 20-fold modulus and strength higher than the chitosan/GP gel, respectively, confirming that compressive properties of these gels were greatly improved. Results obtained from in vivo degradation demonstrated that degradation endurance of the optimized chitosan/SF/GP and chitosan/SF/HA/GP gels was significantly enhanced as compared to the chitosan/GP gel, and the degradation rate of the gels could be regulated by the SF component alone or by the combination of SF and HA components.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Shaohui Guo,Minxuan Yang,Zhilang Xu,Liming Ge,Changdao Mu,Defu Li
Guided bone regeneration (GBR) technique is a standard therapy for reconstructing alveolar bone defects clinically, with the GBR membrane serving as the key medical device in this technique. However, the most commonly used collagen barrier membranes usually have poor mechanical properties and are prone to collapse during clinical use. Herein, a sandwich-like barrier membrane was developed with crosslinked chitosan as dense layer, crosslinked collagen as loose layer and passivated magnesium mesh as the skeleton. Surface modification has improved the corrosion resistance of magnesium mesh. Thanks to the introduction of magnesium mesh skeleton and crosslinking modification, the mechanical properties and supporting effects of barrier membrane have been improved. The dense layer of barrier membrane showed dense structure while the loose layer showed porous structure as expected. The barrier membrane showed good antibacterial performance against gram-positive and gram-negative bacteria owing to the antibacterial activity of chitosan and the added chlorhexidine acetate. Furthermore, the barrier membrane met the requirements of biocompatibility for implanted biomaterials. Interestingly, the barrier membrane had good anti-inflammatory activity to accelerate the transition from inflammatory to proliferative stage and can promote osteogenic differentiation of MC3T3-E1 cells. Overall, the sandwich-like barrier membrane has a wide application prospect to guide bone regeneration.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Minrui Ji,Zaixin Yuan,Yang Zhu,Fei Han,Caichou Zhao,Xinyu Yu,Zhichao Chen,Yaoyu Huang,Haozhe Jiang,Lei Shi,Cong Ye,Fuyin Wan,Ran Tao,Zhenyu Zhou
The management of open bone defects poses a formidable challenge in clinical practice, primarily due to issues such as profuse bleeding, inflammation, bacterial infections, and compromised bone fracture healing. To tackle these complexities, we have devised a novel hemostatic powder, namely the compound strontium-based chitosan quaternary ammonium salt hemostatic powder (QCS@SrT-TA). This innovative powder leverages the self-assembly of tripolyphosphate and strontium ions, facilitated by a positively charged core cross-linker. Furthermore, its surface has been strategically modified with polyphenol and positively charged macromolecules, imparting unique properties. The mesoporous architecture of QCS@SrT-TA facilitates rapid moisture absorption, enhancing its efficacy. In preclinical studies using rat tail artery amputation and liver bleeding models, QCS@SrT-TA exhibited remarkable performance, significantly reducing both bleeding time and volume (62.39 ± 2.89 mg, 35.33 ± 4.16 s in tail amputation, 63.7 ± 5.19 mg, 62.33 ± 9.61 s in liver bleeding). Notably, the positively charged strontium ions and quaternary ammonium salts within the powder were effective in removing bacteria, minimizing the risk of infection. Beyond hemostasis, QCS@SrT-TA demonstrates additional therapeutic benefits. It polarizes M2 macrophage phenotypes and promotes angiogenesis within bone defect sites, accelerating bone healing processes. Ultimately, a substantially enhanced and notable functional recovery is achieved. In summary, the rapid hemostatic, potent antibacterial, anti-inflammatory, and angiogenesis-promoting characteristics of QCS@SrT-TA hold immense promise as a groundbreaking clinical treatment strategy for open bone defects.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Xinru He,Zhanpeng Zhang,Xuan Xuan,Tingyuan Tan,Jiaxuan Sun,Biao Wang,Yu Tian,Heng Chen
The application of chitosan in packaging has always been limited due to its brittle and hygroscopic nature. In this study, hydrophobic short-chain fatty acids (SCFAs) were utilized to modify chitosan to overcome this issue. For the first time, hydrophobic SCFAs, typically hexanoic acid and its homologs, were found to be able to dissolve chitosan in water as well as its hydrophilic analog. After water was removed through evaporation, hydrophobic SCFA-modified chitosan films were obtained. The results of mechanical testing and DSC analysis confirmed that these hydrophobic SCFAs could effectively plasticize the chitosan film. Moreover, water contact angle measurements revealed that the hydrophilicity of these plasticized chitosan films was significantly reduced. The findings from the moisture uptake experiments indicated that linear hydrophobic SCFAs reduced the hygroscopicity of the chitosan film. Additionally, the crystal structures, thermal and gas barrier properties, and antibacterial activities of these hydrophobic SCFA-modified films were systematically examined and compared with those of hydrophilic SCFA-modified chitosan. This study presents an innovative and practical method for modifying chitosan films by regulating the structure of the cosolvent, thereby facilitating the real-world application of chitosan-based food packaging materials.
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iScience
·
2024
·
IF 4.6
Chenming Zou,Ruihua Cai,Yunbing Li,Yu Xue,Guoguang Zhang,Gulimiran Alitongbieke,Yutian Pan,Sanguo Zhang
Recently, increasing evidence has shown the association between liver abnormal inflammation and cognition impairment, yet their age-related pathogenesis remains obscure. Here, our study provides a potential mechanistic link between liver macrophage excessive activation and neuroinflammation in aging progression. In aged and LPS-injected C57BL/6J mice, systemic administration of β-chitosan ameliorates hepatic macrophage-driven inflammation and reduces peripheral accumulations of TNF-α and IL-1β. Downregulation of circulatory pro-inflammatory cytokines then decreases vascular VCAM1 expression and neuroinflammation in the hippocampus, leading to cognitive improvement in aged/LPS-stimulated mice. Interestingly, β-chitosan treatment also exhibits the beneficial effects on the behavioral recovery of aged/LPS-stimulated zebrafish and Caenorhabditis elegans . In our cell culture and molecular docking experiments, we found that β-chitosan prefers shielding the MD-2 pocket, thus blocking the activation of TLR4-MD-2 complex to suppress NF-κB signaling pathway activation. Together, our findings highlight the extensive therapeutic potential of β-chitosan in reversing aged-related/LPS-induced cognitive impairment via the liver-brain axis.
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CELLULOSE
·
2024
·Vol. 31
·期 7
·4291-4303
·
IF 4.9
Xu Diansheng,Yang Jinshan,Lou Tao,Wang Xuejun
To improve the selective adsorption of the target pollutant, this study successfully synthesized chitosan/carboxymethyl cellulose molecularly imprinted hollow vesicles (CS/CMC-MIV) for selective adsorption of acid blue-113 (AB-113). The vesicles were obtained by mixing the carboxymethyl cellulose solution with the chitosan/AB-113 mixture in sequential fast and slow stirring. Benefiting from the molecular imprinting technique, the maximum adsorption capacity of AB-113 by CS/CMC-MIV was 972.7 mg/g, which was 84.8% higher than that of the vesicles without imprinting (526.4 mg/g). The adsorption process could be well in accordance with Langmuir isotherm and pseudo-second-order models. The vesicles exhibited superior stability and reusability, maintaining 92% of the initial adsorption capacity after four adsorption repeats. What's more, CS/CMC-MIV showed excellent selective adsorption ability on mixed dye solutions, which was attributed to the specific recognition sites created during the molecular imprint process. This study provides a facile method to bind dye templates to vesicles and excels at selective dye removal.
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DYES AND PIGMENTS
·
2024
·
IF 4.1
Jie Hu,Hengju Zhou,Xinyao Wang,Shiqiang Cui,Shouzhi Pu
In order to overcome the influences of external environment on the properties photochromic compounds and expend their applications fields, various photochromic microcapsules have been prepared. However, the effects of wall materials on the properties of photochromic compounds need to be further studied. In this study, two photochromic microcapsules were prepared with polyurethane/chitosan as wall materials and a diarylethene molecular as core material. The properties such as photochromism, fatigue resistance, the sealing, and thermal stability of the microcapsules were studied, and the effects of the wall materials on the photochromic properties of the diarylethene were also investigated. Furthermore, the prepared microcapsules have been successfully applied to cotton fabrics of photochromic smart textiles.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Kun Lin,Yu-zhang Zhu,Hua-wei Ma,Jincheng Wu,Chao-nan Kong,Yang Xiao,Hong-cun Liu,Li-lan Zhao,Xiao-lin Qin,Li-fang Yang
In this study, an active film composed of gallic acid (GA), chitosan (CS), and cellulose nanocrystals (CNC) was prepared using a solution casting method and synergistic photodynamic inactivation (PDI) technology. Characterization of the film showed that the CS-CNC-GA composite film had high transparency and UV-blocking ability. The addition of GA (0.2 %–1.0 %) significantly enhanced the mechanical properties, water resistance, and thermal stability of the film. The tensile strength increased up to 46.30 MPa, and the lowest water vapor permeability was 1.16 × e −12 g/(cm·s·Pa). The PDI-treated CS-CNC-GA1.0 composite film exhibited significantly enhanced antibacterial activity, with inhibition zone diameters of 31.83 mm against Staphylococcus aureus and 21.82 mm against Escherichia coli. The CS-CNC-GA composite film also showed good antioxidant activity. Additionally, the CS-CNC-GA 1.0 composite film generated a large amount of singlet oxygen under UV-C light irradiation. It was found that using the CS-CNC-GA 1.0 composite film for packaging and storage of oysters at 4 °C effectively delayed the increase in pH, total colony count, and lipid oxidation in oysters. In conclusion, the CS-CNC-GA composite film based on PDI technology has great potential for applications in the preservation of aquatic products.
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