Advanced Healthcare Materials
·
2025
·
IF 9.6
Jie Zhao,Ming Li,Qiong Wu,Guanzhong Qiao,Hao Jiang,Sheng Zhao,Linhan Zhang,Song Wang,Huijie Jiang
Colorectal cancer (CRC) poses a significant therapeutic challenge due to its immunosuppressive tumor microenvironmentl (TME). In this environment, triggering receptors expressed on myeloid cells 2 (TREM2+) tumor-associated macrophages (TAMs) drive immune evasion and therapy resistance. In this study, CSF1R-IN-3@Mn@MPDA-antiTREM2 (CMMT) is presented, a manganese-doped mesoporous polydopamine nanoplatform conjugated with anti-TREM2 antibodies, which integrates TAM reprogramming and magnetic resonance imaging (MRI)-guided immune monitoring. CMMT has three key characteristics: 1) pH-responsive release of the Colony Stimulating Factor 1 Receptor (CSF1R) inhibitor CSF1R-IN-3 within acidic TME; 2) selective targeting of TREM2+ M2 macrophages, achieving 4.2-fold higher uptake compared to M1 subsets ( P < 0.001); and 3) dual modulation of TREM2 and CSF1R pathways, polarizing M2-TAMs toward pro-inflammatory M1 phenotypes. In orthotopic CRC models, CMMT synergizes with anti-PD-L1 therapy, reducing tumor volume by 72.5% compared to 42.1% for monotherapy ( P < 0.001). It also extends median survival from 28 to 52 days. Importantly, CMMT acts as an MRI contrast agent, with T1 signal intensity correlating with intratumoral TREM2+ macrophage density (r- 0.71, P < 0.05), enabling non-invasive assessment of TME remodeling. This theranostic platform bridges immune modulation and real-time monitoring, providing a promising strategy to overcome immunotherapy resistance in CRC.
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DOI
PubMed
高影响因子
Inorganic Chemistry Frontiers
·
2025
·
IF 6.4
Jia Liu,Long Yu,Xiaoyun Yi,Xin Li,Ziqing Liu,He Wang,Linwei Yang,Xin Yang,Suhua Wang
Low-dimensional lead-free Mn(II)-based organic–inorganic metal halides (OIMHs) are promising luminescent materials, yet molecular-level fine-tuning of organic structures to achieve high quantum yield and functional red-light emission remains challenging. In this study, three Mn(II)-based OIMHs were designed and synthesized using aminomethyl-pyridine isomers as cations. The results show that when 3-(aminomethyl)pyridine (3-AMPY) is employed as the organic ligand, its π-conjugated framework and enhanced molecular polarity facilitate the formation of a highly ordered and rigid zero-dimensional octahedral hybrid architecture, which achieves a high photoluminescence quantum yield (PLQY) of 63.42% with bright orange-red emission at 614 nm. In contrast, 2-AMPY and 4-AMPY counterparts only demonstrate weak red emission with low PLQY of 14.05% and 9.23%, respectively. Notably, (4-AMPY)4Mn3Br15 exhibits sensitive and irreversible red-to-green emission switching upon thermal treatment due to phase transition. To leverage this thermoresponsive luminescence behavior, a heating-assisted digital encryption system has been developed for complex information. This work reveals how cation substitution regulates the OIMH structure–property relationship and enriches the family of lead-free metal halides for anti-counterfeiting, information security, and optoelectronic applications.
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高影响因子
DALTON TRANSACTIONS
·
2018
·Vol. 47
·期 29
·9634-9642
·
IF 4.099
Shuqi Lu,Shanglong Peng,Zhiya Zhang,Yunlong Deng,Tianfeng Qin,Juanjuan Huang,Fei Ma,Juan Hou,Guozhong Cao
Surface passivation in quantum dot-sensitized solar cells (QDSSCs) plays a very important role in preventing surface charge recombination and thus enhancing the power conversion efficiency (PCE). ZnSe passivation with dopant in CdS/CdSe co-sensitized QDSSCs has been demonstrated as an effective way to improve the PCE. In the present study, a series of characterizations revealed that a Mn-doped ZnSe passivation layer can not only reduce surface charge recombination, but also enhance light harvesting. By means of density functional theory calculation along with a systematic study of electronic band structure, it has been found that the valence band of ZnSe moves upward on Mn-ion doping which leads to acceleration of charge separation and broader light absorption range. The impact of the Mn ion on charge recombination and light harvesting has been interpreted reasonably and the PCE of CdS/CdSe co-sensitized QDSSCs with Mn-doped ZnSe passivation layer is as high as 6.46%, which is 1.5 times that of the solar cell without the passivation layer.
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DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Wei Sun,Mushan Xie,Bo Shi,Zhixuan Zhu,Jian Zhang,Ying Wang,Jing Bian,Haibo Wang,Chun Zhao
The selective and simultaneous removal of antibiotics (ABs), antibiotic-resistant bacteria (ARBs), and antibiotic resistance genes (ARGs) from complex water matrices is crucial but remains challenging. Herein, relatively pure nonradical oxidation systems of singlet oxygen ( 1 O 2 ) and reactive trivalent manganese (Mn( III ) aq ) were established through electrofiltration-activated peroxymonosulfate and permanganate processes, respectively. Both systems simultaneously removed ABs, ARBs, and > 99 % of 20 selected ARGs within 15 min, while the addition of anions and nature organic matter slightly inhibited ARB inactivation. A multiperspective investigation confirmed that 1 O 2 demonstrated superior efficacy in ARB inactivation and protein damage compared to Mn( III ) aq , whereas Mn( III ) aq destroyed the ARB cell membrane, induced oxidative stress, and damaged almost all ARGs more rapidly than 1 O 2 . In particular, 1 O 2 exhibited selectivity toward four ARGs, which was attributed to a positive dependence on the 5′-GG-3′ doublet content. Moreover, 1 O 2 and Mn( III ) aq significantly reduced the risks of ARB regrowth and horizontal gene transfer of ARGs while providing resilience in real water matrices with improved energy-effectiveness. The findings of this study offer new insights into nonradical reactive species dominated advanced oxidation processes for controlling antibiotic resistance in real water.
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高影响因子
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
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2014
·
IF 2.291
Li-Na Wen,Meng-Xia Xie
s G-quadruplex DNA is an effective target for anticancer drug, and investigation of the G-quadruplex DNA with natural compounds plays a key role in the development of anticancer drugs. In this article, room temperature phosphorescence sensing system based on l -cysteine-capped Mn-doped ZnS QDs has been established. Sanguinarine can adsorb on the surface of Mn-doped QDs and quenched the phosphorescence emission of the sensor. When the G-quadruplex sequences combined with the sanguinarine of the QDs-sanguinarine system, the phosphorescence intensities of the QDs sensors would be restored, and the binding abilities of the G-quadruplex DNA with the sanguinarine can be evaluated by the phosphorescence recoveries of the sensor system. Based on the developed approach, the interaction of sanguinarine and six G-quadruplex DNA with various sequences (tel24-1, tel24-2, tel22, k-ras, HIF-1α and c-kit1) has been investigated. The results showed that the binding abilities of the G-quadruplex DNA with sanguinarine were related to their number of bases and conformations. The conformational changes of the six G-quadruplex DNA, after binding with sanguinarine, have also been probed by circular dichroism. Combining the changes of the phosphorescence lifetime, the binding mechanism of the G-quadruplex DNA and sanguinarine has been discussed. The developed method was simple, rapid and specific, and can avoid fluorescence interferences of the system, and it would be prospective to evaluate the interaction of the drug with different G-quadruplexes.
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高影响因子
ACS Sustainable Chemistry & Engineering
·
2025
·
IF 7.3
Zhigang Zhang,Yuntao Hu,Xiangyu Sun,Guan Wang,Huaiqing Zhao
Catalytic oxidation plays a pivotal role in the chemical industry. Among various approaches, the strategy involving O2 as a green oxidant and H2O as a solvent for the efficient oxidation of organic compounds has garnered significant interest because it aligns with the principles of sustainable development. However, the inherent inertness of ground-state oxygen molecules poses a significant challenge in the development of non-noble-metal catalysts that can activate O2 to reactive oxygen species. Inspired by the regulatory effects of metal doping on the oxygen vacancy content and electronic properties of materials, we developed a bimetallic oxide catalyst MnxCoOy, derived from Mn-doped ZIF-67, for catalytic oxidation with oxygen. Comprehensive characterization (XRD, XPS, N2 adsorption–desorption, Raman, and FTIR) reveals that Mn species doping substitutes Co2+ at tetrahedral CoO4 sites, modulating the catalyst’s oxygen vacancy concentration and electronic distribution. The optimized MnxCoOy with suitable oxygen vacancy concentration exhibits superior performance in the selective oxidation of organic molecules containing benzyl sp3 C–H bonds. The cyclic and amplification experiments indicate the potential application value of the catalyst. This work provides fundamental insights into the design of multipurpose catalysts for catalytic oxidation through the metal doping strategy, which also offers a sustainable approach for obtaining carbonyl compounds.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
·
IF 9.136
Baicheng Yuan,Xinyi Huang,Shaojinlin Yang,Yi Yang,Zhihong Lin,Raphael Semiat,J. Paul Chen
Heavy metal contamination has become one of the greatest global environmental problems. In this study, a magnetic calcium-alginate hydrogel-sphere encapsulated with Fe–Mn–Zr ternary-metal composite (MCHETC) was prepared through a combined co-precipitation and extrusion approach and used for the adsorption of heavy metals in aqueous solutions. The active sites were dispersed in the MCHETC, which can be separated by the magnetic force for the ease in operation. Above 80% of ultimate adsorption was completed at a contact time of 5 h. The copper uptake history was well described by the intraparticle surface diffusion model, suggesting a multi-step process for the adsorption. The optimum pH for adsorption was 4; the maximum adsorption capacity was 103.1 mg-Cu/g. The adsorption capability well remained after the 5 adsorption–desorption cycles and the copper could be recovered. Furthermore, the adsorbent performed well in the nature water spiked with copper ions. The mechanism studies illustrated that the adsorption was mainly controlled by the ion-exchange reaction. This study demonstrated that the MCHETC adsorption technology may be used for heavy metal removal and recovery with higher efficacy.
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高影响因子
Materials Reports: Energy
·
2024
·
IF 0
Han Wang,Sidra Jamil,Muhammad Fasehullah,Shujuan Bao,Yi Li,Maowen Xu
Lithium-sulfur (Li-S) batteries are one of the most promising energy storage and conversion devices due to the high theoretical capacity and cost-effectiveness of sulfur. However, they still suffer from sluggish redox kinetics and the shuttle effect caused by complex polysulfides. In this work, graphitic carbon nitride (g-C 3 N 4 ) is utilized as a template and further hydrothermally treated with an Mn source and glucose. The pyrolysis of g-C 3 N 4 gives rise to N-doped carbon nanotubes, producing abundant sites for physical confinement and chemical adsorption of polysulfides, while glucose carbonization brings forth amorphous carbon and Mn source produces metal spheres. Afterward, polydopamine (PDA) induces N-doped carbon coating and promotes interface connection as well as electron immigration. This synergistic design possesses a high surface area of micropores and mesopores to aggregate sulfur and accelerate redox kinetics. As a result, the N-doped carbon nanotube with Mn spheres and PDA coating@sulfur (CN/Mn-PDA@S) exhibits a high reversible capacity of 813.5 mAh g −1 at 1 C with a decay rate of 0.064% per cycle and remarkable capacity retention at 2 C with rate performance up to 4 C. Therefore, the novel design of N-doped carbon nanotubes with Mn spheres and PDA coating serves as an efficient polysulfide immobilizer for Li-S batteries.
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DOI
APPLIED SURFACE SCIENCE
·
2024
·
IF 6.3
Pengzu Kou,Zhigui Zhang,Zhaoyang Dong,Runguo Zheng,Zhishuang Song,Zhiyuan Wang,Hongyu Sun,Yanguo Liu
Lithium-rich manganese-based cathode (LRM) is considered to be the most promising cathode materials for next-generation lithium-ion batteries due to its high energy density. However, the low initial coulombic efficiency and poor rate performance are severe problems in the commercialization of LRM. Herein, we use an ascorbic acid (VC) modulation strategy to create spinel-carbon composite coatings and dual defects (oxygen vacancies, stack faults) on the surface of LRM. The composite surface coating and defects play a synergistic role in inhibiting interfacial side reactions, enhancing structural stability, and improving electrical conductivity as well as lithium-ion diffusion kinetics. As a result, the modified LRMs exhibit a specific capacity of 251.7mAh/g with an improved initial coulombic efficiency (ICE) of 82.3 % (pristine 72.9 %), enhanced rate capability (135 mAh/g at 5C), and long-term cyclability of 90 % retention after 200 cycles compared with the pristine (78 % retention after 200 cycles). The performance improvement of the modified LRMs is attributable to the composite coating and the dual defects, which ensure the LRM with a more stable structure (smaller volume change of 2.4 % compared with the original sample of 3.65 %). This strategy provides an efficient and environmentally friendly idea of surface modification for boosting the electrochemical performance.
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高影响因子
JOURNAL OF LUMINESCENCE
·
2025
·
IF 3.6
Zhuoyue Li,Zhenlong Cheng,Maoxiu Huang,Qingkai Chen,Yuanli Liu,Zhiyi He,Jun Ou
In this paper, highly fluorescent, structurally homogeneous, and small-sized NaYF 4 upconversion nanoparticles were synthesized via the hydrothermal method, Yb/Ho/Mn co-doping altered the local symmetry of the crystals, slightly deforming their structure and enhancing the fluorescence intensity of the nanocrystals. The strong green light emission from the synthesized samples was mechanistically explained by energy transfer upconversion combined with excited state absorption process involving Yb-Mn dimers. The highest fluorescence intensity was observed with 15 mol% Mn 2+ , which increased the fluorescence intensity by a factor of approximately 10.88 compared to the undoped sample. Furthermore, this work explored the optical temperature-sensing properties of these upconversion fluorescent nanocrystals for non-contact temperature measurement, leveraging thermal and non-thermal coupling mechanisms. It provided a promising strategy for developing high-performance optical temperature sensors using other transition metal-doped lanthanide materials.
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高影响因子
Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Haishuo Wang,Xinke Tian,Zhichun Li,Jie Zhang,Shiyin Li,Heyong Huang
Lake eutrophication leads to the excessive proliferation of cyanobacteria in aquatic environments, resulting in microcystin-LR (MCLR) concentrations exceeding regulatory limits. The associated environmental risks and health concerns attract widespread attention. As one of the most active chemical substances in aquatic environments, dissolved organic matter (DOM) plays a critical role in the phototransformation of MCLR. In environments where Fe(II) and Mn(II) coexist, the phototransformation process of MCLR may be influenced. Among fulvic acid (FA), humic acid (HA), cyanobacteria-derived DOM (CDOM), and reed leaf-derived DOM (RDOM), FA has the highest apparent reaction rate constant for MCLR at 0.03567 h -1 . Using isopropanol, furfuryl alcohol, and sorbic acid as quenchers, the contributions of different photochemically produced reactive intermediates(PPRIs) to MCLR photodegradation follow the order: 3 DOM⁎ > ·OH > 1 O 2 . As pH increases, changes in the conformation and charge distribution of DOM and MCLR suppress MCLR photodegradation. The addition of Fe(II) or Mn(II) enhances the photodegradation of MCLR by DOM. Electron paramagnetic resonance tests and radical quenching experiments indicate that the introduction of Fe(II)/Mn(II) increases ·OH production. The enhanced ·OH promotes MCLR photodegradation more effectively than the suppression caused by Fe(II)/Mn(II) quenching of ³DOM⁎. Product analysis reveals that demethylation, hydroxylation, decarbonylation, decarboxylation, denitration, and bond cleavage are the main pathways of MCLR photodegradation. These findings provide valuable insights into the migration and transformation of MCLR in complex environments, contributing to a deeper understanding of the fate of pollutants in natural water systems, particularly in the presence of metal ions.
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高影响因子
PROGRESS IN SOLID STATE CHEMISTRY
·
2025
·
IF 10.5
Zhiwei Wang,Yinan Shen,Liangsheng Tian,Suwit Suthirakun,Wongsathorn Kaewraung,Qi Menghang,Hang Zhao,Xin Xin,Ruoxiu Xiao,Peng Jiang,Qu Li,Tingting Lu
The coating optimized with high near-infrared reflectance pigments can effectively reduce the energy consumption for heating and cooling in buildings, thereby alleviating the pressure on global energy consumption. Using a high-temperature solid-state method, blue-violet pigments with high near-infrared reflectance, Ca 2 Zn 1- x M x Si 2 O 7 (M = Mn, 0 ≤ x ≤ 0.4 and Ni, 0 ≤ x ≤ 0.2) solid solutions, were synthesized for the first time, with a maximum solar reflectance of 82.67%. Using XPS analysis, it was determined that the oxidation state of Ni in the pigment is +2, while Mn exists in mixed oxidation states of +2 and +3. UV-VIS-NIR spectroscopy analysis indicates that the blue-violet color of the pigment originates from the d-d transitions of the transition metal ions. As the doping concentration increases, the near-infrared reflectance of the pigment decreases. The DFT calculations have also confirmed that the color of pigments originates from transition metal ions. The as-synthesized pigments were incorporated into acrylic to create colored coatings. Improving the near-infrared solar reflectance of the acrylic coating. The excellent high near-infrared solar reflectance and coating property optimization make the synthesized pigment a potential energy-saving coating.
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高影响因子
危险品化学品经营许可证（带存储）