INORGANIC CHEMISTRY
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2019
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IF 4.85
Qingchun Zhang,Bo Jin,Tian Zheng,Xingyan Tang,Zhicheng Guo,Rufang Peng
The special linear dioxo cation structure of the uranyl cation, which relegates ligand coordination to an equatorial plane perpendicular to the O═U═O vector, poses an unusual challenge for the rational design of efficient chelating agents. Therefore, the planar hexadentate ligand rational design employed in this work incorporates two bidentate catecholamine (CAM) chelating moieties and a flexible linker with a β-dicarbonyl chelating moiety (β-dicarbonyl(CAM)2 ligands). The solution thermodynamics of β-dicarbonyl(CAM)2 with a uranyl cation was investigated by potentiometric and spectrophotometric titrations. The results demonstrated that the pUO22+ values are significantly higher than for the previously reported TMA(2Li-1,2-HOPO)2, and efficient chelation of the uranyl cation was realized by the planar hexadentate β-dicarbonyl(CAM)2. The efficient chelating ability of β-dicarbonyl(CAM)2 was attributed to the presence of the more flexible β-dicarbonyl chelating linker and planar hexadentate structure, which favors the geometric arrangement between ligand and uranyl coordinative preference. Meanwhile, β-dicarbonyl(CAM)2 also exhibits higher antiradical efficiency in comparison to butylated hydroxyanisole. These results indicated that β-dicarbonyl(CAM)2 has potential application prospects as a chelating agent for efficient chelation of a uranyl cation.
研究领域:
无机化学
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放射化学
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配位化学
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药物化学
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环境毒理学
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FOOD CHEMISTRY
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2026
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IF 10.4
Juan Huang,Yueyue Zhang,Taoting Li,Chen Chen,Haiyan Yu,Hu Yang,Huaixiang Tian
The interface interactions in Pickering emulsions are determined by the molecules interaction at the microscopic scale in essence. The interfacial properties of β-CD/Tween 60 co-stabilized emulsions were investigated experimentally and numerically. The results show that Tween 60 can increased the hydrophilicity of β-CD. The interface thickness of the β-CD/Tween 60 co-stabilized emulsion is about twice as thick as that of β-CD stabilized system. The formation of hydrogen bonds and electrostatic interaction between β-CD and Tween 60 might be the reason for the variation of surface characteristics of β-CD. Besides, it was demonstrated that the alkyl chain end of Tween 60 can enter into the cavity of β-CD, indicating the formation of the assemblies, approximately 20–30 hydrogen bonds were formed. The magnitude of van der Waals interactions exceeds that of electrostatic interaction, indicating that both hydrogen bonds and van der Waals interactions are the main driving force.
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BIOMACROMOLECULES
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2026
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IF 5.9
Jin Chen,Lidan Chen,Huanhuan Shi,Jia Hu,Yongmei Wang,Min Gong,Pu Xu,Peng Yu,Yun Wang,Zuquan Hu,Zhu Zeng
Atopic dermatitis (AD) is a chronic inflammatory skin disease whose treatment is limited by side effects and poor drug stability. Dihydromyricetin (DHM) shows promise in alleviating skin inflammation, yet effective localized and sustained delivery remains challenging. Herein, a β-lactoglobulin-based dual-network (BDN) hydrogel was developed by exploiting the structural plasticity of β-lactoglobulin monomers (BLGMs) to construct two distinct β-lactoglobulin-based (BLG-based) polymers, with DHM incorporated to obtain the BDN-DHM hydrogel. Photo-cross-linkable glycidyl methacrylate-modified β-lactoglobulin (BLG-GMA) polymers formed an irreversible covalent network, while β-lactoglobulin fibrils (BLGFs) established a dynamic network through Schiff-base reactions with oxidized dextran (ODEX). The resulting BDN-DHM hydrogel exhibited high mechanical strength, sustained drug release, antioxidant activity, and anti-inflammatory effects. In vivo studies further showed alleviation of AD-like symptoms and enhanced skin repair. Overall, the outcomes demonstrate the BDN-DHM hydrogel as a promising local dressing for AD and underscore the potential of BLGMs as versatile building blocks for multifunctional biomaterials.
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ANALYTICAL CHEMISTRY
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2026
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IF 7.3
Xiaoyu Gu,Yue Li,Xin Xia,Wei Zhang,Ping Li,Wen Zhang,Hui Wang,Bo Tang
The vicious cycle of oxidative stress and cellular senescence is closely associated with the development and progression of atherosclerosis. Targeting the vicious cycle of “oxidative stress-cell senescence” as a combined biological target for atherosclerosis and developing dual-functional probes holds significant importance for the early monitoring and risk assessment of this disease. Therefore, fluorescent nanoprobe GL-1-NPs, capable of simultaneously imaging the aging markers β-galactosidase (β-gal) and peroxynitrite (ONOO–) were synthesized via nanoprecipitation. GL-1-NPs serve as a live-cell imaging tool that enables effective monitoring of changes in β-gal activity and ONOO– levels during the formation process of foam cells. Notably, in the aortas of ApoE–/– mice fed a high-fat diet for 12 weeks, traditional methods such as Oil Red O staining and immunofluorescence revealed no plaque formation or upregulation of the associated proteins CD36 and CD68. Whereas, GL-1-NPs successfully detected enhanced fluorescence signals in the β-gal and ONOO– channels, highlighting their potential for achieving early warning of atherosclerosis.
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BIOMACROMOLECULES
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2026
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IF 5.9
Chun-Yan Lyu,Yanyuqiu Guo,Chaoqun Weng,Mingyuan Lu,Sikang Wan,Kai Liu,Xiaoyan Tang,Hua Lu
Structural regularity in polymers is a double-edged sword, enhancing crystallinity and thermal stability but often reducing processability and toughness. Here, we present a substitution-desymmetrization strategy to address this trade-off in chemically recyclable polythioesters (PTEs). Copolymerizing symmetric β-gem-dimethyl thiolactone with an asymmetric β-methyl-β-ethyl analog via rare-earth metal-catalyzed ring-opening polymerization enables precise backbone symmetry control, yielding tunable melting temperatures (90–170 °C) and ductility. The optimized copolymer self-assembles into hierarchical helical nanofiber bundles, achieving strong adhesion across substrates (lap-shear strength up to 9.48 MPa on iron). The adhesive performs well at extreme temperatures (−196 and 120 °C) and shows superior water resistance compared to commercial cyanoacrylate. Moreover, PTEs remain fully chemically recyclable. This work offers a sustainable platform for high-performance materials via symmetry engineering.
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JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
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2026
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IF 4
Yaqin Zhang,Shilin Hu,Huijie Cao,Yu Zhang,Yan Ma,Mingwu Qiao,Ge Bai
BACKGROUND Phytosterols, particularly β -sitosterol, exhibit well-recognized cholesterol-lowering activity; however, their practical application is constrained by rigid molecular structures and limited structural tunability. Rational molecular modification combined with the introduction of flexible linkers may provide an effective approach to improve their physicochemical and functional properties. RESULTS In this study, a novel sitosteryl ethylene glycol succinate containing a flexible spacer was successfully synthesized via a chemo-enzymatic approach. Under the selected enzymatic conditions (55 °C, 84 h and a substrate molar ratio of 1:2), the esterification rate reached 91.54 ± 1.80%. The chemical structure of the synthesized ester was confirmed using multiple analytical techniques. Analysis of physicochemical properties suggested that the introduction of the flexible ethylene glycol segment altered the crystalline packing and solid-state organization of β -sitosterol. In vitro micellar assays indicated that the derivative enhanced cholesterol-lowering potential relative to β -sitosterol, as evidenced by reduced cholesterol incorporation into mixed micelles. CONCLUSION These results suggest that the incorporation of polar and flexible spacer segments may modulate the amphiphilic balance and structural characteristics of phytosterols, thereby improving their capacity to inhibit cholesterol solubilization. This study provides a potential strategy for the rational design of phytosterol derivatives with improved functional performance. © 2026 Society of Chemical Industry.
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CARBOHYDRATE POLYMERS
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2023
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IF 11.2
Hengye Li,Xingwei Han,Wenjie Yu,Lin Zhang,Wenwen Bie,Meijie Wei,Zhongxia Wang,Fenying Kong,Wei Wang
Herein, through knitting benzylated β-cyclodextrin (BnCD) by dimethoxypillar[5]arene (P[5]), porous copolymers (P[5]-BnCDs) containing two kinds of macrocycles were synthesized with yields not <97 %. The molar ratio of P[5]/BnCD greatly influenced the P[5]-BnCDs' porosity and adsorption performance. When the molar ratio of P[5]/BnCD was 4/1, the P[5]-BnCD (4-1), demonstrated a surface area up to 515.95 m 2 /g and showed fast adsorption kinetic , high adsorption capacity and good reusability towards the model organic micropollutants (OMPs). The adsorption fitted well with the pseudo-second-order and the Langmuir models, while the thermodynamic studies revealed spontaneous physisorption process. The adsorption mechanism was dominant by host-guest and hydrophobic interactions and the adsorption at environmentally relevant concentrations experiments showed the practicality and superiority in extraction of the OMPs at μg/L level. This study paves a way for the development of versatile porous organic polymers with multiple macrocycles for efficient removal of OMPs from water.
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Nanomaterials
·
2023
·Vol. 13
·期 4
·775
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IF 5.3
Hong Su,Jiangping Liu,Yanan Hu,Tianhao Ai,Chenhao Gong,Jichang Lu,Yongming Luo
As a representative sulfur-containing volatile organic compounds (S-VOCs), CH3SH has attracted widespread attention due to its adverse environmental and health risks. The performance of Mn-based catalysts and the effect of their crystal structure on the CH3SH catalytic reaction have yet to be systematically investigated. In this paper, two different crystalline phases of tunneled MnO2(α-MnO2and β-MnO2) with the similar nanorod morphology were used to remove CH3SH, and their physicochemical properties were comprehensively studied using high-resolution transmission electron microscope (HRTEM) and electron paramagnetic resonance (EPR), H2-TPR, O2-TPD, Raman, and X-ray photoelectron spectroscopy (XPS) analysis. For the first time, we report that the specific reaction rate for α-MnO2(0.029 mol g−1h−1) was approximately 4.1 times higher than that of β-MnO2(0.007 mol g−1h−1). The as-synthesized α-MnO2exhibited higher CH3SH catalytic activity towards CH3SH than that of β-MnO2, which can be ascribed to the additional oxygen vacancies, stronger surface oxygen migration ability, and better redox properties from α-MnO2. The oxygen vacancies on the catalyst surface provided the main active sites for the chemisorption of CH3SH, and the subsequent electron transfer led to the decomposition of CH3SH. The lattice oxygen on catalysts could be released during the reaction and thus participated in the further oxidation of sulfur-containing species. CH3SSCH3, S0, SO32−, and SO42−were identified as the main products of CH3SH conversion. This work offers a new understanding of the interface interaction mechanism between Mn-based catalysts and S-VOCs.Keywords:CH3SH decomposition;MnO2;oxygen vacancies;oxygen migration
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Frontiers in Endocrinology
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2023
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IF 5.2
Tingwan Du,Lian Xiang,Jingjing Zhang,Chunmei Yang,Wenxin Zhao,Jialu Li,Yong Zhou,Ling Ma
Introduction The study aimed to explore the association of serum 25(OH)D 3 and hepatic steatosis in non-alcoholic fatty liver disease (NAFLD) patients and to determine whether the effect of vitamin D (VD) is mediated by activation of the peroxisome proliferator-activated receptor α (PPARα) pathway. Methods The study contained a case-control study, in vivo and in vitro experiments. A case-control study was conducted to compare serum parameters between NAFLD patients and controls and to evaluate the association of 25(OH)D 3 and NAFLD. In vivo study, male Wistar rats were randomly divided into control and model groups, fed a standard chow diet and a high-fat diet (HFD), respectively, for 7 weeks to generate an NAFLD model. Then, the rats were treated with VD and a PPARα antagonist (MK886) for 7 weeks. Tissue and serum were collected and assessed by biochemical assays, morphological analysis, histological analysis, and western blot analysis. In vitro , HepG2 cells were incubated with oleic acid (OA) to induce steatosis, which was evaluated by staining. HepG2 cells were pretreated with MK886 followed by calcitriol treatment, and differences in lipid metabolism-related proteins were detected by western blot. Results NAFLD patients were characterized by impaired liver function, dyslipidemia, and insulin resistance. Serum 25(OH)D 3 was negatively associated with alanine aminotransferase (ALT) in NAFLD. VD deficiency was a risk factor for patients with no advanced fibrosis. Adequate VD status (25(OH)D 3 >20 ng/mL) had a protective effect in patients after adjustment for confounding variables. NAFLD rats showed hyperlipidemia with severe hepatic steatosis, systematic inflammation, and lower serum 25(OH)D 3 . VD treatment ameliorated hepatic steatosis both in NAFLD rats and OA-induced HepG2 cells. Further, MK886 inhibited the anti-steatosis effect of VD. Conclusion The study revealed that an adequate VD level may act as a protective factor in NAFLD and that VD may alleviate hepatic steatosis via the PPARα signaling pathway.
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Reaction Kinetics Mechanisms and Catalysis
·
2023
·Vol. 136
·期 2
·771-786
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IF 1.8
Su Haitang,Yang Zhixiu,Xiao Guomin,Gao Lijing,Wei Ruiping,Zhang Jin
A series of cost-effective (X) K 2 CO 3 /γAl 2 O 3 catalysts for efficient conversion of vinyltrimethoxysilane (VTMOS) to vinyltris(β-methoxyethoxy)silane (VTMOEOS) were synthesized. The microstructure and active site of the synthesized catalysts were analyzed by BET, XRD, FT-IR, SEM, and CO 2 -TPD. The results showed that the synthesized catalysts formed K–O–Al strong basic sites while maintaining the original structure, which greatly improved the basic strength of the catalysts. It was found that the 60%K 2 CO 3 /γAl 2 O 3 possessed the highest the catalytic activity under the activation temperature of 600 °C by optimizing the preparation conditions of K 2 CO 3 /γAl 2 O 3 . Moreover, the optimal reaction process conditions were also determined by optimizing the experimental reaction temperature, reaction time, catalyst dosage, and reactant molar ratio under (60%, 600 °C) K 2 CO 3 /γAl 2 O 3 catalysis. Under the optimal reaction conditions, the conversion of VTMOS was 92.5% and the yield of VTMOEOS was 65%. Meanwhile, the 60%K 2 CO 3 /γAl 2 O 3 catalyst was satisfactorily reusable and maintained a high catalytic activity after four cycles of catalytic reactions.
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AAPS PHARMSCITECH
·
2023
·Vol. 24
·期 5
·1-11
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IF 3.3
Zhang Ying,Chen Jiacai,Zhang Zaiyong,Zhu Huajie,Ma Wuzhen,Zhao Xiangyu,Wang Manli,Wang Caifen,Chen Weidong,Naeem Abid,Zhang Jiwen,Guo Tao,Wu Li
Cyclodextrin metal-organic frameworks (CD-MOFs) exhibit a high structural diversity, which contributes to their functional properties. In this study, we have successfully synthesized a novel type of β-cyclodextrin metal-organic framework (β-CD-POF(I)) that exhibits excellent drug adsorption capacity and enhances stability. Single-crystal X-ray diffraction analysis revealed that β-CD-POF(I) possessed the dicyclodextrin channel moieties and long-parallel tubular cavities. Compared with the reported β-CD-MOFs, the β-CD-POF(I) has a more promising drug encapsulation capability. Here, the stability of vitamin A palmitate (VAP) was effectively improved by the solvent-free method. Molecular modeling and other characterization techniques like synchrotron radiation Fourier transform infrared spectroscopy (SR-FTIR), differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), thermogravimetric analysis (TGA), and nitrogen adsorption isotherm were applied to confirm that the VAP was successfully encapsulated into the channel formed by the dicyclodextrin pairs. Furthermore, the mechanism of stability enhancement for VAP was determined to be due to the constraint and separation effects of β-CD pairs on VAP. Therefore, β-CD-POF(I) is capable of trapping and stabilizing certain unstable drug molecules, offering benefits and application possibilities. Graphical abstract
One kind of cyclodextrin particle with characteristic shapes of dicyclodextrin channel moieties and parallel tubular cavities, which was synthesized by a facile process. Subsequently, the spatial structure and characteristics of the β-CD-POF(I) were primarily confirmed. The structure of β-CD-POF(I) was then compared to that of KOH-β-CD-MOF, and a better material for vitamin A palmitate (VAP) encapsulation was determined. VAP was successfully loaded into the particles by solvent-free method. The arrangement of spatial structure made cyclodextrin molecular cavity encapsulation in β-CD-POF(I) more stable for VAP capture than that of KOH-β-CD-MOF.
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CARBOHYDRATE POLYMERS
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2023
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IF 11.2
Ningyue Liu,Siwei Zou,Conghua Xie,Yan Meng,Xiaojuan Xu
Colorectal cancer is the third most common cancer in the world, and therapies with safety are in great need. In this study, the β-glucan isolated from Lentinus edodes was successfully fractionated into three fractions with different weight-average molecular weight ( M w ) by ultrasonic degradation and used for the treatment of colorectal cancer. In our findings, the β-glucan was successfully degraded with the M w decreased from 2.56 × 10 6 Da to 1.41 × 10 6 Da, exhibiting the triple helix structure without conformation disruption. The in vitro results indicate that β-glucan fractions inhibited colon cancer cell proliferation , induced colon cancer cell apoptosis, and reduced inflammation. The in vivo results based on Azoxymethane (AOM)/dextran sulfate sodium (DSS) mouse model demonstrate that the lower-molecular weight β-glucan fraction showed stronger anti-inflammatory and anti-colon cancer activities by reconstructing intestinal mucosal barrier, increasing short chain fatty acids (SCFAs) content, regulating metabolism of gut microbiota , and rebuilding the gut microbiota structure with the increased Bacteroides and the decreased Proteobacteria at the phylum level, as well as with the decreased Helicobacter and the increased Muribaculum at the genus level. These findings provide scientific basis for using the β-glucan to regulate gut microbiota as an alternative strategy in the clinical treatment of colon cancer.
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