Science China-Materials
·
2019
·Vol. 62
·期 12
·1815-1820
·
IF 5.636
Wang Yanhong,Liu Hang,Fu Peng,Lu Hongcheng
A new one-dimensional (1D) antiferromagnetic transition metal hybrid fluoride CoF 2 (H 2 O) 2 (pyz) (pyz = pyrazine) together with two new isostructural MF 2 (H 2 O) 2 (pyz) (M = Ni 2+ , Zn 2+ ) have been successfully synthesized by the hydrothermal method. Their structures were determined by single crystal X-ray diffraction and they all crystallize in the same space group of C2/ m . The magnetic property of CoF 2 (H 2 O) 2 (pyz) 1 was measured and discussed. The Weiss constant of -20.6 K indicates dominant antiferromagnetic interaction and the effective magnetic moment of about 5.66 μ B suggests large unquenched orbital contribution and anisotropy in 1. The quantum fluctuations in the quasi-1D antiferromagnet of 1 prevent the appearance of long range magnetic order until 2.9 K, suggesting good 1D magnetism.
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JOURNAL OF NATURAL PRODUCTS
·
2025
·
IF 3.6
Xijian Wu,Zijie Su,Biling Huang,Xin Peng,Xing Zhang,Shaohua Huang
The detection and analysis of chiral molecules have long been challenging in analytical chemistry. This study introduces a novel approach that utilizes 2-trifluoromethyl benzaldehyde as a small-molecule probe capable of forming a stable Schiff base with chiral amino acids in aqueous solution under alkaline conditions. The amino acid Schiff bases present a strong Cotton effect and UV absorption at wavelengths exceeding 260 nm, enabling chiral analysis, including assignment of absolute configuration, enantiomeric composition, and total concentration. An application of this method was the authentication of the herbal medicine Ophiopogon japonicus. Using principal component analysis and orthogonal partial least squares discriminant analysis, we successfully differentiated O. japonicus samples collected in two distinct locations with 20 samples. This rapid and convenient method offers a new approach to quality control of herbal medicine.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2017
·
IF 4.233
Huifang Xu,Na Du,Yawen Song,Shue Song,Wanguo Hou
Single-tailed short-chain alkyl keto-acids/salts, a class of fatty acid/salt derivatives, such as sodium 2-ketooctanate (KOCOONa), are a kind of weakly acid/salt type amphiphiles and plausible prebiotic molecules, and the current understanding of their aggregation behavior in aqueous solutions is still limited. Herein, the aggregation behavior of KOCOONa in aqueous solution was studied by changing its concentration ( C ), using equilibrium surface tension, conductivity, and fluorescence measurements. The aggregates formed were characterized using freeze-fracture and cryogenic transmission electron microscopy, dynamic light scattering, atomic force microscopy, and confocal laser scanning microscopy. A concentration-driven stepwise aggregation was identified in the KOCOONa solution. Vesicles can spontaneously form from the single-component aqueous solution, with a critical vesicle concentration (CVC) of ∼15 mM, which is obviously lower than that of octanoic acid/salt (120–200 mM). With increasing C , a vesicle-to-micelle transition can occur, showing a critical micelle concentration (CMC) of ∼80 mM. In addition, the membrane permeability of the KOCOONa vesicles was examined using small-size Calcein and large-size FITC-BSA as fluorescence probes, showing a size-selective permeability, similar to short-chain (C8-C11) fatty acid vesicles. For the first time, the aggregation behavior of single-tailed keto-acid salt surfactant is reported.
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高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2025
·
IF 11.3
Zhou-Yang Li,Min Li,Bin Liu,Xue-Ning Zhang,Shan Yi,Wei-Qin Zhuang,Wen Wang,Yi-Lu Sun,Ai-Jie Wang
Microbial anaerobic metabolism is crucial for biogeochemical cycles, impacting both natural and engineered ecosystems. However, the increasing emissions of 6:2 Cl-PFESA, an alternative to PFOS, pose significant risks. In this study, long-term high 6:2 Cl-PFESA concentration level of 10 µg/g TS exposure led to a substantial decrease in methane production from 204.8 ± 4.8 mL/g VS to 143.6 ± 3.5 mL/g VS, indicating a cumulative inhibitory effect on carbohydrate-related anaerobic digestion. Key processes such as polysaccharide release, hydrolysis, acetogenesis, and acetoclastic methanogenesis were contributed by 28.6 %, 9.3 %, 8.9 %, and 11.7 % of significant reduction, respectively, correlating with inhibition in relevant enzymatic activities and gene expressions. Hydrolytic bacteria such as Rectinema and Defluviitoga declined to 11.7 % from 14.3 % and 20.9 % from 23.9 %, reflecting decreased hydrolysis efficiency. Reduced transcription levels of acetogenesis- and acidogenesis-related genes further inhibited these processes. Conversely, methanogens Methanolinea and Methanothrix increased from 35.8 % to 55.7 % and 10.9–40.8 %, suggesting enzyme inhibition rather than methanogen abundance reduction. Additionally, 6:2 Cl-PFESA partially biotransformed into 6:2H-PFESA, facilitated by species like Dechloromonas , unclassified Xanthomonadales , and Betaproteobacteria. These findings confirm that the limited degradation and cumulative inhibitory effects of 6:2 Cl-PFESA during anaerobic digestion highlight its significant disruption to carbon cycling stability within ecosystems.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Guohui Tang,Haoxiang Wang,Dianwen Liu,Zhao Xie,Peilun Shen,Jinpeng Cai,Jianjun Fang
Azurite is an important oxidized copper mineral, and the traditional sulfidation-xanthate flotation process still fails to achieve ideal results. Organic chelating reagents containing donor atoms such as N, S, and O have demonstrated excellent performance in mineral flotation and copper corrosion inhibitor research. However, such reagents have rarely been applied in azurite flotation studies. This study introduces a novel N/S – containing activator, 2-mercaptopyridine (2-MP), for azurite activation, and investigates its modification mechanism and flotation effects on azurite. Micro-flotation tests show that 2-MP significantly improves azurite's flotation performance. The flotation recovery of azurite in the 2-MP-potassium butyl xanthate system increased substantially from 37.54% to 97.23%. Theoretical studies reveal that 2-MP activates the azurite surface to form a dense product layer containing S/N elements. This S/N – enriched hydrophobic layer facilitates effective xanthate adsorption, thereby enhancing flotation recovery. The activation mechanism is elucidated as follows: The N/S atoms in 2-MP interact with copper sites on the azurite surface, forming 2-MP-Cu complexes containing S-Cu and N-Cu bonds that adsorb onto the mineral surface, exposing more copper sites. Simultaneously, Cu(II) is reduced to highly active Cu(I), providing a fresh active surface that greatly promotes xanthate adsorption while improving the mineral's hydrophobicity and floatability. This work reveals the surface modification mechanism of the bidentate organic chelating reagent 2-MP on azurite, offering a new approach for the efficient utilization of oxidized copper mineral resources.
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BIOORGANIC CHEMISTRY
·
2020
·
IF 4.831
Bo Zhang,Xiu-Ting Hu,Kang-Min Zhou,Yu-Shun Yang,Hai-Liang Zhu
Cyclooxygenase is critical for maintaining physiological functions, whereas overexpression of COX-2 was closely implicated in various cancers. In this study, a series of novel aminophosphonate derivatives containing pyrazole moiety were synthesized with their anti-cancer activity evaluated. In vitro assays of the target compounds showed that Z21 displayed excellent COX-2 inhibitory activity against COX-2 (IC 50 = 0.22 ± 0.04 µM) and anti-proliferative activity against MCF-7 cell (IC 50 = 4.37 ± 0.49 µM). The apoptosis induction of compound Z21 was confirmed by flow cytometry and polymerase chain reaction. Further investigation demonstrated that compound Z21 induced apoptosis of MCF-7 cells through a mitochondrion-dependent pathway and involved cell-cycle arrest in G2 phase. Overall, these results provided some new insights into the design of therapeutic drugs for COX-2 inhibitors and indicated the connection between selective COX-2 inhibition and the anti-tumor activity.
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EUROPEAN JOURNAL OF PHARMACOLOGY
·
2020
·
IF 3.263
Min Chen,Qiu-Ping Zhang,Ji-Xiao Zhu,Jie Cheng,Qing Liu,Guang-Hui Xu,Cheng-Fu Li,Li-Tao Yi
It has been reported that liquiritin produced an antidepressant-like effect in rodents. However, little information is known regarding its antidepressant activity with the regulation of fibroblast growth factor 2 (FGF-2), a protein maintaining development and maturation of the nervous central system . Therefore, the aim of the present study was to investigate the underlying FGF-2 modulation involved in the antidepressant-like effects of liquiritin. In the present study, mice were orally administrated with liquiritin for 7 days prior to LPS injection. The depressive-like behaviors , levels of FGF-2, number of Iba1 positive cells, expression of proinflammatory cytokines and density of dendritic spines were evaluated. The results showed that liquiritin significantly ameliorated the depressive-like behaviors in mice response to LPS injection. Liquiritin reversed the reduction of FGF-2 levels in the hippocampus of LPS induced mice. In addition, the microglial activation caused by LPS was attenuated by liquiritin, in accordance with downregulation in mRNA levels of proinflammatory cytokines. Moreover, liquiritin also increased the density of dendritic spines in the hippocampus, which was suppressed by LPS. In conclusion, our findings demonstrated that liquiritin exerted the antidepressant-like effects in LPS-induced depression through FGF-2 enhancement by inhibiting neuroinflammation and maintaining synaptogenesis .
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高影响因子
Journal of the American Chemical Society
·
2018
·
IF 14.357
Mei-Ling Feng,Debajit Sarma,Yu-Jie Gao,Xing-Hui Qi,Wei-An Li,Xiao-Ying Huang,Mercouri G. Kanatzidis
Unconventional ion exchangers can achieve efficient removal of [UO2]2+, Cs+, and Sr2+ ions from complex aqueous solutions and are of great interest for environmental remediation. We report two new gallium thioantimonates, [Me2NH2]2[Ga2Sb2S7]·H2O (FJSM-GAS-1) and [Et2NH2]2[Ga2Sb2S7]·H2O (FJSM-GAS-2), which present excellent ion exchange properties for [UO2]2+, Cs+, and Sr2+ ions. They exhibit high ion exchange capacities for [UO2]2+, Cs+, and Sr2+ ions (qmU = 196 mg/g, qmCs = 164 mg/g, and qmSr = 80 mg/g for FJSM-GAS-1, qmU = 144 mg/g for FJSM-GAS-2) and short equilibrium times for [UO2]2+ ion exchange (5 min for FJSM-GAS-1 and 15 min for FJSM-GAS-2, respectively). Both compounds display active ion exchange with [UO2]2+ in the pH range of 2.9–10.5. Moreover, the sulfide compounds could maintain high distribution coefficients KdU even in the presence of excess Na+, Ca2+, and HCO3–. The distribution coefficient KdU of 6.06 × 106 mL/g exhibited by FJSM-GAS-1 is the highest among the reported U adsorbents. The [UO2]2+-laden products can be recycled by conveniently eluting the uranium with a low-cost method. These advantages combined with facile synthesis, as well as β and γ radiation resistance, make FJSM-GAS-1 and FJSM-GAS-2 promising for selective separations in nuclear waste remediation.
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高影响因子
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
·
2020
·Vol. 103
·期 9
·5013-5027
·
IF 3.502
Yongbao Xiao,Yao Ji,Yichen Ye,Shujing Huang,Weichao Wang
Alkali-earth-metaphosphate-based fluoro-sulfo-phosphate M(PO 3 ) 2 –AlF 3 –MSO 4 (MPFS, M = Ca, Sr, Ba) glasses have been developed via simultaneously incorporating fluoride and sulfate into metaphosphate glass. Their glass-forming regions were efficiently determined under the guidance of thermodynamic calculation method. The physical and structural properties of BaPFS glass were investigated in detail. Furthermore, near-infrared spectroscopic properties of Er 3+ -doped BaPFS (Er–BaPFS) glass were studied. Physical parameters, such as Abbe's number ν d (55-75) and nonlinear refractive index n 2 (1.17-1.86 × 10 −13 esu), of BaPFS glass are strongly depended on P/F/S ratio. The structure of BaPFS glass gradually depolymerizes and tends to become multianionic when Ba(PO 3 ) 2 is substituted by AlF 3 and BaSO 4 . Anion-substitution strategy effectively modulates the property and structure of glass, providing a scheme to derive glass materials. In addition, enhanced emission at ~1.5 μm has been observed from Er–BaPFS glass along with large emission cross section (5.0-5.5 × 10 −21 cm 2 ) and long lifetime (6.7-7.3 ms), resulting in large figure of merit (3.46-3.84 × 10 −23 cm 2 ·s), which is a promising candidate for solid-state laser.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2021
·Vol. 32
·期 10
·13941-13947
·
IF 2.478
Liu Ying,Cao Bo,Zhang Xu,Luo Rong,Luo Chunhua,Lin Hechun,Peng Hui
Layered Co(OH) 2 has been regarded as a potential candidate for pseudocapacitor electrode material, but it is limited by its poor conductivity and low surface area. Herein, carbonated multi-walled carbon nanotubes (MWCNTs-COOH) were used to improve the conductivity of α-Co(OH) 2 nanocomposites. α-Co(OH) 2 nanoflowers were successfully grown and tangled with MWCNTs-COOH to form a randomly oriented network structure mediated by ammonia using water-methanol as co-solvent at room temperature. The capacitance performances of the obtained α-Co(OH) 2 @MWCNT-COOH composites were investigated to find that MWCNT-COOH improved the specific capacitance efficiently. Especially, in the presence of 20% in mole of MWCNT-COOH, the composite gave rise to the high specific capacitance of 1027 F/g at the current density of 2 A/g with good cycle stability, whose specific capacitance remained 78% of its original even after 5000 cycles at 30 A/g current. The large surface area and strengthening the conductivity of the composites lead to the improvement of efficiency in charge/discharge process.
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SYNTHESIS-STUTTGART
·
2020
·Vol. 53
·期 07
·1341-1348
·
IF 2.675
Xinxin Zhao,Lin Guo,Chao Yang,Wujiong Xia
A highly regioselective [3+2] cyclization of alkenes with 2-iodoanilines under the irradiation of UV light is described. This general, metal-free strategy facilitates the direct preparation of 2-mono-/disubstituted indolines as well as spiroindolines through alkene carboamination in one step. Mechanistic studies suggested that the photochemical protocol proceeded via a radical pathway.
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JOURNAL OF CHEMICAL RESEARCH
·
2018
·
IF 0.668
Da-Hua Shi,Xiao-Dong Ma,Yu-Wei Liu,Wei Min,Fu-Jun Yin,Zong-Ming Tang,Meng-Qiu Song,Chen Lu,Xiao-Kai Song,Wei-Wei Liu,Tong Dong
To find novel butyrylcholinesterase inhibitors, three novel 2-phenylthiazole derivatives were synthesised. The synthesised compounds were characterised by NMR and single-crystal X-ray diffraction analysis. Hirshfeld surface analysis and two-dimensional fingerprint plots of the compounds were used as a theoretical approach to assess the driving force for crystal structure formation via the intermolecular interactions in the crystal lattices of the synthesised compounds. Among the three compounds, N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro- 1H-pyrazol-4-yl)-2-(4-methoxyphenyl)thiazole-4-carboxamide showed the best butyrylcholinesterase-inhibition activity with an IC50 value of 75.12 μM. A docking study demonstrated that this compound interacts with the peripheral anionic site of butyrylcholinesterase.
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