BIOMEDICINE & PHARMACOTHERAPY
·
2023
·
IF 7.5
Jinman Liu,Xue Zuo,Mingjun Huang,Jiansong Fang,Weirong Li,Qing Shi,Qi Wang,Yong Liang
This study aimed to investigate the potential effects of Gomisin B, a natural compound known for its inhibition of CYP3A4, on cognitive dysfunction in APP/PS1 transgenic mice with Alzheimer's disease (AD). Additionally, the study explored the combined effects of Gomisin B and Osthole (OST). The research involved male wild-type (WT) mice and 7-month-old APP/PS1 transgenic AD mice. The assessment of behavioral changes included the use of the open field test (OFT) and the Morris water maze (MWM). OST levels in brain tissue were quantified using LC-MS/MS, while levels of oxidative stress were measured through an assay kit. Neuronal apoptosis was studied using Nissl staining, RT-qPCR, and immunofluorescence. Amyloid plaque clearance was assessed using thioflavine-S (Th-S) staining, RT-qPCR, and ELISA. The results of the study revealed that Gomisin B led to a significant improvement in cognitive dysfunction in APP/PS1 mice. Moreover, the simultaneous administration of OST and Gomisin B demonstrated enhanced therapeutic effects. These effects were attributed to the inhibition of β-site APP-Cleaving Enzyme 1 (BACE1) and oxidative stress by Gomisin B, along with its anti-apoptotic properties. The combined use of OST and Gomisin B exhibited a synergistic impact, resulting in more pronounced anti-oxidant and anti-apoptotic effects. In summary, this study pioneers the exploration of Gomisin B's multifunctional anti-AD properties in APP/PS1 mice. The findings provide a solid groundwork for the development of anti-Alzheimer's drugs based on natural active ingredients.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2023
·Vol. 47
·期 40
·18659-18670
·
IF 3.3
Zhentao Wang,Waheed Iqbal,Jingjing Wang,Ninghui Chang,Chuanguang Qin
Degrading dye waste using inexpensive synthetic photocatalysts is intriguing since it provides the dual advantage of treating water and managing waste simultaneously. There is considerable interest in the construction of heterojunctions for their efficiency in using solar energy for the degradation of wastewater contaminants and enhancing the solar conversion efficiency. Herein, BiVO4 microspheres and 2D g-C3N4 nanosheets were used to synthesize a direct Z-scheme BiVO4/g-C3N4 heterojunction through a hydrothermal calcination approach. The distinct 0D/2D intimate contact heterostructure displayed a high interfacial area and broader visible-light absorption range together with high photoexcited charge pair mobility. Optimizing the content of the BiVO4 microspheres in the heterostructure led to the maximum efficiency for the visible-light photodegradation of rhodamine B (RhB), which was about 12.5 and 2.4 times higher than that for pure BiVO4 and g-C3N4, respectively. Moreover, the quenching effects of various scavengers demonstrated that ˙O2− and ˙OH radicals were the principal active species responsible for ameliorating the photocatalytic performance for RhB degradation. The demonstrated strategy for boosting the photocatalytic performance with Z-scheme systems may help the advancement of high-performance photocatalysts for sustainable and efficient pollutant degradation and energy applications.
✓ 已验证
产品关联
DOI
高影响因子
NANOTECHNOLOGY
·
2021
·Vol. 32
·期 17
·175604
·
IF 3.874
Fan Liu,Yuan Jiang,HaiBao Shao,Chunlei Wang,Shuhong Xu,Rong Zhang
Precise control of the structure and bonds of doped carbon dots (CDs) is important, so that their fluorescence can be tuned as desired. Up until now, there has been a lack of effective ways to control the bonds of doped CDs. In this article, we show that the fluorescence of B/N-doped carbon dots (B/N-CDs) can be precisely tuned just by controlling their precursors' pH values. The prepared B/N-CDs exhibit two emission bands, including one emission peak at around 450 nm due to the defect state caused by low sp2 hybridization of carbon atoms, as well as another emission peak at around 360 nm caused by the B-N bond. The results for the ratio of the maximum intensity of the two emission peaks above show a linear relationship. Meanwhile, the role of the pH value of the precursors on the luminescence of B/N-CDs is deeply studied. On the one hand, the pH value affects the bonding process of CDs. N-H bonds tend to form at a low pH value, while more competitive B-N bonds exist at much higher pH value, leading to the pH-dependent intensity of the 360 nm emission band. On the other hand, a high pH value causes higher crystallinity, thus suppressing defect-state fluorescence at 450 nm. The dual effects of pH lead to precisely controlled dual-emission intensities as well as ratiometric fluorescence.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2021
·Vol. 9
·期 8
·2042-2053
·
IF 6.331
Xiaolu Guo,Changchun Wen,Qianxin Xu,Changping Ruan,Xing-Can Shen,Hong Liang
The second near-infrared (NIR-II) window (1000–1350 nm) usually offers further improved light penetration, a higher maximum permissible exposure (MPE), and a lower background signal. Development of NIR-II optical diagnosis and phototherapy technologies is of great significance for precise, efficient tumor therapy. In this work, a new type of Ti-based targeting agent (B-TiO2@SiO2–HA) nanotheranostic system with strong NIR-II absorption was designed and fabricated for the first time. Oxygen vacancies were formed in B-TiO2 and its band gap was narrowed, resulting in nanotheranostic systems with full-spectrum responses to stimulation with light. The experimental results showed that B-TiO2@SiO2–HA not only can enable high NIR-II photothermal conversion and provide excellent reactive oxygen species (ROS) production capacity, but also can enable high-resolution photoacoustic imaging (PAI) under NIR-II laser irradiation. Moreover, HA modification gives the nanotheranostic systems the useful ability to target high-CD44-expression tumor cells and tissues. In vitro and in vivo experiments demonstrated that B-TiO2@SiO2–HA exhibited a targeted photothermal/photodynamic (PTT/PDT) effect that produced tumor-cell ablation and apoptosis under the guidance of real-time NIR-II PA imaging. B-TiO2@SiO2–HA exhibits precise nanotheranostic potential for PAI-guided tumor-targeting phototherapy.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Environmental Chemical Engineering
·
2021
·
IF 5.909
Wei Liu,Shao-Qing Li,Wei-Xing Liu,Qiang Zhang,Jia Shao,Jin-Lei Tian
A convenient and rational route is designed to synthesize B, N co-doped porous carbon materials (BNPCs) via a two-step calcination method derived from adenine-based bio-MOF-1. By using the adenine from bio-MOF-1 precursor as the endogenous N source and boric acid as the exogenous B source, the N and B elements are uniformly doped in metal-free BNPCs. B has lower electronegativity than C, leading to a higher positive charge density and the enhanced activation of C atoms. Owing to the synergistic effect between B and N, the co-doped catalysts not only increase electrical conductivity of catalysts to improve electron transfer , but also produce more additional active sites to intensify the catalytic performance for the reduction of 4-NP. The as-synthesized carbon materials have abundant mesopores , graphite structure, dual heteroatoms doping and thus excellent catalytic performances. In particular, BNPC-1000, obtained by pyrolysis at 1000 °C, shows superior catalytic efficiency of 95.2% and high catalytic cycling stability for the 4-NP reduction.
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Peng Wei,Xiaogang Li,Zhimin He,Xueping Sun,Qirui Liang,Zhengying Wang,Chun Fang,Qing Li,Hui Yang,Jiantao Han,Yunhui Huang
The flexible design and construction of oxygen reduction reaction (ORR) catalysts with high activity, great stability, and superior cost efficiency are essential for metal-air batteries and fuel cells. Hollow carbon nanotubes (CNTs) are considered promising electrocatalysts owing to their outstanding thermal stability, robust chemical properties, and high specific surface area. Herein, a convenient and controllable solid-phase route is proposed for the preparation of porous nitrogen (N) and boron (B) co-doped carbon nanotubes (NBCNT) by using tubular polypyrrole (PPy) and sodium tetraphenylboron ((C 6 H 5 ) 4 BNa), in which (C 6 H 5 ) 4 BNa serves not only as a B source but also as a pore-forming agent that can help to regulate N configuration and expose more active sites. Due to the synergistic effects of porous one-dimensional hollow structure and the binary heteroatom doping, the optimized NBCNT catalyst demonstrates superior catalytic performance for ORR in both acidic and alkaline electrolytes. Moreover, Zn-air batteries are constructed based on the as-prepared catalysts, which reveal a high operating voltage (1.43 V) and peak power density (173.93 mW cm −2 ), further demonstrating a comparable electrocatalytic performance of the catalysts to commercial Pt/C catalyst. This work reveals a novel construction of high-efficiency and cost-effective metal-free catalysts for various energy conversion and storage technologies.
✓ 已验证
产品关联
DOI
高影响因子
ANNALEN DER PHYSIK
·
2021
·Vol. 533
·期 2
·2000464
·
IF 2.987
Xinxi Zeng,Han Zhang,Xiaoqing Xi,Bo Li,Ji Zhou
The terahertz (THz) spectral range offers a platform for experimentally collecting electromagnetic pulses to analyze the intrinsic resonances of matter and has become an important field for applying intrinsic responses to future information devices. However, a lack of numerical methods for signal denoising exists in the knowledge of the THz spectral range. In this paper, numerical methods that employ the Bézier curve and its generalization ( B -spline) to denoise thermally tunable and thickness-dependent terahertz signals are proposed. Different thicknesses of ErFeO 3 are chosen and prepared. Both Bézier curves and B -splines have the ability to denoise the signals and the effect of the Bézier curves on the noise is close to but slightly less than that of the B -splines. Additionally, the B -splines show a better noise reduction effect and have better signal strength stability and robustness than do the Bézier curves. Thus, B -splines are applied to process the raw data, and quantitative insight into the trend of the resonant frequencies, peak heights, and transmittances of antiferromagnetic resonance and ferromagnetic resonance with temperature is obtained.
✓ 已验证
产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2020
·
IF 6.182
Chao Shuai,Zunli Mo,Xiaohui Niu,Yongxin Du,Qinqin Gao,Jingjing Liu,Nijuan Liu,Ruibin Guo
Designing and construction of efficient and robust non-noble-metal electrocatalysts for oxygen evolution reaction (OER) is a pivotal approach in water splitting process. This work developed the dual-metal material system of Ni-Co nanoparticles wrapped in B-doped carbon (Ni1Co3@BC) through simple and economical pyrolysis process for nanosheets NiCo metal-organic framework (Ni1Co3-BDC) precursor. The constitution and structure of characterization were characterized by X-ray diffraction, X-ray photoelectron spectroscopy scanning electron microscope and transmission electron microscope, indicating the homogeneous alloy and less metal boride phase and B doped graphitization structure for Ni1Co3@BC. An optimized Ni1Co3@BC exhibited extraordinary OER performance, providing an overpotential as small as 309 mV at a current density of 10 mA cm −2 , a low Tafel slope of 62 mV dec −1 and excellent stability in 1.0 M KOH solution, which attributed to the synergistic effect of inner NiCo alloy, NiCo boride nanoparticles and external B doping carbon structure. The formation of B doped carbon layer not only provides additional active sites but also protects inner metal alloys. This work clearly stated the design and synthesis of desired-morphology features catalysts from controlled MOFs for energy conversation and storage.
✓ 已验证
产品关联
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2020
·
IF 3.573
Fei Shi,Qianqian Tian,Jingtao Wang,Qi Wang,Feng Shi,Yifan Li,Suzana P. Nunes
In this study, molecular-level mixed matrix membranes are prepared by incorporating two types of carbon quantum dots (QDs), polymer-like QDs (PQD) and graphene oxide QDs (GQD) into Pebax, a poly(ether-b-amide) copolymer. PQD is shown to destroy part of the intrinsic crystalline structure of Pebax as typical fillers do. By comparison, GQD has fewer functional groups and causes an interesting enhancement of the microphase separation of Pebax. The polyether domains become more segregated and more available for the selective CO2 permeation. As a result, the gas separation performance of the membranes is evidently enhanced. GQD outperforms PQD as a filler, and encouraging enhancement occurs at lower loading. The membrane with 0.05 wt % GQD loading shows the optimal gas separation property, while it is 1 wt % for PQD-doped membranes. A possible mechanism is tentatively proposed based on the findings of this study.
✓ 已验证
产品关联
DOI
高影响因子
Scientific Reports
·
2020
·Vol. 10
·期 1
·1-7
·
IF 3.998
Wang Xueni,Liao Xiuling,Zhang Yimin,Wei Linyao,Pang Yuzhou
Schisandrin B (SchB) is the highest content of biphenyl cyclooctene lignans in Schisandra chinensis . It has been reported to have a variety of pharmacological effects, including anti-inflammatory, anti-oxidant, anti-cancer, heart protection, liver protection. In this study, we found that SchB can promote the proliferation of MC3T3-E1 subclone 14 cells. Meanwhile, we found that SchB can regulate the BMP2-SMADs signaling pathway by increasing gene and protein expression of those relative biomolecules. Furthermore, SchB can raise the RUNX2 and SP7 expression in both mRNA and protein levels. Since the role of BMP2-SMADs-RUNX2-SP7 signaling axis in osteoblast proliferation and differentiation has been well documented. The present experimental findings indicate that SchB could promote the proliferation and differentiation of osteoblasts through BMP2-SMADs-RUNX2-SP7 signaling axis.
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2021
·Vol. 56
·期 13
·8079-8090
·
IF 4.22
Liu Jiali,Yang Qiang,Liu Jikai,Luo He’an
Tungsten trioxide (WO 3 ) has been conceived as a promising photoanode material for photoelectrochemical (PEC) water oxidation. Therefore, many efforts have been made to improve its PEC performances. Herein, a novel heterojunction is fabricated through combining rocksalt CoO (R-CoO) or blende CoO (B-CoO) nanosheets with WO 3 nanoplates using a spin-coating method. The typical type II heterojunctions, e.g., WO 3 /R-CoO and WO 3 /B-CoO, both have exhibited higher photocurrent densities than pristine WO 3 photoanode. The photocurrent densities of WO 3 /R-CoO, WO 3 /B-CoO and WO 3 are 0.53 mA cm −2 , 0.45 mA cm −2 and 0.31 mA cm −2 at 1.23 V vs. reversible hydrogen electrode, respectively. For the WO 3 /R-CoO photoanode, the surface charge separation efficiency is 50.95% and the photoconversion efficiency is 0.062%, which are both higher than the WO 3 and WO 3 /B-CoO photoanodes. The enhanced PEC performances are due to the type II heterojunction between WO 3 and R-CoO (or B-CoO), which facilitates the absorption of visible light and charge transport. The better performance of WO 3 /R-CoO than that of WO 3 /B-CoO may be due to the deeper valence band position of R-CoO. Our work demonstrates that R-CoO (or B-CoO) can couple with WO 3 to form a type II heterojunction to improve the PEC water oxidation performance.
✓ 已验证
产品关联
DOI
高影响因子
CRYSTAL GROWTH & DESIGN
·
2020
·
IF 4.089
Yunxia Han,Duanwei He,Dejiang Ma,Qiming Wang,Yusheng Zhao,Shanmin Wang,Mingquan Jiang,Xin Li,Jiawei Zhang
We report high-pressure synthesis of single-crystal boron suboxide (B6O), one of the superhard materials, using a reaction route between B and H3BO3 at 3–5.5 GPa and 600–2200 °C. At optimized pressure and temperature conditions of 5.5 GPa and 2100 °C, large B6O single crystals can be obtained with a crystallite size of more than 2 mm. Boric acid (H3BO3) was used as a starting material because it is easily decomposed into B2O3 and H2O at a lower temperature. The B2O3 produced by the decomposition should have a small particle size and thus have high reactivity, and the reaction byproduct H2O provides a good hydrostatic environment for the growth of B6O. Therefore, it is easier to synthesize and grow B6O by using a B-H3BO3 system as reaction raw materials. This work discussed the B6O growth mechanism in detail. In addition, photoluminescence experiments and first-principles calculations show that B6O is a direct band gap semiconductor material with good orange-red emission characteristics (the band gap is 1.83 eV). The results of this study indicate a method to grow large B6O single crystals that have great potential use in industrial applications.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）