CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Jiaqi Zhou,Jingyi Li,Yu Wang,Kaiwen Liang,Jingjing Yu,Cuicui Ding,Hui Wu,Lihui Chen,Min Zhang
In abdominal wall hernia repair, current mainstream polypropylene (PP)-based patches face challenges such as chronic inflammation, mismatched degradation rates, and insufficient anti-deformation properties. While natural biomaterials offer good biocompatibility and degradability, their clinical application is limited by insufficient mechanical strength. To overcome this challenge, we engineered a chitosan (CS) and cellulose nanofiber (CNF)-reinforced collagen membrane. This design leveraged dual polysaccharide functionalities: CNF provided nanoscale reinforcement, while CS enabled multi-point cross-linking with collagen, synergistically enhancing the membrane's structural stability. To further enhance performance, a sequential approach involving the layer-by-layer blade-coating and induced assembly was employed, producing stacked and oriented lamellar structures. The optimized membrane exhibited raised tensile strength (49.00 MPa) and fracture energy (121.22 MJ/m 3 ), prolonged degradation period (52.7 % weight retention at 28 days), and reduced swelling rate (135.5 %). In vitro biocompatibility assays confirmed the material's non-cytotoxicity and excellent blood compatibility. Moreover, in vivo rat abdominal defect models demonstrated superior tissue regeneration, minimized inflammation, and effective mechanical support when using the developed membrane compared to PP meshes and pure collagen membranes (COL). These findings highlight the potential of this green strategy to provide a balanced solution for hernia repair, addressing both mechanical and biological requirements.
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DOI
PubMed
高影响因子
FUEL
·
2025
·
IF 7.5
Yuanyuan Li,Xiaoling Xu,Ran Zhang,Xingbao Yang,Kun Jia
Traditional coal mine fire suppression methods face critical limitations, including short-term efficacy, poor penetration in concealed coal seams, and environmental risks from chemical residues. To address these challenges, this study developed a biomaterial-based composite inhibitor integrating physical isolation, free radical quenching, and antioxidant slow release for sustainable prevention of spontaneous coal combustion. A novel antioxidant-loaded composite was synthesized using hollow mesoporous TiO 2 nanoparticles (HM-TiO 2 ) as carriers, which were functionalized via layer-by-layer self-assembly (LBL) of chitosan (CS) and phytic acid (PA) to encapsulate tea polyphenol (TP). This design enables the TP antioxidant activity and low release while leveraging CS/PA’s catalytic char-forming capacity. The chemical composition and micromorphology of the composite were systematically characterized through FTIR, XRD, SEM, and TEM analyses. Programmed temperature oxidation experiments combined with thermogravimetric (TG) and thermogravimetric-Fourier Transform Infrared Spectroscopy (TG-FTIR) measurements were conducted to evaluate inhibition performance by tracking mass loss, characteristic gas emissions, and radical intermediates. Key findings demonstrate that the composite inhibitor: Prolongs coal ignition delay by 48 % compared to untreated coal, attributed to the synergistic barrier effect of the TiO 2 @CS-PA framework and TP’s radical scavenging activity; Reduces CO, CO 2 , CH 4 and H 2 O emissions during low-temperature oxidation; Maintains structural stability above 400 °C, with TiO 2 catalyzing dense char layers to isolate oxygen diffusion. This multifunctional composite overcomes the trade-off between inhibition longevity and environmental compatibility observed in conventional inhibitors (e.g., MgCl 2 , KMnO 4 ), offering a scalable solution for fire prevention in high-level mining areas. The bio-based components (CS, PA, TP) further ensure ecological safety, aligning with green mining initiatives.
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高影响因子
Applied Materials Today
·
2020
·
IF 8.352
Yipeng Chen,Baokang Dang,Qingfeng Sun
The concept of replicating the laminated ternary structure of natural nacre with coordinating strength and toughness has generated much interest in exploring future structural materials. Here the ternary lignocellulosic nacre with high performance is fabricated via synergistic toughening of delignified nano-lignocellulose (DNLC) and molybdenum disulfide (MoS 2 ) through freezing-induced assembly followed by hot-pressing process. The high mechanical performance of the lignocellulosic nacre due to lubrication of MoS 2 combine with intermolecular hydrogen bonding between DNLC and chitosan (CS) has effectively verified the synergistic toughening effect. The MoS 2 -CS lignocellulosic nacre exhibits an exceptional balance of strength and toughness, which exceed to other conventional lignocellulosic composites and natural materials. Furthermore, these composites show superior photocatalytic activity. This approach of fabricating the MoS 2 -CS lignocellulosic nacre supplies an imaginative door in the near future for devising and manufacturing the ultra-strong and ultra-tough lignocellulosic nacre for the photooxidation of volatile organic.
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高影响因子
Journal of Renewable Materials
·
2022
·Vol. 11
·期 1
·291-307
·
IF 2.115
Long Li,Yanan Lu,Yu Chen,Jiayi Bian,Li Wang,Li Li
Silver nanoparticles (Ag NPs) are an effective antibacterial agent, but their application in food packaging is limited due to their easy agglomeration and oxidation. In this study, antibacterial microcapsules were fabricated using Ginkgo biloba essential oil (GBEO) as core material and chitosan and type B gelatin biopolymer as capsule materials. These antibacterial microcapsules were then modified with green-synthesized Ag NPs, blended into the biopolymer polylactic acid (PLA), and finally formed as films. Physicochemical properties and antibacterial activity against Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ) were evaluated. Results showed that the prepared antibacterial PLA films exhibited excellent antibacterial activity against foodborne pathogens. Its TVC exceeded the limit value of 7 log CFU/g at 7 days compared with the 5 days of pure PLA films. Therefore, these films can extend the shelf life of grass carp fillets by 2–3 days under refrigeration.
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高影响因子
WATER SCIENCE AND TECHNOLOGY
·
2018
·Vol. 2017
·期 1
·16-26
·
IF 1.247
Liu Zejun,Zhou Shaoqi
In this study, we provide the first documented removal of humic acid (HA) from aqueous solution using polyacrylamide/chitosan (PAAm/CS) semi-IPN hydrogel. The prepared semi-IPN hydrogel was characterized by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FT-IR). The factors effecting HA adsorption performance were individually tested, including initial pH, ionic strength, contact time, initial HA concentration, and temperature. The results indicated that semi-IPN hydrogel was successfully fabricated and can be applied in a wide pH range, from 3 to 9. Low ionic strength effectively enhanced the adsorption capacity. As the ionic strength increased, this enhancement was less obvious but still positive. The adsorption kinetics were fitted to a pseudo-first-order kinetic model, and the adsorption isotherm was described using the Sips isotherm model. The HA adsorption capacity increased with increasing temperature. The maximum adsorption capacity has the potential to attain 166.30 mg g −1 , based on the Sips isotherm at 25 °C. Experiments demonstrated that the HA adsorption process can be primarily attributed to electrostatic interactions, and hydrogen bonding was also involved. Facile synthesis and good adsorptive performance indicate that semi-IPN hydrogel can be used for removing HA from water.
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高影响因子
THERMOCHIMICA ACTA
·
2021
·
IF 3.115
Chen Cheng,Jun Yan,Yanling Lu,Weining Ma,Chen Li,Shiguo Du
Chitosan (CH) and chitosan/lignosulfonate composite (CH/LS) were selected as shell materials for microencapsulated red phosphorus (MRP). MRP samples of RP@CH and RP@CH/LS were prepared and applied as flame retardants for epoxy resin (EP). The microstructure, chemical composition and thermal decomposition of the as prepared samples were systematically characterized. The effects of red phosphorus (RP), RP@CH and RP@CH/LS on the flame retardance performance of EP and the mechanism were investigated in detail. The results showed EP containing 7wt% RP@CH/LS got the limited oxygen index value of 30.6 %, and passed V-0 degree in the vertical burning tests. The peak heat release rate of EP/7wt% RP@CH/LS decreased 59.7 % compared with that of neat EP in the cone calorimeter tests. The shell structures also improved the interfacial compatibility between RP and the organic substrates, which was illustrated by tensile strain tests and scanning electron microscope (SEM) observation.
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高影响因子
Desalination and Water Treatment
·
2024
·
IF 1
Kang Wen,Yi Li,Shuxing Zhang,Xiaoting Zhang,Runping Han
Chitosan-polyvinyl alcohol-iron (CS-PVA-Fe) composite films with acid resistance and large adsorption capacity were prepared by doping trivalent iron, chitosan, and polyvinyl alcohol. The adsorption mechanism of Congo red (CR) on the composite films was investigated by changing the adsorption conditions (temperature, pH, salt) and characterization (isoelectric point, infrared spectroscopy, photoelectric spectroscopy, scanning electron microscopy). The results showed that the adsorption capacity of the composite film was 450 mg g –1 at pH 5.0, and the adsorption of CR by high concentration salt had only a slight negative effect. The adsorption was following Langmuir, pseudo-first-order kinetics and pseudo-second-order kinetics model, which showed that the adsorption process was based on the single-layer heterogeneous adsorption, and there were both physical and chemical adsorption processes. Thermodynamic analysis shows that adsorption was spontaneous, endothermic and entropy increasing process. According to the characterization analysis, the adsorption mechanism of CR was mainly hydrogen bonding, ion exchange, and complexation. Also, the desorption of CR-loaded film can be performed using 75% alcohol at pH 12. The results showed that CS-PVA-Fe composite films are promising as a suitable candidate for the efficient removal of CR from solution.
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高影响因子
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
·
2025
·
IF 3.6
Xiaoguang Liu,Qi Lin,Yi Zhong,Yanling Li,Ji’e Zhang,Yuhua Zhan,Yijia Sun,Ruixia Hou
Catheter-associated urinary tract infections (CAUTIs), the most prevalent hospital-acquired infections globally, remain unresolved despite the development of antimicrobial catheters incorporating silver or antibiotics. To address this challenge, a quaternized chitosan (HTCC)-functionalized catheter was developed through oxygen plasma activation of polyvinyl chloride (PVC) surfaces, followed by polydopamine (PDA) coating and HTCC grafting. This process improves the hydrophilicity of the PVC surface, which is beneficial for reducing urethral mucosal damage in patients, inhibiting the formation of bacterial biofilms, reducing friction and improving patient comfort. This approach eliminated the need for potentially toxic silver nanoparticles and the issue of antibiotic resistance while enhancing surface hydrophilicity. The modified catheter demonstrated superior antibiofilm and antimicrobial efficacy against key uropathogens, including Staphylococcus aureus and Escherichia coli, compared to commercial PVP-urea coated PVC catheters. With its combined advantages in surface wettability, antimicrobial performance, and biocompatibility, this HTCC-based design presents a promising solution for CAUTI prevention and establishes a new paradigm for medical device coatings.
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PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2025
·
IF 2.8
Yubo Liu,Zhenghao Li,Shiwen Xie,Dezhi Lu,Daoyuan Liu,Huiping Xu,Peifeng Wu,Boyu Si,Chaoyi Zhang,Xiangde Lin,Hui Yang
Green hydrogels hold promise for biomedical applications but are limited by weak mechanical properties. Here, we report a chitosan (CS)–reinforced polyvinyl alcohol hydrogel (PVA) fabricated via eco-friendly freeze–thaw cycles, achieving dual enhancement in mechanical strength and antibacterial efficacy. Incorporating 3 wt% chitosan increased compressive strength from 0.36 MPa in pure PVA to 2.92 MPa at 80% strain, while maintaining over 80% recovery after cyclic compression. The porous structure of the fabricated hydrogel and hydrogen-bonded network enabled sustained ciprofloxacin (CIP) release over 72 h. Antibacterial performance against Escherichia coli and Staphylococcus aureus improved significantly with CS addition, reaching 99% efficiency at 3% CS content, while CIP integration achieved complete bacterial eradication (100% efficiency). Synergistic action between the contact-based bactericidal activity of CS and CIP sustained release eliminated colony formation, demonstrating superior inhibition of both Gram-negative and Gram-positive bacteria. This green strategy delivers a mechanically robust, multifunctional hydrogel for infection-resistant biomedical applications.
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高影响因子
MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 11
·1-12
·
IF 5.3
Xiao Wenxiang,Hu Yunqin,Shao Liuwen,Liu Jiannan,Wang Dong,Li Hua
Ultra-stable copper nanoclusters were fabricated for the sensitive determination of cholesterol based on fluorescence turn-off. Red-emitting copper nanoclusters capped with cysteine were first synthesized with a short storage time (15 d). Then, the addition of chitosan and the adjustment of media pH were applied to modulate the unstable clusters into exceptionally stable aggregates with cyan-green emission possessing a long lifetime over 180 days. The aggregation-induced emission (AIE) of chitosan-modified copper nanoclusters (Cys-CuNCs) can be significantly quenched by cholesterol due to the interaction between cholesterol and chitosan. The fluorescence response of Cys-CuNCs to cholesterol exhibits a rapid equilibrium (1 min), high sensitivity with a detection limit of 19.63 μmol·L⁻ 1 (3σ, n = 3), and a wide linear concentration range of 25.0 ~ 1000.0 μmol·L⁻ 1 . The proposed method has good stability and can be employed for cholesterol determination in biofluids. Graphical
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PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Feilin Lin,Wenqi Qin,Kaidi Guo,Jianzhong Jiang
Aqueous two-phase system (ATPS) is widely used in biotechnology owing to their excellent permeability, affinity partitioning, biocompatibility, and mild all-aqueous conditions. However, their extremely low interfacial tension renders them vulnerable to droplet collisions and prone to stratification, resulting in poor stability and low utilization efficiency. Herein, we report an ultra-stable water-in-water ( W /W) emulsion gels derived from an ATPS, using dextran/poly(ethylene glycol) as the template and chitosan (CS) as the emulsifier. The CS molecules were conjugated with 2-furaldehyde (FAL) via imine bonds, enabling the formation of emulsion gels within 2 min. The W /W emulsion gels exhibited no macroscopic phase separation for up to 6 months, and withstood low/high temperatures (−18 °C/70 °C) as well as centrifugation (6000 rpm, for 40 min). They also showed sprayability and excellent physicochemical properties, which effectively alleviated retention and coverage issues by reducing fragmentation and enhancing local pinning and wetting processes. With mangoes used as a model system, microbial proliferation on mango surfaces was significantly inhibited after spraying with the W /W emulsion gels, achieving a 99.8 % antibacterial inhibition rate and reducing mango decay by 46.0 %. This work presents a promising strategy for developing scalable, low-cost, biodegradable, and eco-friendly antibacterial preservation systems.
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PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Zhi-Chao Yan,Weifa Yang,Chunfang Huang,Yuanshuo Zhang,Binyan Zhong,Peilin Li,Haotao Li
The development of protein-free, food-grade emulsifier to stabilize high internal phase emulsions (HIPEs) presents a significant challenge. Chitosan (CS), an abundant natural polysaccharide, holds great potential for this role. The existing strategies often rely on chemical derivatization of CS, which introduces synthetic complications and undesired non-natural ingredients. To overcome the limitations, we develop a tannic acid-chitosan complex (TACS) emulsifier, enabling the fabrication of food-grade HIPEs. A combination of experimental characterization and molecular dynamics simulations reveals that TA acts as a key physical crosslinker to promote the formation of the TACS interfacial film. This enables the fabrication of stable HIPEs whose morphology and rheological properties can be tailored by varying the TACS concentration, TA-CS ratio, and oil fraction. Furthermore, this TACS-based HIPE provides enhanced protective encapsulation for curcumin and demonstrates potent antioxidant activity. This work establishes a generalizable, non-Pickering polysaccharide-based paradigm for stabilizing HIPEs, offering a promising platform for designing fat substitutes applicable for individuals with protein allergies.
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高影响因子
危险品化学品经营许可证（带存储）