JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2013
·Vol. 299
·期 3
·1509-1515
·
IF 1.467
Liu Zhen-feng,Wang Guo-lin,Dong Meng-jie,Jin Jian-wen,Li Jia-jun,Zhang Qian,Zhao Kui,Yang Shu-ye,Lin Xiang-tong
The preparation of 10-(2-[ 18 F]fluoroethoxy)-20( S )-camptothecin, a potential positron emission tomography tracer for the imaging of topoisomerase I in cancers, is described. 10-(2-[ 18 F]Fluoroethoxy)-20( S )-camptothecin was synthesized by the [ 18 F]fluoroalkylation of the corresponding hydroxy precursor molecule with 2-[ 18 F]fluoroethyl bromide ([ 18 F]FEtBr) in dimethylsulfoxide (DMSO) at 55 °C for 20 min; this was followed by purification using high performance liquid chromatography (HPLC) with a total preparation time of 60 min. The overall radiochemical yield was approximately 5.4–12 % (uncorrected), and the radiochemical purity was above 96 %.
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ANALYST
·
2015
·Vol. 140
·期 5
·1731-1738
·
IF 4.107
Di Chen,Yun-Qing Huang,Xiao-Mei He,Zhi-Guo Shi,Yu-Qi Feng
A rapid analysis method by coupling carbon nanotube film (CNTF) microextraction with desorption corona beam ionization (DCBI) was developed for the determination of Sudan dyes (I–IV) and Rhodamine B in chilli oil samples. Typically, CNTF was immersed into the diluted solution of chilli oil for extraction, which was then placed directly under the visible plasma beam tip of the DCBI source for desorption and ionization. Under optimized conditions, five dyes were simultaneously determined using this method. Results showed that the analytes were enriched by the CNTF through the π–π interactions, and the proposed method could significantly improve the sensitivities of these compounds, compared to the direct analysis by DCBI-MS/MS. The method with a linear range of 0.08–12.8 μg g−1 and good linear relationships (R2 > 0.93) in a multiple reaction monitoring (MRM) mode was developed. Satisfactory reproducibility was achieved. Relative standard deviations (RSDs) were less than 20.0%. The recoveries ranged from 80.0 to 110.0%, and the limits of detection (LODs) were in the range of 1.4–21 ng g−1. Finally, the feasibility of the method was further exhibited by the determination of five illegal dyes in chilli powder. These results demonstrate that the proposed method consumes less time and solvent than conventional HPLC-based methods and avoids the contamination of chromatographic column and ion source from non-volatile oil. With the help of a 72-well shaker, multiple samples could be treated simultaneously, which ensures high throughput for the entire pretreatment process. In conclusion, it provides a rapid and high-throughput approach for the determination of such illicit additions in chilli products.
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Journal of Water Process Engineering
·
2024
·
IF 6.3
Zhen Tian,Yiyang Li,Lina Wang,Rui Xu,Aihua Wei,Jun He,Chengjun Wang
An innovative technology for the removal of phenolic and non-phenolic organic pollutants from aqueous solution was developed by combining UV 254 irradiation, peroxymonosulfate (PMS), and iodide ions (I − ). Effects of pH, ratio of [I − ]/[PMS], initial concentration of pollutant, dissolved organic matter (DOM) and typical inorganic constituents of environmental water on the degradation of studied pollutants with UV 254 /PMS/I − system were examined. The results showed that pH and [I − ]/[PMS] exhibited significant impact on the degradation of pollutants during UV 254 /PMS/I − process. As the ratio of [I − ]/[PMS] increased from 0.1 to 10.0, the removal efficiencies of phenolic pollutants remarkably increased, but those of non-phenolic pollutants decreased. The DOM at high concentration obviously inhibited the degradation of pollutants during UV 254 /PMS/I − process. Meanwhile, the occurrence of NO 3 − can slightly enhance the degradation of pollutants, and SO 4 2− , Cl − , and HCO 4 − ions had no significant effects on UV 254 /PMS/I − system. The abundant reactive species including OH, SO 4 − , and I /I 2 − during UV 254 /PMS/I − process were generated based on electron spin resonance, fluorescence spectroscopy and steady-state concentration analysis. Quenching experimental results indicated that I /I 2 − can selectively degrade phenolic pollutants via one-electron oxidation. This study provided a reference for the application of reactive radicals involved oxidative technique in water purification .
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Arabian Journal of Chemistry
·
2024
·
IF 5.3
Jie Lian,Wenyu Gong,Jianing Guo,Mingxing Wu
Construction of mesoporous structure and improving the conductivity of carbon counter electrode are feasible paths to enhance the catalytic activity in dye-sensitized solar cells (DSCs) toward the I 3 - /I - redox couple regenerating (IRR). Herein, mesoporous carbon fiber (PCf) has been first synthesized and the DSCs using PCf counter electrode results in a power conversion efficiency (PCE) of 7.12%, significantly surpassing the PCE of 6.01% generated by the DSCs with carbon fiber (Cf) counter electrode without mesoporous structure. Additionally, doping with heteroatoms B or N can further enhance the catalytic performance of PCf. Consequently, B or N doped Cf (BPCf or NPCf) counter electrode-based DSCs achieve high PCE values of 8.43% and 7.96%, respectively, demonstrating PCE improvements of 40.3% and 32.4%. This enhancement in catalytic activity for IRR in DSCs can be first attributed to the increased specific surface area of Cf which can provide more catalytic activated sites. Meanwhile, the enhanced conductivity of PCf by heteroatoms B or N doping is also an important factor for the improved catalytic activity. This work is expected to provide potential path to enhanced the catalytic activity of carbon counter electrode in DSCs toward IRR.
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ADVANCED FUNCTIONAL MATERIALS
·
2024
·Vol. 34
·期 52
·2411183
·
IF 18.5
Song Yin,Xuewei Jiao,Xudong Liu,Mingxuan Liu,Bingshun Xu,Na Li,Yonghao Lu,Shaopeng Yang,Weiguang Kong
The role of MA in FAMA mixed perovskite remains far from being fully understood, due to the intricate chemical evolutions in the precursor solutions. Adjusting the content of MA in FAMA mixed perovskite arbitrarily remains a great challenge. This study elucidates a synergistic effect between H + and I − oxidation which helps to reduce the content of MA in FA-dominated perovskite. Briefly, excessive H + boosts the balanced and rapid assembly of MA and FA components in FA-dominated perovskite and hampers unfavorable chemical evolution induced by nucleophilic reaction between MA and FA in the precursor solution, while I − oxidation accelerates the in situ crystallization of perovskite. Leveraging this synergistic effect, centimeter-scaled FA x MA (1-x) PbI 3 single crystals with arbitrarily adjustable values of x are successfully fabricated. In addition, peroxyacetic acid is introduced as the additive, enabling the blade-coated FA 0.9 MA 0.1 PbI 3 perovskite solar cells (PSCs) to achieve an impressive efficiency of 23.7%. The efficiency achieved here is among the highest values for blade-coated PSCs with FA content exceeding 90% so far. The optimized solution developed in this study achieved exceptional stability, allowing it to be stored under air conditions for over 2 months without significant degradation in cell efficiency. This outcome satisfies the requirements for commercialization.
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Surfaces and Interfaces
·
2024
·
IF 5.7
Xueling Wei,Yuanhao Yang,Zhen Ma,Qiujie Li,Qian Sun,Dekai Zhang,Enzhou Liu,Hui Miao
Bismuth oxysulfide (Bi 2 O 2 S), as a unique new two-dimensional layered material, has gradually attracted the interest of researchers because of its excellent photoelectric properties. How to enhance its charge kinetics is the key to improve photoelectrochemical (PEC) properties. Herein, the cascade type II-I heterostructure of Bi 2 O 2 S/Bi 2 S 3 /ZnIn 2 S 4 O (oxygen doping) was rationally fabricated by oxygen doping for efficient PEC water splitting through one-step hydrothermal method. Bi 2 S 3 was in close contact with Bi 2 O 2 S through Bi atom sharing, while ZnIn 2 S 4 O has enhanced polarity. The double-synergistic effect of the cascade II-I heterojunction with strong interface interaction and asymmetric crystal modification could greatly promote the transfer efficiency of the surface charge and the bulk charge, inhibited the photogenerated carrier recombination, and enhanced the overall charge dynamics. The results showed that the photocurrent density of Bi 2 O 2 S/Bi 2 S 3 /ZnIn 2 S 4 O composite photoanode was 4.82 mA cm −2 under the condition of 1.23 V vs. RHE, which was 9.09 times with that of monomer Bi 2 O 2 S. This study opened up a new way for the application of Bi 2 O 2 S-based photoelectrodes in the field of PEC water splitting.
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JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
·
2020
·
IF 3.004
Pengru Liu,Xiongdiao Lan,Muhammad Yaseen,Kungang Chai,Liqin Zhou,Jianhua Sun,Ping Lan,Zhangfa Tong,Dankui Liao,Lixia Sun
Purification of small bioactive peptides from complex biological samples is a difficult task due to the interference of concentrated large biomolecules. In this study, a magnetic immobilized metal affinity chromatography matrix modified by poly (ethylene glycol) methyl ether (IMACM@mPEG) was prepared and applied for the rapid purification of angiotensin I-converting enzyme (ACE) inhibitory peptides from casein hydrolysate. The proposed IMACM@mPEG considerably reduced the non-specific adsorption of large proteins and exhibited improved purification efficiency towards ACE inhibitory peptides. A novel peptide with moderate ACE inhibitory activity (IC 50 value of 274 ± 5 μM) was identified as LLYQEPVLGPVR. Lineweaver-Burk plot confirmed the non-competitive inhibition pattern of LLYQEPVLGPVR. The purified peptide was digested after simulated gastrointestinal digestion and produced shorter peptides which contributed to enhanced ACE inhibitory activity. These results indicated that the IMACM@mPEG is an effective method for the prepurification of ACE inhibitory peptide and the purified peptide LLYQEPVLGPVR may have potential as nutraceutical ingredient in functional foods for hypertension treatments.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2025
·
IF 6.2
Xiaoyi Pan,Hongyan Si,Yongqi Zhang,Hanyue Huang,Suhua Yuan,Wuxiong Wang,Wenjing Yuan,Ji Zhang,Jie Song,Shangxing Chen,Shengliang Liao,Zongde Wang
The citral-based acylthiourea derivative e14 was identified as a potent synergist for chlorothalonil (CT) against Colletotrichum fructicola. The optimized mixture (ECS, 25% e14) exhibited strong synergistic activity (synergistic ratio (SR) = 2.30), significantly enhancing disease control efficacy while enabling reduced fungicide dosage. Mechanistic studies revealed that e14 specifically targets mitochondrial complex I by binding to the NADH dehydrogenase subunit 5 (ND5), thereby disrupting oxidative phosphorylation and inducing energy depletion and oxidative stress. This distinct mode of action differs from that of CT, minimizing the risk of cross-resistance. Importantly, e14 exhibits low mammalian cytotoxicity. This study elucidates the synergistic mechanism of ECS and the enhancing role of e14, thereby providing a solid foundation for the development of effective fungicide synergists.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Tong Liu,Jiahao Li,Qinqin Yu,Pengkun Zheng,Yao Liu,Shaoyang Tao,Haoming Wang,Min Zhou,Haobo Hou
Thallium (Tl) is a highly toxic rare element. The selective and efficient removal of Tl(I) from water is critical for water safety, yet remains a significant challenge. Herein, a series of highly effective adsorbents with coordination/ion-exchange sites have been developed for Tl(I) removal through composite modification of zeolites via potassium ion exchange and crown ether loading. Within 1 min, 99.42 % of Tl(I) could be removed by 18C6@K-4 a, and the maximum adsorption capacity derived from the sips isotherm model reached 1199.01 mg·g −1 . The adsorption process of Tl(I) was determined to be spontaneous and exothermic based on thermodynamic studies. X-ray photoelectron spectroscopy (XPS) and density functional theory (DFT) calculations were employed to elucidate the adsorption mechanism and propose optimized adsorption configurations. Both control experiments and computational results consistently demonstrated that the enhanced performance can be attributed to the synergistic effect between exchangeable K + and crown ether complexation, wherein 18-crown-6 captures Tl + through coordination, while K + /Tl + cation exchange contributes to the selectivity and rapid adsorption kinetics. This study offers a straightforward strategy for modifying thallium adsorption materials, which operates under mild conditions, generates no hazardous waste, and leads to significantly improved Tl(I) adsorption performance along with high reusability of the material
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Xuan Ma,Xudong Zheng,Xi Zhang,Youming Zhu,Lin Guo,Jingbo Sun,Jinfeng Mei,Jian Rong,Zhongyu Li
137 Cs and 131 I exhibit pronounced radiotoxicity, prolonged environmental persistence, and high mobility, posing dual threats to ecosystems and human health. The simultaneous removal of Cs + and I − using a single adsorbent is an area of growing research interest. In this study, a rationally designed dual-imprinted membrane (IPA-MC) was engineered via electrospinning and ion-imprinting technology for selective cesium and iodine adsorption. Crosslinking of zwitterionic polyethyleneimine-acrylic acid (PEI-AA) yielded hierarchical porous structures, which enhanced adsorption selectivity and capacity. Optimal adsorption performance occurred at pH 6.0, and its adsorption kinetics followed the pseudo-second-order model, indicating that chemical adsorption was the dominant mechanism mechanisms. IPA-MC maintained efficient and selective adsorption in the presence of interfering ions and demonstrated excellent regeneration capacity. Synergistic amino-carboxyl interactions enhanced adsorption for Cs + and I − , with particularly high efficiency for iodine removal. This work demonstrates an effective strategy for the selective extraction of nuclides using composites through multiple interactions. These composites show significant potential for radioactive wastewater treatment applications.
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Small
·
2025
·
IF 12.1
Lixian Huang,Fei Lv,Yidong Bin,Jingjin Zhao,Caiying Li,Shulin Zhao,Shengqiang Hu,Liangliang Zhang
Hydrogen sulfide (H 2 S) is a vital gaseous signaling molecule that plays a central role in various physiological and pathological processes. Given the complementary advantages of fluorescence (FL) and photoacoustic (PA) imaging, there is a growing demand for dual-ratiometric probes that enable precise in vivo monitoring of H 2 S levels. In this study, the use of 2-mercapto-1,3,4-thiadiazole (MTD) as a novel recognition group of H 2 S is presented for the first time, following conjugation with cyanine dyes to obtain a new PA probe Cy-MTD. To achieve dual-ratiometric imaging, Cy-MTD is incorporated into down-conversion nanoparticle (DCNP), resulting in the creation of a pioneering NIR-II FL/NIR-I PA dual-ratiometric nanoprobe DCNP@Cy-MTD. Cy-MTD undergoes the blueshift in absorption from 840 to 670 nm after reaction with H 2 S, enabling NIR-I ratiometric PA imaging of H 2 S by measuring the ratio of PA signal at 670 and 840 nm (PA 670 /PA 840 ). In addition, due to the strong absorption of Cy-MTD ≈840 nm and the overlapping between the absorption spectrum of Cy-MTD and 808 nm excitation band of DCNP, the 808 nm-excited FL emission (F 1550 nm,808Ex ) of DCNP in DCNP@Cy-MTD nanoprobe is quenched through the competitive absorption, while it is restored upon the interaction with H 2 S because of the blueshift in absorption of Cy-MTD. Using the stable FL emission of DCNP under 980 nm excitation (F 1550 nm,980Ex ) as the reference signal, NIR-II ratiometric FL imaging (F 1550 nm,808Ex /F 1550 nm,980Ex ) of H 2 S is achieved. The dual-ratiometric response features of the DCNP@Cy-MTD nanoprobe offer a significant advancement over traditional single-signal or single-modality imaging techniques. By providing enhanced accuracy and reliability, this probe allows for the diagnosis of hepatitis by monitoring the H 2 S, surpassing the capabilities of conventional histopathological methods, which provides a new way for more effective diagnostic strategies for liver diseases.
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ANALYST
·
2025
·
IF 3.3
Qing Xiang,Hao Wang,Shengdong Liu,Yilong Zheng,Shipan Wang,Huanhuan Zhang,Yonggang Min,Yuguang Ma
Acute myocardial infarction (AMI) is a severe cardiovascular disease, for which early diagnosis is critical for reducing mortality and improving patient outcomes. Cardiac troponin I (cTnI) is widely recognized as the “gold standard” biomarker for AMI due to its high specificity and sensitivity. The concentration of cTnI correlates directly with different stages of AMI. Therefore, the accurate detection of cTnI concentration is of paramount importance. However, the low concentration of cTnI in biological fluids requires ultrasensitive detection methods. In this study, we developed a sandwiched surface enhanced Raman scattering (SERS)-based biosensor composed of SERS-immune substrate, target antigen, and SERS nanotags and realized sensitive and accurate detection of cTnI. The SERS-immune substrate features an ordered, multi-tipped monolayer of Au nanostars fabricated using a three-phase interfacial self-assembly method and 4-(2-hydroxyerhyl)piperazine-1-erhanesulfonic acid (HEPES) buffer modification. Compared to Au nanosphere SERS substrates, the Au nanostar SERS substrates exhibited about a 3-fold increase in Raman enhancement and demonstrated good uniformity and batch stability. This novel SERS detection platform, leveraging dual plasmonic enhancement from both the SERS-immune substrate and SERS nanotags, achieves detection of cTnI with a limit of detection (LOD) as low as 9.09 pg/mL and a relative standard deviation (RSD) as low as 11.24%. Thus, the Au nanostar SERS substrates developed in this study demonstrate significant potential for rapid and accurate detection of cTnI.
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