Cells
·
2022
·Vol. 11
·期 10
·1594
·
IF 7.666
Xu-Dong Yu,Dan Zhang,Chu-Li Xiao,Yu Zhou,Xing Li,Le Wang,Zhiming He,James Reilly,Zhi-Yong Xiao,Xinhua Shu
Depression, a mood disorder, affects one in fifteen adults, has multiple risk factors and is associated with complicated underlying pathological mechanisms. P-coumaric acid (p-CA), a phenolic acid, is widely distributed in vegetables, fruits and mushrooms. P-CA has demonstrated a protective role against oxidative stress and inflammation in various diseases, including cardiovascular disease, diabetes and cancer. In the current study, we investigated the protection of p-CA against depression and memory impairment in a corticosterone (CORT)-induced chronic depressive mouse model. CORT administration resulted in depression-like behaviors and memory impairment. P-CA treatment alleviated CORT-induced depression-related behaviors and memory impairment. Network pharmacology predicted that p-CA had multiple targets and mediated various signaling pathways, of which inflammation-associated targets and signaling pathways are predominant. Western blotting showed CORT-induced activation of the advanced glycation end product (AGE)-receptor of AGE (RAGE) (AGE-RAGE) signaling and increased expression of the proinflammatory cytokines interleukin-1 beta (IL-1β) and tumor necrosis factor-alpha (TNFα) in the hippocampus, while p-CA treatment inactivated AGE-RAGE signaling and decreased the levels of IL-1β and TNFα, suggesting that protection against depression and memory impairment by p-CA is mediated by the inhibition of inflammation, mainly via the AGE-RAGE signaling pathway. Our data suggest that p-CA treatment will benefit patients with depression.Keywords:depression;p-coumaric acid;inflammation;AGE-RAGE signaling pathway;network pharmacology
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2019
·
IF 6.361
Fei Li,Huanshun Yin,Yan Chen,Siyu Wang,Jingyan Li,Yuemei Zhang,Chunxiao Li,Shiyun Ai
DNA formylation (5-formylcytosine, 5fC) is a major epigenetic modification involved in alterations in the DNA double helix structure and protein identification. Due to the low amount in all mammalian tissues and cells, it is necessary to develop a rapid, sensitive and efficient method for detecting 5fC for further understanding the biological functions of 5fC. Thus, a novel PEC biosensor was constructed using P-g-C 3 N 4 -WS 2 nanocomposite as photoactive material. Firstly, AuNPs/P-g-C 3 N 4 -WS 2 /ITO electrode was prepared as substrate electrode. Secondly, the probe DNA and complementary DNA (containing 5fC base) was modified to the electrode surface based on the formation of Au-S bonds between AuNPs and thiol group on the probe DNA and hybridization, respectively. Finally, the amino functionalized MnO 2 nanoflowers were further modified to the electrode surface by covalent interaction between the aldehyde group on the 5fC and the amino group on MnO 2 nanoflowers. The sensitive and specific detection of 5fC can be achieved by oxidizing ascorbic acid with MnO 2 nanoflowers and quenching the photoactivity of P-g-C 3 N 4 -WS 2 nanocomposite. The sensor has a detection range of 0.01–200 nM and a detection limit of 3.8 pM. Moreover, this sensor has excellent detection specificity, stability and reproducibility.
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Nano Research
·
2020
·Vol. 14
·期 1
·222-231
·
IF 8.183
Zhu Huimin,Cao Guodong,Fu Yike,Fang Chao,Chu Qiang,Li Xiang,Wu Yulian,Han Gaorong
Multidrug resistance (MDR) restricts chemotherapy efficacy due to P-glycoprotein (P-gp) mediated drug efflux, whereas current approaches to suppressing P-gp expression suffer from intrinsic challenges, such as low transfection, high toxicity and poor specificity. Here, hollow ferric-tannic acid complex nanocapsules (HFe-TA), which can be effectively degraded by the reaction with adenosine triphosphate (ATP), are synthesized for the delivery of glucose oxidase (GOx) and doxorubicin (DOX) for tumor treatment. The findings indicate that the intracellular ATP is significantly decreased due to the combined effect of HFe-TA degradation and GOx-mediated glucose consumption. Along with this ATP down-regulation, P-gp expression of tumor cells is suppressed remarkably, which in turn promotes the intracellular accumulation and anticancer efficacy of DOX. In addition, the production of OH by Fe ions released from HFe-TA is promoted by the by-products of the oxidation of glucose process by GOx. In consequence, HFe-TA nanocapsules loaded with DOX and GOx enable significant inhibition effect to tumors both in vitro and in vivo due to the synergistic effect of cascade reactions. This study has therefore provided an alternative therapeutic platform for effective tumor inhibition with the potential in overcoming intrinsic MDR.
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CERAMICS INTERNATIONAL
·
2025
·
IF 5.6
Jiaxing Fu,Boyan Fu,Leyao Bi,Jiahui Lin,Junsheng Wen,Wenyue Tian,Chunjie Wang,Yue Wang
Given the potential risks of metabolic toxicity and organ damage associated with ethylene glycol vapor exposure, the implementation of effective monitoring is essential. In this study, LaFeO 3 -SnO 2 composites with varying mass ratios were synthesized via a hydrothermal-water bath method and subsequently evaluated for ethylene glycol sensing properties. Experimental results indicate that the LaFeO 3 :SnO 2 composite with a mass ratio of 1:2 shows the best sensing performance toward ethylene glycol among all samples. At 145 °C, it achieves a response of 89.522–100 ppm ethylene glycol, which is 435.4 % and 3137.7 % higher than the responses of pure SnO 2 and LaFeO 3 , respectively. Moreover, the operating temperature is 90 °C lower than that of pure LaFeO 3 . Meanwhile, the sensor exhibited great selectivity, repeatability and long-term stability. The improved performance could be attributed to the unique morphology of the LaFeO 3 -SnO 2 composite and the formation of a p-n heterojunction, which facilitated enhanced charge transfer and provided more active sites for ethylene glycol adsorption. Furthermore, density functional theory (DFT) calculations were performed to theoretically confirm the enhancing effect of the heterojunction on the sensing performance. This work is expected to provide new insights and serve as a valuable reference for the application of LaFeO 3 -SnO 2 gas sensors in the detection of ethylene glycol.
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ACS Applied Nano Materials
·
2025
·
IF 5.5
Xuewei Yang,Rui Li,Yong Liu,Daohai Zhang,Ning Zhao,Jian Xu
The rapid advancement of high-power integrated electronics has generated an urgent demand for high-performance thermal management materials. Hexagonal boron nitride (h-BN) has been widely explored for efficient thermal management. However, voids within the h-BN films compromise their thermal conduction and mechanical performance. Herein, we employed poly(p-phenylene benzobisoxazole) nanofiber (PBONF) as a polymer matrix to bridge unmodified h-BN microsheets. Highly compact nacre-like structures with enhanced interfacial interaction were obtained via a combination of blend exfoliation, filtration self-assembly, hot pressing, and thermal cross-linking. Remarkably, the films containing only 5 wt % PBONF achieved superior thermal conductivity (46.11 W/mK in-plane and 6.53 W/mK through-plane), alongside outstanding mechanical strength, thermal stability, and flame retardancy. These exceptional properties make the composite a promising candidate for application in extreme environments and next-generation thermal management solutions.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Xing Zhang,Peng Deng,Mengyang Zheng,Yanling Hao,Xiu Gong,Fuzhong Gong,Jing-Chang Li
Anion redox reactions in layered cathode materials have attracted significant attention due to their remarkable potential to enhance the capacity and energy density of lithium-ion batteries. However, in conventional sulfide-based cathodes such as Li x TiS 2 , anionic redox is only partially reversible at high voltages and suffers from rapid capacity fading. These challenges primarily originate from the intrinsic electronic band structure of Li x TiS 2 , where the Ti 3+ /Ti 4+ redox couple lies far above the S 3 p band, suppressing ligand-to-metal charge transfer during Li + (de)intercalation. To overcome this limitation, we introduce a bandgap-engineering strategy via partial substitution of Ti 3+ with Cr 3+ , effectively narrowing the d- p bandgap and activating sustainable sulfur redox chemistry. The Cr-substituted compound, Li 0.80 Cr 0.67 Ti 0.33 S 2 , exhibits sustainable sulfur redox activity, thereby achieving a higher capacity of 223.0 mA h g −1 and nearly doubling the energy density of pristine Li 0.80 TiS 2 . Furthermore, Li 0.80 Cr 0.67 Ti 0.33 S 2 preserves its layered framework throughout the whole (de)lithiation process, indicating effective suppression of structural collapse during sulfur redox. Therefore, it demonstrates outstanding rate performance (77.5% capacity retention at 5.0C) and excellent long-term cycling stability (80% retention after 330 cycles), significantly outperforming its undoped counterpart. These findings highlight the critical role of ligand-metal d- p orbital overlap in enabling and stabilizing sustainable sulfur redox, providing valuable insights for the design of high-performance cathodes for next-generation lithium-ion batteries.
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高影响因子
Journal of Materials Chemistry C
·
2025
·
IF 5.1
Mengmeng Zhang,Zhuoran Song,Daohu Sheng,Yantao Duan,Qi Zhao,Siyao Chen,Weijin Li,Aming Xie
Two-dimensional (2D) materials are considered excellent electromagnetic wave absorbing (EMW) materials because of their ultrathin characteristics, ultra-large specific surface area, and excellent processing properties. However, existing preparation methods (e.g., mechanical stripping, chemical vapor deposition) are difficult to balance between cost, scale and quality. In this study, polymer semiconductor p(C3O2)x with controllable 2D nanosheets micromorphology and enriched with oxygen-containing groups is introduced as a precursor. Its rich oxygencontaining groups can be used as anchor sites for metal ions. The results show that the prepared samples all exhibit a 2D nanosheets structure. Due to the structural features of 2D materials, numerous heterointerfaces are formed within the composites, greatly promoting interfacial polarization. Moreover, oxygen incorporation and crystalline defects substantially improve dipole polarization. The incorporation of metallic components further boosts the magnetic loss performance. Benefiting from the combined influence of multiple attenuation mechanisms and distinctive microstructural properties, the OC-Cu achieves a minimum reflection loss (RLmin ) of -63.7 dB and an effective absorption bandwidth (EAB) of 6.44 GHz. This work provides a new idea for the construction of high-performance EMW absorbing materials.
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JOURNAL OF HAZARDOUS MATERIALS
·
2025
·
IF 11.3
Jia Shi,Liang Zhao,Minghao Fan,Jingwen Yao,Jingwei Wang,Dan Xu,Qiao Ma
The widespread use of p -chloro- m -xylenol (PCMX) as a broad-spectrum antimicrobial agent raises concerns about its ecological risks in ecosystems. While prior studies focused on activated sludge systems, the impacts of PCMX on marine systems remain unknown. Here, we systematically investigated the responses of marine sediment communities to PCMX (0.005–50 mg/L) exposure through integrated enzymatic assays, multi-omics, and enrichment culture approaches. High PCMX exposure (50 mg/L) significantly suppressed dehydrogenase (63.8%) and protease (53.8%) activity, reduced microbial diversity, and inhibited nutrient cycling and ATP production. Meanwhile, antibiotic resistance genes associated with efflux pumps were enriched. Metagenomic analysis revealed upregulated aromatic degradation pathways and stress-response mechanisms (e.g., chemotaxis and biofilm formation) under PCMX stress. A halotolerant marine consortium enriched from high-PCMX sediments demonstrated efficient PCMX degradation (50 mg/L, 72 h) across broad salinity (1.5–5.5% NaCl) and temperature (25–40°C) ranges, with metabolite profiling suggesting ortho -cleavage pathways. This work underscores the need for regulatory measures to mitigate the ecological risks posed by PCMX in marine ecosystems, while simultaneously demonstrating the remediation potential of a halotolerant microbial consortium for remediating contaminated environments. Environmental Implications The ubiquitous discharge of PCMX poses an underregulated yet critical threat to ecosystems. Elevated concentrations of PCMX trigger cascading ecological perturbations, including the suppression of enzymatic activities, reduction in microbial diversity, selective enrichment of antibiotic resistance genes, and disruption of carbon/nitrogen cycling as well as energy production in marine sediment systems. Importantly, the developed microbial consortium demonstrates robust PCMX degradation efficacy across fluctuating conditions, facilitating scalable in situ bioremediation. Collectively, these findings highlight the urgent need for regulations on PCMX discharge, systematic ecotoxicity monitoring, and the advancement of nature-based solutions to enhance coastal ecosystem resilience.
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Small
·
2025
·
IF 12.1
Man Liu,Feihua Liu,Hongmei Qin,Chuanxi Xiong,Hengxue Xiang,Liping Zhu,Meifang Zhu
Polymer dielectric films are widely used in advanced electronics, hybrid vehicles, etc., however, they encounter critical challenges, including significant thermal degradation and heightened leakage currents, which severely constrain their energy density and efficiency under high-temperature conditions. Herein, a novel strategy is proposed for constructing a polyimide (PI) alloy by incorporating high-bandgap copolymer of perfluoropropyl perfluorovinyl ether and tetrafluoroethylene (P(TFE-PPVE)) and fluorinated polyimide (FPI) as a compatibilizer. The highly oriented structural PI/FPI/P(TFE-PPVE) alloy is fabricated via knife casting, which utilized high shear forces to align the P(TFE-PPVE) blocks within the polyamide acid. Simulation results indicate that the high-bandgap P(TFE-PPVE) phase (9.72 eV) with an oriented structure in the PI matrix can effectively suppress electrical tree growth. Furthermore, deep carrier trap at the PI/P(TFE-PPVE) interface (2.98 eV) further reduces leakage current and enhances breakdown strength while minimizing conduction loss. As a result, the PI/FPI/0.25P(TFE-PPVE) alloy demonstrates remarkable dielectric stability under diverse conditions, achieving a discharge energy density of 3.75 J cm −3 with 90% efficiency at 150 °C and 550 MV m −1 . This straightforward blending strategy provides an effective pathway to modulate the condensed structure of all organic polymers, offering promising potential for high-performance polymer dielectrics.
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Advanced Energy Materials
·
2017
·Vol. 8
·期 7
·1702267
·
IF 16.721
Shanshan Yao,Jiang Cui,Jiaqiang Huang,Jian-Qiu Huang,Woon Gie Chong,Lei Qin,Yiu-Wing Mai,Jang-Kyo Kim
This paper reports the rational assembly of novel hollow porous carbon nanospheres (HPCNSs) as the hosts of phosphorous (P) active materials for high-performance sodium-ion batteries (SIBs). The vaporization-condensation process is employed to synthesize P/C composites, which is elucidated by both theories and experiments to achieve optimized designs. The combined molecular dynamics simulations and density functional theory calculations indicate that the morphologies of polymeric P 4 and the P loading in the P/C composites depend mainly on the pore size and surface condition of carbon supports. Micropores of 1–2 nm in diameter and oxygenated functional groups attached on carbon surface are essential for achieving high P loading and excellent structural stability. In light of these findings, HPCNS/amorphous red phosphorus composites with enhanced structural/functional features are synthesized, which present an extremely low volume expansion of ≈67.3% during cycles, much smaller than the commercial red P's theoretical value of ≈300%. The composite anodes deliver an exceptional sodium storage capacity and remarkable long-life cyclic stability with capacity retention over 76% after 1000 cycles. This work signifies the importance of rational design of electrode materials based on accurate theoretical predictions and sheds light on future development of cost-effective P/C composite anodes for commercially viable SIBs.
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Materials Horizons
·
2017
·Vol. 4
·期 2
·274-280
·
IF 10.706
Ke Zhang,Mingzeng Peng,Wei Wu,Junmeng Guo,Guoyun Gao,Yudong Liu,Jinzong Kou,Rongmei Wen,Ying Lei,Aifang Yu,Yang Zhang,Junyi Zhai,Zhong Lin Wang
Flexible functional devices based on two dimensional (2D) materials are extremely suitable for malleable, portable and sustainable applications, such as health monitoring, electronic skin and optoelectronics. In this work, we developed a flexible photodetector based on a p-CuO/n-MoS2 heterojunction with an enhancement in photocurrent and detection sensitivity. Because of the non-centrosymmetric structure in monolayer MoS2, the piezo-potential induced by applied strain adjusts the band structure at the heterojunction interface and broadens the depletion region based on the piezo-phototronic effect. The border depletion can be discreetly used to improve the photo-generated carrier separation and transport to enhance photoresponse performance. When illuminated by a 532 nm laser, the photocurrent of the heterojunction can be enhanced 27 times under a tensile strain of 0.65% compared to strain free conditions and the detection sensitivity can reach up to 3.27 × 108 Jones. As a result, our research provides a new strategy for novel design and performance optimization of 2D material heterostructures in the application of optoelectronics.
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EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
·
2019
·Vol. 2019
·期 9
·1273-1278
·
IF 2.578
Wenqiang Chen,Qun Jing,Qiaoqiao Zhang,Ming-Hsien Lee,Xuefang Lu,Ping Wei,Zhaohui Chen
Introduction transition metal with d 10 electrons and lone pair cations with large radius into phosphate systems are helpful to get new crystal structure configuration. Guided by the above method, the first lead cadmium phosphate, Pb 2 Cd 3 (PO 4 ) 2 (P 2 O 7 ), was synthesized. Pb 2 Cd 3 (PO 4 ) 2 (P 2 O 7 ) features a three-dimensional (3D) structure, in which Pb(1) 2 O 8 dimer and Pb(2)O 5 polyhedra are filled between the two-dimensional (2D) layers, which are composed of unique [Cd 6 P 8 O 30 ] groups. In the Pb II M II PO (M II = without or divalent metal ions) systems, the title compound is the first phosphate containing two different P–O groups simultaneously. The ratios of cation/phosphorus (C/P) and polymerization modes of P–O anions have a close relationship by many structural comparisons. Thermal analysis shows that Pb 2 Cd 3 (PO 4 ) 2 (P 2 O 7 ) melts congruently and is thermally stable. In addition, the UV/Vis-IR diffuse reflectance spectrum and infrared (IR) spectrum have been reported. The relationship between electronic structure and optical properties was clarified by first-principles studies. Graphical The crystal structure of a new cadmium-based compound Pb 2 Cd 3 (PO 4 ) 2 (P 2 O 7 ), containing two kinds of P–O groups, exhibits unique [Cd 6 P 8 O 30 ] ∞ layers.
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