JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2025
·
IF 6.2
Tengyi Du,Ruofei Bai,Yiwei Wang,Zijian Zhao,Congwei Zhou,Yuhao Zhang,Bingyi Xie,Dongmei She,Bohang Zhou,Le Zhou
As part of our continuing investigation on hydrazide antifungal agents, a series of N’-aryl hydrazide derivatives of α,β-unsaturated fatty acids were designed and explored for their inhibitory activity on various phytopathogenic fungi and their mechanism. Most of the compounds showed excellent activity, with average EC50 values of 0.76–5.79 μg/mL on A. solani, A. brassicae, A. alternate, C. gloeosporioides, and P. oryzae. Among N’-substituted phenyl hydrazide derivatives of senecioic acid, 4-fluoro (5a), 4-bromo (5g), 3-cholor-4-fluoro (5s) and 3,4-dicholor (5w) derivatives displayed average EC values of 0.76–0.87 μg/mL on the five fungi, far superior to 2.99 μg/mL of kresoxim-methyl, a commercial fungicide. Especially, 5s was able to completely inhibit the growth in vitro of all the fungi at 20 μg/mL and gave almost the same control effect as the positive fungicide boscalid against the infection of tomato fruits by A. solani at 200 μg/mL. Meanwhile, 5s did not display a visible effect on plant seed germination at 200 μg/mL and seedling growth at 100 μg/mL, nor significant cytotoxicity on normal L929 mouse fibroblasts at 1.0 mg/mL. Scanning electron microscopy, transmission electron microscopy, and fluorescence microscopy studies revealed that 5s could destroy the mycelial morphology and the structure of the cell membranes, increase the ROS level in cells, alter the MMP, and cause cell death. Additionally, 5s could also strongly inhibit the activity of SDH in A. solani, with an IC50 value of 3.54 μg/mL, superior to 4.46 μg/mL of the positive SDHI boscalid. Molecular docking showed that the 4-fluoro group of the benzene ring plays an important role in the binding of 5s to SDH. The SAR indicated that the presence of a 4-halogen atom on the benzene ring is able to dramatically improve the antifungal activity. The N’-aryl hydrazides of α,β-unsaturated fatty acids emerged as novel and promising antifungal lead compounds.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
IONICS
·
2025
·
IF 2.6
Wang Zhaomin,Zhao Chaoyue,Niu Xiaodong,Cheng Yong,Wang Limin,Huang Pai
With high theoretical discharge specific capacity, excellent reversibility of electrochemical reaction, and suitable oxygen evolution overpotential, α -Ni(OH) 2 is an auspicious cathode material for alkaline batteries, which supports the development of high-capacity nickel-based batteries. Nevertheless, α -Ni(OH) 2 exhibits substandard structural stability and is susceptible to crystalline transformation, leading to capacity degradation, affecting the battery charge/discharge performance and cycle life. In this study, the TiO 2 -nickel hydroxide (TiO 2 - α -Ni(OH) 2 ) is prepared by high-energy ball milling. Among them, TiO 2 can be uniformly dispersed on the surface of α -Ni(OH) 2 , which can effectively prevent the collapse of the α -phase structure. Benefiting from the unique elemental doping technology, the TiO 2 - α -Ni(OH) 2 composites as a nickel-metal hydride (Ni-MH) battery cathode can release a reversible specific capacity of 390 mAh g −1 at a 2 C rate for 200 cycles. A reversible specific capacity of 210 mAh g −1 is still released after 200 cycles at a 5 C rate. Consequently, TiO 2 - α -Ni(OH) 2 is a promising candidate for high-power Ni-MH batteries.
✓ 已验证
产品关联
DOI
高影响因子
Reaction Kinetics Mechanisms and Catalysis
·
2025
·
IF 1.7
Cheng Lijun,Lei Juan,Ren Xiaoli,Chang Hong,Ju Baihe
In this study, a series of La-α-MnO 2 catalysts with different La doping amounts were prepared by hydrothermal method. It was found that the introduction of La could reduce the crystallinity of α-MnO 2 and increase the specific surface area of the catalyst. Furthermore, La doping can significantly weaken the Mn–O bond, increase the surface Mn 3+ and O ads content, and enhance the oxygen mobility and low-temperature reducibility. The catalytic results indicated that La doping could significantly improve the catalytic oxidation performance of toluene, and 1%La-α-MnO 2 catalyst exhibited the best catalytic activity for toluene oxidation. The toluene conversion rate reaches 90% when the reaction temperature is only 215 °C. In addition, 1%La-α-MnO 2 catalyst presented good stability and repeatability during 50 h durability test under water vapor.
✓ 已验证
产品关联
DOI
高影响因子
ATMOSPHERIC RESEARCH
·
2023
·
IF 5.5
Jiajia Zhou,Chun Xiong,Xiangyu Pei,Binyu Kuang,Zhengning Xu,Fei Zhang,Yao Song,Mei Li,Zhibin Wang
The aqueous–phase reaction of carbonyls with reduced nitrogen compounds (RNCs) is considered an important pathway for the formation of secondary BrC , and these particles could greatly impact the global climate. However, our knowledge of their properties is still limited. In this study, we measured the optical properties , cloud condensation nuclei (CCN) activity (represented as hygroscopicity parameter κ CCN ), and effective density ( ρ eff ) under varied reaction conditions for BrC mixtures formed by reactions between two α–dicarbonyls (glyoxal GX and methylglyoxal MG) and three RNCs (ammonium sulfate AS, glycine GC, and dimethylamine DA). Our results showed a wide range of particle ρ eff from 1.08 to 1.66 g cm −3 , depending on the type of RNCs reactant. At 532 nm wavelength, the real part n of complex refractive index ranged from 1.41 to 1.60 and the imaginary part k of BrC ranged from 0.024 to 0.043, and the absorption cross section for MG mixtures were 20.3–51.0% higher than those of GX mixtures. These values did not appear to vary significantly with mixing molar ratios between RNCs and α–dicarbonyls (10:1, 1:1, and 1:3) for mixtures with the same reactants, but the mass absorption cross section for mixtures after a reaction time of 14 days were 1.57–74.2% higher than those of mixtures after reaction times of 0.5 and 7 days. The κ CCN values of different BrC were consistent with the order of κ CCN for single RNCs, i.e., AS–containing (0.349–0.428) > GC–containing (0.221–0.352) > DA–containing (0.090–0.131), and showed an overall increasing trend (1.47–59.3%) with the RNCs content. Our results highlight the importance of reaction conditions on secondary BrC properties and are helpful for a more accurate assessment of aerosol radiative forcing .
✓ 已验证
DOI
高影响因子
Journal of Physical Chemistry C
·
2024
·
IF 3.3
Wei-Wang Zeng,Ting Luo,Chuanyao Zhou,Zefeng Ren
Sum-frequency generation vibrational spectroscopy (SFG-VS), a second-order nonlinear spectroscopic technique, has extensive applications in interface science. Accurate normalization of the incident laser beam intensity is essential, particularly for buried interfaces, where incident lasers are absorbed before reaching the interface. We introduce a novel normalization method that exploits both the transmitted and reflected SFG signals from α-quartz, leveraging its benefits in signal amplification and phase referencing. This method shows versatility for both chiral and achiral molecules at interfaces and is extendable to electronic or doubly resonant SFG spectroscopy. We have demonstrated this normalization method by examining the SFG vibrational spectra of sodium dodecyl sulfate molecules on quartz and deducting the IR absorption from CO2 in the gas phase.
✓ 已验证
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2015
·Vol. 133
·期 15
·
IF 1.768
Mi Zhou,Kaiyue Liu,Xin Qian
A series of pH-temperature dual stimuli-responsive random copolymers poly[ N,N -dimethylaminoethyl methacrylate- co -poly(poly(ethylene glycol) methyl ether methacrylate][poly(DMAEMA- co -MPEGMA)] were synthesized by free radical polymerization. The supramolecular hydrogel was formed by pseudopolyrotaxane, which was prepared with the host-guest interactions between α-cyclodextrin (α-CD) and poly(ethylene glycol) (PEG) side chains. Fourier transform infrared (FT-IR), nuclear magnetic resonance ( 1 H NMR), and X-ray diffraction (XRD) confirmed the structures of the hydrogels. The pH-temperature dual stimuli responsive properties of the hydrogels were characterized by rheometer. Finally, the controllable drug release behavior of the hydrogel, which was used 5-fluorouracil (5-Fu) as the model drug, was investigated at different temperatures and different pH values. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133 , 43279.
研究领域:
高分子材料科学
·
药物递送系统
·
生物医学工程
·
智能响应材料
·
药剂学
✓ 已验证
DOI
高影响因子
Innovative Food Science & Emerging Technologies
·
2026
·
IF 6.9
Danli Wang,Le Jia,Shuaibing Shao,Fuping Zheng,Qinqin Chen,Jinyan Gong
Cold plasma (CP) promoted the complexation between chlorogenic acid (CA) and β-lactoglobulin (β-LG) as well as α-lactalbumin (α-LA). In the presence of chemical dissociants (SDS and urea), CP increased the bound CA content onto β-LG and α-LA by more than 4-fold, demonstrating tighter CA association. Molecular docking revealed hydrogen bonds as the dominant force for α-LA-CA binding, while hydrophobic interactions govern β-LG-CA combination. Reactive species produced during CP treatment were quantified. CP-induced complexes exhibited only a slight band shift in electrophoresis, and LC-MS analysis confirmed no covalent adducts existed within the complexes. Circular dichroism, FTIR, UV–vis, and fluorescence spectra, and surface hydrophobicity determination, demonstrated that CP effectively modified the secondary structure and surface microenvironment of proteins, leading to an increase in the binding of CA. Quantitative analyses of carbonyl groups, free sulfhydryl, and free amino groups confirmed mild protein oxidation induced by CP, exposing more binding sites for CA. Furthermore, owing to CP-induced protein modification and enhanced CA interaction, CP-induced complexes showed the larger particle size and zeta-potential, and superior antioxidant capacity. This study clarifies the non-covalent interaction mechanism of CP-induced β-LG/α-LA–CA complexes and provides a theoretical basis for the green preparation of high-performance functional biocomposites.
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Min Ma,Taiyu Liu,Chun Wang,Yunqi Liu,Wanyao Tan,Yingying Zheng,Wenhui Fan,Yue Su,Hong Li,Mingxue Li,Yuemi Zhou,Yongqi Zhang
The mesoporous polydopamine-loaded α-N-thiosemicarbazone was prepared. • A multifunctional photothermal dual-network hydrogel was fabricated. • Hydrogel exhibits injectability, self-healing, and tissue adhesion properties. • It possessed both photothermal antibacterial activity and wound-healing ability. • Hydrogel exhibits antioxidant and excellent biocompatibility. Refractory wounds caused by bacterial infections pose a severe clinical challenge, highlighting the urgent need for wound dressings with both excellent antibacterial activity and advanced tissue regeneration capabilities. Herein, a multifunctional photothermal antibacterial hydrogel (GHUS-mPDA@HL) was fabricated using mesoporous polydopamine-loaded α-N-thiosemicarbazone (mPDA@HL) nanoparticles, ureido-pyrimidinone grafted gelatin (GHU) and sodium alginate as primary components. The hydrogel network was constructed via quadruple hydrogen bonding and an interpenetrating polymer network, rendering it injectable, self-healing, and tissue-adhesive properties. The mPDA@HL nanoparticles combine the antibacterial and antioxidant properties of α-N-heterocyclic thiosemicarbazone compound (HL) with intrinsic photothermal and antibacterial capacity of mesoporous polydopamine (mPDA). Furthermore, under 808 nm near-infrared irradiation, GHUS-mPDA@HL hydrogel exhibits excellent photothermal performance, enabling efficient bacterial eradication, inflammatory mitigation, and accelerated wound healing. The GHUS-mPDA@HL hydrogel achieves synergistic antibacterial effects against both Gram-negative Escherichia coli (99.98%) and Gram-positive Staphylococcus aureus (99.99%) under near-infrared irradiation. Additionally, the hydrogel showed excellent biocompatibility and effective reactive oxygen species scavenging ability. In a full-thickness skin wound mouse model, GHUS-mPDA@HL hydrogel under NIR irradiation remarkably accelerates wound repair, with a healing rate of 98.49% within 10 days. It also promotes collagen deposition and angiogenesis to further facilitate wound closure. Overall, this GHUS-mPDA@HL hydrogel presents an excellent antibacterial activity and potent wound-healing promotion effects, providing a promising strategy for the development of intelligent wound dressings.
✓ 已验证
DOI
PubMed
高影响因子
RENEWABLE ENERGY
·
2026
·
IF 9.1
Jiajin Jiang,Kang Chen,Wenrui Yao,Tianhao Liu,Lideng Yang,Shengyuan Qiu,Qingli Sun,Ce Sun,Haiyan Tan,Yanhua Zhang
In this study, we integrated photocatalysis with biomass thermal liquefaction technology to address the problems of limited yield and unstable quality of biocrude in conventional processes. Specifically, this photo-thermal synergistic system enables the efficient conversion of α-cellulose by fabricating a suspension through the homogeneous dispersion of cellulose and bismuth oxychloride photocatalyst in methanol solvent, followed by conducting the thermal liquefaction reaction under continuous light irradiation. Experiments were performed by selecting different process variables, including the reaction temperature (240-280°C), holding time (10-50min), and the α-cellulose/methanol ratio (CMR, 5-15wt%). Single-factor experimental results demonstrated that photocatalysis, functioning as an external energy input, was observed to facilitate reaction progression under relatively mild conditions. Furthermore, according to biocrude yield prediction model constructed based on the Box-Behnken design (BBD) response surface methodology, a maximum biocrude yield of 54.44wt% was achieved at the optimized conditions of 270°C, 15 min, and CMR of 5wt%. Compared with the yield of 27.52wt% obtained under dark condition without catalyst, this yield increased by 97.8%. In addition, conventional hydrothermal liquefaction (HTL) typically requires temperatures of 300-350°C to achieve optimal biocrude yield and quality, while photo-thermal synergistic system enables high-yield biocrude production at significantly reduced temperatures of 260-280°C. Product analysis revealed that the biocrude sample obtained under the photothermal synergistic system exhibited a relatively higher proportion of light fractions (e.g., C7 glycosidic compounds). This compositional shift contributes to improved fuel properties of the biocrude, rendering it better suited for energy-oriented applications.
✓ 已验证
产品关联
DOI
高影响因子
LANGMUIR
·
2026
·
IF 4.4
Chunyang Wang,Sen Wang,Liyun Lv,Jing Zou
This study systematically investigated the reaction between layered α-titanium phosphate (α-TiP) and oxalates, particularly n-butylammonium oxalate, and provided an in-depth analysis of the abnormal phenomenon observed in the reaction. Contrary to the expectation of a straightforward cation-exchange-driven intercalation process, the results revealed that the oxalate anion also actively participated in the reaction, causing partial decomposition of α-TiP from the crystal edges and facilitating its exfoliation into ultrathin sheets. Further investigations demonstrated that this process could be fully reversed via a restacking reaction initiated by the introduction of phosphoric acid into the product liquid, ultimately resulting in the regeneration of the α-TiP crystal. These findings suggest that despite extensive research on α-metal phosphate materials over the years, critical aspects of their underlying chemistry remain insufficiently understood and warrant further exploration.
✓ 已验证
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
·
2019
·Vol. 54
·期 10
·2854-2862
·
IF 2.281
Liu Aolu,Huang Baohua,Lei Lin,Lu Yu-Jing,Zhou Jin-Lin,Wong Wing-Leung
The rhamnosyl group of naringin dihydrochalcone, neohesperidin dihydrochalcone, naringin and hesperidin was selectively removed by enzymatic hydrolysis using an immobilised α-L-rhamnosidase. Monoglycosylated products, including trilobatin, hesperetin dihydrochalcone-7-O-glucoside, prunin and hesperetin-7-O-glucoside, were isolated and characterised by 1H and 13C NMR and ESI-MS. To optimise the enzymatic reaction conditions and its process costs, the hydrolysis of neohesperidin dihydrochalcone to produce trilobatin was selected as a model reaction. Using a ratio of neohesperidin dihydrochalcone: immobilised α-L-rhamnosidase equal to 1:0.6, the trilobatin yields was over 98%. The recycle of enzyme was also investigated, obtaining trilobatin with a yields of 80% even when the twentieth reaction cycle was conducted. Moreover, antiradical and antimicrobial activities of the obtained flavonoid monoglucosides were examined by DPPH, FRAP and ORAC methods, and compared with the efficacy of parental flavonoid glycosides and their aglycone. The results highlight that some of the obtained flavonoid monoglucosides show significant improvement in the antioxidant activity.
✓ 已验证
DOI
高影响因子
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
·
2026
·
IF 2.5
Ziyi Liu,Yunfang Ping,Huicong Yuan,Jingran Zhang,Ren-You Gan,Kefeng Li,Xu Wang,Ann Van Schepdael
The study presents an approach to identify potential α -glucosidase inhibitors from Chrysanthemum morifolium Ramat (CM) through the immobilization of α -glucosidase on a steel wire coated with bifunctional microporous organic networks. The immobilized α -glucosidase demonstrated improved stability to both temperature and pH. Its reusability was substantially enhanced, as it preserved 72% of the initial enzyme activity following 7 recycling rounds. Subsequently, eight ligands were discovered through UHPLC-Q-TOF-MS/MS analysis. Meanwhile, the molecular docking indicated that they were strong ligands of the α -glucosidase. Enzyme inhibition experiments showed that cynaroside exhibited the most significant inhibitory effecton α -glucosidase, possessing an IC 50 of 40.08 μM, indicating the reliability of the ligand screening method. The fluorescence spectrum analysis revealed alterations to the secondary structure and microenvironment of α-glucosidase. To elucidate the therapeutic mechanism of CM against diabetes, a network pharmacology approach was employed. In summary, the combination of immobilized enzymes with UHPLC-Q-TOF-MS/MS and network pharmacology offered a new idea for studying traditional Chinese herbs in the treating of complex diseases like diabetes.
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）