NEW JOURNAL OF CHEMISTRY
·
2022
·Vol. 46
·期 36
·17331-17337
·
IF 3.925
Chen Chen,Jin-Xin Ma,Hui Wang,Hui-Qiao Liu,Shu-Wei Ren,Jun-Tao Cao,Yan-Ming Liu
It is promising to devise a signal-amplified ratiometric electrochemiluminescence (ECL) sensing platform owing to the eliminated external interference and increased analysis reliability in complex samples. Herein, a spatially resolved ratiometric ECL immunosensor for myoglobin (Myo) detection was developed via resonance energy transfer (RET) for signal amplification. In the ECL system, Ru(bpy)32+-conjugated silica nanoparticles (Ru(bpy)32+@RuSi NPs) and sulfur quantum dots (SQDs) used as the potential-resolved ECL emitters were modified on two spatially resolved electrodes, respectively. Au@Ag2S NPs with a wide light absorption range could serve as perfect acceptors of Ru(bpy)32+@RuSi NPs, between which an effective RET could occur. For Myo detection, the signal from the Ru(bpy)32+@RuSi NP-modified electrode for Myo with various concentrations acted as the working signal (ECLanode) and that from the SQD electrode for Myo with fixed concentration served as a reference signal (ECLcathode). Owing to the steric hindrance and effective RET between Ru(bpy)32+@RuSi NPs and Au@Ag2S NPs, the working signal presented a great decrease in the presence of Myo. The ratio of ECLanode to ECLcathode showed a linear relationship with the logarithm of the Myo concentration in the range from 1.0 × 10−13 to 1.0 × 10−7 g mL−1. The limit of detection of the fabricated biosensor was 5.0 × 10−14 g mL−1. Moreover, it continued to show favorable detection results in human serum samples with recoveries ranging from 83.0 to 110%. The RET and ratiometric strategy on the spatially resolved platform endow the method with the merits of high selectivity, sensitivity, and accuracy and it can be envisioned that the method would provide a general tool for biomarker analysis.
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Journal of Biomedical Nanotechnology
·
2022
·Vol. 18
·期 9
·2264-2277
·
IF 3.641
Du Lidong,Zhang Ruoyu,Zhao Lei,Tang Shaojian,Hou Zhaohua,Xue Peng
Aim: To assess the anticancer activity of nanoparticles synthesized via a green method using American ginseng (AG). Methods: Stem-leaf saponins from AG (SAG) and heat-transformed stem-leaf saponins from AG (TSAG) were used to synthesize different SAG nanoparticles (SAG-NPs)
and TSAG nanoparticles (TSAG-NPs). The NPs were characterized, and their anticancer activity was assessed in vitro. Results: The NPs, which differed in size (16.69 nm∼253.8 nm), were spherical or polyhedral with a low PDI and good stability. The TSAG-NPs inhibited cancer
cells by inhibiting proliferation, promoting cancer cell apoptosis and directly leading cancer cells to necrosis. The small cell lung cancer cell line (SCLC) NCI-H446 was the most sensitive to the TSAG-AgNPs, with an IC50 value of 20.71±2.38 μg/mL, and the TSAG-AgNPs
inhibited invasiveness and reduced the risk of metastasis. Conclusion: TSAG-AgNPs, selected from many SAG-NPs and TSAG-NPs, are sensitive to SCLC and provide a new approach to the currently limited treatment.
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BIOELECTROCHEMISTRY
·
2021
·
IF 5.373
Jintao Liang,Xiaohang Shi,Huafu Feng,Min Chen,Wenzhan Li,Junxiang Lai,Weipeng Hu,Guiyin Li
In this paper, a novel silicon-based light-addressable potentiometric sensor (LAPS) has been designed for the detection of 1,5-anhydroglucitol (1,5-AG) in human serum. Reduced graphene oxide-chitosan-ferrocene (RGO-CS-Fc)/AuNPs nanohybrids and pyranose oxidase (PROD) enzyme is used to fabricate biological sensitive membrane unit by layer-by-layer assembly technology. When a bias voltage is provided to the LAPS system, the catalytic oxidation reaction between 1,5-AG and PROD to produce H 2 O 2 . The by-product H 2 O 2 can oxidize Fc(Fe 2+ ) ions in RGO-CS-Fc nanohybrids into Fc(Fe 3+ ) ions, which cause the potential of the sensitive membrane surface to change and the potential shift of I-V curve will generate a corresponding offset response. Under the optimal conditions, the potential shift of the LAPS is linearly related to the concentration of 1,5-AG at 10 µg·mL −1 –350 µg·mL −1 with the correlation coefficient of 0.97414. The sensitivity is 0.44273 mV/µg·mL −1 and the lowest detection limit is 10 µg·mL −1 . In addition, the biosensor showed good specificity, acceptable stability and satisfactory recovery rates (91.28%-107.66%), which would be a potential testing methods in actual clinical samples.
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高影响因子
Nanoscale
·
2016
·Vol. 8
·期 45
·19161-19173
·
IF 7.76
Qingchi Xu,Jiaxin Zeng,Haiqing Wang,Xingyun Li,Jun Xu,Jianyang Wu,Guangcan Xiao,Fang-Xing Xiao,Xiangyang Liu
A facile and efficient ligand-triggered electrostatic self-assembly strategy has been developed to fabricate a series of Au/CdS nanosheet (Ns) (Au–CdS Ns) nanocomposites with varied weight addition ratios of Au nanoparticles (NPs) by judiciously utilizing the intrinsic surface charge properties of assembly units, through which uniform dispersion and controllable deposition of Au NPs on the CdS Ns were achieved. Versatile probe reactions including photocatalytic oxidation of an organic dye pollutant, selective photocatalytic reduction of aromatic nitro compounds and photocatalytic hydrogen production reactions under visible light irradiation and ambient conditions were used to systematically evaluate the photoredox performances of the as-assembled well-defined Au–CdS Ns nanocomposites. It was unveiled that the photoactivities of Au–CdS Ns nanocomposites strongly depend on the weight addition ratio of Au NPs and the addition of an excess amount of Au NPs is detrimental to the separation of photogenerated charge carriers from CdS Ns. With the optimum addition amount of Au NPs (1 wt%), it was found that spontaneous assembly of Au NPs on the CdS Ns remarkably prolonged the lifetime of the photogenerated charge carriers from CdS Ns under visible light irradiation, thus resulting in significantly enhanced photocatalytic redox activities of Au–CdS Ns nanocomposites compared with those of CdS Ns. The crucial role of Au NPs in the photoredox reactions as efficient electron traps rather than plasmonic sensitizers was determined. Moreover, predominant active species responsible for the photocatalytic process were unambiguously determined and a possible photocatalytic mechanism was elucidated. It is anticipated that our work could open up a new avenue to rationally prepare various 2D semiconductors–metal nanocomposites by utilizing such a simple and efficient self-assembly strategy for extensive photocatalytic applications in a myriad of fields.
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高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2022
·
IF 7.139
Suqing Peng,Weilin Zhong,Hailun Zhao,Chao Wang,Zhipeng Tian,Riyang Shu,Ying Chen
Photocatalytic hydrogen production and thermal storage are effective ways to convert solar energy into storable chemical energy and thermal energy , but they only respond to specific spectrum. In order to improve the energy conversion and storage efficiency of solar energy in the solar spectrum, hydrothermal and photo-deposition method were employed to synthesized photothermal catalyst while and Au/TiO 2 @PCM composite microcapsules were fabricated by electrostatic adsorption self-assembly methods. Micro-morphologies and structures were detailed characterized by SEM , XRD , UV-Vis, etc. As calculated from the DSC results for effective, enthalpy value , the loading rates of Au/TiO 2 shell for the microcapsule were 12.6% and 15.4% corresponding to rod-shaped and sheet-shaped samples. To test their catalytic performance, the samples were dispersed in the same concentration of glycerol solution, and showed that the light to hydrogen efficiencies were 11.4‰ and 5.0‰ for ATR@PCM and ATF@PCM, respectively with the increasement of 53.8% and 56.1% comparing to their corresponding catalyst nanoparticle suspensions. Photo-thermal conversion efficiencies of ATR@PCM and ATF@PCM were 62.74% and 53.32% after 60 min-irradiations, and they were 48.22% and 25.96% higher than that of Me-PCM. Therefore, it was confirmed that the composite phase change microcapsules prepared in this study have the dual functions of energy storage and photothermal catalysis. Higher solar light to hydrogen energy conversion efficiency may be attained in future study if the stored thermal energy can be successfully employed to activate organic components for helping catalytic hydrogen generation .
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RSC Advances
·
2019
·Vol. 9
·期 18
·10272-10281
·
IF 3.049
Yide Xia,Ying Liu,Nannan Shi,Xungao Zhang
In this article, the catalyst Au/γ-Fe2O3@hydroxyapatite (Au/γ-Fe2O3@HAP) consisting of Au nanoparticles supported on the core–shell structure γ-Fe2O3@HAP was prepared through a deposition–precipitation method. The catalyst was characterized by transmission electron microscopy, X-ray powder diffraction, X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, N2 adsorption–desorption and atomic absorption spectrometry. The as-prepared Au/γ-Fe2O3@HAP exhibited excellent performance for the reduction of 4-nitrophenolate (4-NP) to 4-aminophenolate (4-AP) in the presence of NaBH4 at room temperature. Thermodynamic and kinetic data on the reduction of 4-NP to 4-AP catalyzed by the as-prepared catalyst were studied. The as-prepared catalyst could be easily separated by a magnet and recycled 6 times with over 92% conversion of 4-NP to 4-AP. In addition, the as-prepared catalyst showed excellent catalytic performance on other nitrophenolates. The TOF value of this work on the reduction of 4-NP to 4-AP was 241.3 h−1. Au/γ-Fe2O3@HAP might have a promising potential application on the production of 4-AP and its derivatives.
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高影响因子
ANALYST
·
2021
·Vol. 147
·期 2
·303-311
·
IF 4.616
Chao Chen,Chenxi Wang,Pengcheng Zhao,Jin Zhang,Dechong Ma,Junjie Fei
First, the nanocomposite Au@rGO-MWCNT was synthesized by a hydrothermal method. Next, a temperature-controlled composite sensing film was prepared by composite modification of poly(2-(2-methoxyethoxy)ethyl methacrylate) (PMEO2MA) and Au@rGO-MWCNT on a glassy carbon electrode (GCE). This sensor was shown to exhibit good temperature sensitivity and reversibility to dopamine. When the testing temperature is lower than the lower critical solution temperature (LCST) of the polymer, the PMEO2MA chain is in a stretched state, which increases the distance between the Au@rGO layers and leads to the inability of MWCNTs in one layer to contact another Au@rGO layer and to low conductivity. Therefore, in this state, dopamine cannot detect an electrochemical signal, and it is termed an “off” state. When the temperature is higher than the LCST of the polymer, the PMEO2MA chain shrinks, allowing the MWCNTs to make contact with another layer of Au@rGO; the electron transfer rate of the modified film increases, and the electrochemical behavior of dopamine turns to an “on” state. Moreover, the sensor has a wide detection range (0.1 to 9.0 μM and 9.0 to 239.0 μM), and the limit of detection of dopamine is as low as 30 nM. This method has been successfully applied to the determination of dopamine in human serum samples. The on–off sensor provides a new avenue for the application of temperature-sensitive polymers.
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高影响因子
Crystals
·
2022
·Vol. 12
·期 7
·884
·
IF 2.67
Yuanzhao Wu,Mingjie Chen,Haohao Bai,Binjie Wang,Jiye Wang,Yazhou Qin,Weixuan Yao
Hollow urchin-like Au nanocrystals have been widely studied due to their excellent surface plasmon resonance properties and large specific surface area, but the controllable preparation of hollow urchin-like Au nanocrystals is still a challenge. In this article, we successfully prepared hollow urchin-like Au nanocrystals using HAuCl4·3H2O and AgNO3as precursors and ascorbic acid as the reducing agent. No surface ligands or polymer stabilizers are required in the preparation process. HAuCl4·3H2O and AgNO3will first form AgCl cubes, then the reducing agent, ascorbic acid, will reduce the Au3+in the solution to Au0, and Au0will be deposited on the pre-formed AgCl cubes to form AgCl@Au nanocrystals. We characterized the morphology of the prepared Au nanocrystals by scanning electron microscopy and found that by increasing the amount of HAuCl4·3H2O in the reaction, the surface morphology of the Au nanocrystals would change from a rough spherical shape to an urchin-like shape. By further increasing the amount of the precursor HAuCl4·3H2O, urchin-like Au will convert into flake-like morphology. The AgCl in the interior was removed with ammonia water, and finally, hollow urchin-like Au crystals were formed. In addition, we used R6G molecule to explore the surface-enhanced Raman spectroscopy (SERS) enhancement effect of prepared Au crystals. The results show that the minimum detectable concentration of R6G reaches 10−8M. Moreover, we applied hollow urchin-like Au nanocrystals as catalysts and SERS enhancing materials to detect the photocatalytic reaction of 4-NTP. We used a 785 nm laser as both the SERS light source and the catalytic light source to monitor the photocatalytic effect of the laser on 4-NTP in situ by adjusting the laser power.Keywords:Au nanocrystals;sea urchin-like structure;SERS;photocatalytic reaction
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Nanoscience and Nanotechnology Letters
·
2018
·Vol. 10
·期 4
·520-527
·
IF 2.917
Deng Yan,Du Xueting,Ma Yuchan,Zhang Kunlei,Zhang Xi,Li De-Lei,Bai Ruyan,Hu Rong,Yang Yun-Hui
In this paper, an ultrasensitive electrochemical immunoassay based on porous covalent organic framework materials and Au NPs-CoS/graphene oxide (GO) nanocomposite was developed for the detection of C-reactive protein (CRP). Au NPs-CoS/graphene oxide (GO) nanocomposite was synthesized,
and employed as substrate because of their high conductivity to immobilize CRP antibody. A new porous covalent organic framework material (COF-LZU8) was functionalized by gold nanoparticles and doped with thionine (Thi) as the electron transfer mediator to obtain nanocomposite. The reduction
peak signal of Thi/Au NPs-COF-LZU8 at –0.2 V could be directly detected by highly sensitive differential pulse voltammetry (DPV). Due to the high surface area of COF-LZU8, a great quantity of Thi could be adsorbed on the surface of COF, thus, the signal could be greatly amplified. Moreover,
Thi/Au NPs-COF-LZU8 has strong adsorption capacity to the anti-CRP protein macromolecules due to the large specific surface area and good bio-affinity. The concentration of CRP antigen was proportional to the response current, so the quantitative detection of CRP was realized. Under the optimum
conditions, the linear range of CRP was 0.05–150 ng/mL with the detection limit of 0.016 ng/mL (S/N = 3). This immunosensor provides a more effective and sensitive method for detection of CRP.
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高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2023
·
IF 9.9
Muhammad Asim,Bushra Maryam,Shuguang Zhang,Muhammad Sajid,Alibek Kurbanov,Lun Pan,Ji-Jun Zou
The hydrogen evolution from ammonia borane is intriguing but challenging due to its sluggish kinetics. In this regard, the gold nanoparticles amalgamation with metal phosphides is speculated to be more efficient catalysts. Here, the catalysts Au/Ni 2 P and Au/CoP with the high synergetic effect of Au nanoparticles and metal phosphides were synthesized for ammonia borane hydrolysis. The activity of Au/Ni 2 P increases 4.8-fold (i.e., 0.08 to 0.40 L∙h −1 ) compared to pristine Ni 2 P, and the activity of Au/CoP increases 1.7-fold (i.e., 0.74 to 1.27 L∙h −1 ) compared to pristine CoP. This reveals that the synergetic effect of Au δ+ and (Ni 2 P) δ- is stronger than Au δ+ and (CoP) δ- which is manifested by XPS analysis. The kinetics exposes that the activation energy of Au/Ni 2 P (45.28 kJ∙mole -1 ) is greater than Au/CoP (31.45 kJ∙mole -1 ) and the TOF of Au/Ni 2 P is less than Au/CoP. This research work presents an effective approach for producing active sites of Au δ+ and (Ni 2 P & CoP) δ- for ammonia borane hydrolysis to enhance the H 2 evolution rate.
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高影响因子
Journal of Nanoelectronics and Optoelectronics
·
2021
·Vol. 16
·期 7
·1029-1036
·
IF 0.961
Wang Hongzhu,Chen Mengxun,Song Liping,Huang Youju
A key challenge for nanoparticles-based drug delivery system is to achieve manageable drug release in tumour cell. In this study, a versatile system combining photothermal therapy and controllable drug release for tumour cells using temperature-sensitive block copolymer coupled Au NRs@SiO2
is reported. While the Au NRs serve as hyperthermal agent and the mesoporous silica was used to improve the drug loading and decrease biotoxicity. The block copolymer acted as “gatekeeper” to regulate the release of model drug (Doxorubicin hydrochloride, DOX). Through in vivo
and in vitro experiments, we achieved the truly controllable drug release and photothermal therapy with the collaborative effect of the three constituents of the nanocomposites. The reported nanocomposites pave the way to high-performance controllable drug release and photothermal therapy
system.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2022
·
IF 7.139
Weilin Zhong,Chao Wang,Bo Jiang,Suqing Peng,Hailun Zhao,Riyang Shu,Zhipeng Tian,Yanping Du,Ying Chen
Combining solar energy utilization and hydrogen production is an ideal model for renewable energy development. Especially the conversion of broad-spectrum solar energy into chemical energy of hydrogen and thermal energy can enrich solar energy storage methods. Herein, novel multifunctional Au/TiO 2 @n-octadecane microcapsules with core-shell structure were design and synthesized by wet chemical reduction and electrostatic adsorption self-assembly methods for photothermal hydrogen production and thermal storage . The results showed that microencapsulation of photothermal catalysts could provide an effective reaction area and excellent dispersion stability , where hydrogen production and light to hydrogen efficiency were increased in the 43% and 0.3% respectively, compared to the nanoparticle suspension system. Based on the recorded temperature variations caused by the photothermal effect, the calculated photothermal conversion efficiency and specific absorption rate of Au/TiO 2 @n-octadecane was 25.01% and 277% higher than that of Au/TiO 2 suspension. The proposed hydrogen production and thermal storage method via multifunctional microcapsules might shed some light on the study of improving full-spectrum energy conversion efficiency of solar energy.
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