INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
·
IF 8.025
Zhan Shu,Cencen Zhang,Lizhao Yan,Haoqi Lei,Caixing Peng,Shuang Liu,Lihong Fan,Yingying Chu
Repair of periodontal and maxillofacial bone defects is a major challenge in clinical. Guided bone regeneration (GBR) is considered one of the most effective methods. However, the efficacy of currently available GBR membranes for repair is frequently limited by their poor osteogenic potential and lack of antibacterial activity. The first step in this investigation was to construct a zinc-based zeolite-imidazolate framework loaded with copper ions ( [email protected] ). Following that, a novel polycaprolactone/polylactic acid/nano-hydroxyapatite/ [email protected] (PCL/PLA/n-HA/ [email protected] ) GBR membrane was developed using a simple porogen with nonsolvent-induced phase separation (NIPS) approach. The produced membrane with asymmetric porous structure (one smooth side and one rough side) possesses hydrophilicity corresponding to the roughness of its two sides. The superior mechanical property, stability of degradation, and ion release capability of the membrane all contribute to the clinical feasibility. Additionally, in vitro biological experiments demonstrated that the PCL/PLA/n-HA/ [email protected] membrane had favorable osteogenic and antibacterial properties, which suggests the high potential for application in the GBR procedure.
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
·
2020
·
IF 2.69
Zhentao Lei,Qiuju Tang,Yanshan Ju,Yonghui Lin,Xiaowen Bai,Haipeng Luo,Zaizai Tong
Developing the hybrid nanosystems for controlled drug release is still a challenging task. In this work, pH-responsive core-shell nanocomposites have been prepared by the growth of zeolitic imidazolate framework-8 (ZIF-8) on the surface of polymeric aggregates self-assembled from poly(ε-caprolactone)-block-poly (quaternized vinylbenzyl chloride/bipyridine) (PCL-b-q(PVBC/BPy), BCP for short) in water. The core of the micelles or the inner cavity of vesicles serves as the drug storage reservoir for the doxorubicin hydrochloride (DOX) and the ZIF-8 shells act as the gatekeepers to prevent drug premature release at physiological environment. Upon pH stimulus, the core-shell nanocomposites (BCP@ZIF-8) show a retarded drug release behavior compared with DOX-loaded polymeric aggregates counterparts (without the shell of ZIF-8). Moreover, the as-prepared nanocomposites perform good biocompatibility towards MCF-7 cell. Meanwhile, the DOX-loaded BCP@ZIF-8 nanocomposites present lower cytotoxicity compared with DOX-loaded BCP and free DOX. The confocal microscopy study shows the core-shell nanocomposites could be efficiently internalized by cancer cells, and the loaded DOX could be successfully released under acidic intracellular environment. The above result shows that the core-shell nanocomposite could be a promising candidate for pH-responsive drug delivery system in the cancer therapy.
✓ 已验证
DOI
PubMed
高影响因子
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2022
·
IF 7.129
Yixuan Liang,Hanbing Li,Xiaotong Li,Qiyu Zhang,Jiaying Fei,Sumei Li,Sha Chen
Around 6.6 million tons of spent coffee is produced per year, resulting in resources loss and potential environmental risks. Hence, a green technique is required to reuse the spent coffee grains. In this study, coffee grounds were burnt at 900 °C to generate the biochar (BC) for the synthesis of the porous adsorbent (ZIF-8 @BC) by growing ZIF-8 on the surface of BC. We applied the well-prepared ZIF-8 @BC to remove Congo red (CR) in water. The maximum adsorption capacity of ZIF-8 @BC on Congo red in water was up to 1080.4 mg/g, which was significantly higher than that of many different types of BCs reported in previous studies. The reasons for its highly efficient adsorption of CR probably was attributed to metal ions and coordinatively unsaturated sites in the material. Also, BC enabled the less aggregation of ZIF-8 to provide sufficient specific surface area for CR adsorption. From the analysis of the pseudo-second-order kinetic model and Langmuir model, the adsorption of ZIF-8 @BC on CR was a homogeneously chemical adsorption process regulated by electrostatic interaction, π-π stacking and metal coordination.
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2021
·
IF 10.588
Douchao Mei,Lijia Liu,Huan Li,Yudan Wang,Fuqiu Ma,Chunhong Zhang,Hongxing Dong
Herein, a dual-function Zeolitic Imidazole Frameworks (ZIFs) ZIF-90 grafted with malononitrile by Knoevenagel reaction and following with an amidoximation reaction to form an efficient U (VI) adsorbent ( ZIF-90-AO ). The strong chelation power of amidoxime groups (AO) with uranium and ZIF-90 ’s mesoporous structure afforded ZIF-90-AO high maximum uranium adsorption capacity of 468.3 mg/g (pH = 5). In addition, the factors affecting uranium adsorption process were investigated by a batch of adsorption tests under different adsorption conditions. ZIF-90-AO displayed good selectivity to UO 2 2+ in the solution containing multiple co-existing ions and good regeneration property. More importantly, ZIF-90-AO showed excellent antimicrobial property against both E. coli and S. aureus . Therefore, ZIF-90-AO is a U-adsorbent with great application value for removing U (VI) from wastewater due to the high U (VI) adsorption capacity in weak acid condition and good anti-biofouling properties.
✓ 已验证
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2022
·
IF 8.008
Yanping Sun,Tong Shu,Jianxin Ma,Qiong Dai,Peiwen Peng,Ziping Zhou,Xiang Zhou,Lei Su,Xueji Zhang
The development of modern technologies has acclimatized biosensors to complicated applicable scenarios with integrated properties as a whole instead of the pursuit of a single-point breakthrough. Here, we targeted a few concerns in the development of enzyme-based biosensors, including stability, analyte enrichment, and signal transduction, and developed a general biosensing model utilizing enzymes, aggregation-induced emission (AIE) luminogens, and stimuli-responsive framework materials as the units. We propose such proof-of-concept of glucose biosensors by coencapsulating glucose oxidase and AIE-type gold nanoclusters into acid-sensitive zeolite imidazolate framework (ZIF)-8 nanocrystals. The acid-activated degradation of ZIF-8 bridges the molecular signals produced by the enzyme-catalytic reaction of glucose and the photon signals generated by ZIF-8-induced AIE effects of gold nanoclusters, resulting in the “turn-off” model nanoprobes for glucose detection with high selectivity. After embedding the nanoprobes into hollow-out tapes, the formed paper biosensors can conveniently detect glucose with the help of a smartphone.
✓ 已验证
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2017
·
IF 7.504
Yi Jiang,Haiqiang Liu,Xinghua Tan,Limin Guo,Jiangtao Zhang,Shengnan Liu,Yanjun Guo,Juan Zhang,Hanfu Wang,Weiguo Chu
2D hierarchically porous carbon (2D-HPC) nanosheets with unique advantages are highly desired as host materials for lithium sulfur (Li–S) batteries and other energy storage devices. Herein, we propose a self-template and organic solvent-free approach to synthesize nanosheets of monoclinic ZIF-8 at room temperature from which 2D-HPC nanosheets (ZIF-8 nanosheets carbon denoted as ZIF-8-NS-C) are derived to be an efficient sulfur immobilizer for Li–S batteries for the first time. The anisotropic nanosheets are believed to relate to the symmetry of the monoclinic structure. The 2D ZIF-8-NS-C nanosheets with embedded hierarchical pores construct an effective conductive network through “plane-to-plane” modes to endow superior electron transfer and fast electrochemical kinetics. Moreover, the nitrogen-rich feature of ZIF-8-NS-C can increase the affinity/interaction of carbon host with lithium polysulfides, favoring the cyclic performance. The sulfur/ZIF-8-NS-C (S/ZIF-8-NS-C) cathode shows a superior rate capability with high capacities of 1226 mA h g–1 at 0.2 C and 785 mA h g–1 at 2 C, and a sustainable cycling stability with a capacity attenuation of 0.12% per cycle at 0.5 C for 300 cycles. The approach proposed here pioneers the controllable design of MOF-based structures to inspire the exploration of more variable MOF-derived porous materials for energy storage applications.
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Xiaocong Gu,Zong Liu,Hui Liu,Chengang Pei,Ligang Feng
Efficient oxygen evolution nano-catalyst is significant for hydrogen generation in the water-splitting reaction. Herein, we demonstrate that fluorination of ZIF-67 Framework templated Prussian blue analogue hollow nano-box is highly efficient for the oxygen evolution reaction (OER). The structure and morphology observation shows the degree of structural transformation and morphology are influenced by the fluorination temperature, and the catalytic ability for OER is correspondingly correlated to these characters. The product obtained at the annealed temperature of 250 °C exhibits the highest catalytic performance for OER with an overpotential of 243 mV (No IR correction) to offer 10 mA cm −2 when loaded on the inert glass carbon electrode, which is much better than that of the commercial IrO 2 catalysts. High catalytic stability and kinetics are also found for the OER. Moreover, it has the highest intrinsic activity as demonstrated by the specific activity and turnover frequency indicating the intrinsic advantages of fluorination and hollow nano-box structure. This study enriches the application of Prussian blue analogue based hollow materials for OER by facile fluorination at low temperatures.
✓ 已验证
DOI
高影响因子
SOLID STATE IONICS
·
2020
·
IF 3.107
Ying Zhou,Tingting Zhou,Yipeng Zhang,Li Tang,Qing Guo,Mingfeng Wang,Changsheng Xie,Dawen Zeng
Core-shell heterostructures of metal oxide semiconductor (MOS) and metal organic framework (MOF) improve gas-sensing properties due to the MOF's molecular sieving effects. However, the selection of MOF is limited by the requirement of identical metal element in MOF to that in MOS, which is crucial for valid interface adhesion. In this paper, WO 3 @ZIF-71 (zeolitic imidazolate framework) structure with different metal elemental components (W and Zn) was fabricated by a step-by-step (SBS) approach. As a result, ZIF-71 was uniformly coated on the surface of WO 3 . In order to explore the influence of ZIF-71 (pore size: 4.8 Å), the gas sensitivity of WO 3 and WO 3 @ZIF-71 were tested. Different kinetic diameters gases: H 2 S (3.62 Å), CH 3 COCH 3 (4.6 Å), CH 3 CH 2 OH (4.53 Å), NO 2 (5.8 Å) were selected as testing gas. Gases with small molecules (H 2 S, CH 3 COCH 3 and CH 3 CH 2 OH) can pass through the membrane of ZIF-71 and contact with WO 3 , while larger ones (NO 2 ) were blocked outside the membrane. Excitingly, the response of WO 3 @ZIF-71 toward H 2 S gas was significantly improved, which soars from 2.24 of 20 ppm for pure WO 3 to 19.12 for H 2 S at 250 °C, increased about 9 times. These results indicate that the MOS@MOF core-shell structure can be synthesized by the SBS method without the restriction of the same metal elements in MOS and MOF, which is also an effective approach to regulate the selectivity and sensitivity of the MOS@MOF gas sensor.
✓ 已验证
DOI
高影响因子
ACS ES&T Water
·
2020
·
IF 0
Limei Dong,Yiming Li,Dafan Chen,Xiuping Chen,Dan Zhang
The hierarchically structured Fe3O4-MnO2-ZIF-8 composite was successfully synthesized and applied to activate peroxymonosulfate (PMS) for the degradation of bisphenol A (BPA) and other organic pollutants for the first time. Catalytic experiments revealed that the as-prepared Fe3O4-MnO2-ZIF-8 showed highly efficient catalytic activity and deep mineralization for BPA because of the loading of ZIF-8. When 60 mg/L BPA was degraded by the Fe3O4-MnO2-ZIF-8/PMS system, the removal efficiency of BPA reached 100% within 15 min and the TOC removal efficiency reached 80% within 9 min, values that were much higher than those of the catalysts reported recently. Fe3O4-MnO2-ZIF-8 can be separated conveniently from the aqueous phase under magnetic field control and shows better recyclability. Simultaneously, the Fe3O4-MnO2-ZIF-8/PMS system shows an excellent removal capability for other organic pollutants, such as phenol, tetracycline, p-hydroxybenzoic acid, and rhodamine B. Through radical quenching experiments and electron paramagnetic resonance tests, the mechanism of activation of PMS by Fe3O4-MnO2-ZIF-8 was investigated. ZIF-8 loaded on the surface of the Fe3O4-MnO2 composite can accept electrons generated from the Mn(II)/Mn(III)/Mn(IV) redox conjugate triplet and react with PMS to generate more •OH and SO4•–, thus significantly enhancing the catalytic performance. Additionally, on the basis of GC-MS analysis, the intermediates in the process of BPA degradation were tested and the possible degradation pathway was determined. This study indicates that Fe3O4-MnO2-ZIF-8 is a highly efficient catalytic material for PMS-based AOPs for the removal of various pollutants from water.
✓ 已验证
DOI
CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Mantang Chen,Nan Wang,Xiaobo Wang,Yu Zhou,Lihua Zhu
Magnetic Fe 3 O 4 @ZIF-67 composites were prepared, characterized, and used as heterogeneous catalysts to activate peroxymonosulfate (PMS) for the degradation of tetrabromobisphenol A (TBBPA). It was observed that all the added TBBPA (40 mg L −1 ) was completely degraded in 3 min in the Fe 3 O 4 @ZIF-67 (0.1 g L −1 ) + PMS (0.1 g L −1 ) system with a pseudo second-order degradation rate constant ( k ) of 110.3 L g −1 min −1 , being nearly 10 times that (11.8 L g −1 min −1 ) in the ZIF-67 + PMS system and 2000 times that (0.06 L g −1 min −1 ) in the Fe 3 O 4 + PMS system. The observed synergistic catalysis between Fe 3 O 4 and ZIF-67 in Fe 3 O 4 @ZIF-67 enhanced not only the degradation of TBBPA, but also the TOC removal and the release of Br − during the degradation of TBBPA. Multiple reactive species including OH, SO 4 − and 1 O 2 were responsible for the degradation of TBBPA, but 1 O 2 was the dominant one. The synergistic catalytic mechanism of PMS activation by Fe 3 O 4 @ZIF-67 was proposed, which mainly involved the electron donating ability of Fe 2+ in Fe 3 O 4 for enhancing the Co 3+ /Co 2+ cycle. Moreover, Fe 3 O 4 @ZIF-67 showed good recyclability and could be easily recycled by magnetic separation. This work provides an opportunity to construct highly efficient catalysts with magnetic recycling capability.
✓ 已验证
DOI
高影响因子
IET Nanobiotechnology
·
2020
·Vol. 14
·期 7
·595-601
·
IF 1.859
Xinyu Xu,Ye Liu,Zhaoming Guo,Xue-Zhi Song,Xiuyu Qi,Zideng Dai,Zhenquan Tan
Metal-organic frameworks (MOFs) as drug carriers have many advantages than traditional drug carriers and have received extensive attention from researchers. However, how to regulate the microstructure of MOFs to improve the efficiency of drug delivery and sustained release behaviour is still a big problem for the clinical application. Herein, the authors synthesise surfactant-modified ZIF-8 nanoparticles with different microstructures by using different types of surfactants to modify ZIF-8. The surfactant-modified ZIF-8 nanoparticles have the larger specific surface area and total micropore volumes than the original ZIF-8, which enables doxorubicin (DOX) to be more effectively loaded on the drug carriers and achieve controlled drug sustained release. Excellent degradation performance of ZIF-8 nanoparticles facilitates the metabolism of drug carriers. The formulation was evaluated for cytotoxicity, cellular uptake and intracellular location in the A549 human non-small-cell lung cancer cell line. ZIF-8/DOX nano drugs exhibit higher cytotoxicity towards cells in comparison with free DOX, suggesting the potential application in nano drugs to cancer chemotherapy.
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Mengyuan Cao,Bicong Wang,Yuchao Deng,Da-Wei Pan,Xiao-Jie Ju,Rui Xie,Zhuang Liu,Xing-Long Zhou,Mao-Jie Zhang,Wei Wang,Liang-Yin Chu
Anthocyanins are promising natural antioxidants widely present in plants. While enzymatic catalytic hydrolysis is a feasible strategy for the extraction of bioactive compounds from plants, the limited stability of free enzymes poses a significant challenge to this approach. Enzyme immobilization using zeolitic imidazolate framework-8 (ZIF-8) demonstrates considerable potential for improving enzymatic tolerance. However, enzyme@ZIF-8 encounters challenges due to reduced bioactivity, primarily attributed to the microporous structure of ZIF-8. To address these limitations, defect-induced mesopores are created in multi-enzyme@ZIF-8 through in-situ millifluidic synthesis, followed by UV post-treatment to introduce additional surface defects. These multi-enzyme@ZIF-8/UV nanoparticles adhere to black rice powder via electrostatic interactions, thereby facilitating the cell wall breakdown. The anthocyanin extraction yield of multi-enzyme@ZIF-8/UV reaches 10.76 mg/L, representing a 31.7 % increase compared to multi-enzyme@ZIF-8 without UV post-treatment. This study provides defect-engineered porous ZIF-8 biocomposites that simultaneously enhance the stability and catalytic activity of encapsulated enzymes for efficient extraction of plant-derived polyphenolic flavonoids, demonstrating broad potential in sustainable biocatalysis and natural product recovery.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）