MACROMOLECULAR BIOSCIENCE
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2024
·
IF 4.4
Siyu Jiang,Sijia Yang,Wenwei Lei,Zhiwei Liu,Holger Schönherr
The performance of the cell-selective thermoresponsive poly(di(ethylene glycol)methyl ether methacrylate) (PDEGMA) cell harvest system is shown to be drastically enhanced by exploiting the combination of photoresponsive spiropyran derivates and PDEGMA in copolymerized brushes. The analysis of copolymerized 1′-(2-methacryloxyethyl)-3′,3′-dimethyl-6-nitrospiro(2 H -1-benzopyran-2,2′-indoline) (SPMA) (DEMGA) di(ethylene glycol)methyl ether methacrylate brushes revealed that a minor adjustment of the SPMA/DEGMA ratios results in a significant alternation of wettability as well as protein adsorption, when switching the temperature from 37 to 22 °C and alternately irradiating using different light wavelengths (from 530 to 365 nm). Thin P(SPMA- co -DEGMA) layers supported pancreatic tumor PaTu 8988t cells with high cell viability. Copolymer layers with 2.5% SPMA/DEGMA led to the highest efficiency of enzyme-free cell release with very good cell viability. The release is induced by cooling the cell culture medium to 22 °C and irradiating the surface with 365 nm light. Compared to neat PDEGMA, the P(SPMA- co -DEGMA) layers showed a threefold increase in the speed of the change of cell morphology of the attached cells and a >5 times increased fraction of detached cells, which underlines the potential of these dual responsive PDEGMA systems for optimized performance in the facile capture, culture, and release of different cell lines.
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Scientific Reports
·
2024
·Vol. 14
·期 1
·1-11
·
IF 3.8
Tang Lisheng,Jin Yuanyuan,He Xiaoyan,Huang Ran
To address the concern that biodegradable elastomers are environmental-friendly but usually associated with poor properties for practical utilization, we report a star-crosslinked poly(ethylene glycol-glycerol-itaconate-sebacate) (PEGIS) elastomer synthesized by esterification, polycondensation and UV curing, and reinforced by bacterial cellulose (BC). The interpenetrating network of primary BC backbone and vulcanized elastomer is achieved by the “in-situ secondary network construction” strategy. With the well dispersion of BC without agglomeration, the mechanical properties of PEGIS are significantly enhanced in tensile strength, Young’s modulus and elongation at break. The reinforcement strategy is demonstrated to be efficient and offers a route to the development of biodegradable elastomers for a variety of applications in the future.
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RSC Advances
·
2016
·Vol. 6
·期 69
·65186-65195
·
IF 3.289
Ruiqi Na,Pengfei Huo,Xingrui Zhang,Shuling Zhang,Yinlong Du,Kai Zhu,Yaning Lu,Menghan Zhang,Jiashuang Luan,Guibin Wang
In order to meet the requirement of high temperature applications, a high thermal stability solid polymer electrolyte is prepared with a poly(aryl ether ketone)–poly(ethylene glycol) copolymer (i.e., PAEK–PEG) as a polymer host, and LiClO4 as an electrolyte salt. A novel flexible solid-state supercapacitor is then assembled by the resultant solid polymer electrolyte and activated carbon electrodes. The electrochemical properties of the supercapacitor are analyzed over a wide temperature range of 30–120 °C. The fabricated supercapacitor has excellent electrochemical performance especially at high temperature (e.g. high specific capacitance of 103.17 F g−1 at 0.1 A g−1 and an energy density of 6.76 W h kg−1 with a power density of 9.55 W kg−1 at 120 °C). Simultaneously, this solid polymer electrolyte based supercapacitor possesses excellent flexible bending properties and outstanding cycle stability of negligible specific capacitance loss after 2000 cycles at various temperatures, demonstrating its feasibility as an energy device for high temperature applications.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2016
·
IF 2.567
Qian Ren,Jing Wang,Wentao Zhai,Richard Eungkee Lee
A sinterable poly(lactic acid) (PLA) foam is critical to the creation of strong interface bonding for the production of large-size PLA bead foam products. To fabricate such a foam, we blended a polyethylene glycol (PEG) that has a low melting temperature and high CO2 solubility with PLA. Solid-state foaming technology was used to foam the PLA/PEG blends, and CO2 was the blowing agent. The PEG was miscible with the PLA and enhanced the crystallization of PLA at a loading of lower than 10 wt % under a CO2 saturation process. Consequently, the PLA/PEG blends did not foam well because of the matrix’s improved stiffness. The CO2 saturation process induced the PEG’s phase separation because its content was higher than 20 wt %. This weakened the PEG’s plasticization effect on the PLA, but it significantly improved the PLA’s foaming behavior. This was characterized by both the foam expansion ratio, which increased from 4.6 to 11.8–24.1, and the decreased cell size. We discuss the effects of crystallization and the separated PEG phase on cell nucleation and growth in order to explain the possible operational mechanisms. Both the PEG’s self-diffusion behavior and the PLA/PEG’s improved foaming behavior enabled us to fabricate large-size PLA bead foam products.
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THERMOCHIMICA ACTA
·
2013
·
IF 1.989
Wenli Zhang,Yutao Hu,Yun Wang,Juan Han,Liang Ni,Yingchun Wu
Liquid–liquid equilibrium data of aqueous two-phase systems (ATPSs) formed by poly(ethylene glycol) (PEG) of different molecular weights (1000, 2000, 6000) + ammonium carbonate ((NH 4 ) 2 CO 3 ), ammonium tartrate ((NH 4 ) 2 C 4 H 4 O 6 ), diammonium hydrogen phosphate ((NH 4 ) 2 HPO 4 ), ammonium sulfate ((NH 4 ) 2 SO 4 ) + water were determined at 298.15 K, respectively. The binodal data were correlated by using a four-parameter equation. The effect of PEG molecular weight on binodal curves was investigated, and it was found that the biphasic region expanded with an increase in PEG molecular weight. Meanwhile, it was also observed that the ability of the investigated salts for phase separation follows the order: (NH 4 ) 2 HPO 4 > (NH 4 ) 2 SO 4 > (NH 4 ) 2 C 4 H 4 O 6 > (NH 4 ) 2 CO 3 . Furthermore, a relatively simply two parameter equation, Othmer–Tobias and Bancroft equations was successfully used to correlate the tie-line data.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2015
·
IF 2.587
Fan Gao,Guangfa Zhang,Qinghua Zhang,Xiaoli Zhan,Fengqiu Chen
In this study, a novel amphiphilic comb copolymer P(poly(ethylene glycol) (PEG)-r-poly(dimethylsiloxane) (PDMS)) with mixed hydrophilic and low surface energy side chains was synthesized by the free radical polymerization method. The microstructure of the synthesized amphiphilic copolymers was characterized by Fourier transform infrared (FTIR) and the nuclear magnetic resonance proton spectra (1H NMR). The copolymers were blended with poly(ether sulfone) (PES) to fabricate low-fouling ultrafiltration membranes through nonsolvent induced phase separation (NIPS). The surface distribution of the hydrophilic PEG segments and hydrophobic PDMS segments on the membranes via surface segregation during the NIPS process was confirmed by the X-ray photoelectron spectroscopy (XPS), the wetting property, and the surface energy measurements. The multidefense mechanisms from fouling resistant to fouling release for the membranes modified by amphiphilic copolymers P(PEG-r-PDMS) were investigated with bovine serum albumin (BSA) aqueous solution as a model foulant. The antifouling properties of the modified membrane, especially for membrane PES/P(PEG-r-PDMS)∼31.3% (M4), was effectively improved in comparation with pure PES membrane (M0). The flux decline rate of the membrane M4 was as low as 15.6%, and the flux recover ratio was up to 96.6%. The modified membrane also possessed stable and durable antifouling properties after three cycles of BSA filtration and chemical washing. It is promising that the present study can offer an effective approach to construct a low fouling membrane in the application of wastewater treatment and water purification.
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COLLOIDS AND SURFACES B-BIOINTERFACES
·
2013
·
IF 3.554
Fang Du,Haijing Meng,Ke Xu,Yanyun Xu,Ping Luo,Yu Luo,Wei Lu,Jin Huang,Shiyuan Liu,Jiahui Yu
This research is aimed to develop a nanoparticle delivery system based on β-cyclodextrin-grafted diblock copolymer and camptothecin (CPT) inclusion complexes with the purpose of enhancing the stability of CPT in aqueous media. Firstly, mPEG-PBLG diblock copolymer was synthesized by the ring-opening polymerization of γ-benzyl- l -glutamate-N-carboxyanhydride (BLG-NCA) initiated with amine terminated poly (ethylene glycol) monomethyl ether (mPEG-NH 2 ). After removal of benzyl groups, mono-6-amine-β-cyclodextrin (EDA-β-CD) units were coupled to the carboxyl groups of the copolymer as side groups to produce the host macromolecule mPEG-PLG(CD). The highly hydrophobic anticancer drug CPT was employed as the guest component which could be included into the host macromolecule to form supramolecular inclusion-complex mPEG-PLG(CPT@CD). Interestingly, the supramolecular complexes were able to form spherical nanoparticles with an average size of 98 nm in aqueous media confirmed by dynamic light scattering (DLS) and transmission electron microscopy (TEM), suggesting their passive targeting potential to tumor tissue. Due to the protection effect from a dual lock system (the environment of nanoparticles and the exterior surface of β-CD), the active lactone ring of CPT showed remarkably enhanced stability against hydrolysis under physiological condition. The release profile of the mPEG-PLG(CPT@CD) nanoparticles in PBS buffer was found to be gradual and sustaining. It was worthy to note that the release could be accelerated by addition of adamantane carboxylate (ADC) as competitive guest compound, demonstrating the chemically stimulated release behavior of the nanoparticles. Compared with free CPT, the mPEG-PLG(CPT@CD) nanoparticles displayed essentially decreased cytotoxicity against MCF-7 cell line in 24 h because of a sustained release profile of CPT from the nanoparticles, moreover, the carrier mPEG-PLG(CD) itself showed almost no cytotoxicity, indicating its great potential as tumor tissue targeted drug delivery system.
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RSC Advances
·
2015
·Vol. 5
·期 114
·94091-94098
·
IF 3.84
Fei Liu,Junwu Zhang,Jinggang Wang,Haining Na,Jin Zhu
Thermal and tensile properties of thermoplastic elastomers (e.g. poly(butylene terephthalate)-b-poly(tetramethylene glycol) (PBT–PTMG)) are usually tuned by changing the composition of hard and soft segment parts. Simply increasing the amount of soft segment results in a lower melting temperature and better elastic properties, but the thermal stability and tensile properties are inevitably sacrificed. In this work, by incorporation of an aliphatic ring structure (i.e. 1,4-cyclohexanedicarboxylic acid) (CHDA) to partially replace the aromatic ring (i.e. terephthalic acid) in PBT-PTMG, the properties of the material can be tuned in such a way that the melting temperature decreases, while the thermal stability, tensile and elastic properties are not compromised. Moreover, manipulation of the stereo-chemistry of the CHDA unit discloses the “elastic” nature of the non-planar ring structure. Samples with a greater amount of cis-CHDA tend to have better tensile and elastic properties compared with their trans-CHDA counterparts.
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DRUG DELIVERY
·
2017
·
IF 6.402
Peng Li,XiaoYue Zhou,Ding Qu,Mengfei Guo,Chenyi Fan,Tong Zhou,Yang Ling
The aim of this study was to develop an amphipathic polyethylene glycol (PEG) derivative that was bi-terminally modified with celastrol and ginsenoside Rh2 (Celastrol-PEG-G Rh2). Such derivative was capable of forming novel, celastrol-loaded polymeric micelles (CG-M) for endo/lysosomal delivery and thereby synergistic treatment of lung cancer. Celastrol-PEG-G Rh2 with a yield of 55.6% was first synthesized and characterized. Its critical micellar concentration was 1 × 10−5 M, determined by pyrene entrapment method. CG-M had a small particle size of 121.53 ± 2.35 nm, a narrow polydispersity index of 0.214 ± 0.001 and a moderately negative zeta potential of –23.14 ± 3.15 mV. Celastrol and G Rh2 were rapidly released from CG-M under acidic and enzymatic conditions, but slowly released in normal physiological environments. In cellular studies, the internalization of celastrol and G Rh2 by human non-small cell lung cancer (A549) cells treated with CG-M was 5.8-fold and 1.8-fold higher than that of non-micelle control. Combinational therapy of celastrol and G Rh2 using CG-M exhibited synergistic anticancer activities in cell apoptosis and proliferation assays via rapid drug release within endo/lysosomes. Most importantly, the celastrol in CG-M exhibited a long elimination half-life of 445.3 ± 43.5 min and an improved area under the curve of 645060.8 ± 63640.7 ng/mL/h, that were 1.03-fold and 2.44-fold greater than those of non-micelle control, respectively. These findings suggest that CG-M is a promising vector for precisely releasing anticancer drugs within the tumor cells, and thereby exerts an improved synergistic anti-lung cancer effect.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2017
·
IF 3.671
Jun Zhao,Ji-Duan Lin,Jia-Chen Chen,Guo Chen,Xia-Lan Li,Xiao-Qin Wang,Ming-Xia Chen
The self-assembled polypseudorotaxane (PPRX) fabricated with bis-thiolated poly(ethylene glycol) (PEG) and α-cyclodextrin (α-CyD) acted as an activator for α-chymotrypsin (CT) and retained the activity of CT for a long time up to 7 days. The stabilization mechanism was studied, and the interaction between CT and PPRX was analyzed by using circular dichroism, fluorescence spectra and X-ray powder diffraction (XRD). The bis-thiolated PEG and its assembled PPRX with α-CyD exhibited the interaction with the C -terminal region of the CT’s B-chain probably through PEGylation of the surface disulfide bridge of CT. It caused the aromatic chromophores more exposed to the hydrophilic microenvironment, leading to conformational variation of CT that was revealed by spectroscopic analysis. It rendered the peptide chains in a more flexible and active state. As a comparison, the non-thiolated components could not decorate the surface of CT and performed almost no effect on its stability, which demonstrated that the decoration of the surface disulfide bridge was a key factor in retaining the activity of CT. Due to the activation and stabilization effect, bis-thiolated PEG/α-CyD PPRX was an excellent soft-immobilized carrier for CT, and provided an intriguing method for enzyme’s stabilization.
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CERAMICS INTERNATIONAL
·
2024
·
IF 5.1
Xue-Chun Yang,Xuan Yao,Shaqi Fu,Yuyan Cao,Tingzhan Wang,Martin Köckerling,Lingli Cheng,Zheng Jiao,Jing-Tai Zhao
Ethylene glycol (EG) is a widely used material, but its vapor is harmful to human health already in low concentrations. Thus, highly sensitive EG gas sensors are urgently needed. Herein, a series samples of ZnO and carbon dots (CDs) were synthesized at different ratios through a simple mechanical grinding method. The senor made using ZnO/CDs2 exhibits an ultra-high response (Ra/Rg) to 100 ppm EG up to 2798, 1378 and 467, and extremely low detection limit as low as 21 ppb, 13 ppb and 2 ppb, under UV light, visible light, and infrared light, respectively, as well as excellent repeatability and long-term stability. Especially, under UV light irradiation, the response of ZnO/CDs2 to 100 ppm EG is 24 times that of pure ZnO (Ra/Rg = 114.7), and more than 71 times that of 9 other gases. The outstanding gas sensing performance of ZnO/CDs2 can be attributed to the excellent light response ability of CDs at first, which greatly enriches the electron concentration in ZnO/CDs under light irradiation. Furthermore, the photo-induced electron transfer (PET) property of CDs and the p-n heterojunction formed at the interface between ZnO and CDs play a key role in rapid electron transport and transfer, avoiding a large number of electron hole recombination.
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Polymers
·
2024
·Vol. 16
·期 24
·3484
·
IF 4.7
Yiwen Miao,Chenghao Zhang,Ya Sun,Chunlei Wang,Juntao Yan,Sunhua Deng,Ruan Chi
A series of flexible polyacrylonitrile/TiO2(PAN/P25) multi-porous nanotubular membranes were successfully constructed by facile electrospinning combined with an ethylene glycol solvothermal induce strategy. The effects of P25 dosage and solvothermal time on the morphology of samples were systematically investigated, which were characterized in terms of surface morphology, microstructure, specific surface area, thermal analysis, wettability, photoelectrochemical and fluorescence spectra. Rhodamine B (RhB) andEscherichia coli(E. coli) were employed as simulated pollutants to evaluate photocatalytic degradation and antibacterial properties of the PAN/P25-3 multi-porous nanotubular membrane. The PAN/P25-3 membrane exhibited the highest photocatalytic degradation efficiency, with 96.1% degradation of RhB within 120 min under a xenon lamp light source and a photocatalytic inactivation rate of 95.8% forE. coliunder 365 nm monochromatic light irradiation. The photocatalytic degradation mechanism of the PAN/P25-3 multi-porous nanotubular membrane for RhB was deduced from the results of 3D-EEM fluorescence and scavenger experiments of reactive species. Additionally, the cyclic photodegradation experiments demonstrated that the PAN/P25-3 membrane maintained excellent stability and photocatalytic performance after multiple degradation cycles, confirming its potential for sustainable wastewater treatment applications.
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