Food Bioscience
·
2024
·
IF 4.8
Zhengming Xu,Xi Zhu,Jiayi Lian,Yuan Guan,Zhengang Zhao
Exploiting efficient tyrosinase inhibitors and utilizing the inhibition mechanism are of great significance to avoid enzymatic browning in food and skin melanogenesis. Polydatin had excellent tyrosinase inhibitory activity in vitro with IC 50 value of 24.90 μM; however, it exhibited unsatisfactory inhibitory activity intracellularly, which was associated with poor cellular uptake. Fortunately, 6″- O -lauryl polydatin was green-efficiently synthesized by lipase-catalyzed acylation under microwave irradiation. 6″- O -lauryl polydatin exhibited superior mono-/diphenolase inhibitory activity within 100 μM than kojic acid, which had IC 50 of 221 μM. Neither polydatin nor 6″- O -lauryl polydatin bound to the catalytic site, but rather bound noncovalently to the allosteric site 2 of tyrosinase through hydrogen bonds and hydrophobic interactions according to molecular simulations, thereby inducing secondary structure unfolding and reducing tyrosinase activity. 6″- O -lauryl polydatin showed stronger anti-browning effects than polydatin in the natural storage of potato and apple pieces. Polydatin and kojic acid did not induce apoptosis, but 6″- O -lauryl polydatin inhibited human melanin A375 cell proliferation by stimulating ROS overproduction and regulating cell cycle and apoptotic pathways. In addition, lipophilic 6″- O -lauryl polydatin had greater cellular uptake though suffered from intracellular hydrolysis, and exerted better tyrosinase and melanogenesis inhibitory activity than polydatin and kojic acid based on mouse B16F10 melanoma cell model. The results suggested polydatin and 6″- O -lauryl polydatin were promising tyrosinase inhibitors for anti-browning in foods or cosmetics fields.
✓ 已验证
产品关联
DOI
高影响因子
Small
·
2025
·
IF 12.1
Hao Li,Zhihao Zhang,Dingding Zhu,Huiyuan Zheng,Zhongze Zhu,Nana Shen,Zhu Guo,Xiaolin Wu,Xiaoying Qi,Qiang Li,Qingming Ma,Hongfei Xiang
Low back pain (LBP) resulting from sciatic nerve compression presents major challenges in pain management, as traditional therapies provide only short-term relief and pose risks of systemic toxicity. In this study, an innovative Fe 3 O 4 @ZIF-8-RVC (FZR) dual-responsive nanoplatform is introduced that integrates magnetic targeting with pH-sensitive, sustained drug release to overcome these limitations. The FZR nanoplatform encapsulates ropivacaine (RVC) within the ZIF-8-coated Fe 3 O 4 core, enabling precise and prolonged analgesia at the injury site through magnetic guidance and acid-triggered release. In vitro and in vivo assessments indicate that FZR achieves high drug loading, sustained release in acidic environments, and excellent biocompatibility, significantly extending analgesic effects in chronic nerve injury models while minimizing systemic exposure. Behavioral tests and molecular analyses in LBP rat models confirm that FZR effectively suppresses pain-related neuronal activity and central sensitization markers. This dual-responsive nanoplatform FZR offers a safe, long-lasting, and targeted therapeutic approach, holding strong potential for advancing pain relief in LBP and related neuropathic pain conditions.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
LIFE SCIENCES
·
2017
·
IF 2.936
En-Xia Wang,Bo-Yang Zou,Lei Shi,Lin-Ying Du,Yan-Yan Zhu,Ya-Meng Jiang,Xiao-Dong Ma,Xiao-Hui Kang,Chang-Yuan Wang,Yu-Hong Zhen,Li-Dan Sun
Aims To investigate the antitumor effects of 7- O -geranylquercetin (GQ), a novel O -alkylated derivative of quercetin, against non-small cell lung cancer (NSCLC) cell lines A549 and NCI-H1975 and the corresponding mechanisms. Main methods Cell viability was assessed using MTT assay. The expression of proteins involved in apoptosis and autophagy was measured using western blotting. Besides, apoptosis was determined with DAPI staining, Annexin V-PI staining and transmission electron microscopy (TEM) assay, and autophagy was observed with TEM assay. Cell cycle and reactive oxygen species (ROS) level were detected using flow cytometry. Key findings GQ inhibited viability of A549 and NCI-H1975 cells in a dose- and time-dependent manner without apparent cytotoxicity to normal human lung fibroblast cells. GQ down-regulated the expression of apoptosis-related proteins pro-caspase 3 and Bcl-2, and up-regulated the expression of cleaved-PARP and Bax in A549 and NCI-H1975 cells. Meanwhile, GQ-induced cell apoptosis could be attenuated by caspase inhibitor Z-VAD-FMK. Besides, GQ induced autophagosome formation in A549 and NCI-H1975 cells, promoted the expression of autophagy-related proteins LC3-II and Beclin 1, and suppressed the expression of p62. Autophagy inhibition with chloroquine or Beclin 1 siRNA could effectively inhibit GQ-induced apoptosis. Furthermore, GQ treatment increased the generation of ROS, and ROS inhibitor N -acetylcysteine could reverse GQ-induced autophagy and apoptosis. Taken together, GQ could induce apoptosis and autophagy via ROS generation in A549 and NCI-H1975 cells, and GQ-induced autophagy contributed to apoptosis. Significance Our findings highlight that GQ is a promising anticancer agent for the treatment of lung cancer.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Yanqing Zheng,Xiheng Kang,Zi You,Yihan Li,Yongheng Huang,Tieguang He,Tianming Su,Arthur J. Ragauskas,Zhenglong Li,Qiong Wang,Xueping Song
As an “upstream” process in biorefinery, biomass dismantling can dismantle the natural stable structure of lignocellulosic biomass and separate its three major components. To increase the value of the entire biomass by fully utilizing the three main components (cellulose, lignin, and hemicellulose), this study proposes a two-step decomposition system combining formic acid (FA) pretreatment and ethylene glycol-NaOH (EGA) dismantling, aiming to effectively convert sugarcane bagasse into xylose, fermentable glucose, and high-value lignin. In the first step, FA pretreatment removed 79.85 % of hemicellulose at 140 °C for 90 min with 3 % FA. Based on the first step, further combination of EGA dismantling can achieve a hemicellulose removal rate of 92.05 % and a lignin removal rate of 95.90 %. In addition, the solid residue was hydrolyzed by enzymes, and the glucose conversion rate was close to 83.29 % when the cellulase dosage was 10 FPU/g. In addition, the lignin recovered by this system retained 83.62 % of the natural β-O-4 structure, which has the potential to catalyze the formation of aromatic monomers. In summary, this gentle two-step system simultaneously improves the efficiency of lignocellulose decomposition and produces different value-added products, demonstrating the potential for industrial-scale production.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
AICHE JOURNAL
·
2024
·
IF 3.5
Yanru Zhu,Zhen Zhang,Yunfei Zou,Jian Zhang,Zhe An,Xin Shu,Hongyan Song,Jing He
Catalytic conversion of biomass-derived 5-(hydroxymethyl)furfural (5-HMF) into carbon-increased hydrocarbons as drop-in energy-rich biofuels has received a great deal of concern for the development of sustainable chemical industry. Here, we demonstrate a one-pot conversion of 5-HMF into C 9 -alkanes on one single catalyst, acidic–basic layered double oxides (Mg(Al)(Zr)O) supported CuCo alloy. The well-defined multifunctional catalytic sites with harmonious combination carry out cascade catalysis, affording C 9 -alkanes (including 30% of more value-added branched-cycloalkanes) in 83% yield. The basic–acidic sites on Mg(Al)(Zr)O show high activity for aldol condensation of 5-HMF and acetone, producing 4-[5-(hydroxymethyl)-2-furanyl]-3-buten-2-one (HAc) in a yield of >99%. The engineered Co–Cu–Co linkages on supported CuCo perform efficient hydrodeoxygenation, affording C 9 -alkanes in a selectivity of 96% from HAc. C 9 -cycloalkanes are generated from the cyclization of the corresponding monohydric alcohol intermediates by the synergy of acidic and CuCo sites in the hydrodeoxygenation reaction.
✓ 已验证
产品关联
DOI
高影响因子
Inorganic Chemistry Frontiers
·
2024
·
IF 6.1
Tianhao Yu,peng gao,Hong Du,ling dong
The oxygen evolution reaction (OER) requires the development of a strong and efficient electrocatalyst due to its slow mechanism and high overpotential. Hence, we assembled POM and NiCo-ZIF-67 to obtain the amorphous hollow core-shell material NiCo-ZIF-67@POM (donated as NiCo-ZIF@POM) with high catalytic activity. NiCo-ZIF@POM (1:3) presents a low overpotential (η≈150 mV@10 mA cm-2), a small Tafel slope (100 mV dec-1), and great stability for OER in 1 M KOH solution. Theoretical calculations indicate that the excellent activity of NiCo-ZIF@POM might be attributed to the charge rearrangement due to the interaction between Co and W. In addition, the low electronegativity of P and the high oxidation state of W in POM could accelerate the rapid OH- transfer and induce the intermediates to adsorb on the Co-O-W bridge bond conformation, which improves the performance of the catalytic OER. This study provides a new idea for the secondary assembly of POM and MOF materials.
✓ 已验证
产品关联
DOI
高影响因子
FOOD HYDROCOLLOIDS
·
2025
·
IF 12.4
Long Deng,Junqiu Liao,Weiqi Liu,Shiyuan Liu,Xiaoxiao Liang,Rujin Zhou,Yanbin Jiang
Overcoming gastrointestinal tract barriers to enhance bioavailability is a major challenge for oral delivery. The innovative design of multi-compartment functional Pickering emulsions would provide an ideal option for targeted co-delivery of bioactive components. In this study, pH-responsive water-in-oil-in-water (W/O/W) Pickering double emulsions co-loaded with curcumin and fluorouracil were fabricated by zein/anthocyanin (ACN)/Zn 2+ nanoparticles (ZAZn NPs) via a one-step emulsification process. The unique emulsifier was designed by depositing ACN-Zn 2+ complexes on zein nanoparticles (zein NPs). The binding of ACN to the nanoparticle surface through hydrogen bonding interaction enhanced the hydrophilization and stimuli-response of zein NPs. Furthermore, the co-ordination of Zn 2+ and ACN facilitated the formation of nanoparticles with near-neutral wettability, which served as the dominant driving force for the one-step generation of W/O/W Pickering emulsions. The droplet size, distribution and internal structure of Pickering double emulsions were influenced by nanoparticle concentration and oil fraction. Due to Zn 2+ complexation with curcumin at the oil/water interface, the W/O/W Pickering emulsions obtained exhibited high curcumin encapsulation efficiency (91.2%) and free fatty acid release degree (65.9%), resulting in increased bio-accessibility (71.0%). The simulated gastrointestinal release demonstrated that curcumin and fluorouracil achieved controlled intestinal release, which was driven by a pH-mediated competitive adsorption-desorption mechanism. Moreover, in vitro cell experiments showed that co-encapsulated Pickering double emulsions exhibited 2.5 times greater bio-activity than those containing fluorouracil only. This facile strategy for preparing Pickering double emulsions is promising for the co-delivery of different physico-chemical bio-active compounds, which would improve oral bio-accessibility and bio-activity.
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry A
·
2024
·
IF 10.7
Xiao Liu,Jicong Wang,Fangyuan Zhu,Yanrui Li,Wenchao Tian,Weijia Wang,Ruiyun Guo,Laijun Liu,Jing Shi
Photocatalytic conversion of CO2 into renewable fuels is an exciting and challenging approach to mitigate carbon emissions and energy crisis. The efficiency is hindered by the insufficient carrier transport capacity and high electron-hole pair complexation of catalysts. The inherent spontaneous polarization in ferroelectric materials can affect the generation, transportation, and isolation of intermediates within catalytic reactions in modulating the pace and effectiveness of photocatalytic processes. Herein, ferroelectric bismuth sodium titanate (BNT) decorated by oxygen vacancies (OVs) via in-situ reduction is first explored to promote photocatalytic CO2 reduction reaction (CO2RR). The chemical states and coordination environment of the cations and OVs are elaborated by using the X-ray absorption fine structure to probe weakened Bi-O bonds and enhanced lattice distortion. Besides built-in electric fields originating from intrinsic spontaneous polarization, carrier dynamics and reactive sites are optimized with extended visible light absorption thanks to the special morphology and OVs. Remarkably, defected catalysts show 18 times higher CO reduction yield than pristine BNT, outperforming state-of-the-art bulk ferroelectrics for single photocatalytic CO2RR. Interestingly, the product selectivity can be tailored after a poling treatment. This work provides a systematic approach to designing efficient ferroelectric photocatalysts, and meanwhile expands the ferroelectric photocatalysts family for advancing CO2 conversion.
✓ 已验证
产品关联
DOI
高影响因子
ELECTROCHIMICA ACTA
·
2025
·
IF 5.6
Haikuo Lei,Yanli Ruan
The slow kinetics of the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) significantly limit the performance and broader applications of zinc-air batteries. To address this, a series of M-N-C catalysts were synthesized using W,O-doped ZIF-67 as a precursor. By modifying the surface electronic structure through doping and improving oxygen intermediate adsorption, these catalysts demonstrated excellent bifunctional catalytic activities for OER and ORR. Among them, W,O-CoNC700 achieved the half-wave potential and overpotential of 0.81 V and 359 mV, respectively. DFT calculations revealed that doping with W atoms affected the d-band center of the Co site, thus enhancing its catalytic ability. The maximum power density of a W,O-CoNC700-based zinc-air battery reached 174.8 mW/cm², outperforming the commercial Pt/C + IrO₂ catalysts. Under constant current discharge at 5 and 10 mA/cm², the cell maintained 1100 and 450 h, respectively.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
·
IF 6.3
Hongyu Wang,Tao Wang,Gonghao Li,Bo Wu,Ruijun Gao
Balancing increased recoverable strain with high phase transformation temperature is crucial for Cu-Al-Mn SMAs to cost-effectively overcome the service temperature limitation (<100°C) of NiTi-based SMAs. This study fabricated four types of Cu-12.5Al-3Mn SMAs modified with nano-Al₂O₃ p (0, 0.5, 1.0, and 1.5 wt%) using wire arc additive manufacturing (WAAM) with cored wires. It investigated the effects of nano-Al₂O₃ p on shape memory properties, exploring mechanisms via microstructural, phase, and hardness analysis. Results show that adding an appropriate amount of nano-Al₂O₃ p significantly enhances memory performance while maintaining high martensite transformation temperatures. The 0.5 wt% nano-Al₂O₃ p modified alloy exhibited optimal properties: a shape recovery rate of 87.77 % (13.8 % higher than the base alloy) and a recoverable strain of 7.02 % (>40 % higher than the commonly reported 5 %) under 8 % bending pre-strain. Its Ms temperature remained above 100°C (As, Af, Mf were largely unchanged), and full recovery time was halved compared to the unmodified alloy. The enhancement is attributed to nano-Al₂O₃ p strengthening the parent phase and improving thermoelastic martensite order via pinning. Their high stability under WAAM's high-energy heat source minimizes impact on alloy composition, while dispersed particles create lattice distortion and stress fields, reducing the energy barrier for martensitic transformation.
✓ 已验证
产品关联
DOI
高影响因子
Materials Today
·
2025
·
IF 22
Hang Yue,Sichen Huo,Xinyu Wang,Mingyi Wang,Heyuan Sun,Yanjie Chen,Ying Dai,Mingyang Liu,Jinlong Zou
Due to restrictive linear relationship between intermediates in adsorption evolution mechanism (AEM) of oxygen evolution reaction (OER), a higher overpotential must be overcome for conversion of *O to *OOH. Activating lattice oxygen mechanism (LOM) can address the AEM’s challenges by facilitating O-O coupling. However, via LOM pathway, extracting electrons from metal-oxygen (M−O) bonds usually results in structural instability. Herein, we propose an effective method to stabilize LOM-catalysts by combining cerium dioxide with cobalt phosphide (CeO 2 /CoP heterostructure). CeO 2 acts as an electron buffer to retain/provide electrons at different stages, while CoP with strong Co-P covalency enhances structural/catalytic stability in strongly-alkaline conditions. CeO 2 /CoP exhibits an OER overpotential of only 225 mV at 10 mA cm −2 . Initially, CeO 2 acquires electrons from CoP to accelerate surface reconstruction and form high-valence Co δ+ (CoOOH). Then, CoOOH acquires electrons from the 4 f -orbital of Ce through the Ce-O-Co interface, rather than from the M−O bond, thus ensuring OER stability. For water splitting, bifunctional CeO 2 /CoP-assembled electrolyzer requires a cell-voltage of only 1.54 V to achieve 10 mA cm −2 and retains 89.5 % of its activity after 72 h of cycling. It highlights that leveraging electron-buffering metal species can enhance the LOM stability, thereby enabling its application in bifunctional electrocatalysis.
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2024
·
IF 8.5
Shuhua Li,Shen Zhang,Jizhong Wu,Imran Mahmood Khan,Min Chen,Tianhui Jiao,Jie Wei,Xiaomei Chen,Qingmin Chen,Quansheng Chen
Pesticide residues in agricultural products pose a significant threat to human health. Herein, a sensitive fluorescence method employing upconversion nanoparticles was developed for detecting organophosphorus pesticides (OPs) based on the principle of enzyme inhibition and copper-triggered o -phenylenediamine (OPD) oxidation . Copper ions (Cu 2+ ) oxidized the colorless OPD to a yellow 2,3-diaminophenazine (oxOPD). The yellow solution oxOPD quenched the fluorescence of upconversion nanoparticles due to the fluorescence resonance energy transfer. The high affinity of Cu 2+ for thiocholine reduced the level of oxOPD, resulting in almost no fluorescence quenching . The addition of dimethoate led to the inhibition of acetylcholinesterase activity and thus prevented the formation of thiocholine. Subsequently, Cu 2+ oxidized OPD to form oxOPD, which attenuated the fluorescence signal of the system. The detection system has a good linear range of 0.01 ng/mL to 50 ng/mL with a detection limit of 0.008 ng/mL, providing promising applications for rapid detection of dimethoate .
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）