APPLIED CLAY SCIENCE
·
2026
·
IF 5.2
Yi Wei,Lu Chen,Yichun Wang,Yanqi Xu,Linjiang Wang,Wenbin Yu,Cunjun Li
The low bioavailability of nutraceuticals, due to chemical instability and non-targeted release, remains a major delivery challenge. To address this, biodegradable core-shell hydrogel microspheres with controllable diameters ranging from 800 to 2850 μm were fabricated via an extrusion method for the co-delivery of hydrophilic and hydrophobic nutraceuticals. These microspheres employ Fe 2 O 3 -loaded montmorillonite (Fe Mt) as the reinforcing scaffold, sodium carboxymethyl cellulose (CMC) as the core, and chitosan (CS) as the shell. They were co-loaded with hydrophilic l -glutamine (L-Gln) and hydrophobic curcumin (Cur) as model nutraceuticals. The incorporation of Fe Mt overcomes the low encapsulation efficiency and mechanical weakness of polymer microspheres. Meanwhile, at Fe Mt contents of 6.00 wt% (for L-Gln) and 5.00 wt% (for Cur) relative to the CMC weight, the encapsulation efficiencies reach up to 75.42% and 63.16%, respectively. The CS shell thickness increases from 10.83 to 16.05 μm as the CS concentration rises from 10.0 to 25.0 g/L. This thickness governs the release kinetics and pH-responsive behavior, wherein the microspheres contract in acidic environments and swell under neutral/alkaline conditions to facilitate targeted delivery in the gastrointestinal tract. In simulated digestion, cumulative release of nutraceuticals from the microspheres was 93.02% for L-Gln and 88.37% for Cur within 12 h. Additionally, the microspheres exhibited good storage stability (ca. 1.03% loss after 45 days). This work presents a highly promising and versatile platform for the co-delivery of hydrophilic and hydrophobic nutraceuticals with controlled release profiles.
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JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2026
·
IF 4
Jingfeng Xu,Pingxiong Cai,Yuanfeng Pan
BACKGROUND Faced with the relentless depletion of fossil fuels and the global environmental crisis, the strategic utilization of abundant biomass resources has drawn significant attention, offering vast application prospects in the field of food packaging. This study pioneers an investigation into the effects of incorporating purple tea extract (PTE) in chitosan (CS) films on their fundamental physical properties and functionalization, leading to an active and intelligent CS/PTE composite film with pH-responsive characteristics and improved physical properties. RESULTS X-ray diffraction and Fourier transform infrared analyses indicate that CS and PTE interact primarily through hydrogen bonding, demonstrating high compatibility. The impact of varying PTE concentrations on the water vapor permeability, transparency, mechanical properties, antioxidant activity, antimicrobial performance, and pH responsiveness of the CS film was systematically investigated. The experimental results show that PTE significantly enhances the films’ light and water vapor barrier properties. Specifically, films containing more than 6% PTE exhibit improved antioxidant, antimicrobial, and food preservation capabilities. The resulting composite film demonstrated excellent antioxidant and antibacterial performance with a DPPH radical scavenging rate of 83.2%, and inhibitory rates exceeding 90% against Escherichia coli and Staphylococcus aureus , as well as pH-responsive color changes. CONCLUSION Overall, the CS/PTE composite film represents a highly promising active and intelligent food packaging material. It not only expands the range of naturally available materials for smart packaging films but also holds significant potential for practical applications in the food industry. © 2026 Society of Chemical Industry.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2026
·
IF 4.1
Zheng Yongfang,Huang Shuijing,Zhu Xinyu,Chen Yuyuan,Tian Shuli,Pang Yuxuan,Zhuang Chaojie,Zhu Hu
Nanozymes (primarily peroxidase mimics) coupled with glucose oxidase (GOx) have emerged as an important approach for glucose sensing. However, the widespread application of this strategy is hampered by a critical pH mismatch, as most such nanozymes require an acidic environment for high activity, preventing one-step detection at physiological pH. Here, we report a cascade colorimetric sensing platform based on our previously reported haloperoxidase (HPO) mimic HH-Cu, which exhibits high HPO-like activity exclusively under neutral and alkaline conditions, enabling one-step glucose detection at physiological pH. In this system, GOx catalyzes the oxidation of glucose to generate H 2 O 2 , which is utilized by HH-Cu along with externally added Br − to convert phenol red into bromophenol blue (λmax = 590 nm) through its HPO-like activity, resulting in a visible color change from orange to blue. Spectrophotometric analysis yielded a linear detection range of 1–600 μM and a detection limit of 0.99 μM for glucose, with recovery rates of 90.8%–106.6% and relative standard deviations (RSD) below 7% in urine samples. A smartphone-based analysis platform was also developed and showed performance comparable to the spectrophotometric method, with a linear range of 2.5–600 μM, a detection limit of 2.20 μM, and recovery rates of 105.5% in biological samples. Both platforms were also successfully applied to the sensitive detection of H 2 O 2 at physiological pH. This work not only overcomes the key limitation of pH mismatch in conventional enzyme/nanozyme-based colorimetric glucose detection but also broadens the application horizon of HPO mimics in biosensing. Graphical
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Zhihao Guo,Linyun Xiu,Yumei Li,Cailing Wei,Ji-Liang Li
Intravitreal chemotherapy is a widely employed therapeutic strategy for retinoblastoma. However, its clinical efficacy and safety are considerably compromised by rapid drug clearance from the vitreous cavity and off-target toxicity. To address these limitations, we developed a pH-responsive, hyaluronic acid-based dual drug-loaded nanoplatform (HDLNs) for intravitreal co-delivery of doxorubicin and lapatinib. The nanoscale dimensions and negative surface charge of HDLNs facilitate efficient diffusion within the vitreous gel network while enhancing cellular uptake by Y79 cells. Upon exposure to the acidic intracellular microenvironment, HDLNs rapidly disassemble and trigger the synchronized release of both payloads, thereby synergistically inhibiting tumor cell proliferation and migration. In vivo investigations demonstrated that intravitreal administration of HDLNs significantly prolonged intraocular drug retention and effectively suppressed tumor progression in an intraocular Y79 retinoblastoma mouse model. Importantly, HDLNs substantially mitigated ocular and systemic toxicities associated with intravitreal chemotherapy, exhibiting a favorable in vivo safety profile. Collectively, this tailored drug delivery nanoplatform represents a promising and feasible strategy for safe and effective intravitreal chemotherapy against retinoblastoma.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2026
·
IF 5.4
Jiaqi Huang,Jianyu Wang,Wei Xiang,Meiping Wu,Xiaojin Miao
A dual-responsive self-healing epoxy coating was developed by incorporating a smart microcapsule (rGO@SiO₂-95S-P). PDMAEMA acted as a responsive gatekeeper, enabling faster 95S release under acidic conditions and at temperatures below its LCST range. Meanwhile, the photothermal conversion of rGO increased the coating temperature under 808 nm NIR irradiation, enhancing epoxy-chain mobility and promoting partial scratch closure. UV-Vis spectroscopy, infrared thermography, optical microscopy, electrochemical measurements, and SEM/EDS were employed to evaluate the responsive release, scratch-recovery behavior, and corrosion protection of the coating. Under NIR irradiation for 600 s, the composite coating reached 48.6 °C and exhibited an average scratch-width reduction of 0.5321 mm. After scratching and NIR treatment, the coating maintains a relatively high |Z| f= 0.01Hz of 5.08 × 10 5 Ω·cm 2 and an R ct of 8.922 × 10 5 Ω·cm 2 . At pH= 3, the composite coating exhibited an I corr of 1.286 × 10 −8 A·cm −2 and an R ct of 2.053 × 10 7 Ω·cm². SEM/EDS observations further revealed a comparatively uniform Q235 steel surface with fewer coarse corrosion products under acidic conditions. These results demonstrate that the combination of responsive inhibitor release, NIR-induced partial scratch closure, and physical barrier protection provides the composite coating with effective corrosion protection, particularly under acidic conditions. Download: Download high-res image (140KB) Download: Download full-size image
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ACS ES&T Water
·
2026
·
IF 4.5
Zhan Qihong,Rao Zepeng,Xiao Xin,Chen Baoliang
Micronanobubbles
(MNBs) offer enhanced interfacial area and distinct
interfacial physicochemical properties, but the mechanistic role of
interfacial charge in governing ozone-derived reactive oxygen species
(ROS) remains inadequately understood. Herein, the pH-dependent interfacial
charge characteristics of ozone micronanobubbles (O 3 -MNBs)
were systematically examined to elucidate their influence on sulfamethoxazole
(SMX) degradation. O 3 -MNBs increased the apparent degradation
rate by approximately 4-fold relative to macrobubbles, with initial
enhancement driven by facilitated ozone dissolution and subsequent
acceleration governed by interfacial reaction processes. ζ potential
measurements and ROS probe analyses demonstrated that solution pH
modulates MNB interfacial charge, thereby regulating pollutant interfacial
enrichment and shifting ROS dominance. Acidic conditions promoted
hydroxyl radical ( • OH) formation through interfacial
instability, whereas neutral and alkaline conditions favored the generation
of superoxide radicals (O 2 •– )
and singlet oxygen ( 1 O 2 ). Quadrupole time-of-flight
mass spectrometry (Q-TOF-MS) further confirmed that these distinct
ROS regimes correspond to divergent SMX transformation pathways. The
findings establish interfacial charge regulation as a critical determinant
of reaction selectivity in O 3 -MNB systems and provide mechanistic
guidance for optimizing MNB-assisted ozonation in advanced water treatment.
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ACS Applied Polymer Materials
·
2026
·
IF 5.2
Guo Ruixue,Chen Guangluo,Wu Wanqing,Guo Ping,Li Jingtai,Du Min,Wang Buqing,Wang Wenjie,Shi Haokun,Ning Ye,Guo Yuanyuan,Li Chengzhuo,Zheng Qinggong
Marine biofouling necessitates durable, low-toxicity
coatings.
We developed a hydrolyzable polysiloxane-polyurethane acrylate nanocomposite
combining surface self-renewal with pH-responsive natural antifoulant
release. The polymer matrix, synthesized from polydimethylsiloxane,
hexamethylene diisocyanate, and hydroxyethyl acrylate, contains ester
side chains enabling gradual hydrolysis and self-polishing. Zeolitic
imidazolate framework-8 loaded with arbutin (ZIF-8/Arb) and nano-SiO 2 provided responsive antifoulant delivery and mechanical reinforcement.
The optimized coating showed controlled mass loss (0.6 mg cm –2 over 60 days), strong adhesion (5B), high lap-shear strength (14.1
MPa), and excellent abrasion resistance (only 5 ° water-contact-angle
drop after 20 sand-drop cycles). Hydrolysis continuously removed the
fouling-prone surface layer, while ZIF-8/Arb released arbutin and
Zn 2+ under bacterial acidic microenvironments, minimizing
unnecessary release. The coating achieved >99% antibacterial efficacy
against Escherichia coli and Staphylococcus aureus , retained >90% activity
after
30 days, inhibited Chlorell growth
by >30%, and suppressed protein adsorption. In 35 day marine field
tests, it exhibited sparse diatom settlement and negligible macrofouling.
This work demonstrates that integrating hydrolysis-driven self-polishing
with responsive natural-antifoulant release offers a sustainable antifouling
strategy, providing design insights for durable, efficient, and eco-friendly
polymer nanocomposite coatings with reduced biocide dependence.
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BIOMACROMOLECULES
·
2026
·Vol. 27
·期 8
·5795-5806
·
IF 5.9
Yang Xue,Huang Menglin,Wu Hongjing,Li Wen,Chen Hongqi,Dai Xiaomei,Gao Feng
Bacterial pneumonia, a prevalent respiratory disease
with high
global morbidity and mortality rates, remains a formidable therapeutic
challenge. Herein, pH/reactive oxygen species (ROS) dual-responsive
zwitterionic polymer (PODEA- b -P(ROS-CA-EG)n) micelles
are developed for bacterial pneumonia therapy. The zwitterionic shell
can facilitate the micelles to effectively penetrate through the mucus.
These micelles exhibit pH-responsive charge reversal performance,
which is conducive to the cellular internalization and bacterial killing.
Meanwhile, the micelles respond to the acid and overexpressed ROS
microenvironment at the lesion site to release cinnamaldehyde (CA),
enhance ROS generation, and activate an immune reaction to eliminate
extracellular and intracellular bacteria collaboratively. In bacterial
pneumonia, PODEA- b -P(ROS-CA-EG)n micelles can effectively
eliminate bacteria and alleviate lung inflammation. These pH/ROS dual-responsive
zwitterionic polymer micelles could provide a synergistic therapeutic
strategy against bacterial pneumonia.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2026
·
IF 6
Wanmei Zhou,Zixin Wang,Chengdong Nie,Haiting Tian,Xiaoyi Duan,Lina Fu,Quan Zhou,Litao Wang,Yujie Fu
Triple-negative breast cancer (TNBC) lacks effective tumor-selective strategies, particularly limiting ferroptosis-based therapies that depend on oxidative stress. Here, we develop a structurally reinforced ternary redox-cycling nanoreactor that integrates Zr 4 ⁺-stabilized zeolitic imidazolate framework-8 (ZIF-8) with redox-active Cu/Mn centers and ultrasmall Au nanodots, while co-loading paclitaxel (PTX) for acidic tumor microenvironment-responsive release. The Cu-Mn-Au interfaces enable rapid electron shuttling, sustaining multivalent metal cycling, accelerating Fenton-like reactive oxygen species (ROS) generation, depleting GSH, and promoting lipid peroxidation. Density functional theory (DFT) calculations further support its self-perpetuating redox mechanism. Dual surface modification with 4 T1 cell membranes and folic acid confers homotypic and receptor-mediated targeting. Mechanistic studies reveal coordinated GPX4/SLC7A11 suppression, PTX-enhanced cell-cycle arrest, and NCOA4/HO-1-mediated ferritinophagy, collectively amplifying ferroptosis. Unlike conventional metal–organic frameworks (MOFs), this Zr-reinforced trimetallic system maintains continuous redox cycling under reductive conditions. Overall, the nanoreactor achieves sustained ROS amplification, iron-homeostasis remodeling, and enhanced tumor-selective ferroptosis, offering a promising therapeutic strategy for TNBC. Download: Download high-res image (197KB) Download: Download full-size image
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MOLECULAR PHARMACEUTICS
·
2026
·
IF 4.9
Ning Yang,Yule Song,Junliang Song,Jian Qin,Mingwei Fu,Feng Yao,Huan Xu
Renal fibrosis (RF), a critical pathogenic mechanism in chronic kidney disease (CKD), now has exceedingly few therapeutic alternatives. This study presents a new sigma1 receptor (σ1R)-targeted nanodelivery system utilizing the natural polyphenolic medicine resveratrol (Res) as a therapeutic agent, addressing its low bioavailability and inadequate targeting properties, thereby providing a significant advancement in the treatment of RF. We engineered and produced a multifunctional material, aminoethyl anisamide-poly(2-ethyl-2-oxazoline)-cholesterol hemisuccinate (APC)-with benefits including active targeting, prolonged circulation, and pH sensitivity. In vitro investigations demonstrated that in the high glucose-induced HK-2 cell fibrosis model, the absorption efficiency of APC-modified liposomes was markedly enhanced, effectively suppressing the expression of fibrotic and inflammatory factors. In two typical animal models of RF, namely diabetic nephropathy and glomerulonephritis, APC@Res demonstrated therapeutic advantages, including modulation of the TGF-β1/Smad3 signaling pathway to impede fibrosis, a notable reduction in oxidative stress levels, enhanced renal function parameters, and diminished expression of inflammatory and fibrotic markers. This study innovatively employs the renal microacidic environment and sigma1 targeting to develop an effective delivery system, offering a novel treatment strategy for reversing RF.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2026
·
IF 9.6
Muhammad Arif,Min He,N.A. Samreen,Hasi Hays,Ling Wang,Xiyuan Zhang,Bingqiang Zhang,Guotai Li,Tengbo Yu,Qihui Zhou
The increasing prevalence of antibiotic-resistant Helicobacter pylori (R- H. pylori ) poses a significant clinical challenge, contributing to persistent gastritis, peptic ulcers, and gastric cancer. Conventional antibiotic therapies are increasingly limited by resistance, incomplete eradication, and disruption of the gut microbiota. To address these challenges, we developed pH-responsive iron-doped ammonium citrate carbon dots (Fe-CDs), a nanozyme with intrinsic specificity for targeting and eradicating R- H. pylori within the acidic gastric microenvironment. Fe-CDs exhibit dual oxidase (OXD)- and peroxidase (POD)-like catalytic activities that are selectively activated under acidic conditions, driving the localized generation of reactive oxygen species (ROS) via Fenton and Fenton-like reactions involving Fe(II) and endogenous hydrogen peroxide (H₂O₂). The nanozyme shows strong binding affinity for H. pylori through ammonium (NH 4 + )-mediated interactions and specifically targets Urel, thereby inhibiting urease activity and disrupting bacterial acid resistance. This dual mechanism—acid-enhanced ROS production combined with urease suppression—confers potent bactericidal effects against R- H. pylori while preserving commensal microbiota and minimizing off-target damage. Transcriptomic analysis of infected gastric tissue revealed that Fe-CDs induce ROS-mediated stress pathways and metabolic disruption in H. pylori . In vivo studies confirmed that Fe-CDs significantly reduce bacterial load in R- H. pylori -infected mice with negligible toxicity. These findings highlight Fe-CDs as a targeted, antibiotic-free therapeutic strategy for resistant gastric infections and offer a promising alternative to conventional treatments.
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Gels
·
2026
·Vol. 12
·期 4
·284
·
IF 6.4
Chubin He,Xiuru Xu
A dual-mode electrical–optical nanocomposite hydrogel is developed by integrating carboxyl-modified upconversion nanoparticles (UCNPs-COOH) and quaternized chitosan (CQAS) into a polyacrylamide (PAAm) covalent network. The hydrogel exhibits high optical transparency (>90% in the visible region), excellent mechanical properties (fracture strain of 1742%, tensile strength of 0.85 MPa, toughness of 6.57 MJ/m3), and robust adhesion to various substrates. The synergistic covalent–noncovalent hybrid network enables efficient energy dissipation, while CQAS-enhanced dispersion of UCNPs significantly improves upconversion luminescence intensity and stability, as evidenced by prolonged fluorescence lifetime from 0.564 ms to 0.691 ms at 539 nm. Leveraging distinct electrical and optical signal transduction pathways, the hydrogel functions as a highly sensitive resistive strain sensor with multistage gauge factors up to 13.85 and excellent cyclic stability over 1200 loading–unloading cycles at 100% strain for human motion monitoring. It also serves as a ratiometric optical pH sensor over a broad range (pH 1–13) based on phenolphthalein-sensitized upconversion luminescence, with excellent repeatability. By integrating real-time resistance responses with optical readouts within a single soft material, this work demonstrates a reliable dual-mode sensing strategy for simultaneous mechanical and chemical monitoring, holding promise for wearable electronics, smart healthcare, and environment-responsive sensing systems.
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