Reaction Chemistry & Engineering
·
2025
·
IF 3.1
Xue Luo,Jiahui Liu,Danhui Li,Lili Zhao,Hualiang An
Cyclopentanone self-condensation to 2-cyclopentylidenecyclopentanone is one of the key steps in synthesizing high-density fuels. In this study, MgAl-LDO(NO3−) catalysts, prepared via coprecipitation, demonstrated good catalytic performance. Meanwhile, Mg2Al-LDO(NO3−) catalysts with different Mg/Al ratios were explored. Characterization by XRD, NH3-TPD and CO2-TPD revealed that Mg2Al-LDO(NO3−) possessed appropriate acid–base active sites, correlating with its enhanced catalytic performance. Under optimized reaction conditions, cyclopentanone conversion reached 85.9% with 98.8% selectivity toward 2-cyclopentylidenecyclopentanone. Furthermore, the reusability of the catalyst was investigated. XRD, SEM, and N2 adsorption–desorption analyses indicated that structural changes in the Mg2Al-LDO(NO3−) catalyst led to its deactivation. GC-MS analysis of the reaction system identified the primary by-product as 2,5-dicyclopentylidenecyclopentanone. Based on these findings, a plausible reaction network is proposed.
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ACS Infectious Diseases
·
2025
·
IF 3.8
Feifei Zhao,Yizhen Zhu,Lingxiang Mao,Honghao Huang,Wei Wei,Qiangcheng Deng,Youzhi Tang,Ning Han,Zhenling Zeng
Staphylococcus aureus poses a global threat to livestock health and public health security, necessitating a novel antibiotic. Pleuromutilin, a natural antibiotic, has served as a promising foundation for developing new antibacterial agents through structural modification. This study aims to evaluate the antibacterial potential, safety, and pharmacokinetic profile of a novel pleuromutilin derivative 2-3 (22-[2-(L-prolylamino)phenylsulfanyl]-22-deoxypleuromutilin). The compound 2–3 exhibited potent antibacterial activity (MIC = 0.25 μg/mL), concentration-dependent bactericidal effects, and prolonged post-antibiotic effects (PAEs). Safety assessments revealed low cytotoxicity (CC50 = 62.63 μg/mL) and no observable hemolytic activity. In vitro metabolic studies indicated species-dependent clearance, primarily mediated by CYP3A4. Pharmacokinetic in rats showed rapid absorption and elimination, with oral and intramuscular bioavailability of 16.03% ± 8.82% and 53.36% ± 12.27%, respectively. Notably, 2–3 demonstrated superior efficacy over tiamulin in a neutropenic murine thigh infection model. Molecular docking revealed a stronger binding free energy between 2–3 and the 50S ribosomal subunit compared to tiamulin. Collectively, these results highlight 2–3 as a promising clinical candidate against S. aureus infections, characterized by enhanced efficacy and a favorable safety profile.
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PubMed
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JOURNAL OF CHEMICAL RESEARCH
·
2016
·
IF 0.661
Hui-Long Zhu,Yu-Wei Liu,Wei-Wei Liu,Fu-Jun Yin,Zhi-Ling Cao,Juan Bao,Meng Li,Ling-Yan Qin,Da-Hua Shi
Four 5-benzyl-1,3,4-thiadiazol-2-amine derivatives were synthesised from phenylacetic acid derivatives. The structures of the 5-benzyl-1,3,4-thiadiazole derivatives were characterised by NMR spectroscopy and X-ray crystallography. The acetylcholinesterase-inhibition activities were also tested. Among the four compounds, 5- (4-bromobenzyl)-1,3,4-thiadiazol-2-amine showed the best acetylcholinesterase-inhibition activity with an IC50 of 49.86 μM. The docking study performed with AUTODOCK demonstrated that this compound could interact with the catalytic active site of acetylcholinesterase.
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Journal of Biobased Materials and Bioenergy
·
2016
·Vol. 10
·期 5
·378-384
·
IF 0.635
Chen Wei,Jiang Yetao,Sun Yong,Wang Yanjun,Li Zheng,Wang Xiaoyu,Zeng Xianhai,Liu Shijie,Lin Lu
5-Dimethylaminomethyl-2-Furanmethanol (DMMF) is an essential precursor for the production of ranitidine, a drug for gastropathy. Herein a facile pathway to the value-added pharmaceutical intermediate DMMF from carbohydrates, such as glucose and fructose, was developed for the first
time. The reaction was carried out under catalyst-free conditions using N, N-dimethyl formamide (DMF) as the amine donor in formic acid (FA). A plausible reaction mechanism from carbohydrates to DMMF was also proposed.
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高影响因子
GREEN CHEMISTRY
·
2016
·Vol. 18
·期 10
·3075-3081
·
IF 8.506
Dezhang Ren,Zhiyuan Song,Lu Li,Yunjie Liu,Fangming Jin,Zhibao Huo
A novel approach for the production of 2,5-hexanedione (HDN) and 3-methyl-2-cyclopenten-1-one (3-MCO) from 5-hydroxymethylfurfural (HMF) by water splitting with Zn is reported for the first time. The use of high temperature water (HTW) conditions is the key for the efficient conversion of HMF to HDN and 3-MCO. Parameters regarding the Zn amount, temperature and reaction time are optimized and HDN and 3-MCO are produced in 27.3% and 30.5% yields, respectively. The roles of HTW and ZnO obtained by oxidation of Zn in water for the conversion of HMF, together with intermediate structures, are discussed to understand the mechanism of the reaction.
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JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
·
2015
·
IF 1.648
Ye Tian,Benzhi Ju,Shufen Zhang,Xiuling Duan,Daopeng Dong
2-Hydroxy-3-butoxypropyl hydroxyethyl celluloses (HBPEC), which are thermoresponsive polymers, are prepared by grafting butyl glycidyl ether onto hydroxyethyl cellulose. The effects of several factors on the cloud point (Tc) of the HBPEC are also investigated. The Tc of HBPEC can be tuned to a ranging from 17.0 to 43.0 °C by changing the molar substitution of hydrophobic groups. Increasing the concentration of HBPEC leads to a faster phase transition as well as a corresponding linear decrease in the Tc. A series of salts with common anions or cations are used to investigate the effects of specific anions or cations on the Tc of HBPEC aqueous solutions. It is discovered that the Tc of HBPEC is largely influenced by the variation of cation identity and concentration. Plotting Tc as a function of cation activity shows that the Tc can be classified by charge density.
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PubMed
高影响因子
Frontiers in Chemistry
·
2018
·
IF 4.155
Jiang Zi-Min,Xu Ting-Ting,Yan Cong-Cong,Ma Cai-Yun,Dai Shu-Ge
Here, we report our finding in the fabrication of novel porous urchin-like Ni2/3Co1/3(CO3)1/2(OH)·0. 11H2O (denoted as NC) nanomaterial composed of numerous nanoneedles through an one-step hydrothermal method, which deliveres a high specific capacity of 318 C g−1 at a current density of 1 A g−1. Moreover, an architectural composite electrode consisting of the porous NC nanoneedles wrapped by reduced graphene oxide (rGO) nanosheets exhibits large specific capacity (431 C g−1 at 1 A g−1), high rate capability and long cycling life (94% capacity retention after 5,000 cycles at 20 A g−1). The presence of rGO in the composite electrode greatly improves the electronic conductivity, providing efficient current collection for fast energy storage.
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PubMed
高影响因子
Research
·
2023
·
IF 11
Guangchun Song,Jia Xu,Hong Zhong,Qi Zhang,Xin Wang,Yitong Lin,Scott P. Beckman,Yunbo Luo,Xiaoyun He,Jin-Cheng Li,Kunlun Huang,Nan Cheng
The enzyme-mimicking catalytic activity of single-atom nanozymes has been widely used in tumor treatment. However, research on alleviating metabolic diseases, such as hyperglycemia, has not been reported. Herein, we found that the single-atom Ce-N4-C-(OH)2 (SACe-N4-C-(OH)2) nanozyme promoted glucose absorption in lysosomes, resulting in increased reactive oxygen species production in HepG2 cells. Furthermore, the SACe-N4-C-(OH)2 nanozyme initiated a cascade reaction involving superoxide dismutase-, oxidase-, catalase-, and peroxidase-like activity to overcome the limitations associated with the substrate and produce •OH, thus improving glucose intolerance and insulin resistance by increasing the phosphorylation of protein kinase B and glycogen synthase kinase 3β, and the expression of glycogen synthase, promoting glycogen synthesis to improve glucose intolerance and insulin resistance in high-fat diet-induced hyperglycemic mice. Altogether, these results demonstrated that the novel nanozyme SACe-N4-C-(OH)2 alleviated the effects of hyperglycemia without evident toxicity, demonstrating its excellent clinical application potential.
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Optical Materials Express
·
2019
·Vol. 9
·期 9
·3835-3842
·
IF 2.673
Xianshun Lv,Xianshun Lv,Xianshun Lv,Ping Wang,Huajian Yu,Huajian Yu,Yanyan Hu,Yanyan Hu,Huadi Zhang,Huadi Zhang,Chengcheng Qiu,Chengcheng Qiu,Jing Li,Jing Li,Jing Li,Xuping Wang,Xuping Wang,Bing Liu,Bing Liu,Yuanyuan Zhang,Yuanyuan Zhang,Yuanyuan Zhang
A colorless crystal of Ba2Mg(BO3)2 about 37 × 25 × 17 mm3 has been grown successfully by the Kyropoulos method. Thermal analyses results show that Ba2Mg(BO3)2 melts congruently. The phase purity of the raw materials and the grown crystals were confirmed by powder X-ray diffraction. Ba2Mg(BO3)2 exhibits a low UV cutoff of 187 nm and high transmittance below 3000 nm. The refractive indices of the crystal have been measured and the the least-squares fitting method was used to obtain the Sellmeier dispersion equations. The results indicate that Ba2Mg(BO3)2 is a potential birefringence crystal with large birefringence of 0.10422 at 546 nm.
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JOURNAL OF LUMINESCENCE
·
2022
·
IF 4.171
Xueai Yin,Shuchen Lü
In this study, Sr 0.3 Ca 0.7 (MoO 4 ) 2 :xDy 3+ , yEu 3+ phosphors with and without charge compensation were produced using the coprecipitation method. Their crystal structure, luminescence performances, charge compensation, fluorescence lifetime , thermal extinguishing behavior as well as energy transfer mechanism were explored in detail. The X-ray diffraction patterns show that the appropriate amount of Dy 3+ /Eu 3+ single and co-doped in the lattice has no obvious influence on the crystal structure. The luminescence results showed that Sr 0.3 Ca 0.55 (MoO 4 ) 2 : 0.1Eu 3+ with charge compensation exhibited luminescence intensity 4.98 times higher than that of Sr 0.3 Ca 0.6 (MoO 4 ) 2 : 0.1Eu 3+ non-charge compensation. The luminescence intensity of Dy 3+ /Eu 3+ co-doped Sr 0.3 Ca 0.7 (MoO 4 ) 2 phosphors was significantly improved by charge compensation. Furthermore, efficient energy transfer from Dy 3+ → Eu 3+ was confirmed by emission spectra , excitation spectra, attenuation curves, and thermal quenching curves. This suggests that the charge compensation could significantly improve the Eu 3+ red emission. Therefore, the investigated SrCa(MoO 4 ) 2 : Eu 3+ , Dy 3+ phosphors may be a favorable candidate for promising applications in lighting.
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VACCINE
·
2025
·
IF 3.5
Yingjie Zhong,Huimin Yang,Wenqin Chai,Danyu Chen,Yannan Xue,Min Li,Xiongyan Meng,Shuai Meng,Jing-Ren Zhang,Chao Wu,Chengli Zong
Streptococcus suis serotype 2 (SS2) is a major zoonotic pathogen responsible for severe infections in both pigs and humans. Despite its clinical significance, no effective vaccine is currently available, and the influence of capsular polysaccharide (CPS2) structural features on host immunity remains unclear. Here, we identified a fast-growing SS2 strain from a panel of 40 clinical isolates and established a novel, reliable CPS2 purification method. This approach combines polyethylenimine-mediated nucleic acid precipitation with phenol-based protein denaturation, eliminating the need for column chromatography and enabling gram-scale CPS2 recovery per liter of culture while preserving structural integrity. To examine the role of sialic acid, we compared antibody responses induced by native and desialylated CPS2 conjugates in mice, which revealed no significant differences. Based on this finding, a native CPS2 conjugate vaccine was subsequently evaluated in pigs, where it induced robust IgG responses and conferred significant protection against virulent SS2 challenge. The effects of different adjuvants and dosages were also investigated. Collectively, these results establish an efficient CPS2 production platform, clarify the limited impact of sialic acid on conjugate-induced antibody responses, and highlight the potential of CPS2-based conjugates as promising vaccine candidates against SS2 infection.
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PubMed
高影响因子
Industrial Chemistry & Materials
·
2025
·
IF 11.9
Rongkai Cui,Minlei Yin,Xiaoyan Chen,Xiaoyu Lou,Chen Yang,Ting Qiu,Jie Chen
To achieve sub-angstrom separation of N-methylpyrrolidone and 1,5-dimethyl-2-pyrrolidone, cyclodextrin-derived carbon materials with distinct pore environments and surface functionalities were synthesized via hydrothermal carbonization and high-temperature pyrolysis. Three types of carbons were obtained: non-porous carbons rich in surface functionalities, carbons with both functionalities and microporous structures, and carbons with limited functionalities but diverse micropore environments. Systematic adsorption experiments, supported by density functional theory and molecular dynamics simulations, were conducted to establish the structure–performance relationships. The results demonstrate that surface functionalities alone are insufficient for separation, whereas pore confinement is the decisive factor. A 7.3 Å pore was identified as the optimal confinement space, providing the strongest thermodynamic interactions and the fastest diffusion kinetics, thereby enabling highly selective adsorption of 1,5-dimethyl-2-pyrrolidone from N-methylpyrrolidone. This work not only clarifies the pore formation mechanism of cyclodextrin-derived carbons but also highlights precise pore-size tuning as a paradigm for sub-angstrom molecular separation, offering theoretical guidance for the design of advanced adsorbent materials.
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