Nanoscale
·
2017
·Vol. 9
·期 22
·7391-7396
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IF 7.367
Qiang Jing,Mian Zhang,Xiang Huang,Xiaoming Ren,Peng Wang,Zhenda Lu
In recent years, there has been an unprecedented rise in the research of halide perovskites because of their important optoelectronic applications, including photovoltaic cells, light-emitting diodes, photodetectors and lasers. The most pressing question concerns the stability of these materials. Here faster degradation and PL quenching are observed at higher iodine content for mixed-halide perovskite CsPb(BrxI1−x)3 nanocrystals, and a simple yet effective method is reported to significantly enhance their stability. After selective etching with acetone, surface iodine is partially etched away to form a bromine-rich surface passivation layer on mixed-halide perovskite nanocrystals. This passivation layer remarkably stabilizes the nanocrystals, making their PL intensity improved by almost three orders of magnitude. It is expected that a similar passivation layer can also be applied to various other kinds of perovskite materials with poor stability issues.
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STROKE
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2024
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IF 7.8
Zimu Jiang,Jiating Wei,Jiahui Liang,Weixian Huang,Fubing Ouyang,Chunyong Chen,Pingping Li,Suhan Cao,Yuangui Cai,Jianle Li,Baozi Huang,Jinsheng Zeng,Yicong Chen
BACKGROUND:Remote secondary neurodegeneration is associated with poststroke cognitive impairment (PSCI). Dl-3-n-butylphthalide (NBP) improves PSCI clinically. However, whether it ameliorates PSCI by alleviating secondary neurodegeneration remains uncertain. Nonhuman primates provide more relevant models than rodents for human stroke and PSCI. This study investigated the effects of NBP on PSCI and secondary neurodegeneration in cynomolgus monkeys after permanent left middle cerebral artery occlusion (MCAO).METHODS:Thirteen adult male cynomolgus monkeys were randomly assigned to sham (n=4), MCAO+placebo (n=5), and MCAO+NBP groups (n=4). The MCAO+placebo and MCAO+NBP groups received saline and NBP injections intravenously, respectively, starting at 6-hour postsurgery for 2 weeks, followed by soybean oil and NBP orally, respectively, for 10 weeks after MCAO. Infarct size was assessed at week 4 by magnetic resonance imaging. Working memory and executive function were evaluated dynamically using the delayed response task and object retrieval detour task, respectively. Neuron loss, glia proliferation, and neuroinflammation in the ipsilateral dorsal lateral prefrontal cortex, thalamus, and hippocampus were analyzed by immunostaining 12 weeks after MCAO.RESULTS:Infarcts were located in the left middle cerebral artery region, apart from the ipsilateral dorsal lateral prefrontal cortex, thalamus, or hippocampus, with no significant difference between the MCAO+placebo and MCAO+NBP group. Higher success in delayed response task was achieved at weeks 4, 8, and 12 after NBP compared with placebo treatments (P<0.05), but not in the object retrieval detour task (all P>0.05). More neurons and less microglia, astrocytes, CD68-positive microglia, tumor necrosis factor-α, and inducible NO synthase were observed in the ipsilateral dorsal lateral prefrontal cortex and thalamus after 12 weeks of NBP treatment (P<0.05), but not in the hippocampus (P>0.05).CONCLUSIONS:Our findings indicate that NBP improves working memory by alleviating remote secondary neurodegeneration and neuroinflammation in the ipsilateral dorsal lateral prefrontal cortex and thalamus after MCAO in cynomolgus monkeys.
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Energy & Environmental Science
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2024
·
IF 32.4
Cong Liu,Anweng Gong,Chen Zuo,Tao Liu,Xiaoyang Liang,Donglou Ren,Kai Shen,Jianzha Zheng,Qifan Xue,Zhiqiang Li,Ruud E. I. Schropp,Bingsuo Zou,Yaohua Mai
High-quality heterojunctions are crucial for achieving high power conversion efficiency (PCE) in the antimony selenosulfide (Sb2(S,Se)3) solar cells. Here, we introduce lithium fluoride (LiF) doping of the precursor solution to improve the conductivity, morphology, and n-type characteristics of cadmium sulfide (CdS) films. In addition, Li-ions have high mobility, which enhances in situ diffusion into the Sb2(S,Se)3 absorber layer during subsequent hydrothermal deposition. Li effectively passivates selenium vacancies (VSe) and antimony anti-site (SbS) defects through the formation of Li–S(e) bonds. This lithiation process not only realizes a twofold optimization of the CdS buffer layer and the Sb2(S,Se)3 absorber layer, but also yields a favorable energy level arrangement and a wider depletion region at the CdS/Sb2(S,Se)3 heterojunction. By this way, we have achieved a champion PCE of 10.76% compared to a certified value of 10.50% for Sb2(S,Se)3 solar cells, which is the highest certified efficiency reported for Sb-based solar cells so far. This study provides a convenient method to optimize dual functional layers and heterojunctions for high-performance Sb2(S,Se)3 solar cells.
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Cell Discovery
·
2024
·Vol. 10
·期 1
·1-14
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IF 13
Li Hao,Du Yu,Cheng Kaiwen,Chen Yuxi,Wei Ling,Pei Yujun,Wang Xiaoyu,Wang Lan,Zhang Ye,Hu Xiaoxin,Lu Yi,Zhu Xiangjia
High myopia (HM) is a leading cause of blindness worldwide with currently no effective interventions available. A major hurdle lies in its often isolated perception as a purely ocular morbidity, disregarding potential systemic implications. Recent evidence suggests the existence of a gut-eye axis; however, the role of gut microbiota in the pathogenesis of HM remains largely unexplored. Herein, we provide a potential crosstalk among HM’s gut dysbiosis, microbial metabolites, and scleral remodeling. Utilizing 16S rRNA gene sequencing, we observed an altered gut microbiota profile in HM patients with a significant reduction in probiotic abundance compared with healthy controls. Subsequent targeted metabolic profiling revealed a notable decrease in plasma levels of the gut microbiota-derived metabolite indole-3-acetic acid (3-IAA) among HM patients, which is closely associated with the reduced probiotics, both negatively correlated with HM severity. Genetic analyses determined that gut microbiota are causally associated with myopia risk. Importantly, when mice subjected to HM modeling receive fecal microbiota transplantation from healthy donors, there is an increase in 3-IAA plasma levels and simultaneous retardation of HM progression along with better maintenance of collagen type I alpha 1 (COL1A1) expression in the sclera. Furthermore, 3-IAA gavage achieves similar effects. Mechanistic investigations confirm the transcriptional activation of COL1A1 by 3-IAA via promoting the enrichment of SP1 to its promoter. Together, our findings provide novel insights into the gut microbiota-eye axis in the pathogenesis of HM and propose new strategies for HM intervention by remodeling the gut microbiota and indole supplementation.
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FOOD CHEMISTRY
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2024
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IF 8.5
Liumei Wu,Dongming Li,Fuyang Bi,Chao Yu,Yufei Zhang,Mingming Zheng
A novel Pickering interfacial biocatalysis (PIB) system has been, for the first time, successfully applied for the enzymatic selective hydrolysis of algae oils and fish oils to enrich n-3 PUFAs glycerides. Lipase AY 400SD was identified and adsorbed on hydrophobic hollow core-shell silica nanoparticles, resulting in the formation of the immobilized enzyme AY 400SD@HMSS-C 18 . The biocatalyst was employed as an emulsifier to stabilize the water-in-oil Pickering emulsion, resulting in the successful construction of the PIB system. The newly developed PIB system resulted in a notable enhancement of the n-3 PUFAs content of the six oils, with a mean increase ranging from 9.17 % to 23.09 %, and with the recovery rate of n-3 PUFAs exceeded 90 %. The platform demonstrated to be stable and recyclable. The present research illustrated that the PIB has the potential to be a viable alternative for the purpose of enhancing the content of n-3 PUFAs in glycerides.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-11
·
IF 14.7
Qin Shaojie,Zhang Yi,Shi Mingying,Miao Daiyu,Lu Jiansen,Wen Lu,Bai Yu
Comprehensive single-cell metabolic profiling is critical for revealing phenotypic heterogeneity and elucidating the molecular mechanisms underlying biological processes. However, single-cell metabolomics remains challenging because of the limited metabolite coverage and inability to discriminate isomers. Herein, we establish a single-cell metabolomics platform for in-depth organic mass cytometry. Extended single-cell analysis time guarantees sufficient MS/MS acquisition for metabolite identification and the isomers discrimination while online sampling ensures the high-throughput of the method. The largest number of identified metabolites (approximately 600) are achieved in single cells and fine subtyping of MCF-7 cells is first demonstrated by an investigation on the differential levels of 3-hydroxybutanoic acid among clusters. Single-cell transcriptome analysis reveals differences in the expression of 3-hydroxybutanoic acid downstream antioxidative stress genes, such as metallothionein 2 (MT2A), while a fluorescence-activated cell sorting assay confirms the positive relationship between 3-hydroxybutanoic acid and target proteins; these results suggest that the heterogeneity of 3-hydroxybutanoic acid provides cancer cells with different ability to resist surrounding oxidative stress. Our method paves the way for deep single-cell metabolome profiling and investigations on the physiological and pathological processes that occur during cancer.
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JOURNAL OF HAZARDOUS MATERIALS
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2024
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IF 12.2
Puyue Liu,Yiming Dong,Xiaoxuan Li,Yu Zhang,Zhi Liu,Yingying Lu,Xuewen Peng,Ruifang Zhai,Yiping Chen
The misuse and overuse of chloramphenicol poses severe threats to food safety and human health. In this work, we developed a magnetic solid-phase extraction (MSPE) pretreatment material coated with a multilayered metal – organic framework (MOF), Fe 3 O 4 @ (ZIF-8) 3 , for the separation and enrichment of chloramphenicol from fish. Furthermore, we designed an artificial-intelligence-enhanced single microsphere immunosensor. The inherent ultra-high porosity of the MOF and the multilayer assembly strategy allowed for efficient chloramphenicol enrichment (4.51 mg/g within 20 min). Notably, Fe 3 O 4 @ (ZIF-8) 3 exhibits a 39.20% increase in adsorption capacity compared to Fe 3 O 4 @ZIF-8. Leveraging the remarkable decoding abilities of artificial intelligence, we achieved the highly sensitive detection of chloramphenicol using a straightforward procedure without the need for specialized equipment, obtaining a notably low detection limit of 46.42 pM. Furthermore, the assay was successfully employed to detect chloramphenicol in fish samples with high accuracy. The developed immunosensor offers a robust point-of-care testing tool for safeguarding food safety and public health.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2018
·
IF 2.196
Xiangyu Zhang,Neng Gao,Yongping Wu,Guangming Chen
To improve the performance of an absorption system, ionic liquids (ILs) have been chosen as additives to conventional working fluid (lithium bromide aqueous solution) in recent years. In this paper, 1-ethyl-3-methylimidazolium acetate ([Emim]Ac) was added to lithium bromide aqueous solution (mass ratio LiBr/[Emim]Ac = 3) to measure the vapor–liquid equilibrium (VLE) data of the ternary system. The experiment was conducted by means of boiling point method, at temperatures between 303.94 K and 405.41 K and mass fractions of absorbent between 0.20 and 0.60. The experimental data were regressed using an Antoine-type equation, and the average absolute relative deviation (AARD%) between the experimental and calculated values was 0.34%, which showed excellent accuracy and consistency. The experimental ternary system was compared with the conventional LiBr + H2O system and two other ternary systems from the literature; the result revealed that the experimental ternary system had lower vapor pressures, which will benefit the process of releasing latent heat in absorption cycles.
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JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
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2024
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IF 4.1
Ting Yu,Ying Liang,Zejun Zhou,Fengjie Chen,Yingjun Wang,Yunjun Mei,Mengxi Cao,Bolei Chen,Pu Wang,Yawei Wang
The photocatalytic generation of hydrogen peroxide (H 2 O 2 ) using artificial synthetic methods is promising. However, the sluggish hole-induced water oxidation half-reaction that hinders charge separation severely limits H 2 O 2 generation efficiency. This study used the oxidation half-reaction of tetracycline (C 22 H 24 N 2 O 8 , TC) to accelerate charge separation over GaOOH/In(OH) 3 composites with Type II heterojunctions under sunlight irradiation to increase the H 2 O 2 generation efficiency. The results demonstrated that the H 2 O 2 generation efficiency significantly increased from 74.7 to 389.8 µmol L −1 h −1 as the TC degradation efficiency increased from 0.02 to 0.37 mg L −1 h −1 . Radical quenching experiments further indicated that TC degradation consumed holes, increasing the electron formation rate and enhancing H 2 O 2 generation. A comparison with density functional theory calculations revealed that H 2 O 2 generation was a one-step 2-electron route (O 2 + 2e − + 2H + → H 2 O 2 ). These findings are expected to provide new strategies for promoting photocatalytic synthesis of H 2 O 2 .
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JOURNAL OF FOOD COMPOSITION AND ANALYSIS
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2024
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IF 4
Jing Liang,Yu Ya,Dejiao Ning,Cuiwen Jiang,Yanli Wang,Liping Xie,Xiaochuan Huang,Tao Li,Li Tang,Feiyan Yan
Copper (II) (Cu 2+ ) and 3-nitropropionic acid (3-NPA) are harmful substances usually found in foods. Therefore, establishing rapid, sensitive, and accurate detection method for both of these substances is significant research work. A pyrene-based fluorescent sensor (PP) was synthesized to enable highly selective and sensitive simultaneous detection of Cu 2+ and 3-NPA in food samples. Initially, PP showed weak fluorescence because of the photo–induced electron transfer process (PET). Upon the presence of Cu 2+ , the emission of PP at 454 nm enhanced owing to the coordination between PP and Cu 2+ which hindered the PET. Additionally, under 365 nm UV irradiation, the color of the PP solution transitions from orange to bright blue, allowing for naked-eye detection. The sensor PP demonstrated high selectivity and sensitivity toward Cu 2+ compared to other competitive metal ions, with the detection limit was 0.036 μM, within a linear range of 0–20 μM. The binding stoichiometry between PP and Cu 2+ is determined to be 2:1 using the Job’s plot method, with a binding constant (K a ) of 7.2 ×10 3 M −1/2 . Furthermore, at lower pH (in the range 2.55–5.98), the emission of PP was also enhanced due to the protonation of PP which suppresses the PET process. Given its sensitive and linear response to acidic pH, PP exhibits excellent sensing performance for detecting 3-NPA, with a low detection limit of 0.32 μM, surpassing previously reported methods in terms of detection sensitivity.
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BIORESOURCE TECHNOLOGY
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2012
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IF 4.98
Yongshui Qu,Chongpin Huang,Yanlei Song,Jie Zhang,Biaohua Chen
The dehydration of fructose or glucose to 5-hydroxymethylfurfural (5-HMF) using room temperature ionic liquids (ILs) as a solvent is a promising method for producing liquid fuels from renewable resources . The IL, 1-hydroxyethyl-3-methylimidazolium tetrafluoroborate ([C 2 OHMIM]BF 4 ), was used a catalyst—rather than as a solvent—in the conversion of fructose or glucose to 5-HMF. With glucose, the yield of 5-HMF reached as high as 67.3% after 1 h at 180 °C in dimethylsulfoxide (DMSO) as solvent. The catalyst was separated from the reaction mixture by distilling solvent and reused six times without loss of activity. Furthermore, a kinetic analysis was carried out to illustrate the formation of 5-HMF, and the values of the activation energy and the pre-exponential factor for the reaction were 55.77 kJ mol –1 and 1.6 × 10 4 min –1 respectively.
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INORGANIC CHEMISTRY
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2024
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IF 4.3
Ya-Lan Deng,Chun-Li Hu,Jiang-Gao Mao
The π-conjugated [C3H6+xN6]x+ (x = 0–3) cations are good functional groups, which are widely employed in the preparations of nonlinear optical (NLO) and birefringent materials due to their high hyperpolarizability and optical anisotropy. In this paper, the first melamine hydroxyborate [C3H7N6]3[B3O5(OH)2] (MelBO-I) was synthesized by the boric acid melting method under the molar ratio of H3BO3:C3H6N6 = 1:1. MelBO-I (P21/c) exhibits a two-dimensional (2D) {[C3H7N6]3[B3O5(OH)2]}∞ layer composed of [C3H7N6]+ cations and [B3O5(OH)2]3– anions interconnected via hydrogen bonds. MelBO-I exhibits significant birefringence (Δn = 0.286@546 nm). Under the molar ratio of H3BO3/C3H6N6 = 3:1, [C3H8N6]4[B12O19(OH)6] (MelBO-II) was isolated. In MelBO-II (P21), highly polymerized [B12O19(OH)6]8– groups form a 3D network through hydrogen bonding, featuring 1D tunnels of 8-membered and 16-membered rings filled by [C3H8N6]2+ cations. MelBO-II is the first noncentrosymmetric (NCS) bifunctional melamine borate with a moderate SHG response (0.4 × KDP) and large birefringence (Δn = 0.285@546 nm). The results indicate that incorporating [C3H6+xN6]x+ (x = 0–3) cations into borate can effectively induce birefringence. A high concentration of boric acid promotes the formation of large boric acid cluster anions and facilitates the transformation from the CS to NCS structure.
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