Biomaterials Research
·
2023
·Vol. 27
·期 1
·1-20
·
IF 11.3
Fu Shiyao,Wang Mingao,Li Bin,Li Xu,Cheng Jianjun,Zhao Haitian,Zhang Hua,Dong Aijun,Lu Weihong,Yang Xin
Background Multi-component nano-delivery systems based on chemotherapy (chemo)- photodynamic therapy (PDT)- chemodynamic therapy (CDT) have gained increased attention as a promising strategy to improve clinical outcomes in cancer treatment. However, there remains a challenge in developing biodegradable, biocompatible, less toxic, yet highly efficient multicomponent nanobased drug delivery systems (DDS). Here, our study presents the screening and development of a novel DDS based on co-assemblies natural small molecule (NSMs). These molecules (oleanolic acid, and betulinic acid) are combined with photosensitizers Chlorine6 (Ce6) and Cu 2+ that are encapsulated by tumor cell membranes. This nanocarrier encapsulated in tumor cell membranes achieved good tumor targeting and a significant improvement in tumor accumulation. Methods A reprecipitation method was used to prepare the co-assembled nanocarrier, followed by the introduction of Cu 2 + into the DDS (OABACe6 NPs). Then, by wrapping the surface of NPs with the cell membranes of 4T1 which is a kind of mouse breast cancer cells (CM@OABACe6/Cu NPs). and analysis of its structure and size distribution with UV–Vis, XPS, FT-IR, SEM, TEM, and DLS. The synergistic effects of in vitro chemotherapy, CDT and PDT and targeting were also validated by cellular and animal studies. Results It was shown that CM@OABACe6/Cu NPs achieved good tumor targeting and a significant improvement in tumor accumulation. In the composite nano-assembly, the NSMs work together with the Ce6 to provide effective and safe chemo and PDT. Moreover, the effect of reduced PDT due to the depletion of reactive oxygen species (ROS) by excess glutathione (GSH) in the tumor can be counteracted when Cu 2 + is introduced. More importantly, it also confers CDT through a Fenton-like catalytic reaction with H 2 O overexpressed at the tumor site. Conclusions By constructing CM@OABACe6/Cu NPs with homologous targeting, we create a triple synergistic platform for cancer therapy using PDT, chemo, and CDT. We propose here a novel combinatorial strategy for designing more naturally co-assembled small molecules, especially for the development of multifunctional synergistic therapies that utilize NSMs.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Pharmaceutics
·
2023
·Vol. 15
·期 5
·1500
·
IF 5.4
Yi Lu,Ting Xiao,Rongrong Lai,Ziyi Liu,Weixuan Luo,Yixuan Wang,Shijia Fu,Guihong Chai,Jinjing Jia,Yuehong Xu
Rheumatoid arthritis (RA) is an autoimmune disease of synovial inflammation that affects populations worldwide. Transdermal drug delivery systems for treating RA have increased but remain challenging. We fabricated a dissolving microneedle (MN) system with photothermal (PT) polydopamine (PDA) to co-load the non-steroidal anti-inflammatory drug loxoprofen (Lox) and the Janus kinase inhibitor tofacitinib (Tof), with the aim of co-delivering Lox and Tof directly to the articular cavity, aided by the combination of MN and PT. In vitro and in vivo permeation studies showed that the PT MN significantly promoted drug permeation and retention in the skin. An in vivo visualization of the drug distribution in the articular cavity showed that the PT MN significantly promoted drug retention in the articular cavity. Importantly, compared to the intra-articular injection of Lox and Tof, the application of the PT MN to a carrageenan/kaolin-induced arthritis rat model exhibited superior performance in reducing joint swelling, muscle atrophy, and cartilage destruction. Furthermore, the PT MN downregulated the mRNA expression levels of proinflammatory cytokines, including TNF-α, IL-1β, iNOS, JAK2, JAK3, and STAT3. The results show that the PT MN transdermal co-delivery of Lox and Tof is a new synergetic therapy with high compliance and good therapeutic efficacy for RA.Keywords:loxoprofen;tofacitinib;microneedle;photothermal therapy;rheumatoid arthritis
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
·
2023
·
IF 6.1
Yun Xue,Yue-Lin Wang,Yu Li,Wen-Da Xu,Fu-Qiu Ma,Yang-Hai Zheng,Qing-Guo Zhang,Zhi Zhang,Mi-Lin Zhang,Yong-De Yan
Cation exchange resins (CERs) are widely applied to purify waste liquids generated during the operation of nuclear reactors. The radioactive nuclides 60 Co and 58 Co are important corrosion activation products in reactor cooling water. In this study, the simulated Co doped CERs were oxidized with ternary carbonate. According to the thermogravimetric analysis (TG), the decomposition of Co doped CERs includes three processes: 1. Elimination of the osmotic water; 2. Pyrolysis of sulfonic acid group; 3. Destruction of styrene–divinylbenzene copolymer . The X-Ray Diffraction (XRD) patterns indicate that sulfur mainly exists in the form of sulfate in waste salt. The Co 2+ undergoes the path of CoS 2 → Co 3 O 4 with the increase of temperature and the transition point is 650 °C. Combined with Fourier Transform Infrared Spectrometer (FT-IR) spectra and X-ray Photoelectron Spectroscopy (XPS) analysis, sulfonic acid groups begin to decompose at 350 °C. During the molten salt oxidation process , most of the sulfur in sulfonic acid groups is entrapped by carbonate as the form of sulfate, and a little of which remains as sulfone group, sulfoxide group and sulfur bridge in residue. When the resins are oxidized at 800 °C, the retention rate of Co 2+ is 97.3%, indicating that the molten salt oxidation can effectively remain Co 2+ and convert it into a more stable substance.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2023
·
IF 9.9
Zheng-Xue Wu,Le-Qing Fan,Jiao-Juan Chen,Xu-Geng Deng,Tao Tang,Yun-Fang Huang,Ji-Huai Wu
Ternary metal sulfides employed in supercapacitors exhibit better electrochemical performances than their counterpart oxides due to their superior conductivity. However, the insertion/extraction of electrolyte ions can lead to a significant volume change in electrode materials , which can result in poor cycling stability. Herein, novel amorphous Co-Mo-S nanospheres were fabricated through a facile room-temperature vulcanization method. It involves the conversion of crystalline CoMoO 4 by reacting it with Na 2 S at room temperature . In addition to the conversion of the crystalline state into an amorphous structure with more grain boundaries, which is beneficial for the transport of electron/ion and can accommodate the volume change generated by the insertion/extraction of electrolyte ions, the production of more pores led to an increased specific surface area. The electrochemical results indicate that the as-prepared amorphous Co-Mo-S nanospheres had a specific capacitance of up to 2049.7F/g@1 A/g together with good rate capability. The amorphous Co-Mo-S nanospheres can be used as the cathode of supercapacitors and assembled with an activated carbon anode into an asymmetric supercapacitor possessing a satisfactory energy density of 47.6 Wh kg −1 @1012.9 W kg −1 . One of the prominent features exhibited by this asymmetric device is its remarkable cyclic stability, with a capacitance retention of 107% after 10,000 cycles.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Sustainable Chemistry & Engineering
·
2023
·
IF 8.4
Zhiren Wang,Kexia Jin,Khak Ho Lim,Pingwei Liu,Dan Lu,Xuan Yang,Wen-jun Wang
The enhancement of mechanical properties is highly required for the expanded applications of biodegradable polymers like poly(butylene adipate-co-terephthalate) (PBAT). The use of nanocellulose as reinforcing fillers is one of the effective approaches while preserving the biodegradability of polymers, but the dispersion of nanofibers in polymer matrixes is a great challenge. Here, we report an in situ fibrillation method to prepare nanocellulose-reinforced PBAT composite films with superior mechanical properties and enhanced degradability while promoting the easy dispersion of natural plant fibers in the polymer matrix, which overcome the limitation of natural fiber composites for thin film applications. A hemicellulose-rich holocellulose fiber was selected and silanized prior to melt compounding with PBAT, in which in situ fibrillation of fibers and the dispersion of in situ fibrillated cellulose nanofibrils (CNFs) occurred simultaneously. The nanostructure, mechanical properties, and degradability of the resulting composite films were characterized. Compared with pristine PBAT, the incorporation of 1 wt % CNF fillers increased the tensile modulus by 82% while possessing a tensile strength of 26 MPa, an elongation of 372%, and a toughness of 75 MJ/m3, surpassing most reported data. Moreover, the degradability of PBAT was enhanced as well. Altogether, this study paves a new way of making biodegradable nanocomposites, which expand the application areas, especially where films are required.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2023
·
IF 5
Jing Su,Weijia Lu,Yexuan Guo,Zhuoyi Liu,Xu Wang,Hong Yan,Rui Xue Zhang
Periocular routes represent a promising approach to chronic eye therapy due to its unique exploitation of scleral structure. Especially, for ophthalmic infection requiring prolonged medication, sclera-traversing dosage forms capable of co-delivery of multiple drugs are highly desirable. Herein, phosphatidylcholine-based liposomes co-loading water soluble steroid dexamethasone and antibiotics moxifloxacin (LIP-DM) was developed for transscleral delivery of dual drugs. The size, mono-dispersity and drug entrapment of LIP-DM prepared by microfluidics were highly influenced by varying amounts of lipid composition. Final LIP-DM composing 63mol% phospholipid and 37mol% cholesterol was characterized of colloidal stable unilamellar structure with sub-100 nm size and entrapment of 0.412 mg and 1.21 mg for dexamethasone and moxifloxacin, respectively. Transport of LIP-DM using rabbit scleral tissues showed time-dependent particle penetration and accumulation from episcleral to intraocular side. Compared to immediate release of drugs in solution, LIP-DM exhibited differential release of dual drugs with fast antibiotics release and slow steroid release within 1 day, which in turn increased the transscleral contact time yet maintained effective permeability of dual drugs, leading to the rapid bacteriostatic onset and enhanced inhibition of proinflammatory cytokines in human retinal pigment epithelial cells. The results highlight liposomes as a potential transscleral depot of drug combination for the long-term vision care.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2023
·
IF 9.9
Yan An,Xiaoping Hu,Xinyu Wang,Jian Tian
Solar energy conversion into hydrogen (H 2 ) energy has attracted much attention. However, the low light utilization rate and fast carrier recombination of photocatalysts extremely limit the practical application of photocatalytic H 2 production. In this paper, MoSe 2 -NiSe with abundant active sites and interfacial electronic structures as dual co-catalysts were assembled on g-C 3 N 4 nanosheets (NSs) vis a solvothermal reaction process. MoSe 2 -NiSe/g-C 3 N 4 NSs composite exhibited improved light absorption and photoelectrochemical properties. The photocatalytic H 2 production rate of MoSe 2 -NiSe/g-C 3 N 4 composite achieved 2379.04 μmol·h −1 ·g −1 , which is 99.25, 1.44, and 3.67 times those of pure g-C 3 N 4 nanosheets (23.97 μmol·h −1 ·g −1 ), MoSe 2 /C 3 N 4 (1654.57 μmol·h −1 ·g −1 ), and NiSe/C 3 N 4 (649.08 μmol·h −1 ·g −1 ), respectively. The apparent quantum efficiency (AQE) value of MoSe 2 -NiSe/g-C 3 N 4 achieved 4.07 % under light at λ = 370 nm. The corresponding characterization and experiments proved that 2D ultrathin g-C 3 N 4 NSs with a large surface area and short charge-transfer distance could facilitate light scattering and the transport of photoexcited electrons. MoSe 2 -NiSe, as a dual co-catalyst, showed strong electronic synergistic interaction between the interfaces, thus improving the conductivity and promoting the electron transfer process.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MRS Communications
·
2023
·Vol. 13
·期 4
·538-545
·
IF 1.9
Yin Jinkun,Chu Yaoqing,Tan Lianjiang
Cu/N co-doped TiO 2 nanopowder was prepared with a facile sol–gel method. In the absence of stabilizing agents, the co-doped nanopowder with nanoscaled particle sizes was obtained. Doping didn’t change the anatase crystal structure of TiO 2 . Cuprite Cu 2 Cl(OH) 3 formed in the co-doped nanopowder. Based on ultraviolet–visible (UV–vis) spectroscopy and X-ray photoelectron spectroscopy (XPS) data, the mechanisms of significantly improved photocatalytic activity of the co-doped nanopowder were discussed. The antibacterial evaluation and cytotoxicity test suggested the nanopowder inhibited bacteria significantly under visible light and had ultralow cytotoxicity. This work provided a promising antibacterial agent with potential biomedical applications.
Graphical abstract
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2023
·
IF 7.2
Yuelong Xu,Jingyue Wang,Shasha Wang,Zuozhao Zhai,Bin Ren,Zhi Tian,Lihui Zhang,Zhenfa Liu
Multifunctional electrocatalysts are desirable for overall water splitting and zinc-air batteries. In this work, N, S co-doped carbon nanotubes (CNT-NS) with a plentiful of defects were obtained through a novel molecular-level codoped and lattice defect construction method. Thiamine hydrochloride and thiocarbamide were adopted as new precursors in situ doping N and S into multi-walled CNTs surfaces, and lattice defects were constructed by in situ chemical etching using ammonium chloride and ammonium bicarbonate . These surface defects and N,S biatom co-doping synergistic effects can accumulate the CNT-NS to exhibit the superior behavior for electrocatalysis of water splitting and zinc-air batteries. The overpotential for overall water splitting was 1.61 V and the specific capacity for zinc-air batteries was 781 mA h g −1 , which was superior to previous works. According to the Operando Raman spectroscopy measurements, the S atoms can serve as the intrinsic catalytic sites for HER and OER , and the defective CNT structures could enhance the catalytic kinetics by the electron-transfer process. Further, density functional theory (DFT) results also indicated the contribution of binary atoms co-doping for low ΔG H∗ values. Therefore, this work provides the valuable reference for rational design/construction for metal-free catalysts of overall water splitting.
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Peng Liu,Jianyue Yan,Hao Huang,Wenbo Song
Electrochemical reduction of nitrate to ammonia is an eco-friendly strategy to remove the nitrate pollution in waste effluents. Developing new-type electrocatalysts with high activity for NO 3 RR has attracted worldwide attention. Owing to the numerous active single-metal sites, electric conductivity and ordered in-plane porous structure, conductive metal–organic frameworks (cMOFs) are promising alternative to construct the next-generation NO 3 RR electrocatalysts. In this work, a bimetallic cMOF (Cu x Co y HHTP) is proposed for efficient NO 3 – electroreduction to ammonia and the synergy effect between different types of single-metal sites is also revealed. As the result, the optimal Cu 1 Co 1 HHTP exhibits an outstanding electrocatalytic activity with a high NH 3 yield rate of 299.9 μmol h −1 cm −2 and a large Faradic efficiency of 96.4%. Both theoretical and experimental results reveal that the Co sites can affect the electron structure of Cu sites in Cu 1 Co 1 HHTP slab and decrease the ΔG of potential determining step in NO 3 RR process. Moreover, the Co sites bring a higher selectivity to Cu active sites for reducing *NO 2 to *NO, rather than the desorption of NO 2 – . The bimetallic c-MOFs strategy will innovate the design concept of next-generation catalyst, paving the way to investigate catalytic mechanism of single-metal-atom and open up their application prospects.
✓ 已验证
产品关联
DOI
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2023
·
IF 6.6
Haiyan Zhang,Zhiguang Xu,Tao Zhang,Yan Zhao
Superhydrophobicity and hygroscopicity are two properties that are theoretically exclusive to each other. The fabrication of functional fabrics with these two properties remains very challenging. In this work, it is demonstrated that a non-sticky superhydrophobic and hygroscopic fabric coating can be prepared via the photo polymerization of hexadecyl acrylate and methacrylic acid. On coating surface , the phase-separation-induced chemical heterogeneity has a unique feature of possessing elevated continuous hydrophobic domain and depressed hydrophilic domain, as evidenced by atomic force microscopy measurement. The elevation of hydrophobic domain (i.e., depression of hydrophilic domain) allows the hydrophilic domain to make negligible contribution to the surface wettability to water drop, but can absorb water molecules, thus inducing the unique superhydrophobic but hygroscopic property. The coating has a very low total surface energy of 22.61 mN m −1 , with its polar part (0.01 mN m −1 ) being negligible, thereby showing a high static water contact angle of ~112° on flat glass slide. The coated polyester fabric shows a non-sticky superhydrophobicity with a static water contact angle of ~151° and a water shedding angle of ~10°, as well as good hygroscopic and anti-static properties. We anticipate that this novel coating and the reported strategy of generating the particular chemical heterogeneity may lead to the development of advanced special wettability coatings for various applications.
✓ 已验证
产品关联
DOI
高影响因子
Acta Biomaterialia
·
2023
·
IF 9.7
Zaixiang Fang,Ling Lin,Zhiqian Li,Lei Gu,Dayi Pan,Yunkun Li,Jie Chen,Haitao Ding,Xiaohe Tian,Qiyong Gong,Kui Luo
The combination of chemotherapy and photodynamic therapy (PDT) has the potential to complement single-drug therapies, but chemotherapeutic agents and photosensitizers often have compromised therapeutic efficacies and strong toxic effects. In this study, we exploited nanotechnology to address this challenge by utilizing heparin as a carrier for co-delivery of chemotherapeutic drugs and photosensitizers for synergistic cancer therapy. Specifically, heparin-paclitaxel (HP-PTX) and heparin-pyropheophorbide-a (HP-Ppa) were synthesized by attaching paclitaxel (PTX), a small molecular chemotherapeutic drug, through a reactive oxygen species (ROS)-responsive linker and Ppa, a photosensitizer, to heparin, respectively. Two conjugates were co-assembled into a nanomedicine , HP-PP nanoparticles (NPs), for controllable co-delivery of Ppa and PTX into tumor cells. HP-PP NPs significantly enhanced the in vitro stability of HP-Ppa and the photostability of Ppa, and the synergistic actions of chemotherapy and PDT were confirmed by both in vitro and in vivo antitumor studies. Notably, HP-PP NPs enhanced tumor accumulation of Ppa up to 11-fold and the treatment of 4T1 tumor-bearing mice with HP-PP NPs resulted in a tumor growth inhibition of 98.1% without systemic toxicity. The strategy of co-assembly of heparin conjugates may offer great potential in enhancing the efficacy of combination therapy. Statement of significance We proposed a nano-delivery system, HP-PP NPs, which was constructed by co-assembly of heparin-paclitaxel (HP-PTX) and heparin-pyropheophorbide-a (HP-Ppa), to co-deliver PTX and Ppa for synergistic cancer therapy. HP-PP NPs enhanced the photostability and the in vitro stability of Ppa and HP-Ppa, and induced greater cytotoxicity than HP-PTX NPs or HP-Ppa NPs. This co-delivery system displays enhanced tumor accumulation and has a remarkable synergistic antitumor effect with a tumor growth inhibition of 98.1%.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）